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WO/2005/021481A1 |
Provided is, N,N’-dibentzyl ethylenediamine salt of 2-(alpha-hydroxypentyl) benzoic acid, which has significant effect in inhibitting blood platelet aggregation and improving cerebral circulation, the pharmaceutical activity against ca...
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WO/2005/012221A1 |
A compound represented by the general formula (I): (wherein rings A, B, and D each independently represents an optionally substituted cyclic group; W represents a spacer whose main chain has 1 to 8 atoms; X represents a spacer whose main...
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WO/2005/000781A1 |
The present invention relates to compounds of formula (1) wherein R1, R2 , R3 , R4 , m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof and to pharmaceutical compositions thereof. Th...
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WO/2004/103074A1 |
Compounds are described, having general formula (I): A . Cu wherein A represents the bibasic ion of an organic acid which can have the meanings (A1) - (A8) and Cu represents the copper 2+ ion; and the use of compounds having formula (I),...
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WO/2004/099280A2 |
This invention concerns a process for the manufacture of a press molded material, comprising applying diisocyanate, polyol, and catalyst to a wood material, wherein the catalyst is a tertiary amine-carboxylic acid salt that is blocked at...
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WO/2004/099279A2 |
This invention concerns a compound formed from a tertiary amine-carboxylic acid salt, where the carboxylic acid and tertiary amine are selected such that the catalyst salt is blocked at room temperature and becomes unblocked at an elevat...
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WO/2004/092344A2 |
A biocatalytic method for preparing para-hydroxystyrene from para-hydroxycinnamic acid is described. The method uses an enzyme source having para-hydroxycinnamic acid decarboxylase activity to catalyze the decarboxylation of para-hydroxy...
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WO/2004/092249A1 |
The invention relates to a deuterated polyimide whose skeleton comprises an alternation between at least one repeating unit of the formula (I), wherein Y is a single linkage or a spacer group and at least one repeating unit of the follow...
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WO/2004/092392A2 |
Methods are provided for the production and recovery of multifunctional aromatic compounds from a fermentation medium. Preferred multifunctional aromatic compounds include para-hydroxycinnamic acid (pHCA), cinnamic acid (CA), and para-hy...
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WO/2004/089885A1 |
The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
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WO/2004/084631A1 |
Disclosed are compounds of formula (I) or the salts thereof, wherein R1 represents carboxy or a derivative of the carboxyl group, preferably a radical of formula -CN, -C(=X)-Y-R, or -C(=X)-Het wherein X represents a divalent radical of f...
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WO/2004/080377A2 |
This invention relates to compounds of the general formula (I) useful as modulators of the KCNQ channel, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.
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WO/2004/073611A2 |
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, artherosclerosis and arteriosclerosis are disclosed. Formula (I) where...
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WO/2004/069782A2 |
Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8...
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WO/2004/067489A2 |
The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Dis...
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WO/2004/063148A1 |
The present invention relates to a compound of the formula ((I): in which: n is an integer chosen from 1, 2 and 3; Y represents O; N-OR9, in which R9 represents H or a saturated hydrocarbon-based aliphatic group; CR10R11, in which R10 an...
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WO/2004/058747A1 |
The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention ...
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WO/2004/058679A2 |
Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1,...
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WO/2004/054956A1 |
A method for producing a carboxylic acid, which comprises reacting an aldehyde-containing oily solution with an aqueous hydrogen peroxide solution in the presence of a catalyst comprising a polymer compound having a sulfonic acid group i...
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WO/2004/048309A1 |
The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1a,25 dihydroxy vitamin D3. These compounds are useful for treating bone disea...
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WO/2004/046096A2 |
The invention relates to novel compounds corresponding to formula (I) below: and to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosm...
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WO/2004/041266A1 |
A GPR40 receptor function controlling agent which contains a compound having an aromatic ring and a group capable of releasing a cation and is useful as a insulin secretion promoting agent or a preventive/remedy for diabetes, etc.
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WO/2004/039753A2 |
Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds an...
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WO/2004/037213A2 |
Novel and nonobvious compounds that function, alone or in combination, as nuclear hormone receptors for the stimulation and/or improvement of murine, mammalian skin. Specifically, beta-ionol analog and fatty acid analog compounds that ar...
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WO/2004/037806A1 |
The present invention relates to a compound of the formula (I) : in which T, A, R, B Xi, Yi and n are as defined in Claim 1, and to the pharmaceutically usable derivatives, solvates and stereoisomers thereof, comprising a mixture thereof...
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WO/2004/031117A1 |
This invention provides a novel group of diphenyl ethene derivatives, pharmaceutically acceptable salts thereof, the process of making these compounds, their pharmaceutical composition and the use of these compounds as agents for treatin...
