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Matches 301 - 350 out of 1,171

Document Document Title
WO/1998/003497A1
Compounds, constructed in modular manner, of formula (I), wherein I is the monovalent residue of an ionophore, F is the monovalent residue of a fluorophore, G is a functional group, T is a trivalent organic radical and R�01?, R�02? a...  
WO/1998/002421A1
New dibenzodihydropyridinecarboxylic esters are provided which comply with formula (1) or (2), wherein: R?1� is substituted alkyl or cyano; R?2� and R?3� are independently hydrogen, alkyl, substituted alkyl, aryl or substituted ary...  
WO1997027179A3  
WO/1997/040014A1
Fluoroionophores of formula (I) wherein R06 is H or substituted or unsubstituted C1-C20alkyl, R6 is H or substituted or unsubstituted C1-C30alkyl or C1-C30alkoxy, R1 is a bridging group, and F is a residue of a fluorophore. The fluoroion...  
WO/1997/039337A1
Fluoroionophores that are functionalised with reactive groups and correspond to the formula I-R1-F-R2-G, wherein I is a monovalent residue of an ionophore, wherein F is a divalent residue of a fluorophore, wherein G is a functional group...  
WO/1997/038999A1
The present invention relates to several novel acridone-derived compounds of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as Human Immunodeficiency Virus. In addition,...  
WO/1997/027179A2
The invention relates to the use of a compound of formula (I), wherein R1 and R2 are independently amino, N-alkylamino, N,N-dialkylamino, cycloalkylamino, amidino, N-lower alkylamidino, N,N-di-lower alkylamidino, guanidino, N-lower alkyl...  
WO/1997/026245A1
Novel heterocyclic compounds which generate chemiluminescence on reaction with a phosphatase enzyme are provided as well as a process for their preparation and intermediates useful therein. The compounds comprise a nitrogen, oxygen or su...  
WO/1997/021681A1
The present invention provides cholinesterase inhibitors of general formula (I) wherein R is H or (C1-C4)alkyl, Y is a linking group and Z is an alkyl or aryl group, including heteroaryl groups, and the pharmaceutically acceptable salts ...  
WO/1997/019929A1
Compounds of Formula (I), methods for their preparation, pharmaceutical formulations and use thereof.  
WO/1997/019054A1
The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective a...  
WO/1997/013748A1
According to the present invention, are provided sulfoxide derivatives of nitrogen-mustard represented by general formula (I), wherein R1 represents a hydrogen, or haloethyl; R2 represents a lower alkyl or phenyl group substituted or non...  
WO/1997/012872A1
Novel acridone compounds represented by general formula (I) or pharmacologically acceptable salts thereof efficacious in the prevention and treatment of diseases in which chemical transmitters (histamine, leukotriene, etc.) participate, ...  
WO/1997/012871A1
An acridone derivative represented by general formula (I) and a pharmacologically acceptable salt thereof, efficacious in preventing or treating deseases wherein histamine, leucotriene and the like participate and allergic diseases such ...  
WO/1997/011067A1
The invention relates to compounds of formula (I), (IIa) or (IIb), wherein R1, R2, R5 and R6 are each independently of one another hydrogen, -SO2-(C1-C6)alkylphenyl, C1-C30alkyl, C1-C30alkyl-CO- or a radical of formula -(CnH2n-O-)m-R10; ...  
WO/1997/007101A1
A method of treating neoplastic disease which comprises the steps of: (a) administering to a patient in need of such treatment an effective amount of a radiation-activated cytotoxin prodrug (RACP) which has low toxicity, which can be red...  
WO/1997/002034A1
The invention pertains to medicine and biologically active substances. The objective is to produce a drug with enhanced therapeutic effects and a broad spectrum of therapeutic properties and suitable for use in the production of highly s...  
WO/1996/041197A1
The present invention features an adduct protection assay involving the use of a labelled binding partner and a signal altering ligand. The signal altering ligand can preferentially alter the ability of label which is not part of a bindi...  
WO/1996/037465A1
The invention relates to a chiral compound of general formula (I), wherein the groups R are the same or different but preferentially the same and are aliphatic C1-10 groups or optionally substituted aromatic groups or that both groups R ...  
WO1996013612A3  
WO/1996/014844A1
Disclosed herein are the heterocyclic compounds and pharmaceutically acceptable salts thereof which have been found to be useful in the treatment of nitric oxide synthase mediated diseases and disorders.  
WO/1996/014737A1
Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo u...  
WO/1996/013612A2
The invention relates to methods for simultaneously or sequentially detecting multiple nucleic acid analytes in a single medium utilizing oligonucleotide hybridization probes coupled to different chemiluminescent labeling reagents. The m...  
WO/1996/007912A1
A chemiluminescent assay method, compositions, kits and chemiluminescent acridan compounds are described which use a two-step chemiluminescent reaction process. The reaction involves an acridan compound, preferably a derivative of an N-a...  
WO/1996/007911A1
A chemiluminescent assay method, compositions and kits are described which use a protected phenolic enhancer compound which is deprotected by a hydrolytic enzyme and then enhances a chemiluminescent reaction. The reaction involves an acr...  
WO/1996/000738A1
Novel antagonists of endothelin containing an N-terminal fragment (I) are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute an...  
WO/1996/000392A1
The synthesis of 10,10'-substituted-9,9'-biacridine molecules and their derivatives is disclosed. These molecules are shown to catalyze the production of light by chemiluminescence in the presence of a signal solution having at a pH from...  
