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WO/2018/132660A1 |
Disclosed herein are inhibitors of the Integrator complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable...
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WO/2018/129609A1 |
Compounds of formula (II) are useful in modulating voltage-gated sodium channel activity. Their preparation and use for reducing the severity of convulsant activity in a subject, for example in the treatment of epilepsy, is presented.
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WO/2018/128314A1 |
The present invention relates to a plasticizer composition in which three types of cyclohexane 1,4-diester-based compounds prepared through transesterification and hydrogenation are mixed, the plasticizer composition having an alkyl subs...
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WO/2018/123890A1 |
The present invention addresses the problem of providing a novel method for manufacturing a difluoromethylene compound. The problem is solved by a method for manufacturing a difluoromethylene compound having a –CF2- part, the manufactu...
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WO/2018/124172A1 |
A method is provided by which an alcohol compound having a satisfactory purity is obtained from an ester compound in a simple manner. A high-purity alcohol compound can be obtained by: passing a solution which contains both an ester comp...
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WO/2018/124613A1 |
A method for preparing an aromatic carbonic acid diester of the present invention comprises the steps of: performing a transesterification reaction of an aliphatic carbonic acid diester and an aromatic alcohol in the presence of an organ...
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WO/2018/125879A1 |
A method of treating an organic carbonate stream comprising passing the organic carbonate stream through a fixed bed to remove contaminants and produce a less contaminated stream wherein the fixed bed comprises a weak base.
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WO/2018/120325A1 |
A molecular structure of a vertical aligning agent material is shown in Formula I. Therein, Q is a polar anchor group, L1 is a rigid group, P is a polymerizable group, L2 is a linking group, R is a terminal flexible group, and n is 1-3. ...
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WO/2018/125878A1 |
A method of treating an organic carbonate stream comprising passing the organic carbonate stream through a fixed bed to remove contaminants and produce a less contaminated stream wherein the fixed bed comprises alumina or silica.
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WO/2018/120094A1 |
Provided are a method for preparing a 2-(cyclohexenylene) malonic acid derivative and the use thereof. In the method, an olefin and a 2-substituted malonic acid derivative are used as raw materials and are subjected to a cyclization reac...
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WO/2018/112776A1 |
The present invention is directed to a process for synthesizing at least one levulinate ester, said process comprising the reaction of furfuryl alcohol with at least one other alcohol in the presence of water and at least one catalyst, s...
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WO/2018/116664A1 |
Provided is a lubricating base oil containing an ester compound, wherein the ester compound contains a mixture comprising a compound represented by general formula (1) (in formula (1), R1 and R2 independently represent a hydrogen atom, a...
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WO/2018/114747A1 |
The invention relates to an integrated process for the production of ethylene and vinyl acetate (VAM), comprising contacting in a first reaction zone a gas stream comprising ethane and optionally ethylene with an oxygen- containing gas s...
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WO/2018/113240A1 |
Provided is a process for synthesizing at least one levulinate ester, said process comprising the reaction of furfuryl alcohol with at least one other alcohol in the presence of water and at least one catalyst, said furfuryl alcohol bein...
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WO/2018/112777A1 |
The present invention is directed to a process for synthesizing at least one levulinate ester, said process comprising the reaction of furfuryl alcohol with at least one other alcohol in the presence of water and at least one catalyst, s...
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WO/2018/116775A1 |
Provided is a method for regenerating an aromatic amide compound into the corresponding aromatic nitrile compound, the method rendering a dehydration reaction possible, in which a desired compound can be selectively obtained in a high yi...
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WO/2018/115434A1 |
The invention relates to a method for the production of acetylsalicylic acid lysinate, optionally lysine acetylsalicylate · glycine, comprising the following steps: a) providing a solution of acetylsalicylic acid in ethanol; b) providin...
