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Matches 1 - 50 out of 23,943

Document Document Title
WO/2018/130063A1
The present invention provides an (R)-4-hydroxy-2-oxo-1-pyrrolidineacetamide crystal form, which has diffraction peaks when 2θ is 12.423±0.2°, 16.465±0.2°, 17.344±0.2°, 21.889±0.2°, and 25.054±0.2°. The present invention can p...  
WO/2018/130062A1
The present invention provides a method for preparing an (R)-4-hydroxy-2-oxo-1-pyrrolidineacetamide crystal form, which has diffraction peaks when 2θ is 12.423±0.2°, 16.465±0.2°, 17.344±0.2°, 21.889±0.2°, and 25.054±0.2°. The ...  
WO/2018/131657A1
The present invention provides a method by which a dinitro compound that is a precursor of a diamine compound which serves as a production starting material for a polyamic acid and/or a polyimide is produced with high purity and high yie...  
WO/2018/129552A1
The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-sta...  
WO/2018/124453A1
The present invention relates to a method for producing an N-substituted maleimide using a heterogeneous solid acid catalyst. Specifically, the purpose of the present invention is to provide a method for producing an N-substituted maleim...  
WO/2018/121689A1
The present invention provides a sulfonamide-aryl amide compound and a use thereof as a drug for treating hepatitis B. Particularly, the present invention provides a compound as an HBV replication inhibitor and having the structure shown...  
WO/2018/124140A1
Provided are: a method for producing a diamine compound represented by formula (1), the method comprising a step of reacting the bismaleimide compound represented by formula (A) with either a diamino compound in which P1 in the compound ...  
WO/2018/115421A1
The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).  
WO/2018/119108A1
The present invention relates to solid, oral dosage forms of asimadoline comprising lactose monohydrate.  
WO/2018/118384A1
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein R1, R2, R3, R4, R5, R6, J2, Q1, Q2, T and Y are as defined in the disclosure. Also disclosed are compositions containing the compound...  
WO/2018/111803A1
The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of RORγ and the treatment of diseases related to the modulation of RORγ. The present inventio...  
WO/2018/109192A1
The present invention relates to novel cationic azomethine direct dyes of formula (I) and the leuco forms thereof of formula (II), and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair...  
WO/2018/107167A1
This present disclosure is directed to compounds of formula (I): (I) where R1a, R1b, R1c, R1d, R1e, R3, R4a, R4b, R4c, R4d, R6, R7, and R8 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically...  
WO/2018/104856A1
A process of obtaining a purified geometric isomer of an unsaturated macrocyclic compound is disclosed herein. The process is effected by contacting an ion exchange medium comprising silver ions with a mixture comprising at least one geo...  
WO/2018/104307A1
Substituted aromatic sulfonamides of formula (I), pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a d...  
WO/2018/104305A1
Substituted aromatic sulfonamides of formula (I) which are antagonists or negative allosteric modulators of P2X4, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a ph...  
WO/2018/107072A1
Disclosed herein are compounds which inhibit the kinase activity of dual leucine zipper (DLK) kinase (MAP3K12), pharmaceutical compositions, and methods of treatment of DLK-mediated diseases, such as neurological diseases that result fro...  
WO/2018/102252A1
Described herein are bacteriochlorins comprising an annulated isocyclic ring. Also described are methods and intermediates for the synthesis of bacteriochlorins comprising an annulated isocyclic ring, and methods of using such bacterioch...  
WO/2018/098781A1
The present invention provides compounds which are of the formula (I) and (II), wherein X is selected from the group consisting formula (III), (IV), (V) and (VI); R is selected from the group consisting of formula (VII), (VIII), (IX), (X...  
WO/2018/102419A1
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.  
WO/2018/102006A1
The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of indoleamine-2,3-dioxygenase (IDO) activity, and methods of treating IDO-related disorders.  
WO/2018/100560A1
The present invention concerns Au and Cu-based mononuclear coordination compounds, drug formulations thereof, the relating synthesis and encapsulation method in macromolecules or supramolecular aggregates or nanostructures, as well as th...  
WO/2018/100515A1
The invention relates to novel ruthenium complexes of formula (9). The invention also relates to the method for preparation of novel metal complexes of formula (9) and their use in olefin metathesis reactions.  
WO/2018/095488A1
The invention relates to sulfobetaine compounds, a process for synthesizing same, and the uses of sulfobetaine compounds for synthesizing antimicrobial materials, antistatic materials, antifouling materials, printing inks, surface-active...  
WO/2018/095422A1
Provided in the present invention are a di-substituted maleic amide linker conjugated to an antibody and a preparation method and use thereof. In particular, the present invention conjugates a strongly cytotoxic active substance to a bio...  
