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WO/2023/121975A1 |
The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.
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WO/2023/119110A1 |
The present invention relates to a process for the preparation of diketones and pyrrole derivatives, optionally substituted in the 2 and/or 5 positions, from furans.
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WO/2023/112033A2 |
The present invention relates to various compounds, which are novel and useful intermediates in novel methods for preparation of certain compounds referred to as Saturated Targets and amorphous and crystal forms thereof, and certain mark...
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WO/2023/115002A1 |
The present disclosure relates to compound Formula (I) methods for making the compounds and methods for their use.
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WO/2023/114977A1 |
Described herein are compounds useful as S1PR4 receptor antagonists, pharmaceutical compositions comprising said compounds, methods of making said compounds and pharmaceutical compositions, and methods of using said compounds and pharmac...
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WO/2023/114428A1 |
The disclosure provides heterocycle derivatives of Formula (I) for the inhibition of the oligosaccharyltransferase complex and the treatment of disease.
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WO/2023/107563A1 |
Provided herein are compounds and compositions thereof for modulating S1P5. In some embodiments, the compounds and compositions are provided for treatment of neurological diseases. Formula (I).
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WO/2023/100110A1 |
The present invention is directed to a novel compound, (4R)-1-((S)-1-carboxypropyl)-2-oxo-4-propylpyrrolidine-3-car
boxylic acid, which can be used as an intermediate in the preparation of brivaracetam. The invention is also directed to ...
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WO/2023/101595A1 |
The present invention is directed towards compounds of formula (I), capable of binding to sortilin and thereby useful as sortilin inhibitors in the treatment of diseases, disorders and conditions associated with sortilin activity and bin...
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WO/2023/099462A1 |
The present invention relates to amine-containing vinyldisiloxane compounds which are useful in the manufacture of elastomeric polymers that can be used in rubber articles such as tires. The present invention further relates to a process...
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WO/2022/272248A9 |
The invention provides compounds, compositions thereof, and methods of using the same for the inhibition of Cbl-b, and the treatment of a variety of Cbl-b-mediated diseases, disorders or conditions, associated with modulating the immune ...
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WO/2023/096512A1 |
A group of chemical compounds has been disclosed, especially for the treatment of neurological diseases, which are modified alanine derivatives whose structures has been designed based on the bioisosteric and selective replacement of hyd...
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WO/2023/087632A1 |
The present invention belongs to the field of medicinal chemistry, and specifically disclosed are an anti-inflammatory analgesic compound and the use thereof. The compound of the present invention is a compound having a structure shown i...
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WO/2023/090853A1 |
The present invention relates to a novel urea-based or carbamate-based P2X7 receptor antagonist compound. The novel urea-based or carbamate-based P2X7 receptor antagonist compound according to the present invention can effectively inhibi...
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WO/2023/090942A1 |
The present invention relates to a pyrrole derivative or a pharmaceutically or sitologically acceptable salt thereof, and a composition for the prevention, amelioration or treatment of gastrointestinal disorders, comprising same as an ac...
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WO/2023/084545A1 |
The present invention provides pharmaceutical composition of non-steroidal antiandrogens. The present invention provides pharmaceutical composition of non-steroidal antiandrogens having high drug loading. The present invention provides a...
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WO/2023/082465A1 |
The present invention relates to the technical field of chemical catalytic reaction. Disclosed are a method for preparing an amino alcohol by asymmetric hydrogenation and an application thereof. A starting raw material of the chemical re...
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WO/2023/079538A1 |
The present invention relates to a process for preparation of 5-hydroxy-5-aryl-pyrrol-2- ones of formula (I) from their intermediate arylated furanone intermediates of formula (II). The present invention relates to a two-stage process fo...
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WO/2023/078277A1 |
An intermediate of a polyamine derivative, a preparation method therefor, and a use thereof. The intermediate is easy to prepare and high in purity; and when the intermediate is used for preparing the polyamine derivative, the obtained p...
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WO/2023/076567A1 |
This invention relates to compounds, pharmaceutical compositions and their use for treating fibrotic disorders, proliferative disorders, cardiovascular diseases, acute and chronic inflammatory disorders, primary and metastatic cancer, pu...
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WO/2023/076626A1 |
The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such ...
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WO/2023/074936A1 |
The present disclosure relates to a bifunctional compound using a UBR box domain-binding ligand. The UBR box domain is a domain commonly present in the UBR (Ubiquitin protein ligase E3 component n-recognin) protein of the N-end rule path...
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WO/2023/074259A1 |
The present invention provides a maleimide compound and a curable resin composition that exhibit superior heat resistance and electrical properties as well as good curing properties, and an amine compound that serves as a starting materi...
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WO/2023/072096A1 |
Provided are a tetrahydrofuran-containing polycyclic derivative and a pharmaceutically acceptable salt thereof, and a preparation method therefor and the use thereof. In particular, provided are a compound as represented by general formu...
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WO/2023/069770A1 |
Described herein are compounds, pharmaceutical compositions and methods of using these compounds and pharmaceutical compositions for treating and/or preventing conditions such as, for example, those caused by any viral family causing res...
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WO/2023/067825A1 |
The present invention provides, inter alia: a method for producing an antibacterial composition, the method including producing a melanoidin by heating a reducing sugar selected from xylose or ribose, and an amino acid selected from phen...
