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Matches 1 - 50 out of 23,748

Document Document Title
WO/2018/010656A1
A pyrrolidine derivative serving as a PPAR agonist, and applications thereof in treating diseases of pathways related to a PPAR receptor, such as nonalcoholic steatohepatitis, complication fibrosis, insulin resistance, primary biliary ch...  
WO/2018/006795A1
Disclosed are an aromatic acetylene or aromatic ethylene compound, an intermediate, a preparation method, a pharmaceutical composition and a use thereof. The aromatic acetylene or aromatic ethylene compound has a significant inhibitory e...  
WO/2018/009830A1
The present invention relates to a compound having the structure of formula (I), wherein R1, R2, R3, R4, R5, R6, and R7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula...  
WO/2017/222881A1
Disclosed herein are novel uses of a polyhydroxylated pyrrolidine for the manufacture of a medicament for treating Fabry disease (FD). Accordingly, the present disclosure provides a method of treating a subject having or suspected of hav...  
WO/2017/222917A1
This invention is directed to novel aliphatic prolinamide derivatives of Formula I, and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or redu...  
WO/2017/222438A1
The invention relates to a composition for joining of polyvinylchloride (PVC) components, the composition comprising 50-95 wt% 1-butylpyrrolidin-2-one and 5–40 wt% polyvinylchloride and/or polyvinylacetate. The inventionfurther relates...  
WO/2017/218959A1
A porphyrin compound and composition made therefrom comprising a therapeutically effective dose of a porphyrin hound via a linker to an anti-cancer agent useful in treating cancer in a patient in need thereof or to treat cancer cells in-...  
WO/2017/216028A1
The invention relates to specific Antibody-Drug-Conjugates (ADCs) with KSP inhibitors and anti- CD 123 -antibodies, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for pr...  
WO/2017/212423A1
The invention is directed to substituted pyrrolidine derivatives. Specifically, the invention is directed to compounds according to Formula III: wherein A, B, L1, L2, L3, R1, R2, R3, R4, R5, R6, R9, R10, R30, Y1, Y2, z2, z4, z5, and z6 a...  
WO/2017/212273A1
The present invention provides co-crystals of glycopyrronium bromide with lactose. The glycopyrronium bromide and lactose in the novel co-crystals are present in a stoichiometric ratio of from about 1 :2 to 2: 1. These are characterized ...  
WO/2017/214201A1
Pharmaceutical carriers which provide an environment of physical and chemical stability comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound of structure I, one or more antioxidants, one or ...  
WO/2017/206688A1
The present invention provides a substituted pyrrolidine compound, a pharmaceutical composition, and applications thereof. The pyrrolidine compound is a compound represented by formula (1), or a polymorph, a pharmaceutically acceptable s...  
WO/2017/210696A1
Embodiments relate to pharmaceutical compositions, comprising one or more beta-3 adrenoceptor agonists that are useful for the treatment of lower urinary tract symptoms such as, for example, overactive bladder, prostate disorders and met...  
WO/2017/206827A1
Disclosed are a crystal form of an L-proline cocrystal of a sodium-glucose cotransporter 2 inhibitor, a preparation method therefor, and a pharmaceutical composition and a use therof. Particularly involved are the crystal form of the L-p...  
WO/2017/209237A1
The present invention provides a compound having a low melting point and excellent thermal resistance. This substituted or unsubstituted allyl group-containing maleimide compound is characterized by being represented by formula (1) (in f...  
WO/2017/209322A1
The present invention relates to a five-membered heterocyclic compound having an analgesic effect and a pharmaceutical composition comprising a derivative of the five-membered heterocyclic compound. More specifically, the present inventi...  
WO/2017/209236A1
Bismaleimide (BMI) exhibits excellent thermal resistance (a high Tg and high thermal decomposition resistance) compared to epoxy resins and phenolic resins and has therefore been studied for use in electrical material applications in rec...  
WO/2017/208905A1
The present invention addresses the problem of providing a method for producing a polymethine compound with higher yield and higher efficiency compared with the conventional methods by preventing the production of by-products effectively...  
WO/2017/202274A1
Disclosed are a nicotinyl alcohol ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the present invention relates to nicotinyl alcohol ether derivative represented by formul...  
WO/2017/199778A1
The present invention provides: a polymerizable compound having at least one monovalent group (A); a polymerizable composition containing the same; a liquid crystal composite prepared therefrom; and a liquid crystal display element havin...  
WO/2017/201314A1
The present invention relates to novel 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild condit...  
WO/2017/197377A1
The present invention is directed to compounds, compositions and methods for preventing, treating or curing Norovirus infection in human subjects or other animal hosts.  
WO/2017/196806A1
The present invention is directed to a compound of Formula I or Formula III or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt: wherein...  
WO/2017/195873A1
The present invention relates to a yeast cell of Yarrowia lipolytica, a cell culture product thereof or an extract of the same. The aforesaid yeast cell, cell culture product and extract of the same are characterized by containing L-hydr...  
