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WO/2003/045920 |
The present invention is concerned with compounds of the general Formula I : and pharmaceutically acceptable salts thereof, which are useful as melanin concentrating hormone receptor antagonists, particularly MCH-1R antagonists. As such,...
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WO/2003/039488 |
The present invention is directed to a method for treating inflammatory bowel disease in a patient comprising administering to said patient a pharmaceutical compositions comprising a pharmaceutically effective amount of an anti-malarial ...
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WO/2003/039546 |
The present invention is directed to the use of anti-malarial compound for the treatment and prophylaxis of infections by adenovirus or rhinovirus.
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WO/2003/037853 |
The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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WO/2003/038399 |
A novel chemiluminescent acridinium compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel compound to the analyte and ...
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WO/2003/035768 |
The present invention relates to squaraine dye containing terminal aminoanthracene or acridine groups and to a process for the preparation thereof.
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WO/2003/027050 |
A process for preparing substituted pentacene compounds comprises the step of cyclizing substituted bis(benzyl)phthalic acids using an acid composition comprising trifluoromethanesulfonic acid, the substituted bis(benzyl)phthalic acids b...
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WO/2003/025192 |
Intracellular enzyme-activated fluorescent substrates that can be transported into a cell are provided. The membrane transportable fluorescent substrates are complexes (e.g., ionic complexes) formed between an enzyme activated fluorescen...
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WO/2003/025017 |
A crystalline composition comprising a crystal of the IL-6 receptor I chain is provided. Also provided are methods of using the crystal and related structural information to screen for and design compounds that interact with IL-6R, or va...
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WO/2003/004091 |
The present invention discloses novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb low-energy ultraviolet, visible, or near-inf...
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WO/2002/099097 |
The present invention relates to a chemical compound comprising a light emitting moiety precursor (eg. acridine, luciferine) and a precursor of a leaving group (eg. oxazine, anilide), bound to each other by an amide or by an ester bond a...
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WO/2002/099424 |
Disclosed are new acridone dye derivatives having characteristic fluorescence lifetimes. Also disclosed are methods for labelling target biological materials employing the acridone dyes and use of the labelled materials in biological ass...
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WO/2002/099428 |
The present invention relates to substituted hydrazides of a luciferin dye or to substituted hydrazides of a dye analogous thereto. These chemical compounds comprise the luciferin dye or the dye analogue thereto as a light emitting moiet...
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WO/2002/079166 |
This invention relates to process for producing annulated pyridine bases by reacting cyclic ketones with aliphatic aldehyde in presence of ammonia in gaseous phase in the presence of a catalyst. This process provides an eco-friendly, mor...
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WO/2002/079191 |
Bifunctional molecules based on viologen linked acridines or derivatives thereof, which can be used as phototherapeutical and catalytic photoactivated DNA clevaing agents, a process for the process for the preparation thereof and pharmac...
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WO/2002/067704 |
A smoking article (10) having reduced ignition propensity is disclosed. The smoking article includes a tobacco column (12), a wrapper (14) surrounding the tobacco column (12), and a filter element (16). The wrapper (14) has a base permea...
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WO/2002/064545 |
The present invention relates to acylated indanyl amines according to the general formula (I) where R?1¿-R?4¿ have the meanings given in the description, A is CH¿2? CHOH or CH-(C¿1?-C¿3?-alkyl), B is CH¿2? or CH-(C¿1?-C¿3?-alkyl)...
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WO/2002/059096 |
Synthetic processes and intermediates are disclosed for the preparation of N-arylacridancarboxylic acid derivatives. The derivatives are esters, thioesters, amides and sulfonimides. A key feature of the processes is the preparation of N-...
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WO/2002/055503 |
In accordance with the present invention, nanometer-scale reversable electronic switches are provided that can be assembled to make cross-bar circuits that provide memory, logic, and communications functions. The electronic switches, or ...
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WO/2002/051942 |
The present invention relates to a process for dyeing or printing manufactured natural polymer or synthetic hydrophobic fibre materials, characterized in that it comprises using dyes of the formula (I), where R¿1? is hydrogen, hydroxyl ...
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WO/2002/043449 |
A luminescent element which comprises an anode, a cathode, and a luminescent substance interposed therebetween and which luminesces upon reception of electric energy, characterized by having at least one of the following compounds (a) to...
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WO/2002/036568 |
Compounds useful for the treatment of pain in accord with the following structural diagram, wherein R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ are any of a number of groups as defined in the specification, A and D are as defined in the specifi...
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WO/2002/032875 |
The invention relates to an agent which inactivates pathogens and to the use thereof. Said agent contains an element that bonds with the nucleic acids of the pathogens and a conjugate, which destroys nucleic acid. The conjugate is produc...
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WO/2002/028837 |
The present invention concerns compounds of formula. In a preferable embodiment, X represents O; R?1¿ represents C¿1-6?alkyl; cycloC¿3-12?alkyl or (cycloC¿3-12?alkyl)C¿1-6?alkyl, wherein one or more hydrogen atoms in a C¿1-6?alkyl-...
