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JP4109893B2 |
In the production of aziridines or N-vinyl amides respectively from an alkanolamine or an alkanolamide by the known method comprising a reaction step, a collecting step and/or a condensation step, a purifying step, and a recovering step,...
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JP4082883B2 |
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JP4061433B2 |
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JP4064451B2 |
There are described novel coupling reactions useful for the preparation of cyclitol and/or carbohydrate conjugates and carbocyclic analogs thereof. Such coupling reactions employ epoxides and/or aziridines described herein as electrophil...
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JP2008050336A |
To provide an isoquinuclidine derivative which enables to easily synthesize oseltamivir or an analogue thereof.The invention relates to the isoquinuclidine derivative represented by formula (1) or a mirror image structure of formula (1)....
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JP2007538106A |
The invention provides N-cyclic sulfonamido compounds for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula I, wherein R4, R5, R6, R7, and R8, are as d...
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JP2007536363A |
The present invention relates to the use of a therapeutically effective amount of 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone
(RH1), in the manufacture of a medicament for the treatment of a cancerous condition.
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JP3995060B2 |
Monomodal or polymodal catalyst carriers or catalysts have a BET specific surface of 0.01 to 250 m<2>/g. The mean pore size is from 50-300000 nm as measured by the Hg pressure porosity method. The pore size distribution is such that 10-9...
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JP3995666B2 |
The invention provides a nitroreductase, obtainable from a bacterium having the following characteristics as exemplified by examples isolated from Escherichia coli B and Bacillus amyloliquifaciens: 1. It is a flavoprotein having a molecu...
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JP2007145817A |
To provide a compound having plant disease controlling effect and a plant disease controlling agent containing the compound.The amide compound is expressed by formula (1) (X1 is a fluorine atom or methoxy group; X2 is a hydrogen atom, fl...
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JP3905570B2 |
To obtain novel compounds useful for the treatment of arrhythmia and the prevention, etc., of unexpected death caused by arrhythmia as medicaments capable of acting on the cardiovascular system. This substituted benzenesulfonyl(thio)urea...
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JP2007055958A |
To provide a method for industrially efficiently producing a nitrogen-containing heterocyclic compound.This method for producing the nitrogen-containing heterocyclic compound comprises reacting an iodide with an amide and an olefin in th...
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JP2006514939A |
Methods of making substituted phenylalkynes of formula (I).
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JP3772219B2 |
To provide a method for producing an optically active aziridine compound and amine compound with high enantioselectivity by using a nitrene precursor that is readily available and economical. In this production method, a specific optical...
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JP3759950B2 |
PCT No. PCT/GB94/02280 Sec. 371 Date Mar. 15, 1996 Sec. 102(e) Date Mar. 15, 1996 PCT Filed Oct. 19, 1994 PCT Pub. No. WO95/11230 PCT Pub. Date Apr. 27, 1995A process for the preparation of an oxirane, aziridine or cyclopropane of formul...
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JP2006509731A |
A method for stereoselective chemical synthesis, includes the steps of: (A) reacting a nucleophile and chiral or prochiral cyclic subtrate, said substrate comprising a carbocycle or a heterocycle having a reactive center susceptible to n...
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JP2006069922A |
To provide a new compound which can introduce a functional group stable against anionic polymerization into a propagation initiating terminal, a terminating terminal or the inside of a polymer chain, a functionalized polymer obtained usi...
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JP2006036770A |
To selectively inhibit virus (particularly influenza virus), especially glycolytic enzymes like neuraminidase, above all, viral or bacterial neuraminidase.Novel compounds of Formula (III) or Formula (IV) are described. The compounds gene...
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JP2005524707A |
This invention relates to methods and compositions for the modification of nucleic acids.
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JP2005517227A |
A crystalline composition comprising a crystal of the IL-6 receptor I chain is provided. Also provided are methods of using the crystal and related structural information to screen for and design compounds that interact with IL-6R, or va...
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JP2005517023A |
Methods are provided for treatment of diseases. The methods include preventing or inhibiting transcription and/or replication of a nucleic acid molecule by administering to a subject in need of such treatment an effective amount of one o...
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JP2005511740A |
Disclosed are substituted phenylalkynes of formula (I), wherein R1, R2, R3, R4, R5 and n are as defined, compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
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JP3622983B2 |
The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), such as those having formulas (I)-(IV), useful in the synthesis of neura...
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JP3590643B2 |
The invention provides a novel method for producing compounds of the formula I: wherein X and R are defined in the specifications. The invention also provides a method for making intermediates useful to produce the compounds of formula I...
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JP2004262903A |
To provide a method for simply and inexpensively producing an aziridine directly from an epoxide under a mild condition.An aziridine is directly synthesized from an epoxide through one step. In this case, the epoxide represented by formu...
