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Matches 301 - 350 out of 1,112

Document Document Title
WO/1996/013612A2
The invention relates to methods for simultaneously or sequentially detecting multiple nucleic acid analytes in a single medium utilizing oligonucleotide hybridization probes coupled to different chemiluminescent labeling reagents. The m...  
WO/1996/007911A1
A chemiluminescent assay method, compositions and kits are described which use a protected phenolic enhancer compound which is deprotected by a hydrolytic enzyme and then enhances a chemiluminescent reaction. The reaction involves an acr...  
WO/1996/007912A1
A chemiluminescent assay method, compositions, kits and chemiluminescent acridan compounds are described which use a two-step chemiluminescent reaction process. The reaction involves an acridan compound, preferably a derivative of an N-a...  
WO/1996/000738A1
Novel antagonists of endothelin containing an N-terminal fragment (I) are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute an...  
WO/1996/000392A1
The synthesis of 10,10'-substituted-9,9'-biacridine molecules and their derivatives is disclosed. These molecules are shown to catalyze the production of light by chemiluminescence in the presence of a signal solution having at a pH from...  
WO/1995/028495A1
Aryl N-alkylacridanthiocarboxylate compounds are used with peroxide and peroxidase to generate chemiluminescence. The compounds are used as a substrate in assays for various analytes. The figure shows a graph for a comparison of the ligh...  
WO/1995/027702A1
Novel acridinium esters that are useful, either alone or when incorporated into liposomes, as chemiluminescent agents in binding assays (e.g., immunoassays and gene probe assays) with improved sensitivity are disclosed. In addition, the ...  
WO/1995/026973A1
The present invention relates to genetic mutations in mitochondrial cytochrome c oxidase genes that segregate with Alzheimer's disease (AD), diabetes mellitus, Parkinson's disease and other diseases of mitochondrial origin. The invention...  
WO/1995/025093A1
The present invention provides a compound having structure (I), wherein R is -H, -CH3, or -C2H5; R1 and R2 are independently -H, -OH, -NH2, -OCH3, -C(CH3)3, or a halogen atom; n is 2 to 6; X and X' are independently -N or -NO2; Y and Y' ...  
WO/1995/023971A1
Acridans which are reactable with a peroxidase and peroxide. The acridans are characterized by having an aromatic leaving group ArO which is a di- or polyhalosubstituted phenoxy group. The compounds are useful in assays where one member ...  
WO/1995/023137A1
The invention relates to new acetic acid derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said acetic acid amide derivatives for the treatment of diseases and for the ...  
WO/1995/019976A1
Heterocyclic chemoluminescent derivatives of acridinium (and substituted derivatives thereof), phenanthridium (and substituted derivatives thereof), quinolenium (and substituted derivatives thereof) and isoquinolenium (and substituted de...  
WO/1995/003279A1
Novel antitumor sulfonamide and sulfonic ester derivatives each having a tricyclic hetero ring, represented by general formula (I), and a process for producing the same, wherein G represents a 5- or 6-membered aromatic ring; L represents...  
WO/1995/001341A1
Intercalator compounds are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds provide a high affinity for binding to the...  
WO/1995/000478A1
Described are aryltriflates and related derivatives of raclopride, riluzole, cisapride, omeprazole, lanzoprazole, pantoprazole, paroxetine, fenfluramine, sotalol, estradiol, RU 486, tacrine, moclobemide, ifenprodil, brofaromine, melatoni...  
WO/1994/026927A1
N-alkylacridan carboxylic acid derivative compounds (I) are used to generate chemiluminescence by the action of a peroxidase enzyme and an oxidant. The compounds (I) are useful in assays of all types. The figure is a graph showing a comp...  
WO/1994/025439A1
Novel 3-dimethylamino acridine derivatives of general formula (1) and the therapeutically acceptable salts of these molecules. The invention also concerns the application of these compounds in therapy and methods for their preparation.  
WO/1994/022837A1
The application concerns a biologically active compound obtained by chemical synthesis and belonging to the class of heterocyclic compounds (specifically, the secondary acridones), namely: N-methyl-N-/alpha,DELTA-glucopyranozil/ammonia-2...  
WO/1994/021823A1
An assay method incorporating at least two different chemiluminescent compounds for detection and/or quantitation of at least two substances in a test sample is described. The synthesis of chemiluminescent reagents or conjugates for use ...  
WO/1994/008966A1
Compounds of Formula (I) wherein R2, R3, R4, R10 and R11 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the treatment of urinary incontinence. Also disclosed are pharmaceuti...  
WO/1994/005276A1
Compounds are disclosed which display cytotoxic effects against estrogen-independent tumors. These compounds may be represented by the formula X-R1 wherein X is a phenyl ring which may be substituted with one or more nitro, methyl or tri...  
WO/1994/003433A1
Biological applications of synthetic and natural alkaloids derived from the tunicate Eudistoma sp., as well as the preparation of synthetic pyridoacridines, and particularly methods for the synthesis of Eilatin are disclosed. A method re...  
WO/1993/023049A1
The present invention provides a compound having structure (I) wherein R1 and R2 are independently the same or different and are hydrogen, an acetyl group; an acyl group having the formula -CO(CH2)nCOCH3, wherein n = 1-3; -CO(CH2)nCOOM, ...  
WO/1993/021176A1
Novel cyclic amino acids which are useful in preparing biologically active peptides as well as a process for the preparation of D and L enantiomers of the cyclic amino acids are described where an N-protected derivative of the racemic cy...  
WO/1993/020074A1
Novel haptens and related conjugates based on acridine-9-carboxylic acid, as well as methods for making and using such conjugates. Haptens based on the above core structure may be substituted at positions 3 or 6. Using tethered intermedi...  
WO/1993/011120A1
Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeuticall...  
