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Matches 1 - 50 out of 5,265

Document Document Title
WO/2020/191151A1
The present invention relates to compounds and compositions capable of acting as inhibitors of small ubiquitin-like modifier (SUMO) family of proteins. The compounds and compositions may be used in the treatment of cancer. There are disc...  
WO/2020/184670A1
The present invention relates to a method for monodeuterated lower alkylating an amine moiety of a compound which contains an amine that is protected by an aralkyl group, wherein a monodeuterated lower alkyl is introduced into the amine ...  
WO/2020/185080A1
The invention is directed to a tissue-adhesive multi-arm polymer comprising a core from which polymeric arms extent, which polymeric arms are substituted with a hydroxyl-substituted aromatic group based on compounds such as dopamine, L-D...  
WO/2020/169971A1
A solidification or crystallisation method is disclosed providing at least a first organic compound, providing at least one volatile co-former organic compound, forming a mixture of at least the first organic compound and the co-former o...  
WO/2020/171073A1
The present application discloses a method for producing (R)-4-methyl-1-(2-methyl-4-(3-methyl-1H-pyrazol-1-yl)benzoyl )-5-oxo-2, 3, 4, 5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester by methylating 1-(2-methyl-4-(3-methyl-1...  
WO/2020/156359A1
Disclosed in the present invention are a quaternary ammonium salt compound and a preparation method therefor and a use thereof, relating to the field of medicinal chemistry. Disclosed in the present invention is the compound shown in for...  
WO/2020/136547A1
The present invention refers to a new process for the production of epsilon caprolactam (CPL) from 6-aminocaproic acid (6-ACA) which can be obtained either from traditional petro chemical processes or which can be obtained from biochemic...  
WO/2019/120258A8
Provided are a benzazepine derivative, a preparation process thereof and an application thereof in medicine. Specifically, the invention relates to a novel benzazepine derivative represented by formula (I), a process for preparing the sa...  
WO/2020/099537A1
The present invention is directed to benzazepin-1,7-diol-derived compounds (I) for use in the diagnosis of NMDA (N-methyl-D-aspartate) receptor-associated diseases or disorders by positron emission tomography (PET), single-photon emissio...  
WO/2020/072377A1
The present disclosure relates to compounds of the general formula (I) and pharmaceutical compositions containing them. The compounds are suitable as modulators of hemoglobin and thus useful in treating disorders mediated by hemoglobin s...  
WO/2019/133574A3
The present disclosure is concerned with benzoannulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, dengue, influen...  
WO/2020/050160A1
A hydrogenation catalyst for amide compounds which comprises hydroxyapatite and, fixed thereto, platinum and vanadium, characterized in that 15-80% of the surface of the platinum is covered with vanadium. With the catalyst, it is possibl...  
WO/2020/047192A1
The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and m...  
WO/2020/027304A1
Provided are carotenoid derivatives having exceptional hydrophilicity and oral absorptivity. A carotenoid-related compound represented by the formula (in the formula, X represents a carbonyl group or a methylene group, and Z1 and Z2 are ...  
WO/2020/023073A1
Disclosed herein are compounds which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided.  
WO/2020/018291A1
The invention provides compositions and methods of treating autism. Specifically, the invention relates to treating the core symptoms of autism by administering alpha-methyl-DL-tyrosine.  
WO/2019/245287A1
The present invention relates to a modified polymerization initiator and a preparation method therefor, wherein the modified polymerization initiator can bear various intramolecular functional groups by comprising a unit derived from a c...  
WO/2019/220293A1
Described herein is a perfluorinated aminoolefin compound of general formula (I): CFY=CXN(Rf)CF2Rf' where: (a) Rf and Rf' are (i) independently selected from a linear or branched perfluoroalkyl group having 1-8 carbon atoms, optionally c...  
WO/2019/217933A1
A compound for use in treating a disease associated with activating mutations in RAS, or for use in treating a disease treatable by a reduction in RAS activity, is selected from a compound of Formula (I), salts and esters thereof. The co...  
WO/2019/210130A1
Disclosed herein are derivatives of 7-methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]az epin-1-ol, including radiolabeled derivatives, which are found to be NR2B receptor subunit ligands. Pharmaceutical compositions comprising t...  
WO/2019/170538A1
The present invention relates to a method for producing an isomer-enriched mixture of 3S- and 3R-caranon of 3-caran epoxide, a 3S-caranon obtained therefrom, a method for producing 3S-caranlactam from 3-carene, a method for producing 3R-...  
WO/2018/119362A8
Provided herein are compounds and methods for inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).  