WO/2018/091153A1
The present invention relates to novel substituted N-(3-fluoropropyl)-pyrrolidine compounds of formula (l-A): wherein R1 and R2 represent independently a hydrogen atom or a deuterium atom; A represents an oxygen or nitrogen atom; and SER...  
WO/2018/091222A1
Compositions comprising a lactam. Pharmaceutical compositions comprising such lactams for use in methods of treatment.  
WO/2018/090787A1
Provided herein are the crystalline form of chlorfenapyr of formula (I), the crystal preparation process, the analyses of the crystal through various analytical methods, using the crystal to prepare stable agrochemical formulation, and t...  
WO/2018/094335A1
The present invention relates to novel small molecule modulators of Nav1.6 channels of the general formulae (I), (II), (III) and (IV), and the uses thereof.  
WO/2018/091221A1
Compositions comprising a lactam. Pharmaceutical compositions comprising such lactams for use in methods of treatment.  
WO/2018/089402A1
There are described RORγ Gamma modulators of the formula (I), (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutic...  
WO/2018/087685A1
Adducts are described formed between pyrrole derivatives of formula (I) an carbon allotropes in which the carbon is sp2 hybridized, such as for example carbon nanotubes, graphene or nanographites, carbon black. The pyrrole derivatives be...  
WO/2018/086530A1
Provided is a series of sulfonamide compounds as a cccDNA inhibitor. Particularly, the present invention relates to a compound represented by formula (I) as a cccDNA inhibitor or a pharmaceutically acceptable salt thereof.  
WO/2018/087019A1
The invention relates to a method for producing amide bonds, particularly peptide bonds, with the aid of new amide coupling reagents containing an anion of formula (I); the invention also relates to these new reagents and to the producti...  
WO/2018/087688A1
Adducts are described, obtainable from the reaction product of a secondary amine and a diketone, with carbon allotropes in which the carbon is sp2 hybridized, such as graphene, graphite, fullerene, carbon nanotubes and the like, and an i...  
WO/2018/089406A1
There are described RORɣ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical composi...  
WO/2018/086507A1
The invention discloses a naphthalene sulfonamide type compound, a preparation method thereof and an application thereof for regulating plant growth activity. A general formula of a structure of the naphthalene sulfonamide type compound ...  
WO/2018/081814A1
The present technology provides compounds according to Formula I or Formula III as well as compositions including such compounds useful for the treatment of metastatic cancer and/or glaucoma.  
WO/2018/080269A1
The present invention relates to novel functional derivatives of alanine and proline amino acids. The compounds of the present invention were confirmed to have a very superior antifungal or fungicidal effect. In addition, the compounds o...  
WO/2018/076784A1
A crystalline form of (R)-4-hydroxy-2-oxo-1-pyrrolidineacetamide is disclosed. The crystalline form has a diffraction peak when a diffraction angle, 2θ, is 16.66±0.2°, 17.54±0.2°, 21±0.2°, 22.16±0.2°, or 30.96±0.2°. The crysta...  
WO/2018/072739A1
Disclosed is a method for comprehensive recycling of a by-product slurry during polyphenylene sulfide (PPS) production. Na2CO3 is added to the slurry, and then a solvent NMP is recovered by distillation and drying, then an acid solution ...  
WO/2018/072689A1
The present invention provides a stachydrine derivative, a preparation method therefor, and applications thereof in the preparation of drugs for treating cardiovascular and cerebrovascular diseases. The stachydrine derivative is a compon...  
WO/2018/074566A1
The present invention provides an efficient production method for industrial mass synthesis of a pyrrolidine compound represented by formula (I) or a salt thereof, the method comprising reacting a compound represented by formula (II) or ...  
WO/2018/069732A1
This invention relates to compounds that are agonists of the muscarinic M1 receptor or M1 and M4 receptors and which are useful in the treatment of muscarinic M1 or M1/M4 receptor mediated diseases. Also provided are pharmaceutical compo...  
WO/2018/071741A1
The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoim...  
WO/2018/071893A1
Methods of treating neuropathic pain in spinal cord injured individuals by administering levetiracetam or brivaracetam are described.  
WO/2018/065962A1
The invention discloses compounds of Formula (I), wherein R1, R2, R2A, R3, R3A, R4, R4A, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their produc...  
WO/2018/065921A1
The invention discloses compounds of Formula (I) wherein R1, R2, R2A, R3, R3A, R4, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, ...  
WO/2018/066646A1
The present invention addresses the problem of finding a novel medicine which has an excellent tryptophanase inhibitory effect, suppresses indoxyl sulfate production in blood to thereby prevent deterioration of renal function, and thus c...  
WO/2018/065311A1
The present invention provides a composition comprising (A) a compound of formula (I): (I) wherein R is methyl or methoxy, R is hydrogen, methyl or ethoxy and A is a substituted heteroaryl group, or an N-oxide or salt form thereof, and (...  

Matches 1 - 50 out of 23,943