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Patent Searching and Data


Matches 101 - 150 out of 1,153

Document Document Title
WO/2007/104695A1
Novel quinolyl and acridinylhydrazone compounds of formula (I), which present remarkable biological activity especially against the choloroquine-resistant Plasmodium falciparum strains, useful for the treatment and prevention of malaria ...  
WO/2007/092847A2
Acridinium-functionalized solid-phase supports and methods for making acridinium-functionalized solid-phase supports are disclosed. The acridinium- functionalized solid-phase supports comprise a solid phase support linked to a chemilumin...  
WO/2007/092847A3
Acridinium-functionalized solid-phase supports and methods for making acridinium-functionalized solid-phase supports are disclosed. The acridinium- functionalized solid-phase supports comprise a solid phase support linked to a chemilumin...  
WO/2007/058568A2
The invention relates to 1-alkylamino-1-desoxy-polyols and 9-oxoacridine-10-acetic acid salts of general formula (I), wherein A is (II), in which R is selected from an ethyl, propyl and butyl group, to medicinal preparations containing a...  
WO/2007/058568A3
The invention relates to 1-alkylamino-1-desoxy-polyols and 9-oxoacridine-10-acetic acid salts of general formula (I), wherein A is (II), in which R is selected from an ethyl, propyl and butyl group, to medicinal preparations containing a...  
WO2006095139A3
The present invention relates to a 3,6,9 acridine compound and optionally substituted derivatives thereof that may be useful in the treatment of cancer. The invention also provides compositions comprising the compounds and uses thereof. ...  
WO/2006/130736A2
The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by t...  
WO/2006/130736A3
The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by t...  
WO2006088541A3
This disclosure provides a new class of compounds referred to as "reversed chloroquines" (RCQs), which are highly effective against CQR and CQS malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog ...  
WO2006094237A3
Provided herein are sirtuin-modulating compounds which are derivatives of guioline or acridine and methods of use thereof . The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventin...  
WO/2006/095139A2
The present invention relates to a 3,6,9 acridine compound and optionally substituted derivatives thereof that may be useful in the treatment of cancer. The invention also provides compositions comprising the compounds and uses thereof. ...  
WO/2006/092395A1
The invention relates to compounds according to general formula (1) and/or their enantiomers, diastereomers as well as their pharmaceutically compatible salts, and to the use thereof for producing a medicament suited for treating disease...  
WO/2006/094237A2
Provided herein are sirtuin-modulating compounds which are derivatives of guioline or acridine and methods of use thereof . The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventin...  
WO/2006/073424A3
New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and (1,2)-dioxetanes. Among the new acridane­based compounds are water-soluble acridanes, enhancer coupled acrida...  
WO/2006/051489A1
Use of 1,4-bis (3-aminoalkyl) piperazine derivatives as defined in formula I or II for the manufacture of a pharmaceutical composition intended for the treatment of neurodegenerative diseases, related neurodegenerative diseases, developm...  
WO/2006/034036A1
The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.  
WO/2005/121073A1
The present invention relates to a benzamide derivative comprising a head, spacer and cap group wherein the spacer includes a benzene ring substituted with an additional spacer and wherein the additional spacer is an unsaturated group.  
WO2004069804A8
The invention relates to novel chromogenic enzyme substrates which are used to detect aminopeptidase activity in micro-organisms or to determine whether at least one bacterium belongs to the Gram-positive group or the Gram-negative group...  
WO2004091485A3
This invention relates to treating inflammatory and immune diseases with certain aminoquinoline compounds that bind to CXCR3 receptors. The aminoquinoline compounds are covered by the formula (I) shown below. Each variable is defined in ...  
WO2005051296A3
Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r) and Plasmodium faciparum. Prodrugs of these compounds can be used as an oral tre...  
WO2005043124A3
One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the aryl group is an optionally substituted acr...  
WO/2005/051915A1
The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatri...  
WO/2005/051296A2
Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r) and Plasmodium faciparum. Prodrugs of these compounds can be used as an oral tre...  
WO/2005/043124A2
One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the aryl group is an optionally substituted acr...  
WO2004092125A3
Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with azaaromatic compounds and/or nitrogen heterocycle compounds to produce functionalized azaaromatic compounds and functionalized nitrogen heterocycle co...  
WO2004085418A3
Compound that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods of inhibiting the DNA-PK biological activity, methods of sensitizing cells the agents that cause DNA lesions, and methods of potentiating ...  