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WO/2004/031113A1 |
A process for production of hydroxybenzoic acids which comprises reacting a phenol with an alkali metal compound through dehydration to form an alkali metal salt of the phenol and reacting the alkali metal salt with carbon dioxide, chara...
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WO/2004/031118A1 |
Compounds represented by the following general formula (I) and nontoxic salts thereof: (I) wherein each symbol is as defined in the description. Because of binding to LPA receptors and antagonizing the same, the compounds represented by ...
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WO/2004/011465A1 |
This invention provides phenyl-substituted pyrimidopyrimidines, dihydropyrimido-pyrimidines, pyridopyrimidines, naphthyridines,and pyridopyrazines of the general formula (I) that inhibit cyclin-dependent kinase and tyrosine kinase enzyme...
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WO/2004/009528A1 |
The present invention relates to novel compounds of formula (I) and to the salts, solvates and prodrugs thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful for the trea...
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WO/2004/002934A1 |
The invention relates to novel dicarboxylic acids of formula (I), where E and n have the meanings given in claim 1. The dicarboxylic acids are suitable for the production of polymers stable to high temperatures such as employed in microe...
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WO/2004/002947A1 |
Compounds of formula (I), wherein R01 is hydrogen, C1-C8alkyl, C3-C8alkenyl or C3-C8alkynyl; or R01 is phenyl or phenyl-C1-C6alkyl, it being possible for the phenyl rings in turn to be mono- to penta-substituted by halogen and/or mono-, ...
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WO/2004/000295A1 |
A compound of formula (I) wherein R1 represents aryl optionally substituted by a heterocyclic group or a heterocyclic group optionally substituted by aryl wherein each aryl or heterocyclic group is optionally substituted; the group -(CH2...
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WO/2003/104178A1 |
Where Y, R¿1?-R¿8? and R¿101?-R¿108? are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting M...
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WO/2003/104203A1 |
Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) as defined herein, is provided. The invention also relates to methods of t...
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WO/2003/101928A1 |
The invention relates to novel biaryl compounds corresponding to the general formula (I) below: and to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or al...
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WO/2003/101945A1 |
Novel ligands that are inhibitors of the RAR receptors, process for preparing them and use thereof in human medicine and in cosmetics. The invention relates to novel bicyclic compounds corresponding to the general formula (I) and to the ...
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WO/2003/096996A1 |
A non-colorant hair treatment composition comprising a styling compound of formula (1); wherein n is any integer from 0 to 6, R1 is a H , OH, alkyl, alkoxide group or salts thereof; R2, R3, R4, R5 and R6 are independently selected from O...
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WO2003006570B1 |
New, efficient methods for making novel platform molecules and polymerizable mesogens are provided, as well as the novel mesogens and methods of using same.
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WO/2003/095412A1 |
The present invention relates to a new compound of 2-(&agr -hydroxypentyl) benzoate, its preparation and the pharmaceutical composition in which the compound is used as active ingredient; the invention also relates to the use of the comp...
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WO/2003/093823A2 |
A method for identifying a solid support in combinatorial synthesis or determining the structure of a compound in combinatorial synthesis. The method involves attaching, detaching and identifying at least one tag by detaching the tag fro...
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WO/2003/091196A1 |
The invention relates to a novel process for synthesizing organic compounds of general Formula (I). The said process may be carried out on an industrial scale and makes it possible to obtain from a mixture of racemic alcohols of formula ...
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WO/2003/084915A1 |
This invention relates to novel compounds according to the general formula : which are thyroid receptor ligands, preferably antagonists, partial antagonists or partial agonists and to methods for using such compounds in the treatment of ...
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WO/2003/084917A1 |
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: (I) wherein A, R1 , R2 , Rx , R8 , R9 and n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions c...
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WO/2003/083063A2 |
The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affi...
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WO/2003/082787A1 |
Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate,or salt thereof; pharmaceutical compositions containing such compounds,...
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WO/2003/082794A1 |
The present invention provides a novel bioactive compound 12- (2'-CARBOXY- 5'-METHOXYPHENYL)-2,12-DIHYDROXY-DODECA-4-ONE 'Sporotricolone', mainly as acetylcholinesterase (AchE) inhibitor, along with a process for the isolation of said co...
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WO/2003/080542A2 |
The invention relates to a method for producing 3-hydroxy-2-methylbenzoic acid or solutions containing salts of 3-hydroxy-2-methylbenzoic acid, with naphthalene as the starting substance. Said method essentially comprises the following s...
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WO/2003/048101A1 |
The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals wi...
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WO/2003/043971A1 |
Fungicidal compositions are described, containing one or more salts of derivatives of salicylic acid having formula (I): in any molar ratio, with at least one fungicidal compound not corresponding to a salt of derivatives of salicylic ac...
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