Document |
Document Title |
JPH0366302B2 |
A compound of the formula:wherein R1 and R2 are the same or different and each represents hydrogen or methyl and X isprovided that when R1 is hydrogen, R2 is hydrogen or methyl and X isand when R1 is methyl, R2 is methyl and X isis produ...
|
JPH0315633B2 |
Macbecin derivatives are produced by bringing Macbecins into contact with a microorganism, or its processed matter, of the genus Streptomyces or Nocardia. The Macbecin derivatives are useful as antibacterial, antifungal or antiprotozoal ...
|
JPH0312062B2 |
There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable amounts of 1-alkyl substituted-azacyclo...
|
JPH0327357A |
NEW MATERIAL:A compound expressed by formula I or salt of said compound [R1 to R3 are H, halogen, 1-3C alkyl, 1-3C alkoxy or amino, etc.; R4 and R5 are H, 1-3C alkyl or cyano, etc.; R6 is H, 1-3C alkyl or benzyl; X is single bond, -CHR7-...
|
JPH033662B2 |
|
JPH032150B2 |
|
JPH02292281A |
NEW MATERIAL: A compd. represented by formula I or II [wherein R0 is a 1-4C alkyl, an alkoxy, OH or a halogen, R2 and R3 are each H, a 1-4C alkyl, a 3-6C alkenyl, a cycloalkyl or benzyl, R1 is H, a 1-8C alkyl, a 3-7C cycloalkyl or phenyl...
|
JPH02279669A |
NEW MATERIAL:An aminoethanesulfonic acid derivative shown by formula I [R1 and R2 are R, 1 to 6C alkyl, carboxyl or R1 and R2 are bonded to form (substituted) benzene ring; (n) is 1 to 5 integer]. EXAMPLE: 2-(1-Pyrrolidinyl)ethanesulfoni...
|
JPH02256614A |
PURPOSE: To obtain a medicine containing a specific lactam imide and capable of being administered together with one or more of other antiprotozoal medicines to treat or prevent the infections of medicine-resistant protozoa. CONSTITUTION...
|
JPH0244830B2 |
|
JPH02502824A |
PCT No. PCT/US88/00817 Sec. 371 Date Sep. 19, 1989 Sec. 102(e) Date Sep. 19, 1989 PCT Filed Mar. 18, 1988 PCT Pub. No. WO88/07527 PCT Pub. Date Oct. 6, 1988.The amino-9,10-secosteroids (I) of the present invention contain an amino group ...
|
JPH02218612A |
PURPOSE: To obtain an ophthalmic composition which contains an ACE inhibitor, in some cases, additionally a CA inhibitor and is used for treatment of glaucoma and for ocular hypertension accompanied thereby. CONSTITUTION: This ophthalmic...
|
JPH02200812A |
PURPOSE: To obtain a polyester fiber reduced in carboxyl end group concentration and having good heat resistance and strength characteristics by adding a specific dilactim ether compound to a high-molecular weight polyester, reacting the...
|
JPH0227328B2 |
|
JPH02129168A |
NEW MATERIAL: A compd. represented by formula I [wherein R of RCO is an acyl containing a carbocyclic or heterocyclic aromatic ring; R1 and R2 are each H, an alkyl, an alkenyl, a cycloalkyl, a cycloalkylalkyl or combined to form a polyet...
|
JPH0212207B2 |
|
JPH0253765A |
NEW MATERIAL: A compound of formula I [wherein R1, R2 are each H, an alkyl, alkoxyl, halogen, CF3; R3 is H, -C(=O)-alkyl, -C(=O)-Z(wherein Z is an aryl), etc.; R4 is a 3-6C alkyl; R5 is H, an alkyl, -CH2-R10 (wherein R10 is phenyl, a het...
|
JPH0253725A |
PURPOSE: To obtain a calcium antagonistic substance composed of a specific lactam imide and useful as an antianginal agent, a vasodilator, a hypotensor, an antimaniac agent, etc. CONSTITUTION: This calcium antagonistic substance is compo...
|
JPH0240363A |
NEW MATERIAL:The 1,2-qinonediazide compound of formula I (Ra is H, halogen or 1-4C alkyl; when m is ≤3, the plural Ra groups may be different atoms or groups; D is 1,2-naphthoquinonediazido-4-sulfonyl, 1,2-naphthoquinonediazido-5- sulf...
|
JPH024740A |
NEW MATERIAL: A compd. represented by formula I [wherein V is O, S, NR (wherein R is H or a 1-4C or 1-4C alkyl or -CH2-, R1 and R2 are each H, OH, a 1-6C alkyl, alkoxy, halogen or 1-4 substituents at a benzo region of CF3CN, R3 and R4 ar...
|
JPH023615A |
PURPOSE: To obtain the heading compound which is an intermediate in the synthesis of a compound useful as an antihistaminic agent, etc., etc., simply and advantageously without by-products by contacting a specified amino acid with a Grig...
|
JPH01308229A |
PURPOSE: To prepare a therapeutic medicine for cerebral ischaemia containing a heterocyclic derivative including a new compound acting as an agonist in κ-opioid receptor. CONSTITUTION: This heterocyclic derivative is a new compound of f...