WO/1993/008165A1
Compounds having the formula X-A-Y are disclosed where X and Y are groups capable of intercalating DNA and comprise optionally substituted fused bi- or polycyclic, carbocyclic or heterocyclic at least partially aromatic ring systems havi...  
WO/1992/022534A1
Polyhydroxylated and dehydrogenated metabolites of 9-amino-1,2,3,4-tetrahydro-acridine (Tacrine) in which attached to at least two of the carbon atoms numbered 1,2,3 and 4 is a hydroxyl group and to the others either hydrogen, hydroxyl o...  
WO1992017549A3  
WO/1992/019598A1
New chemical compounds, derivatives of 9-aminoacridine of general formula (I) where R = H, CH3; R1 = H, CH3, Br; R2 = H, CH3; R3 = alkyl-C1-C5, arylmethyl, diethylaminoethyl; X = C = O, CHOH; Y = CH2; X + Y = CH = CH; and their salts wit...  
WO/1992/017549A2
Methine dyes have the polyketone grouping (I), in which the variables have the following meaning: A represents (a) or (b); R?1� represents a 5 or 6-membered cycloaliphatic residue with one or two heteroatoms from the group -NR?4�-, -...  
WO/1992/016509A1
The present invention provides a compound having structure (I) wherein R2 and R3 are the same or different and are hydrogen, a saturated or unsaturated alkyl group having 1 to 5 carbon atoms, a hydroxy group, a saturated or unsaturated a...  
WO/1992/012132A1
Compounds of general formula (I), wherein A represents an oxygen or a sulphur atom, a bond or a group (CH�2?)�l?NR?9� (where l represents zero or 1 and R?9� represents a hydrogen atom or a methyl group); B represents a C�1-4?al...  
WO/1992/011531A1
The present invention provides for the use of the fluorescent label 2-aminoacridone for use in separating carbohydrate mixtures and analyzing the structure of carbohydrates. Carbohydrates for analysis may be labelled by 2-aminoacridone a...  
WO/1992/009894A1
The presence or quantity of a selected subset of cells, which is part of a subpopulation of a mixed cell population, is determined by a method in which a detectable reporter substance is uniformly incorporated into substantially all cell...  
WO/1992/009580A1
Novel chemiluminescent compounds are suitable for use in labeling biological molecules for assays such as immunoassays. These chemiluminescent labels are characterized by the incorporation of stable leaving groups. One class of these che...  
WO/1992/006412A1
A photopolymerizable composition comprising 100 parts by weight of a compound having at least one ethylenically unsaturated group, 0 to 400 parts by weight of a thermoplastic organic polymer and 0.01 to 20 parts by weight of a photopolym...  
WO/1991/013080A1
Pseudonucleosides and pseudonucleotides are useful in the synthesis of oligomers which contain these components as a means to derivatize the resulting oligonucleotide. In general, these pseudonucleotide components are of formula (1), whe...  
WO/1991/005770A1
The compounds of the subject invention can be represented by formula (I), wherein each of R1, R2, R3, R4 are the same or different and are hydrogen (H), or a lower alkyl group of from about 1-4 carbon atoms, or a lower alkoxy group of fr...  
WO/1991/002725A1
Chemical compounds derived from 5-amino-1,2,3,4-tetrahydroacridine (THA) having the general formula (I) wherein R may represent a glycosyl group such as ascorbate, a substituted glycosyl group such as an inosinyle, adenosinyle or guanido...  
WO/1991/001974A1
The present invention relates to compounds comprising a 1,2,3,4-tetrahydroacridinyl group coupled via an ester functionality to a dimethylaminoethyl group, and the acid addition salts thereof, and to processes for their preparation and p...  
WO/1990/014435A1
Analytes, having a characteristic determinant that selectively interacts with a specific binding substance, are determined by coupling a reporter substance to the analyte, or to the specific binding substance, causing complex formation b...  
WO/1989/010758A1
Compounds, compositions, their methods of preparation and use in binding bio-affecting substances to the surface membrane of bioparticles, such as eukaryotic cells, without producing appreciable detrimental effect on morphology or physio...  
WO/1989/008256A1
A method of preparing a labelled specific binding partner, such as a biological probe in the form of an antibody or oligonucleotide probe, using a protected label, the corresponding unprotected label being susceptible to inactivation, su...  
WO/1989/006231A1
This invention concerns chemiluminescent moieties useful as labels in assays and immunoassays, and compositions and assay kits incorporating the moieties. The chemiluminescent moieties are of the type wherein attack by peroxide or molecu...  
WO/1989/002739A1
Compounds of formula (I) wherein R1, R2, A and B are defined hereinbelow. The compounds of the present invention inhibit brain acetylcholinesterase and are useful in the treatment of Alzheimer's disease.  
WO/1989/002740A1
Compounds of formula (I), wherein R1, R2, A and B are defined hereinbelow. The compounds of the present invention inhibit brain acetylcholinesterase and are useful in the treatment of Alzheimer's disease.  
WO/1988/002256A1
A method for treating central nervous system or peripheral nervous system cholinergic deficit states such as Alzheimer's disease in a mammal, said method comprising administering to said mammal an amount of a monoamine acridine derivativ...  
WO/1987/005014A1
Compounds represented by general formula (I), (wherein Y-Z represents (II), -CH=CH- or -CH2CH2-, R1 and R2 each represents a substituent, R3 represents hydrogen, alkyl or alkoxy, R4 represents hydrogen, alkyl, optionally substituted alke...  
WO/1987/004163A1
Novel compositions of matter which are multifunctional amino zirconium aluminum metallo organic complexes which are comprised of a chemically united complex aluminum moiety, a tetravalent zirconium moiety, and a multifunctional amino aci...  

Matches 301 - 350 out of 1,112