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Matches 101 - 150 out of 1,112

Document Document Title
WO/2005/121073A1
The present invention relates to a benzamide derivative comprising a head, spacer and cap group wherein the spacer includes a benzene ring substituted with an additional spacer and wherein the additional spacer is an unsaturated group.  
WO2004069804A8
The invention relates to novel chromogenic enzyme substrates which are used to detect aminopeptidase activity in micro-organisms or to determine whether at least one bacterium belongs to the Gram-positive group or the Gram-negative group...  
WO2004091485A3
This invention relates to treating inflammatory and immune diseases with certain aminoquinoline compounds that bind to CXCR3 receptors. The aminoquinoline compounds are covered by the formula (I) shown below. Each variable is defined in ...  
WO2005051296A3
Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r) and Plasmodium faciparum. Prodrugs of these compounds can be used as an oral tre...  
WO2005043124A3
One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the aryl group is an optionally substituted acr...  
WO/2005/051296A2
Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r) and Plasmodium faciparum. Prodrugs of these compounds can be used as an oral tre...  
WO/2005/051915A1
The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatri...  
WO/2005/043124A2
One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the aryl group is an optionally substituted acr...  
WO2004092125A3
Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with azaaromatic compounds and/or nitrogen heterocycle compounds to produce functionalized azaaromatic compounds and functionalized nitrogen heterocycle co...  
WO2004085418A3
Compound that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods of inhibiting the DNA-PK biological activity, methods of sensitizing cells the agents that cause DNA lesions, and methods of potentiating ...  
WO/2005/007643A1
The invention relates to novel acridine derivatives of general formula (I), the production and use thereof as medicaments, in particular, for the treatment of tumours.  
WO/2004/099340A1
A luminescent-polymer composition comprising a luminescent polymer and ion pairs, wherein the ion pairs each has an anion having such a specific structure that the anion has one atom of a Group 13 element and is bonded to either an aryl ...  
WO2004018418A3
In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and ...  
WO2004067675A3
A blue electroluminescent material based on a binaphtyl compound of the general formula (I). Particular embodiments having the general formula have good solubilities in common organic solvents, resist crystallization and can be sublimed ...  
WO/2004/091485A2
This invention relates to treating inflammatory and immune diseases with certain aminoquinoline compounds that bind to CXCR3 receptors. The aminoquinoline compounds are covered by the formula (I) shown below. Each variable is defined in ...  
WO/2004/092125A2
Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with azaaromatic compounds and/or nitrogen heterocycle compounds to produce functionalized azaaromatic compounds and functionalized nitrogen heterocycle co...  
WO/2004/085418A2
Compound that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods of inhibiting the DNA-PK biological activity, methods of sensitizing cells the agents that cause DNA lesions, and methods of potentiating ...  
WO/2004/078731A1
The invention relates to compounds, substituted guinoline-carboxylic acids and the derivatives thereof of general formula (1, 2, 3), the pharmaceutically acceptable salts thereof, N-oxides or hydrates and methods for the production there...  
WO/2004/069804A1
The invention relates to novel chromogenic enzyme substrates which are used to detect aminopeptidase activity in micro-organisms or to determine whether at least one bacterium belongs to the Gram-positive group or the Gram-negative group...  
WO/2004/067675A2
A blue electroluminescent material based on a binaphtyl compound of the general formula (I). Particular embodiments having the general formula have good solubilities in common organic solvents, resist crystallization and can be sublimed ...  
WO2004032929A3
A family of compounds of formula (I) wherein: X is one of the following radicals: (a), (b), (c) which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile...  
WO/2004/032929A2
A family of compounds of formula (I) wherein: X is one of the following radicals: (a), (b), (c) which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile...  
WO/2004/020372A1
A fluorene compound represented by the following general formula [I]: is used to provide an organic luminescent device. Such a device has an optical output exhibiting a high luminance with an extremely high efficiency, and has an extreme...  
WO/2004/020373A1
Provided are a novel spiro compound, and an organic luminescence device using the spiro compound and having anoptical output with an extremely high efficiency and a high luminance, and an extremely high durability. The spiro compound is ...  
WO/2004/020371A1
A new condensed polycyclic compound represented by general formula [I]: wherein R¿1? is hydrogen, halogen, cyano, a substituted amino or a group selected from the group consisting of alkyl, aralkyl, aryl, heterocyclic, each having no su...  
WO/2004/018418A2
In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and ...  
WO2003027050A3
A process for preparing substituted pentacene compounds comprises the step of cyclizing substituted bis(benzyl)phthalic acids using an acid composition comprising trifluoromethanesulfonic acid, the substituted bis(benzyl)phthalic acids b...  