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WO/2002/008192 |
The invention relates to novel heteroaryl derivatives of general formula (1), the production thereof and the use of the same as pharmaceuticals, especially for treating tumours.
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WO/2002/008190 |
The invention relates to novel pyridine derivatives of general formula (1), the production and use thereof as medicaments, in particular for the treatment of tumours.
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WO/2002/008194 |
The invention relates to novel acridine derivatives of general formula (1), the production thereof and the use of the same as pharmaceuticals, especially for treating tumours.
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WO/2002/008193 |
The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is =O, L is -H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is...
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WO/2002/000726 |
Methods are disclosed for producing electrochemiluminescence by electrochemically oxidizing an acridan compound at an electrode in the presence of a peroxide. Maintaining a sufficiently positive potential results in continuous oxidation ...
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WO/2001/092218 |
Novel 'bispolyamine' inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins,...
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WO/2001/087830 |
The present application is directed to chemical compounds of formula (I-A) or formula (II-A) (in which the variables are as defined in the claims), compositions containing them and uses of the compositions for treating sleepiness, tiredn...
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WO/2001/083484 |
The present invention provides novel compounds of formula (I), which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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WO/2001/076567 |
The present invention provides an anti-tumor chemotherapeutic to a patient having a tumor, the composition comprising: microspheres incorporating the anti-tumor chemotherapeutic; and, a suspending solution which surrounds the microsphere...
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WO/2001/070699 |
Compounds of the general formula (II), particularly BF-009, useful as probes in the diagnostic imaging for diseases due to accumulation of amyloid; and compositions and kits for the diagnostic imaging for diseases due to accumulation of ...
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WO/2001/064645 |
The invention provides a compound of formula (I), wherein A, Ra, Rb, R¿1? to R¿5?, m and t are as defined as disclosed, or a pharmaceutically acceptable salt or ester thereof, useful as alpha-2 antagonist. The compounds I can be used f...
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WO/2001/060801 |
The invention is directed to novel 9-hydroxyalkylamino-, 9-alkoxyalkylamino-1-nitroacridine derivatives. Methods of preparation, pharmaceutical compositions comprising said derivatives and their medical use are also encompassed by this i...
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WO/2001/060822 |
The invention concerns compounds of formula (I) wherein: 0$m(F)n$m(F)3; 0$m(F)m$m(F)6; R¿3? and R¿4? together form a phenyl ring; B represents a heteroaryl group; R¿1? and R¿2? represent a hydrogen atom or groups as defined in the de...
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WO/2001/047899 |
The invention relates to substituted piperazine derivatives of general formula (I), wherein R¿a? to R¿c?, Y¿a?, Y¿b?, X and n have the meanings given in claim no.1, and isomers and salts thereof, especially physiologically suitable s...
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WO/2001/041773 |
Therapeutic compounds and compositions for the treatment of infectious diseases are disclosed. The compounds are xanthones and xanthone derivatives, such as 3,5-bis-$g(e)-(N,N-diethylamino)amyloxyxanthone. The described compositions incl...
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WO/2001/037826 |
NPYY5 receptor antagonists which contain compounds represented bygeneral formula (I), prodrugs thereof, pharmaceutically acceptable salts thereof or solvates of the same wherein R?1¿ represents lower alkyl, cycloalkyl, etc.; R?2¿ repre...
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WO/2001/035103 |
The object of the present invention is to provide a new means of stabilizing a luminescent acridinium compound in an aqueous medium thereby preventing a decrease in the emission yield from the compound over time in storage in the aqueous...
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WO/2001/023497 |
An organic electroluminescent element which has a high color purity, high luminescent efficiency, and long life and emits a red color; and a novel compound. The organic electroluminescent element comprises at least one pair of electrodes...
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WO/2001/017529 |
A series of tacrine derivatives has been synthesized and disclosed. These tacrine derivatives were claimed to be new and be useful for the treatment of Alzheimer's disease alone or in combination with other drugs for Alzheimer's disease....
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WO/2001/012584 |
Compounds or their salts of general formula (I): A$m(Y)B$m(Y)N(O)¿s? wherein: s is an integer equal to 1 or 2; A = R$m(Y)T¿1?-, wherein R is the drug radical and T¿1? = (CO)¿t? or (X)¿t'?, wherein X = O, S, NR¿1c?, R¿1c? is H or a...
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WO/2001/009372 |
Chemiluminescent substrates of hydrolytic enzymes are disclosed having general Formula Lumi-M-P, where Lumi is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached, wherein the ...
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WO/2000/076982 |
The present invention relates generally to the field of immunology. More particularly it concerns compositions and methods for inhibiting stimulation of the immune system. The compounds and methods comprise compounds that are analogs and...
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WO/2000/066175 |
Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are prov...
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WO/2000/066782 |
The present invention relates to genetic mutations in mitochondrial genes that segregate with diabetes mellitus. The invention provides methods for detecting such mutations, as a diagnostic for diabetes mellitus, either before or after t...
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WO/2000/066587 |
Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. A...
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WO/2000/066528 |
Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
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