WO/2019/119141A1
The present application is directed to compounds of Formula (I): compounds of Formula (II): compounds of Formula (III): and compounds of Formula (IV): compositions comprising these compounds and their uses, for example as medicaments and...  
WO/2019/120258A1
Provided are a benzazepine derivative, a preparation process thereof and an application thereof in medicine. Specifically, the invention relates to a novel benzazepine derivative represented by formula (I), a process for preparing the sa...  
WO/2019/118884A1
Various compositions are disclosed for the treatment of viral infections. The compositions comprise antibody constructs directed to the liver, attached to myeloid cell agonists, specifically TLR7 and TLR8 agonists, via a linker. Addition...  
WO/2019/115531A1
The present invention is directed to a process for the manufacture of a compound of formula (I) wherein Y is CHR7, CR7R8 or O, n is 0, 1 or 2, R1 and R2 are independently of each other selected from the group consisting of H, F, Cl, meth...  
WO/2019/116325A1
The present invention relates to 5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepine derivatives of general formula (I) and/or salts thereof and/or geometric isomers thereof and/or stereoisomers thereof and/or enantiomers thereof and/or ...  
WO/2019/116324A1
The present invention relates to 5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepine derivatives of general formula (I) and/or salts thereof and/or geometric isomers thereof and/or stereoisomers thereof and/or enantiomers thereof and/or ...  
WO/2018/125880A8
Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.  
WO/2019/096322A1
Disclosed are a pyrazolone-pyrimidine compound, a preparation method therefor and an application thereof. The present invention provides a pyrazolone-pyrimidine compound as represented by formula (I), and an enantiomer, a diastereomer, a...  
WO/2019/094920A1
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical composi...  
WO/2019/082910A1
Provided are: a V2 receptor antagonist which has high water solubility and which is particularly suitable for injections; and a medicine containing the V2 receptor antagonist or the like. The present invention is a compound represented b...  
WO/2019/080226A1
The present invention belongs to the technical field of pesticides, and involves more specifically a substituted benzonitril diketone compound or a tautomer, a salt thereof, a preparation method therefor, a herbicide, and an application ...  
WO/2019/081691A1
The present invention relates to new compounds of formula (I) that show great affinity and activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), or dual activity towards the subunit α2δ of voltage-gated calcium c...  
WO/2019/040106A3
The present disclosure relates to compounds according to Formulae disclosed herein, useful for treating diseases.  
WO/2019/063069A1
The invention relates to the use of a compound of formula (I) as described herein as an aromatic substance. The invention also relates to novel compounds of formula (I) as described herein or mixtures comprising at least one different co...  
WO/2019/060034A1
The present disclosure describes a process for the production of alkylaromatics that may be performed using a loop reactor comprising the steps of: introducing an alkylatable aromatic compound; introducing an olefin; introducing a cataly...  
WO/2019/040106A2
The present disclosure relates to compounds according to Formulae disclosed herein, useful for treating diseases.  
WO/2019/033590A1
Disclosed are a substituted benzoyl cyclohexanedione compound or a tautomer and salt thereof, a preparation method therefor, a herbicidal composition and the use. The substituted benzoyl cyclohexanedione compound or a tautomer and salt t...  
WO/2019/031470A1
[Problem] The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. [Solution] The invention provides: a compound represented by formula (I) o...  
WO/2019/032941A1
Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the amino acid (southern) region. The lincosamides may have further modification at the C-1 and C-7 positions ...  
WO/2019/008025A1
The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylure...  
WO/2019/006291A1
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: (I) which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical com...  
WO/2019/004421A1
The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin V1a and V2 antagonisms, and medical uses thereof. In the formula, R1 is optionally substituted C1-6 alkyl, etc.; L is -C(=O)-...  
WO/2019/003433A1
The present invention provides: a novel benzazepine compound which is represented by formula (1) and has vasopressin V1a and V2 antagonism, or a salt thereof; and a pharmaceutical use thereof. [In formula, R1 represents optionally substi...  
WO/2019/006295A1
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical composi...  
WO/2018/235966A1
The present invention provides a compound which has an excellent inhibitory activity on histone acetyltransferase of EP300 and/or CREBBP, or a pharmacologically acceptable salt of the compound. A compound represented by formula (1) or a ...  
WO/2018/216800A1
The present invention provides: a compound represented by general formula (I) or a salt thereof; an LSD1 inhibitor which contains the compound or a salt thereof as an active ingredient; a pharmaceutical composition which contains the com...  
WO/2018/213938A1
This application pertains to group 5 metal complexes having the structure of Formula I; and their potential utility in catalyzing α-alkylation of secondary amine-containing moieties.  
WO/2018/152286A1
The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or method...  

Matches 1 - 50 out of 5,265