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Matches 1 - 50 out of 776

Document Document Title
WO/2018/067842A1
The invention relates to new amino dimeric naphthoquinone compounds with antileukemic activity. Compounds of the invention demonstrated increased aqueous solubility compared to previously available dimeric naphthoquinones and potent nano...  
WO/2018/004066A1
The present invention relates to an aryl ethane derivative, for inhibiting an estrogen-related receptor gamma (ERRγ) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, an...  
WO/2018/004065A1
The present invention relates to an aryl ethane derivative, for inhibiting an estrogen-related receptor gamma (ERRγ) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, an...  
WO/2017/162156A1
An iridinesulfonamide compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity, pharmaceutically-acceptable salts, solvates or hydrates thereof, a pharmaceutical composition, as well as use of the compound or the pharmaceuti...  
WO/2017/104589A1
Provided is a method for producing a perfluoroalkylated compound at low cost, safely and with high efficiency. A method for producing a perfluoroalkylated compound, comprising reacting a bis(perfluoroalkanoyl)peroxide with a compound tha...  
WO/2017/098533A3
The present invention relates to a process for preparation of lisdexamphetamine and its pharmaceutically acceptable salts via a novel aziridine intermediate of Formula IV.  
WO2017011418A1
The present invention provides a various organic reaction that utilize an α,β-unsaturated compound to produce aziridine compounds and dihydrofuran compounds. In particular, the present invention provides a method for producing an aziri...  
WO/2015/142001A2
Disclosed are a compound having cardiotonic activity and a pharmaceutical composition containing the same, and the composition containing the compound, according to the present invention, is useful for preventing and treating heart failure.  
WO/2015/142001A3
Disclosed are a compound having cardiotonic activity and a pharmaceutical composition containing the same, and the composition containing the compound, according to the present invention, is useful for preventing and treating heart failure.  
WO/2015/120820A1
The present invention discloses a class of carboxylic acid derivatives and use thereof in preparation of prodrugs. The carboxylic acid derivatives have the general formula (I): R1 being H or an alkyl; X being H or F; Y being F or a fluor...  
WO/2015/103505A2
A method for the direct stereospecific conversion of structurally diverse mono-, di-, tri- and tetra-substituted olefins to N-H, N-alkyl, N-cycloalkyl, or N-aralkyl aziridines using a hydroxylamine amination agent with transition metal c...  
WO/2015/103505A3
A method for the direct stereospecific conversion of structurally diverse mono-, di-, tri- and tetra-substituted olefins to N-H, N-alkyl, N-cycloalkyl, or N-aralkyl aziridines using a hydroxylamine amination agent with transition metal c...  
WO/2015/094710A1
The present disclosure is directed to a curable precursor of a pressure sensitive adhesive comprising: a) a (co)polymeric material comprising the reaction product of a (co)polymerizable material comprising a (meth)acrylate ester monomer;...  
WO/2015/090084A1
The present invention relates to a catalyst for synthesizing ethylenimine as well as a preparation method and application thereof. The related catalyst comprises a carrier and metal ions loaded on the carrier; the carrier is a composite ...  
WO/2015/090085A1
Disclosed are a joint production method and device for aziridine, piperazine and triethylenediamine. The method comprises: reaction 1, preparing piperazine and triethylenediamine by taking ethanol amine as a raw material under the existe...  
WO/2015/083066A1
The present disclosure provides crystalline piperidine sulfamoyl intermediates of formula 8 and 9. The present disclosure also relates to an improved process for the preparation of cobicistat using compounds of formulae 8 and 9.  
WO/2015/073622A1
Described herein are compositions and compounds having one or more aziridinyl groups, and methods of making the same. The compounds can also have one or more nitrogen atoms that each can be positively charged. The composition and compoun...  
WO/2015/018676A1
The invention relates to a method for producing tris-aziridinomethane (I) by reacting aziridine with chloroform, characterized in that the molar ratio of aziridine to choroform is at most 3: 1.  
WO/2014/124988A1
The invention relates to the use of amide derivatives of the formula (I) wherein X1, X2, X3, X4, Z1 and Y are as defined in the specification as herbicides. Furthermore, the present invention relates to certain novel substituted amide de...  
WO/2014/106310A1
The invention discloses a halogen-containing optically active oxazolidinone derivative and a preparation method therefor. The structural formula of the compound is shown as formula I. In the present invention, N-bromosuccinimide is used ...  
WO/2014/057498A3
The present invention relates to cobicistat intermediates, processes and further conversion to cobicistat with improved yield and quality.  
WO/2014/057498A2
The present invention relates to cobicistat intermediates, processes and further conversion to cobicistat with improved yield and quality.  
WO/2013/190497A2
The invention provides pharmaceutical compositions and methods for treatment of an inflammatory disease of the lung caused by inhalation of a toxic agent or an irritant, more particularly, chlorine inhalational lung injury, as well as ce...  
WO/2013/190497A3
The invention provides pharmaceutical compositions and methods for treatment of an inflammatory disease of the lung caused by inhalation of a toxic agent or an irritant, more particularly, chlorine inhalational lung injury, as well as ce...  