WO/2005/007643A1
The invention relates to novel acridine derivatives of general formula (I), the production and use thereof as medicaments, in particular, for the treatment of tumours.  
WO/2004/099340A1
A luminescent-polymer composition comprising a luminescent polymer and ion pairs, wherein the ion pairs each has an anion having such a specific structure that the anion has one atom of a Group 13 element and is bonded to either an aryl ...  
WO2004067675A3
A blue electroluminescent material based on a binaphtyl compound of the general formula (I). Particular embodiments having the general formula have good solubilities in common organic solvents, resist crystallization and can be sublimed ...  
WO2004018418A3
In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and ...  
WO/2004/092125A2
Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with azaaromatic compounds and/or nitrogen heterocycle compounds to produce functionalized azaaromatic compounds and functionalized nitrogen heterocycle co...  
WO/2004/091485A2
This invention relates to treating inflammatory and immune diseases with certain aminoquinoline compounds that bind to CXCR3 receptors. The aminoquinoline compounds are covered by the formula (I) shown below. Each variable is defined in ...  
WO/2004/085418A2
Compound that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods of inhibiting the DNA-PK biological activity, methods of sensitizing cells the agents that cause DNA lesions, and methods of potentiating ...  
WO/2004/078731A1
The invention relates to compounds, substituted guinoline-carboxylic acids and the derivatives thereof of general formula (1, 2, 3), the pharmaceutically acceptable salts thereof, N-oxides or hydrates and methods for the production there...  
WO/2004/069804A1
The invention relates to novel chromogenic enzyme substrates which are used to detect aminopeptidase activity in micro-organisms or to determine whether at least one bacterium belongs to the Gram-positive group or the Gram-negative group...  
WO/2004/067675A2
A blue electroluminescent material based on a binaphtyl compound of the general formula (I). Particular embodiments having the general formula have good solubilities in common organic solvents, resist crystallization and can be sublimed ...  
WO2004032929A3
A family of compounds of formula (I) wherein: X is one of the following radicals: (a), (b), (c) which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile...  
WO/2004/032929A2
A family of compounds of formula (I) wherein: X is one of the following radicals: (a), (b), (c) which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile...  
WO/2004/020373A1
Provided are a novel spiro compound, and an organic luminescence device using the spiro compound and having anoptical output with an extremely high efficiency and a high luminance, and an extremely high durability. The spiro compound is ...  
WO/2004/020371A1
A new condensed polycyclic compound represented by general formula [I]: wherein R¿1? is hydrogen, halogen, cyano, a substituted amino or a group selected from the group consisting of alkyl, aralkyl, aryl, heterocyclic, each having no su...  
WO/2004/020372A1
A fluorene compound represented by the following general formula [I]: is used to provide an organic luminescent device. Such a device has an optical output exhibiting a high luminance with an extremely high efficiency, and has an extreme...  
WO2003027050A3
A process for preparing substituted pentacene compounds comprises the step of cyclizing substituted bis(benzyl)phthalic acids using an acid composition comprising trifluoromethanesulfonic acid, the substituted bis(benzyl)phthalic acids b...  
WO/2004/018418A2
In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and ...  
WO2003082350A3
The present invention is concerned with radiolabelled quinoline and quinolinone derivatives according Formula (I-A)* or (I-B)* showing metabotropic glutamate receptor antagonistic activity, in particular mGlu1 receptor activity, and thei...  
WO/2004/011946A1
Disclosed are compounds of formula: (I) In which D is a fluorescent dye selected from an acridone and a quinacridone dye; F comprises a target bonding group selected from a carboxylic acid thioester group and a 1,2-aminothiol group; M is...  
WO2003055447A3
Compounds having the formula (I), wherein R<3> is selected from H, OH and NH<2>; R<30> is selected from =O and =S; W is -C(=O)-, -S(=O)-, or -S(O)2-; or W may be -CH2- if X is -C(=O)-; X is selected from -CH2-, -N(R<4>)-, and -O-, except...  
WO2003059269A3
Compounds having formula (I), wherein R<3> is selected from H, OH and NH2; R<30> is selected from =O and =S; W is -C(=O)-, -S(=O)-, or -S(O)2-; or W may be -CH2- if X is -C(=O)-; X is selected from -CH2-, -N(R<4>)-, and -O-, except that ...  
WO2003038399A3
A novel chemiluminescent acridinium compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel compound to the analyte and ...  
WO2002099424A3
Disclosed are new acridone dye derivatives having characteristic fluorescence lifetimes. Also disclosed are methods for labelling target biological materials employing the acridone dyes and use of the labelled materials in biological ass...  
WO2003004091A3
The present invention discloses novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb low-energy ultraviolet, visible, or near-inf...  

Matches 101 - 150 out of 1,153