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Matches 601 - 650 out of 809

Document Document Title
JPH0366302B2
A compound of the formula:wherein R1 and R2 are the same or different and each represents hydrogen or methyl and X isprovided that when R1 is hydrogen, R2 is hydrogen or methyl and X isand when R1 is methyl, R2 is methyl and X isis produ...  
JPH0315633B2
Macbecin derivatives are produced by bringing Macbecins into contact with a microorganism, or its processed matter, of the genus Streptomyces or Nocardia. The Macbecin derivatives are useful as antibacterial, antifungal or antiprotozoal ...  
JPH0312062B2
There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable amounts of 1-alkyl substituted-azacyclo...  
JPH0327357A
NEW MATERIAL:A compound expressed by formula I or salt of said compound [R1 to R3 are H, halogen, 1-3C alkyl, 1-3C alkoxy or amino, etc.; R4 and R5 are H, 1-3C alkyl or cyano, etc.; R6 is H, 1-3C alkyl or benzyl; X is single bond, -CHR7-...  
JPH033662B2  
JPH032150B2  
JPH02292281A
NEW MATERIAL: A compd. represented by formula I or II [wherein R0 is a 1-4C alkyl, an alkoxy, OH or a halogen, R2 and R3 are each H, a 1-4C alkyl, a 3-6C alkenyl, a cycloalkyl or benzyl, R1 is H, a 1-8C alkyl, a 3-7C cycloalkyl or phenyl...  
JPH02279669A
NEW MATERIAL:An aminoethanesulfonic acid derivative shown by formula I [R1 and R2 are R, 1 to 6C alkyl, carboxyl or R1 and R2 are bonded to form (substituted) benzene ring; (n) is 1 to 5 integer]. EXAMPLE: 2-(1-Pyrrolidinyl)ethanesulfoni...  
JPH02256614A
PURPOSE: To obtain a medicine containing a specific lactam imide and capable of being administered together with one or more of other antiprotozoal medicines to treat or prevent the infections of medicine-resistant protozoa. CONSTITUTION...  
JPH0244830B2  
JPH02502824A
PCT No. PCT/US88/00817 Sec. 371 Date Sep. 19, 1989 Sec. 102(e) Date Sep. 19, 1989 PCT Filed Mar. 18, 1988 PCT Pub. No. WO88/07527 PCT Pub. Date Oct. 6, 1988.The amino-9,10-secosteroids (I) of the present invention contain an amino group ...  
JPH02218612A
PURPOSE: To obtain an ophthalmic composition which contains an ACE inhibitor, in some cases, additionally a CA inhibitor and is used for treatment of glaucoma and for ocular hypertension accompanied thereby. CONSTITUTION: This ophthalmic...  
JPH02200812A
PURPOSE: To obtain a polyester fiber reduced in carboxyl end group concentration and having good heat resistance and strength characteristics by adding a specific dilactim ether compound to a high-molecular weight polyester, reacting the...  
JPH0227328B2  
JPH02129168A
NEW MATERIAL: A compd. represented by formula I [wherein R of RCO is an acyl containing a carbocyclic or heterocyclic aromatic ring; R1 and R2 are each H, an alkyl, an alkenyl, a cycloalkyl, a cycloalkylalkyl or combined to form a polyet...  
JPH0212207B2  
JPH0253765A
NEW MATERIAL: A compound of formula I [wherein R1, R2 are each H, an alkyl, alkoxyl, halogen, CF3; R3 is H, -C(=O)-alkyl, -C(=O)-Z(wherein Z is an aryl), etc.; R4 is a 3-6C alkyl; R5 is H, an alkyl, -CH2-R10 (wherein R10 is phenyl, a het...  
JPH0253725A
PURPOSE: To obtain a calcium antagonistic substance composed of a specific lactam imide and useful as an antianginal agent, a vasodilator, a hypotensor, an antimaniac agent, etc. CONSTITUTION: This calcium antagonistic substance is compo...  
JPH0240363A
NEW MATERIAL:The 1,2-qinonediazide compound of formula I (Ra is H, halogen or 1-4C alkyl; when m is ≤3, the plural Ra groups may be different atoms or groups; D is 1,2-naphthoquinonediazido-4-sulfonyl, 1,2-naphthoquinonediazido-5- sulf...  
JPH024740A
NEW MATERIAL: A compd. represented by formula I [wherein V is O, S, NR (wherein R is H or a 1-4C or 1-4C alkyl or -CH2-, R1 and R2 are each H, OH, a 1-6C alkyl, alkoxy, halogen or 1-4 substituents at a benzo region of CF3CN, R3 and R4 ar...  
JPH023615A
PURPOSE: To obtain the heading compound which is an intermediate in the synthesis of a compound useful as an antihistaminic agent, etc., etc., simply and advantageously without by-products by contacting a specified amino acid with a Grig...  
JPH01308229A
PURPOSE: To prepare a therapeutic medicine for cerebral ischaemia containing a heterocyclic derivative including a new compound acting as an agonist in κ-opioid receptor. CONSTITUTION: This heterocyclic derivative is a new compound of f...  