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WO/2023/065606A1 |
Disclosed is a new deuterated cyano compound as represented by formula I, or a pharmaceutically acceptable salt, an isomer or a prodrug thereof. Further disclosed are a method for preparing the deuterated compound, and a composition and ...
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WO/2023/067273A1 |
The invention relates to the uses of cyclic amine monoamides for extracting uranium(VI) and/or plutonium(IV) from an acidic aqueous solution and also for completely or partially separating the uranium(VI) from the plutonium(IV) starting ...
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WO/2023/068112A1 |
Provided are: a method for producing an antimicrobial composition, said method comprising heating a reducing sugar selected from xylose and ribose and an amino acid selected from phenylalanine and proline to produce a melanoidin and blen...
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WO/2023/064493A1 |
This invention provides compounds for the inhibition of papain-like proteases (PLpros) for the inhibition of viruses, including compounds of formula (I"), and pharmaceutically acceptable salts thereof.
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WO/2023/064370A1 |
Compounds and methods to treat or prevent CNS diseases, such as Alzheimer's disease and brain injury inflammation, are disclosed herein. The compounds are soluble epoxide hydrolase (sEH) inhibitors and have improved physical properties, ...
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WO/2023/062627A1 |
Provided herein are compounds that inhibit the protein-protein interaction of serine acetyltransferase (SAT) with O-acetyl serine sulfhydrylase (OASS), and can therefore be used as herbicides.
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WO/2023/061999A1 |
The present invention discloses a distinct mode of action of a nickel catalyst to forge C-0 bonds to unlock the mild utilization of N2O as O-atom transfer reagent in the synthesis of complex phenols from the corresponding aryl halides.
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WO/2023/057548A1 |
The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.
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WO/2023/051657A1 |
Provided are a compound as represented by formula I, and a racemate, an enantiomer, a diastereomer and a pharmaceutically acceptable salt thereof, and the use thereof in the prevention or treatment of related diseases caused by coronavir...
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WO/2023/046768A1 |
The invention relates a method for producing amine N-oxide compounds of the formula (I) or (II), in which the R1 are selected from hydrocarbon groups with 4 to 26 C atoms and optionally at least one O or S atom; R2, R3, and R5 are select...
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WO/2023/046885A1 |
There is provided herein compounds of formula I and pharmaceutically acceptable salts thereof, wherein R1, ring A and the ring containing Q1 to Q5 have meanings as provided in the description. There is also provided medical uses of such ...
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WO/2023/048337A1 |
The present specification relates to a compound represented by chemical formula 1, a salt, a stereoisomer, a solvent or a hydrate thereof, an antibacterial composition, a composition for inhibiting bacterial infections, a composition for...
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WO/2023/047107A1 |
The present invention relates to compounds of formula (I) which may be used to treat a microbial infection or allergic reaction. In some embodiments, the microbial infection is leishmaniasis.
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WO/2023/044333A1 |
The present disclosure details various lipids, compositions, and/or methods of optimized systems and delivery vehicles for the delivery of nucleic acid sequences, polypeptides or peptides for use in vaccinating against infectious agents.
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WO/2023/044031A1 |
Many active pharmaceutical ingredients (API) are available in tablet form. Particles of the API should have a favorable compaction profile in order to be compressed into tablets, especially when the API is present in a large weight perce...
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WO/2023/036217A1 |
The present invention relates to a class of acrylamide compounds and the use thereof, and specifically relates to a compound as represented by formula (I) and a pharmaceutically acceptable salt thereof.
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WO/2023/036945A1 |
The invention relates to a compound of formula (I) wherein A is NH or CH2; G1 is a linear or a cyclic alkyl; Y1 is CH or N; Y2 is O, N or CH, W is O, N or CH; Z is NH or O; X1 and X2 and R, and R1 to R8 are functional groups.
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WO/2023/038093A1 |
Provided is a deuterium-enriched composition comprising a deuterium-substituted carboxylic acid or a salt thereof, wherein the carboxylic acid or the salt thereof includes an α hydrogen of a carboxy group and a hydrogen other than the Î...
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WO/2023/036093A1 |
A class of ketoamide derivatives and an application thereof are disclosed. Specifically disclosed are a compound of formula (IV) and a pharmaceutically acceptable salt thereof.
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WO/2023/035571A1 |
Provided is a new synthesis method for an intermediate of esaxerenone. The method comprises: (1) reacting 2-(trifluoromethyl)phenylacetic acid as a raw material with ethyl chloroformate or isobutyl chloroformate in an inert solvent in th...
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WO/2023/031335A1 |
The present invention relates to a process for the preparation of an optically pure (+) or (-) enantiomer of an iminium salt having the formula (I), aid process comprising the following steps: • a) a reduction step of an iminium salt h...
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WO/2023/034510A1 |
Provided herein is a process for the preparation of 3,4-methylenedioxymethamphetamine, (R)-3,4-methylenedioxymethamphetamine and (S)-3,4-methylenedioxymethamphetamine.
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WO/2023/029236A1 |
The present application provides a method for synthesizing a key intermediate II-a of upadacitinib. The asymmetric hydrogenation of unsaturated carboxylic acid I-a can be catalyzed by means of Ru(OAc)2-(R)-OSPD to synthesize chiral carbo...
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WO/2023/030279A1 |
Provided are a 3, 3-difluoroallylic onium salt as represented by formula (C), and a preparation method of the substance. Cheap industrial raw materials are used to prepare the important fluorine-containing reagent, which can be used as a...
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