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WO/2018/118461A1 |
The present invention provides methods comprising washing or, preferably, washing and neutralizing a sulfur acid containing crude MMA stream to generate a two phase stream containing at least methacrylic acid, methacrylamide (MAM), water...
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WO/2018/114422A1 |
The invention relates to a method for obtaining pure butyl acrylate from raw butyl acrylate by distillation, wherein butyl stands for n-butyl or isobutyl, characterized in that the method is carried out in a dividing wall column (1) havi...
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WO/2018/114425A1 |
The invention relates to a method for obtaining pure tert-butyl (methy)acrylate from raw tert-butyl (methy)acrylate by distillation, characterized in that the method is carried out in a dividing wall column (1) having dividing built-in c...
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WO/2018/112778A1 |
The present invention is directed to a process for synthesizing at least one levulinate ester, said process comprising a step of introducing furfuryl ether into a reaction medium and a step of conversion of furfuryl ether into levulinate...
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WO/2018/116079A1 |
Fluoroalkyl (meth)acrylate polymers or copolymers are described. These fluoroalkyl (meth)acrylate polymers or copolymers are prepared from at least 96% by weight of one or more fluoroalkyl (meth)acrylate monomers, wherein the fluoroalkyl...
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WO/2018/114073A1 |
The invention relates to a fragrance mixture and the applications of same, particularly perfume oils, cosmetic agents, agents for application or detergents and cleaning agents, containing a sensorially effective amount of (i) (E)-2-methy...
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WO/2018/114752A1 |
The invention relates to an integrated process for the production of ethylene and vinyl acetate (VAM), comprising contacting in a first reaction zone a gas stream comprising ethane and optionally ethylene with an oxygen-containing gas st...
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WO/2018/113242A1 |
Provided is a process for synthesizing at least one levulinate ester, said process comprising the reaction of furfuryl alcohol with at least one other alcohol in the presence of water and at least one catalyst, said furfuryl alcohol bein...
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WO/2018/117216A1 |
Provided is a high-diacylglycerol-content fat containing α-linolenic acid in a large amount, the fat being inhibited from crystallizing at low temperatures and being less apt to opacify or form a precipitate. The fat is a fat compositio...
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WO/2018/112779A1 |
The present invention is directed to a process for synthesizing at least one levulinate ester, said process comprising the reaction of furfuryl alcohol polymer with at least one other alcohol in the presence of water and at least one cat...
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WO/2018/114429A1 |
The invention relates to a method for obtaining pure 2-ethylhexyl acrylate or pure 2-propylheptyl acrylate from the corresponding raw alkyl acrylate by distillation, characterized in that the method is carried out in a dividing wall colu...
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WO/2018/109040A1 |
The invention relates to a method for obtaining pure cyclohexyl(meth)acrylate by distillation of a mixture containing cyclohexyl(meth)acrylate, cyclohexanol and entraining agent, wherein the mixture is fed as a side stream to a rectifica...
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WO/2018/111746A1 |
A vegetable oil-based alkoxylate composition comprising a mixture of mono-, di-, and/or triacyl alkoxylated glycerides and alkoxylated glycerin. A method of reacting a vegetable oil and an alkoxylated glycerin via a transesterification r...
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WO/2018/110142A1 |
This lubricant base oil includes a condensation ester of an alcohol (A) and a carboxylic acid (B), wherein the alcohol (A) contains a polyhydric alcohol represented by general formula (1) (in formula (1), R1-R4 independently represent a ...
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WO/2018/107284A1 |
Sprayable compositions comprising a pyrethroid, a viscosity building agent, an emulsifier or surfactant, and an emollient are provided. The compositions have a viscosity that allows for delivery of the spray from a pressurized container ...
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WO/2018/102914A1 |
The use of a composition comprising an effective amount of medium-chain triglycerides (MCT) or medium-chain fatty acids (MCFA), such as caprylic acids and/or capric acids, for preventing or reducing a metabolic condition selected from in...