WO/1995/028495A1
Aryl N-alkylacridanthiocarboxylate compounds are used with peroxide and peroxidase to generate chemiluminescence. The compounds are used as a substrate in assays for various analytes. The figure shows a graph for a comparison of the ligh...  
WO/1995/027702A1
Novel acridinium esters that are useful, either alone or when incorporated into liposomes, as chemiluminescent agents in binding assays (e.g., immunoassays and gene probe assays) with improved sensitivity are disclosed. In addition, the ...  
WO/1995/026973A1
The present invention relates to genetic mutations in mitochondrial cytochrome c oxidase genes that segregate with Alzheimer's disease (AD), diabetes mellitus, Parkinson's disease and other diseases of mitochondrial origin. The invention...  
WO/1995/025093A1
The present invention provides a compound having structure (I), wherein R is -H, -CH3, or -C2H5; R1 and R2 are independently -H, -OH, -NH2, -OCH3, -C(CH3)3, or a halogen atom; n is 2 to 6; X and X' are independently -N or -NO2; Y and Y' ...  
WO/1995/023971A1
Acridans which are reactable with a peroxidase and peroxide. The acridans are characterized by having an aromatic leaving group ArO which is a di- or polyhalosubstituted phenoxy group. The compounds are useful in assays where one member ...  
WO/1995/023137A1
The invention relates to new acetic acid derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said acetic acid amide derivatives for the treatment of diseases and for the ...  
WO/1995/019976A1
Heterocyclic chemoluminescent derivatives of acridinium (and substituted derivatives thereof), phenanthridium (and substituted derivatives thereof), quinolenium (and substituted derivatives thereof) and isoquinolenium (and substituted de...  
WO/1995/003279A1
Novel antitumor sulfonamide and sulfonic ester derivatives each having a tricyclic hetero ring, represented by general formula (I), and a process for producing the same, wherein G represents a 5- or 6-membered aromatic ring; L represents...  
WO/1995/001341A1
Intercalator compounds are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds provide a high affinity for binding to the...  
WO/1995/000478A1
Described are aryltriflates and related derivatives of raclopride, riluzole, cisapride, omeprazole, lanzoprazole, pantoprazole, paroxetine, fenfluramine, sotalol, estradiol, RU 486, tacrine, moclobemide, ifenprodil, brofaromine, melatoni...  
WO/1994/026927A1
N-alkylacridan carboxylic acid derivative compounds (I) are used to generate chemiluminescence by the action of a peroxidase enzyme and an oxidant. The compounds (I) are useful in assays of all types. The figure is a graph showing a comp...  
WO/1994/025439A1
Novel 3-dimethylamino acridine derivatives of general formula (1) and the therapeutically acceptable salts of these molecules. The invention also concerns the application of these compounds in therapy and methods for their preparation.  
WO/1994/022837A1
The application concerns a biologically active compound obtained by chemical synthesis and belonging to the class of heterocyclic compounds (specifically, the secondary acridones), namely: N-methyl-N-/alpha,DELTA-glucopyranozil/ammonia-2...  
WO/1994/021823A1
An assay method incorporating at least two different chemiluminescent compounds for detection and/or quantitation of at least two substances in a test sample is described. The synthesis of chemiluminescent reagents or conjugates for use ...  
WO/1994/008966A1
Compounds of Formula (I) wherein R2, R3, R4, R10 and R11 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the treatment of urinary incontinence. Also disclosed are pharmaceuti...  
WO/1994/005276A1
Compounds are disclosed which display cytotoxic effects against estrogen-independent tumors. These compounds may be represented by the formula X-R1 wherein X is a phenyl ring which may be substituted with one or more nitro, methyl or tri...  
WO/1994/003433A1
Biological applications of synthetic and natural alkaloids derived from the tunicate Eudistoma sp., as well as the preparation of synthetic pyridoacridines, and particularly methods for the synthesis of Eilatin are disclosed. A method re...  
WO/1993/023049A1
The present invention provides a compound having structure (I) wherein R1 and R2 are independently the same or different and are hydrogen, an acetyl group; an acyl group having the formula -CO(CH2)nCOCH3, wherein n = 1-3; -CO(CH2)nCOOM, ...  
WO/1993/021176A1
Novel cyclic amino acids which are useful in preparing biologically active peptides as well as a process for the preparation of D and L enantiomers of the cyclic amino acids are described where an N-protected derivative of the racemic cy...  
WO/1993/020074A1
Novel haptens and related conjugates based on acridine-9-carboxylic acid, as well as methods for making and using such conjugates. Haptens based on the above core structure may be substituted at positions 3 or 6. Using tethered intermedi...  
WO/1993/011120A1
Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeuticall...  
WO/1993/008165A1
Compounds having the formula X-A-Y are disclosed where X and Y are groups capable of intercalating DNA and comprise optionally substituted fused bi- or polycyclic, carbocyclic or heterocyclic at least partially aromatic ring systems havi...  
WO/1992/022534A1
Polyhydroxylated and dehydrogenated metabolites of 9-amino-1,2,3,4-tetrahydro-acridine (Tacrine) in which attached to at least two of the carbon atoms numbered 1,2,3 and 4 is a hydroxyl group and to the others either hydrogen, hydroxyl o...  

Matches 301 - 350 out of 1,171