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WO/2020/111252A1 |
Provided is a compound that is usable as an active ingredient of an anticancer agent. Preferably, provided is a compound that has a DOCK1-inhibiting activity and exerts an anticancer effect based on the activity. A compound represented...
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WO/2020/108941A1 |
The present invention relates to crystalline compounds comprising vadadustat and L-proline and processes for their preparation. Furthermore, the invention relates to a pharmaceutical composition comprising one or more of the crystalline ...
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WO/2020/104822A1 |
The present invention relates to a compound of formula (Ia), or a pharmaceutically acceptable salt or hydrate thereof, wherein: the group X-Y is -NHSO2- or -SO2NH-; R1 is H or alkyl; R2 is selected from COOH and a tetrazolyl group; R3 is...
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WO/2020/106642A1 |
The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin, and methods for their use in treating disorders mediated by hemoglobin.
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WO/2020/105694A1 |
Provided is a film-forming material for lithography containing a compound having a formula (OA) group: [chemical compound 1] and a formula (OB) group: [chemical compound 2] (in formula (OB), R is independently selected from a group consi...
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WO/2020/105536A1 |
Provided is a carbamate ester compound represented by the general formula Z-OCONH(CH2)nNHCOO-Z [I] wherein Z is [i], [ii], or [iii] and n is an integer from 2 to 10 (wherein R1 and R2 are each independently a C1-5 lower alkyl group, R3 i...
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WO/2020/104484A1 |
The present invention relates to the synthesis of N-trifluoromethylcarbonyl compounds starting from isothiocyanates, which can be converted into N-trifluoromethylcarbamoyl fluorides or similar compounds, which later on can be derivatized...
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WO/2020/103856A1 |
Disclosed are inhibitors of mycobacterial membrane protein MmpL3, compositions comprising the inhibitors, and methods of preparation and use thereof.
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WO/2020/098710A1 |
Provided in the present application are a substituted bis-aryl amide compound and a preparation method and an application therefor, the substituted bis-aryl amide compound or a pharmaceutically acceptable salt thereof having the structur...
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WO/2020/102643A1 |
Highly efficient processes are provided for preparing key intermediates in the synthesis of compounds (I). The process are broadly applicable and can provide selected components having a variety of substituents. Some intermediates are cl...
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WO/2020/102053A1 |
The invention provides novel methods for preparing a compound of formula (Ila) which can be used to prepare indolinobenzodiazepine dimer compounds.
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WO/2020/094403A1 |
A process for the synthesis of lactams suitable for use in antimicrobial, anti-biofilm and bacteriostatic compositions.
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WO/2020/097450A1 |
The invention relates to crystalline forms of the bis-HCl salt of a compound represented by Structural Formula (1), and pharmaceutical compositions comprising crystalline forms of the bis-HCL salt of a compound represented by Structural ...
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WO/2020/095322A1 |
Disclosed herein is an efficacious process for preparation of highly purified Glycopyrrolate tosylate in high yield. The process is being cost effective, environment friendly and easily scalable to high volume industrial production.
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WO/2020/093686A1 |
The present invention relates to the field of bilirubin IX α preparation. Disclosed is a method for preparing high-content bilirubin IX α using biliverdin IX α. The method comprises the following steps (a hydrolysis-before-reduction r...
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WO/2020/097363A2 |
Provided herein are compositions and processes for producing compositions from an algae to provide heme and a red or red-like color to edible compositions including ingredients and finished food products. Also provided are methods of gro...
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WO/2020/097370A2 |
Provided herein are compositions and processes for producing compositions from an algae that overproduces protoporphyrin IX (PPIX). Also provided are methods of growing PPIX overproducing algae, methods of isolating PPIX-containing porti...
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WO/2020/094754A1 |
The present invention relates to a compound having the following formula (I): wherein: - A is a (hetero)aryl radical comprising from 5 to 10 carbon atoms, possibly substituted by at least one substituent chosen from the group consisting ...
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WO/2020/086890A1 |
The invention provides novel co-crystals of epicatechin with a carboxy-N-heterocyclic co-crystal former such as trigonelline or proline and their pharmaceutical compositions. Methods of preparing the co-crystals and methods of using them...
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WO/2020/084094A1 |
The present invention relates to a process for preparing a nitrated compound, comprising the step of reacting a compound (A) comprising at least one substituted or unsubstituted aromatic or heteroaromatic ring, wherein said heteroaromati...
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WO/2020/086732A1 |
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.
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WO/2020/077459A1 |
There are provided compounds of formula (IF) in which R2 and R11 can represent various different possibilities. These compounds can be useful as anticancer agents as well as anti-inflammatory agents, anti-proliferative agents and/or anti...
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WO/2020/080979A1 |
This disclosure relates to new phthalimide and isoindolinone derivatives and other PFKFB3 inhibitors for use in the treatment of diseases. The invention further relates to pharmaceutical compositions containing such PFKFB3 inhibitors, me...
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WO/2020/075199A1 |
Described is a process for the preparation of crystalline Form C of Vadadustat. Also described are Vadadustat co-crystals and processes for the preparation thereof.
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WO/2020/072377A1 |
The present disclosure relates to compounds of the general formula (I) and pharmaceutical compositions containing them. The compounds are suitable as modulators of hemoglobin and thus useful in treating disorders mediated by hemoglobin s...
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WO/2020/064564A1 |
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, and their uses as insecticides.
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WO/2020/068661A1 |
Methods of preparing, and solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-
yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(m
ethylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide,
and salts, s...