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JP3538144B2 |
Herbicidal fluorovinyloxyacetamide compounds of formula (I) are useful for protecting crops from weeds:wherein:R1 is a phenyl group optionally having one or more substituents selected from the group consisting of C1-6 alkyl, halogen-subs...
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JP2004510699A |
The invention is directed to the cross-metathesis and ring-closing metathesis reactions between geminal disubstituted olefins and terminal olefins, wherein the reaction employs a Ruthenium or Osmium metal carbene complex. Specifically, t...
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JP2004509947A |
The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one s...
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JP2004509968A |
Disclosed are substantially enantiomerically pure bis-phosphine compounds comprising a substantially enantiomerically pure chiral backbone linking two phosphine residues wherein one of the phosphine residues has three phosphorus-carbon b...
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JP3511092B2 |
To provide a novel light-emitting material which remarkably enhances the emission intensity of a fullerene by selectively using a fullerene derivative having an aromatic group as the substituent introduced on the nitrogen atom of an azir...
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JP2004067611A |
To efficiently obtain an aziridine derivative by using an industrially easily available reagent by a simple and industrially excellent method.The method for producing the aziridine derivative comprises subjecting an α-phenylethylaminoal...
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JP2004505950A |
This invention relates to compounds of Formula I having an aziridine-2-carboxylic group and a menthol group, a process for preparing such compounds, a method for obtaining optically active aziridine-2-carboxylate derivatives by optical r...
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JP3494465B2 |
PURPOSE: To profitably obtain the subject compound by treating a carboxyl group and imino group-protected (S)- or (R)-aziridine-2-carboxylic acid derivative as a raw material with a diorgano copper acid lithium salt. CONSTITUTION: A (S)-...
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JP3426763B2 |
PURPOSE: To improve adhesion between layers in a multilayer flexoprinting plate. CONSTITUTION: The flexible plate which contains a flexible base material prime- coated with an aziridine functional material and in which the flexible base ...
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JP2003176238A |
To provide a means and a method for inactivating viruses and other organisms in a composition containing cells or biopolymers without substantially denaturating the proteins and the other biopolymers.The composition to be treated is brou...
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JP2003104970A |
To provide an aziridine derivative useful as a cross-linking agent for various kinds of polymers because of both excellent cross-linking ability and hydrophilicity-imparting ability.This aziridine derivative is represented by formulas (1...
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JP2003503372A |
A process for the heterogeneous and enantioselective hydrogenation of prochiral organic alpha-keto compounds with platinum as the catalyst in the presence of a soluble or immobilized chiral aromatic nitrogen base with at least one basic ...
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JP2003002888A |
To provide a new synthetic method and a composition; especially a method for preparing an intermediate useful for the synthesis of neuraminidase inhibitors, to obtain a composition useful itself as an intermediate for the synthesis of ne...
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JP2002541057A |
A range of aziridin-1-yl nitrobenzamides are provided for use as prodrugs in conjunction with nitroreductase (NR) enzymes. The amides may have 1 or 2-substituents which may be bulky and polar. For example, 5-(aziridin-1-yl)-N-[2-(4-morph...
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JP2002535389A |
This invention provides a method for synthesizing ethyleneimine dimer which includes reacting 2-(2-aminoethylamino)ethanol with an aqueous HX solution to produce N-(2-haloethyl)-1,2-ethanediamine dihydrohalide; reacting this product with...
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JP2002535343A |
Methods and compositions for the inactivation and removal of contaminants of a biological composition are disclosed. The methods include the steps of: (a) contacting the biological composition with an inactivating agent including an azir...
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JP2002534414A |
(57) [Summary] The present invention relates to the synthetic chemical formation of certain known nerve growth stimulating and neuroprotecting compounds, as well as intermediates useful for producing certain known multidrug resistance in...
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JP2002524442A5 |
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JP2002524442A |
The invention provides agents and compounds (see (I) and (II)) for use in the treatment or prophylaxis of disease conditions caused or exacerbated by mammalian papillomaviruses, such as human papillomaviruses, as well as methods for the ...
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JP3307966B2 |
PURPOSE: To provide a new sulfonamide deriv. which strongly suppresses the biological activity of TXA2 and is used for the treatment and prevention of ischemia, cerebrovascular diseases, peripheral vascular diseases and lipid imbalance, ...
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JP2002522515A |
The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral cata...
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JP3300365B2 |
Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibit...
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JP2002512238A |
The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.
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JP2002510282A |
This invention is directed to processes for producing acyclic or cyclic alcohols or glycols, carbonyls, oxiranes or aziridines from hydrocarbyl group-containing compounds, particularly lower alkanes such as methane, ethane, propane or bu...
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JP3264928B2 |
1-Benzyl-3(S)-Ä2-(S)-(tert.-butoxy-carbonylamino) propionylaminoÜ-pyrrolidine and its use as an intermediate.
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