|
JPH0154346B2 |
|
JPH01279870A |
NEW MATERIAL:A compound shown by formula I {R1 and R2 are H, -COOR [R is (substituted) lower alkyl or (substituted) lower alkyl] or acryl group obtained by removing hydroxy part from carboxyl group of amino acid (amino group or side-chai...
|
JPH01265080A |
NEW MATERIAL:An alkylenediamine derivative expressed by the formula (R1 is H, aliphatic hydrocarbon, alicyclic hydrocarbon, aryl, aryl-substituted alkyl, etc.; Y is O or S; R2 is aliphatic hydrocarbon, aryl-substituted alkyl, etc.; R3-R5...
|
JPH01246258A |
NEW MATERIAL: A compd. of formula I [R1 and R2 are each H, alkyl, alkenyl, cocyloalkyl, etc., R1 and R2 together form polymethylene or alkenylene but are not simultaneously H; R3 is H, alkyl or phenyl, R3 and R1 together form (CH2)3 or (...
|
JPH0140027B2 |
A 1,3-disubstituted urea or 2-thiourea having the formula wherein R1, R2, R3, R6, R7 and R8 represent independently a hydrogen atom, an alkyl radical containing 1 to 4 carbon atoms, an alkenyl radical containing 2 to 4 carbon atoms, an a...
|
JPH0137119B2 |
|
JPH01175971A |
PURPOSE: To chemically and readily obtain the title compound useful as an antimicrobial agent, antitumor agent, arterialization inhibitor, etc., by oxidizing hydroquinone part of the antibiotic NK86-0085 from the antibiotic to paraquinon...
|
JPH01175970A |
PURPOSE: To obtain the title substance useful as an antibacterial agent, antitumor agent and inhibitor of arterialization, by selectively reducing para- quinone part of herbimycin A with a reducing agent such as ascorbic acid. CONSTITUTI...
|
JPH01168671A |
NEW MATERIAL:The Q-1047H substance expressed by formula I (R is group of formula IIIWIV). EXAMPLE: Q-1047H-A expressed by formula V. USE: An antioxidant capable of removing active oxygen compound from living body, effective in preventing...
|
JPH0132240B2 |
The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart failure. The compounds of the present inven...
|
JPH0130824B2 |
Compounds of the formula (I) and a process for their preparation by reacting azabutadienes with dienes, especially 1,3-butadiene, in the presence of catalysts are described. In the formula I, R1 and R3 independently of one another are hy...
|
JPH01143868A |
NEW MATERIAL:Q-1047R substance having a plane chemical structure of the formula. USE: Since it can remove active oxygens in vivo, the substance is useful as an antioxidant to prevent or reduce the formation of peroxidized lipid. For exam...
|
JPS6412272B2 |
|
JPS6447748A |
NEW MATERIAL: The compd. of formula I [one or two of R1 to R4 are halogen, methoxy and the others are H; R5 is H or phenyl; R6 is OR12 or NR13R14 (R12 is H, 1 to 10C alkyl, etc.; R13 is H or 1 to 4C alkyl,; R14 is H, pyridyl, etc.); R7 i...
|
JPS642593B2 |
|
JPS649976A |
NEW MATERIAL:Antibiotic NK-86-0084 shown by the formula and a salt thereof. USE: A drug. An active ingredient for an antimicrobial agent, carcinostatic agent and suppressant against arterialization being expected to as a preventive and r...
|
JPS63295509A |
PURPOSE: To obtain the titled preparation useful for preventing and treating diseases becoming critical by abnormal multiplication of blood vessel, such as nodse rheumatism or diabetic retinopathy, having inhibitory action on arterializa...
|
JPS63503223A |
PCT No. PCT/FR87/00055 Sec. 371 Date Nov. 5, 1987 Sec. 102(e) Date Nov. 5, 1987 PCT Filed Mar. 5, 1987 PCT Pub. No. WO87/05289 PCT Pub. Date Sep. 11, 1987.A method for forming bridged biaryl compounds via the intramolecular oxidative bia...
|
JPS63502508A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
|
JPS63218664A |
NEW MATERIAL:A hitachimycin derivative shown by formula I (R1 and R2 are H or 2W6C alkanoyl with the proviso that R1 and R2 are neither H nor acetyl at the same time). EXAMPLE: 11,15-Di-O-propionylhitachimycin. USE: An antibiotic having ...
|
JPS63218620A |
PURPOSE: To obtain a normalizing agent for cancerated cell having reduced toxicity, by using a herbimycin derivative as an active component. CONSTITUTION: A compound of formula I [R1 and R2 are H, (CH3)2N, group of formula II, formula II...
|
JPS6345662B2 |
|
JPS63208590A |
NEW MATERIAL:The compound of formula I {A is R2-N< [R2 is (substituted) lower alkyl, lower alkenyl, lower alkynyl or adamantyl] or group of formula II; m and n are 0W2; X is O or S; R1 is H, (substituted) lower alkyl, lower alkenyl, lowe...
|
JPS6342612B2 |
A compound of the formula: I wherein the double bond is in the trans configuration and R1 is a radical of formula IIa, IIa R2, R3, R5, R7 and R8 are each hydrogen, R4 is methyl, and R6 is a radical of formula IIIa -C 3BOND C-R11 IIIa whe...
|
JPS6341885B2 |
|
JPS6334866B2 |
|
JPS63150230A |
This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administ...
|
JPS63150229A |
This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administ...
|