WO/2013/179052A1
The present invention relates to methods of synthesising aziridines including isotopically labelled aziridines, said methods comprising contacting an imine or one or more precursors thereof with a diazo compound in the presence of a phos...  
WO/2013/152156A3
Compositions containing a solution of a polyfunctional aziridine component in a non-reactive solvent, and methods of applying such compositions to proteinaceous substrates, such as fingernails and toenails, to provide primed substrates w...  
WO/2013/116715A1
Methods and intermediates useful for preparing a compound of formula I and salts thereof.  
WO/2013/103973A1
This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compunds as at le...  
WO/2013/093458A3
This invention relates to derivatives of antiviral drug compounds. It also relates to pharmaceutical formulations of derivatives of antiviral drug compounds. It also relates to uses of the derivatives in treating viral infections and in ...  
WO/2013/083744A3
This invention relates to the modification of polymeric materials containing reactive carbon-to-carbon unsaturation and to amines, including aziridines, which are used in such modification. A polymeric material containing carbon-to-carbo...  
WO/2013/081549A1
The invention relates to a method for preparing 2H-azirine carboxylic esters. More specifically, the invention relates to a method for preparing 2H-azirine carboxylic esters starting from α-diazo-β-keto oxime ethers in the presence of ...  
WO/2013/061340A1
The present invention discloses high yielding enantioselective process for synthesis of Oseltamivir from readily available starting material, cis-1,4-butene diol.The process features incorporation of chirality using sharpless asymmetric ...  
WO/2012/072036A1
Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having...  
WO/2011/087664A1
Described is a pre-adhesive, curable composition comprising an acid-functional (meth)acrylate copolymer and a novel (meth)acryloyl-aziridine crosslinking agent, which when crosslinked provides a pressure-sensitive adhesive composition.  
WO/2011/070459A1
The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of...  
WO/2011/035064A2
Homogenous and heterogenous catalysts comprising 1,2,4-triazole ligands and transition metals are described. The catalysts can be used to catalyze the oxidation of hydrocarbons and other reactions. In particular, the catalysts can be use...  
WO/2011/035064A3
Homogenous and heterogenous catalysts comprising 1,2,4-triazole ligands and transition metals are described. The catalysts can be used to catalyze the oxidation of hydrocarbons and other reactions. In particular, the catalysts can be use...  
WO/2011/021223A3
The present invention relates to novel salts of ethyl (3R,4S,5R)- 4,5-imino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate and its use in the preparation of (3R,4R,5S)-4-(acetylamino)-5-amino-3-(1-ethyl propoxy)-1-cyclohexene-1-carboxyli...  
WO/2010/114291A2
The present invention relates to an improved method for preparing dipeptidyl peptidase-IV inhibitor and intermediate. The present invention is able to reduce preparation costs by using low cost reagents on reaction and is able to be used...  
WO/2010/114291A3
The present invention relates to an improved method for preparing dipeptidyl peptidase-IV inhibitor and intermediate. The present invention is able to reduce preparation costs by using low cost reagents on reaction and is able to be used...  
WO/2010/104645A1
A crosslinkable, pre-adhesive composition is described comprising an acid- functional (meth)acrylate copolymer and an aziridine crosslinking agent, which when crosslinked provides a pressure-sensitive adhesive and pressure-sensitive adhe...  
WO/2010/099206A2
A process for the asymmetric aziridination of an alkene comprising treating the alkene with a sulfonyl azide, preferably trichloroethoxysulfonyl azide, in the presence of a cobalt(II) porphyrin.  
WO/2010/099206A3
A process for the asymmetric aziridination of an alkene comprising treating the alkene with a sulfonyl azide, preferably trichloroethoxysulfonyl azide, in the presence of a cobalt(II) porphyrin.  
WO/2010/065355A1
A photoactive compound that is the Michael addition reaction product of an aziridine compound and a photoinitiator-functional (meth)acrylate is described. The compound can be used to crosslink (meth)acrylic polymers via a hydrogen abstra...  
WO/2010/055887A1
A novel β-(trifluoromethyl)vinyldiaryl sulfonium salt represented by general formula (I), which can be used for simple syntheses of various useful compounds each containing a trifluoromethyl group, or the like. (In formula (I), R1 and R...  
WO/2010/041748A1
Disclosed is a prophylactic or therapeutic agent for diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, heart failure, cardiomyopathy, myocardial ischemia, cer...  
WO/2010/018154A1
The present invention relates to a process for the production of (3aR, 4S, 7aR)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxyli c acid methyl ester (I), of carbamic acid (2-chloroethyl)(3-oxocyclohexyl)-alkyl ester enantiomers (I...  
WO/2009/146032A3
Cobalt(II) complex of P1 [Co(P1)], a new porphyrin that was designed on the basis of potential hydrogen bonding interactions in the metal-nitrene intermediate, is a highly active catalyst for olefin aziridination with azides. The [Co(P1)...  
WO/2009/146032A2
Cobalt(II) complex of P1 [Co(P1)], a new porphyrin that was designed on the basis of potential hydrogen bonding interactions in the metal-nitrene intermediate, is a highly active catalyst for olefin aziridination with azides. The [Co(P1)...  
WO/2009/129387A3
Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.  

Matches 1 - 50 out of 776