JPH0154346B2  
JPH01279870A
NEW MATERIAL:A compound shown by formula I {R1 and R2 are H, -COOR [R is (substituted) lower alkyl or (substituted) lower alkyl] or acryl group obtained by removing hydroxy part from carboxyl group of amino acid (amino group or side-chai...  
JPH01265080A
NEW MATERIAL:An alkylenediamine derivative expressed by the formula (R1 is H, aliphatic hydrocarbon, alicyclic hydrocarbon, aryl, aryl-substituted alkyl, etc.; Y is O or S; R2 is aliphatic hydrocarbon, aryl-substituted alkyl, etc.; R3-R5...  
JPH01246258A
NEW MATERIAL: A compd. of formula I [R1 and R2 are each H, alkyl, alkenyl, cocyloalkyl, etc., R1 and R2 together form polymethylene or alkenylene but are not simultaneously H; R3 is H, alkyl or phenyl, R3 and R1 together form (CH2)3 or (...  
JPH0140027B2
A 1,3-disubstituted urea or 2-thiourea having the formula wherein R1, R2, R3, R6, R7 and R8 represent independently a hydrogen atom, an alkyl radical containing 1 to 4 carbon atoms, an alkenyl radical containing 2 to 4 carbon atoms, an a...  
JPH0137119B2  
JPH01175971A
PURPOSE: To chemically and readily obtain the title compound useful as an antimicrobial agent, antitumor agent, arterialization inhibitor, etc., by oxidizing hydroquinone part of the antibiotic NK86-0085 from the antibiotic to paraquinon...  
JPH01175970A
PURPOSE: To obtain the title substance useful as an antibacterial agent, antitumor agent and inhibitor of arterialization, by selectively reducing para- quinone part of herbimycin A with a reducing agent such as ascorbic acid. CONSTITUTI...  
JPH01168671A
NEW MATERIAL:The Q-1047H substance expressed by formula I (R is group of formula IIIWIV). EXAMPLE: Q-1047H-A expressed by formula V. USE: An antioxidant capable of removing active oxygen compound from living body, effective in preventing...  
JPH0132240B2
The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart failure. The compounds of the present inven...  
JPH0130824B2
Compounds of the formula (I) and a process for their preparation by reacting azabutadienes with dienes, especially 1,3-butadiene, in the presence of catalysts are described. In the formula I, R1 and R3 independently of one another are hy...  
JPH01143868A
NEW MATERIAL:Q-1047R substance having a plane chemical structure of the formula. USE: Since it can remove active oxygens in vivo, the substance is useful as an antioxidant to prevent or reduce the formation of peroxidized lipid. For exam...  
JPS6412272B2  
JPS6447748A
NEW MATERIAL: The compd. of formula I [one or two of R1 to R4 are halogen, methoxy and the others are H; R5 is H or phenyl; R6 is OR12 or NR13R14 (R12 is H, 1 to 10C alkyl, etc.; R13 is H or 1 to 4C alkyl,; R14 is H, pyridyl, etc.); R7 i...  
JPS642593B2  
JPS649976A
NEW MATERIAL:Antibiotic NK-86-0084 shown by the formula and a salt thereof. USE: A drug. An active ingredient for an antimicrobial agent, carcinostatic agent and suppressant against arterialization being expected to as a preventive and r...  
JPS63295509A
PURPOSE: To obtain the titled preparation useful for preventing and treating diseases becoming critical by abnormal multiplication of blood vessel, such as nodse rheumatism or diabetic retinopathy, having inhibitory action on arterializa...  
JPS63503223A
PCT No. PCT/FR87/00055 Sec. 371 Date Nov. 5, 1987 Sec. 102(e) Date Nov. 5, 1987 PCT Filed Mar. 5, 1987 PCT Pub. No. WO87/05289 PCT Pub. Date Sep. 11, 1987.A method for forming bridged biaryl compounds via the intramolecular oxidative bia...  
JPS63502508A
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.  
JPS63218664A
NEW MATERIAL:A hitachimycin derivative shown by formula I (R1 and R2 are H or 2W6C alkanoyl with the proviso that R1 and R2 are neither H nor acetyl at the same time). EXAMPLE: 11,15-Di-O-propionylhitachimycin. USE: An antibiotic having ...  
JPS63218620A
PURPOSE: To obtain a normalizing agent for cancerated cell having reduced toxicity, by using a herbimycin derivative as an active component. CONSTITUTION: A compound of formula I [R1 and R2 are H, (CH3)2N, group of formula II, formula II...  
JPS6345662B2  
JPS63208590A
NEW MATERIAL:The compound of formula I {A is R2-N< [R2 is (substituted) lower alkyl, lower alkenyl, lower alkynyl or adamantyl] or group of formula II; m and n are 0W2; X is O or S; R1 is H, (substituted) lower alkyl, lower alkenyl, lowe...  
JPS6342612B2
A compound of the formula: I wherein the double bond is in the trans configuration and R1 is a radical of formula IIa, IIa R2, R3, R5, R7 and R8 are each hydrogen, R4 is methyl, and R6 is a radical of formula IIIa -C 3BOND C-R11 IIIa whe...  
JPS6341885B2  
JPS6334866B2  
JPS63150230A
This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administ...  
JPS63150229A
This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administ...  

Matches 601 - 650 out of 809