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WO/2018/104677A1 |
The subject of the invention is a process for continuously producing a (meth)acrylic ester by transesterification reaction between a light C1-C4 alkyl (meth)acrylate and a heavy alcohol in the presence of a catalyst, characterized in tha...
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WO/2018/105237A1 |
A novel method for producing a trioxopropane compound is provided. The present invention provides a method for producing a trioxopropane compound represented by general formula (1), the method being characterized by reacting a dioxopropa...
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WO/2018/101057A1 |
Provided are a compound useful as a mold release agent, a mold release agent containing same, a curable composition, and a nanoimprint lithography resin material. Specifically, the present invention provides: a calixarene compound with a...
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WO/2018/099835A1 |
An object is to provide a carbon-comprising underlayer-forming composition having goodcoating formation property and gap filling property. Another object is to provide a method for manufacturing a device using the carbon-comprising under...
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WO/2018/099271A1 |
The prevent invention provides a method for preparing deuterated chemicals, and deuterated chemicals. The method comprises the step of: making halides undergo a deuteration reaction with a deuterium source under the catalytic action of a...
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WO/2018/102793A1 |
Animal and seed based triglycerides are oils used in cosmetics, pharmaceuticals, animal feed, energy generation, etc. These triglycerides or glycerol esters are a mixture of triglycerides and free fatty esters (FFA) along with unsaponifi...
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WO/2018/101329A1 |
The purpose of the present invention is to develop a therapeutic agent for inflammatory diseases such as inflammatory bowel disease and NASH, said therapeutic agent having few adverse effects and high efficacy. The present invention prov...
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WO/2018/096176A1 |
A precursor compound of a fragrant aldehyde is provided, as well as a method of forming such a compound, a kit comprising said compound, and certain uses thereof. The precursor compound has formula (I), wherein A is a hydrocarbon residue...
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WO/2018/096938A1 |
This polymerizable compound is represented by expression (I) (in the expression, Ar represents an aromatic hydrocarbon ring group/aromatic heterocyclic group optionally having a substituent; D represents an organic group of 1-67 carbons ...
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WO/2018/096040A1 |
The invention relates to polysubstituted hexaric acids and the ester derivatives thereof, of general formula (I), wherein R1 and R2 are a hydrogen atom or an optionally substituted C1-C18 alkyl group, and Q1, Q2, Q3 and Q4 are a caffeoyl...
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WO/2018/096039A1 |
The present invention concerns an extract of plants from the Tagetes genus enriched with leontopodic acid B, a method for preparing such an extract and a cosmetic composition and a nutraceutical composition and a pharmaceutical compositi...
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WO/2018/097919A1 |
A method for preparation of phenolic (meth)acrylates. The method comprises contacting acetic anyhydride, a phenolic compound and (meth)acrylic acid to form a reaction mixture.
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WO/2018/094756A1 |
Disclosed is a process for producing triethyl citrate, comprising the following steps: raw material preparation – preparation of an aqueous citric acid solution – preparation of an esterified solution – adjustment of the pH value â...
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WO/2018/094687A1 |
Provided is a method for preparing a low-grade unsaturated fatty acid ester. The method comprises: dimethoxymethane (DMM) and low-grade fatty acid or ester with a molecular formula being R1-CH2COOR2 undergo an aldol condensation reaction...
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WO/2018/094960A1 |
The present invention relates to a cinnamic acid benzoyl methyl ester compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are as defined in the description. The present invention also relates t...
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WO/2018/096088A1 |
The present invention relates to compounds having a benzotropolone core, and compositions containing said compounds acting as ATG4B inhibitors, thereby inhibiting autophagy. Moreover, the present invention provides processes for the prep...
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WO/2018/096248A1 |
The invention relates to a composition comprising: at least one alkanesulfonic acid of formula R-SO3H, in which R is a linear or branched saturated hydrocarbon chain of 1 to 4 carbon atoms, optionally substituted with at least one haloge...
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