WO2003082350A3
The present invention is concerned with radiolabelled quinoline and quinolinone derivatives according Formula (I-A)* or (I-B)* showing metabotropic glutamate receptor antagonistic activity, in particular mGlu1 receptor activity, and thei...  
WO/2004/011946A1
Disclosed are compounds of formula: (I) In which D is a fluorescent dye selected from an acridone and a quinacridone dye; F comprises a target bonding group selected from a carboxylic acid thioester group and a 1,2-aminothiol group; M is...  
WO2003055447A3
Compounds having the formula (I), wherein R<3> is selected from H, OH and NH<2>; R<30> is selected from =O and =S; W is -C(=O)-, -S(=O)-, or -S(O)2-; or W may be -CH2- if X is -C(=O)-; X is selected from -CH2-, -N(R<4>)-, and -O-, except...  
WO2003059269A3
Compounds having formula (I), wherein R<3> is selected from H, OH and NH2; R<30> is selected from =O and =S; W is -C(=O)-, -S(=O)-, or -S(O)2-; or W may be -CH2- if X is -C(=O)-; X is selected from -CH2-, -N(R<4>)-, and -O-, except that ...  
WO2003038399A3
A novel chemiluminescent acridinium compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel compound to the analyte and ...  
WO2002099424A3
Disclosed are new acridone dye derivatives having characteristic fluorescence lifetimes. Also disclosed are methods for labelling target biological materials employing the acridone dyes and use of the labelled materials in biological ass...  
WO2003004091A3
The present invention discloses novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb low-energy ultraviolet, visible, or near-inf...  
WO/2003/082350A2
The present invention is concerned with radiolabelled quinoline and quinolinone derivatives according Formula (I-A)* or (I-B)* showing metabotropic glutamate receptor antagonistic activity, in particular mGlu1 receptor activity, and thei...  
WO2002008193A3
The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is =O, L is -H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is...  
WO2003053915A3
This invention relates to compounds of the Formula (I):(Chemical formula should be inserted here as it appears on abstract in paper form)(I)or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the tre...  
WO/2003/074490A1
The invention relates to pharmaceutical preparations containing a dibenzocyclooctane lignan derivative for prevention and treatment of neurodegenerative disease.  
WO/2003/059269A2
Compounds having formula (I), wherein R?3¿ is selected from H, OH and NH¿2?; R?30¿ is selected from =O and =S; W is -C(=O)-, -S(=O)-, or -S(O)¿2?-; or W may be -CH¿2?- if X is -C(=O)-; X is selected from -CH¿2?-, -N(R?4¿)-, and -O...  
WO/2003/059885A1
This invention pertains to certain acridone and acridine compounds of the formula (1) which inhibit telomerase, regulate cell proliferation, etc., and/or treat cancer, proliferative conditions, etc.: wherein either: (a) K is =O, L is -H,...  
WO2003039488A3
The present invention is directed to a method for treating inflammatory bowel disease in a patient comprising administering to said patient a pharmaceutical compositions comprising a pharmaceutically effective amount of an anti-malarial ...  
WO/2003/055447A2
Compounds having the formula (I), wherein R?3¿ is selected from H, OH and NH?2¿; R?30¿ is selected from =O and =S; W is -C(=O)-, -S(=O)-, or -S(O)¿2?-; or W may be -CH¿2?- if X is -C(=O)-; X is selected from -CH¿2?-, -N(R?4¿)-, an...  
WO/2003/053934A1
Novel compounds comprising a C-C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a...  
WO/2003/053915A2
This invention relates to compounds of the Formula (I):(Chemical formula should be inserted here as it appears on abstract in paper form)(I)or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the tre...  
WO/2003/045920A1
The present invention is concerned with compounds of the general Formula I : and pharmaceutically acceptable salts thereof, which are useful as melanin concentrating hormone receptor antagonists, particularly MCH-1R antagonists. As such,...  
WO/2003/039488A2
The present invention is directed to a method for treating inflammatory bowel disease in a patient comprising administering to said patient a pharmaceutical compositions comprising a pharmaceutically effective amount of an anti-malarial ...  
WO/2003/039546A1
The present invention is directed to the use of anti-malarial compound for the treatment and prophylaxis of infections by adenovirus or rhinovirus.  
WO/2003/037853A1
The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.  
WO2002008194A8
The invention relates to novel acridine derivatives of general formula (1), the production thereof and the use of the same as pharmaceuticals, especially for treating tumours.  
WO/2003/038399A2
A novel chemiluminescent acridinium compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel compound to the analyte and ...  

Matches 101 - 150 out of 1,112