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WO/2020/067797A1 |
The present invention provides a method and an apparatus for efficiently recovering an amide-based compound, such as N-methyl-2-pyrrolidone, from an aqueous solution containing an amide-based compound, such as N-methyl-2-pyrrolidone.
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WO/2020/063388A1 |
The present invention relates to a substituted 5-oxopyrrolidine derivative as shown in general formula I, a preparation method therefor and the use thereof, and in particular, the present invention relates to the use of the derivative as...
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WO/2020/067398A1 |
The purpose of the present invention is to provide: a novel compound that inhibits cell invasion of filovirus; a medicinal composition that comprises the compound; an anti-filovirus agent or an inhibitor for cell invasion of filovirus; a...
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WO/2020/064260A1 |
The invention relates to substituted 5-(sulfanyl)-3,4-dihydro-2h-pyrrol-4-carboxamides of general formula (I) (I) and to the their use as herbicides, in particular for controlling weeds and/or weed grasses in crops of useful plants and/o...
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WO/2020/059812A1 |
4-(\{(4S)-1-(4-Carbamimidoylbenzoyl)-4-[4-(methylsulfonyl)pi
perazin-1-yl]-L-prolyl\}amino)benzoic acid di(4-toluenesulfonic acid) salt or dibenzenesulfonic acid salt or a crystal form of the salt has low hygroscopicity and excellent sto...
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WO/2020/060213A1 |
The present invention relates to a method for producing a 4-methoxy pyrrole derivative. According to one embodiment, the present invention can provide a useful advantage of industrial mass production of a 4-methoxy pyrrole derivative, as...
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WO/2020/061300A1 |
Disclosed are compounds, methods, reagents, systems, and kits for the preparation and utilization of monomeric or polymeric metal-based compounds. These metal-based compounds are organometallic catalysts composed of substituted dipyrrin ...
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WO/2020/061228A1 |
Disclosed herein are methods for treating or preventing a hypoperfusion related disease in a subject in need thereof, comprising identifying a subject with cerebral hypoperfusion and administering an effective amount of an alpha 5 beta 1...
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WO/2020/053105A1 |
The invention relates to a modified textile comprising a) a textile substrate; and, b) a lactam coating; and to the use of a lactam to impart anti-biofilm properties to a textile; and to the use of a lactam to inhibit biofilm growth on a...
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WO/2020/054526A1 |
Provided is a maleimide resin with superior solution stability. Also provided is a cured product with a superior dielectric characteristic that is obtained by curing a curable resin composition in which said maleimide resin is used. The ...
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WO/2020/051796A1 |
Disclosed in the present invention are a preparation method for brivaracetam and intermediates thereof. The raw materials for the preparation method for brivaracetam of the present invention have simple structure and a low price, and are...
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WO/2020/052545A1 |
A method for preparing Brivaracetam, intermediates thereof and a method for preparing the intermediates. The raw materials for the method have simple structures, low price and are easy to access. All the steps have mild reaction conditio...
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WO/2020/053106A1 |
The invention relates to a wipe suitable for application to a hard surface comprising from 0.0001 to 5 wt.% of a lactam; to the use of said wipe on a surface to reduce microorganism buildup on said surface; and, to the use of a lactam in...
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WO/2020/052647A1 |
Involved are a class of spiro-heterocyclic compounds which can act as lysine-specific demethylase 1 (LSD1) inhibitors, and the use of same in the preparation of drugs for treating LSD1-related diseases. Specifically involved are a compou...
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WO/2020/054226A1 |
A thermal base generator is represented by formula (N1). This photosensitive resin composition contains the thermal base generator and a precursor of a heterocycle-containing polymer. In formula (N1), RN1 and RN2 each independently repre...
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WO/2020/050160A1 |
A hydrogenation catalyst for amide compounds which comprises hydroxyapatite and, fixed thereto, platinum and vanadium, characterized in that 15-80% of the surface of the platinum is covered with vanadium. With the catalyst, it is possibl...
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WO/2020/049153A1 |
Herein is provided a novel process for the preparation of methyl 6-(2,4-dichlorophenyl)- 5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-
dihydro-7H-benzo[7]annulene-2- carboxylate by a Suzuki coupling of compound (3), wherei...
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WO/2020/049150A1 |
Herein are provided novel salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolid
in-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxy
late namely the oxalate salt (I) and the dibenzoyltartrate salt (II).
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WO/2020/050368A1 |
The purpose of the present invention is to provide: a method for preparing a Vilsmeier reagent, that can be carried out safely, easily, and at a low cost; and a method for producing an aromatic aldehyde or an aromatic ketone, a carboxyli...
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WO/2020/043033A2 |
Provided are a JAK inhibitor upadacitinib intermediate and a preparation method therefor, and a preparation method for a JAK inhibitor upadacitinib. The upadacitinib intermediate is as shown in formula (II) or formula (III), wherein R is...
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WO/2020/045247A1 |
A heterocycle-containing amino acid compound represented by general formula (1) or a salt thereof. (In the formula, R1 and R2 may be the same or different and represent a hydrogen atom or a protective group of a carboxyl group, R3 repres...
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WO/2020/043831A1 |
The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof useful as inhibitors of Cyclophilins and modulators of cyclophilin-like proteins. The invention also relates to uses of said compound...
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WO/2020/045856A1 |
The present invention relates to a novel hypoxia-inducible factor 1α (HIF-1α) inhibitor, a preparation method therefor, and a pharmaceutical composition for preventing or treating angiogenesis-associated eye disease, containing same as...
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