WO/2017/191000A1
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...  
WO/2017/191001A1
The present invention relates to new methods for producing cis-alkoxy substituted spirocyclic 1-H-pyrrolidine-2,4-dione derivatives and new intermediates or starting compounds that are used in the method according to the invention.  
WO/2017/192665A1
This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative ...  
WO/2017/185430A1
A liquid crystal aligning agent, comprising a polyamide acid and a polyimide polymer obtained after high-temperature curing of the polyamide acid. The polyamide acid is obtained by reacting a tetracarboxylic dianhydride and a diamine. Th...  
WO/2017/186140A1
The present invention relates to a method for preparing a tyrosine kinase inhibitor and a derivative thereof. The present method has a short synthesis route, low costs, easy operation, and is suitable for large-scale production.  
WO/2017/181791A1
Provided is an application of a compound comprising 10B for preparing a pharmaceutical product specifically binding an amyloid β-protein. After the pharmaceutical product specifically binding the amyloid β-protein binds the amyloid β-...  
WO/2017/177326A1
The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to ta...  
WO/2017/177763A1
A system and method for separating N-Methyl-2-pyrrolidone (NMP)/chloroform. By combining a falling film evaporator, a forced circulation evaporator, and a fractionating column with a corresponding technological operation method, the syst...  
WO/2017/177316A1
There are provided compounds of formula (I) in which R2, R2, R3, R4 and Q can represent various different possibilities. These compounds can be useful as anticancer agents as well as anti-inflammatory agents, anti-proliferative agents an...  
WO/2017/173604A1
Provided herein are compounds of the formula (I) : as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containin...  
WO/2017/169503A1
[Problem] Provided are: a method for producing a nitrogen-containing aromatic amide, in which method a monomer unit obtained under mild reaction conditions can be used, and which is performed by the catalytic formation of amide linkages;...  
WO/2017/168368A1
Derivatives of pyrrole-2,5-diones having formula (I): (I) are described, together with agronomic compositions containing said derivatives having formula (I) and the use thereof for the control of phytopathogenic fungi in agricultural crops.  
WO/2017/173323A1
The present disclosure is directed to a phosphorus-modified ionic liquid compound, the synthesis thereof and an electrochemical cell electrolyte containing the phosphorus-modified ionic liquid compound.  
WO/2017/164575A1
The present invention provides a novel acid addition salt of 1-(5-(2,4-difluorophenyl)- 1 -((3 -fluorophenyl)sulfonyl)-4-methoxy- 1 H-pyrrol-3 -yl)-N-memylmethanarnine. The above- described acid addition salt can have not only excellent ...  
WO/2017/165119A1
The present invention is related to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof. The present invention is further related to a method of healing and/or inhibiting formation of scar tissue in an extern...  
WO/2017/164576A1
The present invention provides a novel crystalline form I of hydrochloride, a crystalline form II of hydrochloride, a crystalline form of succinate, a crystalline form of tartrate, a crystalline form I of fumarate and a crystalline form ...  
WO/2017/159484A1
[Problem] To provide an agent for inhibiting aggregation of tau and/or amyloid β. [Solution] A compound represented by formula (I) or a salt thereof. This compound is used in therapy, diagnosis, and symptom alleviation and in prevention...  
WO/2017/160925A1
Disclosed herein are compounds of Formulae (I), and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.  
WO/2017/161140A1
Provided herein are compositions including oxotremorine (e.g., Oxotremorine methiodide or Oxo-M) and 4-PPBP (e.g., 4-PPBP maleate). Also provided are methods of treating a connective tissue defect in a subject with oxotremorine and 4-PPBP.  
WO/2017/159100A1
The purpose of the present invention is to provide: a novel liquid crystalline compound shown below which exhibits liquid crystallinity in a body temperature range; and a use of the liquid crystalline compound. (In formula [I], X represe...  
WO/2017/157727A1
Solution comprising a sulfone polymer and a N-acyl-pyrrolidine of formula I wherein R1 to R9 independently from each other are a hydrogen atom or a methyl group. The solution is applied in membrane formation with polyvinylpyrrolidone as ...  
WO/2017/156255A1
The present invention is directed to compounds, compositions and methods for preventing, treating or curing Hepatitis B (HBV) infection in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts...  
WO/2017/156239A1
This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a lactam with a chiral Ni catalyst, an aryl n...  
WO/2017/154767A1
The purpose of the present invention is to provide: nano emulsion particles which can be used as a metal-free contrast agent for MRI or the like; and an organic nitroxide radical compound which makes it possible to easily prepare the nan...  
WO/2017/147146A1
Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.  
WO/2017/147417A1
Bispyridines improve the labeling of nucleophiles, including amines and thiols and are particularly useful for improving labeling with acidic and basic labels. Use of bispyridines with such labels dramatically increases labeling compared...  

Matches 1 - 50 out of 23,748