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Matches 1 - 50 out of 24,056

Document Document Title
WO/2018/189157A1
Methods are disclosed for converting a carboxylic acid by using a diboron reagent to convert the carboxylic acid or imide ester derivative of a carboxylic acid to a boronic ester. The method may involve providing an imide ester, such as ...  
WO/2018/189214A1
The present invention relates to a method for binding to a target molecule comprising an aldehyde a compound derived from N- (2-aminoethyl)pyrrole, which compound also comprises a moiety of interest, to compounds (conjugates) obtained by...  
WO/2018/189546A1
The present invention relates to chemical linkers and protecting groups, compounds and compositions containing the chemical linkers or protecting groups, and intermediates and processes that can be used to prepare them. The chemical link...  
WO/2018/188356A1
Provided are a crystalline form of spirotetramat of formula (I), a crystal preparation process, the analyses of the crystal through various analytical methods and using the crystalline form to prepare a stable agrochemical formulation. T...  
WO/2018/186040A1
Provided is an ionic liquid, characterized in containing a cationic component and an anionic component, and in that the cationic component comprises a group having a perfluoropolyether chain and a group having a hydroxyl group.  
WO/2018/184890A1
Described are substituted pyrrolidinones of general formula (I) and the use thereof as herbicides, in particular for controlling weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the gr...  
WO/2018/187411A1
Described herein are methods, compositions, and kits for treating and/or preventing in a subject one or more side effects associated with radiation and/or chemotherapy exposure, including methods, compositions and kits that include an ac...  
WO/2018/183538A1
Disclosed herein, inter alia, are nucleotide analogues, and methods of use thereof, having cleavable orthogonal linkers.  
WO/2018/177837A1
The invention relates to 4-cyclopentyl- and 4-cyclopropyl-2-oxopyrrolidine-3-carboxamide derivatives and related compounds of general formula (I) as herbicidal plant protection agents, in particular for controlling weeds and/or weed gras...  
WO/2018/178397A1
The invention relates to the synthesis of amphiphilic amino acid derivatives, in particular to a method for the N-alkylation of an unprotected amino acid or the N-terminus of an oligopeptide substrate, comprising reacting said unprotecte...  
WO/2018/183261A1
The present invention relates to a compound of Formula (I): where ℗ R, R1, R2, R3, and Z are as described herein and to a process for preparing a compound of Formula (I). This invention also relates to a process for the synthesis of a ...  
WO/2018/177836A1
The invention relates to N-cyclopropyl-2-oxopyrrolidine-3-carboxamide derivatives and related compounds of general formula (I) as herbicidal plant protection agents, in particular for controlling weeds and/or weed grasses in crops of use...  
WO/2018/178936A1
The application is drawn to radiolabeled biomolecules and methods for radiolabeling biomolecules with radioactive halogen atoms that minimizes loss of the radioactive halogen due to dehalogenation in vivo, preserves the biological activi...  
WO/2018/177861A1
The present invention relates to tris-aryl-amide derivatives having an anti-heparanase activity, in particular it relates toureido/thioureido/ether tris-aryl-amide derivatives of formula (I). The invention also relates to the use of such...  
WO/2018/179239A1
Provided is a distilling apparatus which enables on-site recycling of spent NMP recovered from, for example, a process of manufacturing electrodes for lithium-ion secondary batteries, and is capable of simply and safely refining the NMP ...  
WO/2018/177863A1
The present invention relates to ureido derivatives of naphtalenesulfonic acids having an anti-heparanase activity. In particular, it relates to compounds of formula (I), (I) wherein the meanings of the substituent are specified in the d...  
WO/2018/176134A1
The present disclosure relates to compounds for use as electrode additives or as salts in electrolyte compositions, and their methods of preparation. The majority of compounds are anions of imidazoles bearing a sulphonyl or a carbonyl gr...  
WO/2018/178014A1
Described are substituted pyrrolidinones of general formula (I) and the use thereof as herbicides, in particular for controlling weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the gr...  
WO/2018/172423A1
The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p¸ q, L, ׇ, X and m are as defined herein. The compound...  
WO/2018/175226A1
This application is directed to a compound of Formula II Also disclosed is a process for preparing a compound of Formula II comprising using the compounds of Formulae IV and V Also disclosed is a method for preparing a compound of Formul...  
WO/2018/175449A1
The present invention relates to proline amide compounds and their azetidine derivatives of formula I wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition c...  
WO/2018/174283A1
Provided is a sustained-release formulation of evocalcet or a pharmacologically acceptable salt thereof. A polyethylene glycol derivative of evocalcet or a pharmacologically acceptable salt thereof is used.  
WO/2018/169818A1
The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological di...  
WO/2018/166819A1
The invention relates to a process for the production of compounds of formula (I), comprising Step A of reacting compounds of formula (II) with 2,3-dihalopropionitrile or 2-haloacrylonitrile in the presence of DIPEA. It also relates to a...  
WO/2018/167776A1
The present application provides novel process for the preparation of glycopyrrolate tosylate.  
WO/2018/170371A1
Provided herein are novel polyaromatic compounds which, upon cure, produce high refractive index polymers. In accordance with certain aspects of the present invention, there are provided high refractive index formulations containing the ...  
WO/2018/164191A1
The present invention provides a substituted pyrrolidine compound having orexin receptor type 2 agonist activity. A compound represented by the formula (in the formula, each symbol is as described in the specification) or a salt thereof ...  
WO/2018/164192A1
The present invention provides a substituted pyrrolidine compound having orexin-2 receptor agonistic activity. A compound represented by formula (I) (wherein the symbols are as described in the description) or a salt thereof has orexin-2...  
WO/2018/159459A1
Provided is a diarylamine-based compound represented by a general formula (1) (in general formula (1), A1 and A2 each independently represent an arylene group which has 6-18 carbon atoms and may have a substituent, and A3 and A4 each ind...  
WO/2018/154597A1
Provided herein are processes for preparation of glycopyrronium bromide comprising reaction of N-methylpyrrolidin-3-ol with compounds of Formula I or Formula II followed by additional steps.  
WO/2018/153820A1
The invention relates to a novel process for the preparation of a chiral pyrollidine-2-yl-methanol derivative or a salt thereof of the formula (I), wherein R1 is aryl or heteroaryl and both aryl or heteroaryl are optionally substituted b...  
WO/2018/152950A1
Provided is a method for preparing brivaracetam, comprising using optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one as the raw material, and subjecting same to steps such as ring opening, halogenation, condensation and ring closure to...  
WO/2018/152134A1
Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF 1 receptor. Methods, compounds and compositions for modulat...  
WO/2018/150906A1
This liquid crystal display device 10 is provided with: a pair of substrates which have conductive films 14, 15, respectively; a liquid crystal layer 12 which is arranged between the pair of substrates and contains liquid crystals; and a...  
WO/2018/147292A1
The present invention addresses the problem of providing a novel plant growth suppression agent and a plant growth suppression method that uses the same. This plant growth suppression agent includes, as an active ingredient, a compound e...  
WO/2018/147290A1
The present invention addresses the problem of providing a novel plant growth suppression agent and a plant growth suppression method that uses the same. This plant growth suppression agent includes, as an active ingredient, at least one...  
WO/2018/141276A1
Disclosed are a novel crystal form of a brivaracetam intermediate compound (I) and preparation method thereof, and a novel crystal form of brivaracetam and preparation method thereof, specifically a crystal form A of a compound I and a c...  
WO/2018/144620A1
Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating d...  
WO/2018/140512A1
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): (I) or a pharmaceutically acceptable salt, isotopic form, stereoisomer or prodrug thereof, wherein A, B, X,...  
WO/2018/139438A1
[Problem] To provide a compound useful as a cathepsin S inhibitor. [Solution] The present inventors have studied on a compound which has a cathepsin S-inhibiting activity and can be used as an active ingredient for a pharmaceutical compo...  
WO/2018/140275A3
A compound according to the general Formula (8): wherein R1 is hydrogen or C1-C4 alkyl; R2 is C1-C4 alkyl, benzyl, or 1H-indol-3-ylmethyl; T is selected from the group consisting of -CH(OR3)-R4, -C(=O)-OR3, or -C(=O)-NR3 R5, wherein R3 i...  
WO/2018/140435A1
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.  
WO/2018/133846A1
The present invention relates to a cyclothiourea compound and the use thereof. In particular, disclosed in the present invention are a compound having the structure as shown in formula (A) which can be used as an HBV replication inhibito...  
WO/2018/130063A1
The present invention provides an (R)-4-hydroxy-2-oxo-1-pyrrolidineacetamide crystal form, which has diffraction peaks when 2θ is 12.423±0.2°, 16.465±0.2°, 17.344±0.2°, 21.889±0.2°, and 25.054±0.2°. The present invention can p...  
WO/2018/130062A1
The present invention provides a method for preparing an (R)-4-hydroxy-2-oxo-1-pyrrolidineacetamide crystal form, which has diffraction peaks when 2θ is 12.423±0.2°, 16.465±0.2°, 17.344±0.2°, 21.889±0.2°, and 25.054±0.2°. The ...  
WO/2018/131657A1
The present invention provides a method by which a dinitro compound that is a precursor of a diamine compound which serves as a production starting material for a polyamic acid and/or a polyimide is produced with high purity and high yie...  
WO/2018/129552A1
The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-sta...  
WO/2018/124453A1
The present invention relates to a method for producing an N-substituted maleimide using a heterogeneous solid acid catalyst. Specifically, the purpose of the present invention is to provide a method for producing an N-substituted maleim...  
WO/2018/121689A1
The present invention provides a sulfonamide-aryl amide compound and a use thereof as a drug for treating hepatitis B. Particularly, the present invention provides a compound as an HBV replication inhibitor and having the structure shown...  
WO/2018/124140A1
Provided are: a method for producing a diamine compound represented by formula (1), the method comprising a step of reacting the bismaleimide compound represented by formula (A) with either a diamino compound in which P1 in the compound ...  

Matches 1 - 50 out of 24,056