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Matches 1 - 50 out of 1,045

Document Document Title
WO/2018/129552A1
The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-sta...  
WO/2018/110799A1
Provided are a compound represented by any one of chemical formulas 1 to 3, or an isomer, derivative, solvate, or pharmaceutically acceptable salt thereof, a production method therefor, and a use thereof. According to this, antibacterial...  
WO/2018/104856A1
A process of obtaining a purified geometric isomer of an unsaturated macrocyclic compound is disclosed herein. The process is effected by contacting an ion exchange medium comprising silver ions with a mixture comprising at least one geo...  
WO/2018/100029A1
The invention relates to heterocyclic compounds, particularly for use in electronic devices. The invention further relates to a method for producing the compounds according to the invention, and to electronic devices comprising same.  
WO/2018/098390A1
Provided herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein L1 and L2 are each independently a covalent bond or a divalent linking group, R is a detectable label or therapeutic drug and B is an alb...  
WO/2018/039521A1
This invention relates to deuterated forms of cenicriviroc, racemic and (R) forms thereof, free base forms of any of the foregoing and pharmaceutically acceptable salts of the free base forms. In one aspect, the invention provides a comp...  
WO/2018/009417A1
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to macrocyclic α-keto amide derivatives and their use as therapeutic agents.  
WO/2018/002114A1
The invention relates to a method for reactivating homogeneous catalyst systems from organic reaction mixtures. The catalyst systems are suitable for oxidating organic compounds such as, for example cyclododecene. The reactivation is car...  
WO/2017/156071A1
The present technology relates to cyclic keto-amide compounds of general formulae I to XXXII, compositions and kits thereof as calpain modulators and methods useful for the treatment of various diseases or disorders such as fibrotic dise...  
WO/2017/109178A1
A subject of the present invention is the use of a compound having the general formula (I): (I) wherein V, W, X4, X5, X6, X7, X'4, X'5, X'6, X'7, Y, Y', R3, R'3, R4 and R'4 are as defined in any one of claims 1 to 11, for the detection, ...  
WO/2016/172795A1
The present invention concerns a method for the prevention and/or treatment of an activation-induced deaminase (AID)-associated disease in a subject in need thereof, said method comprising administering an effective amount of an uracil-D...  
WO/2016/149581A1
Provided herein are compounds of formula (I) useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.  
WO/2016/105527A1
The disclosure includes high purity compounds having CCR5 and/or CCR2 antagonism, or a salt thereof, and processes for synthesizing the same.  
WO/2016/100033A9
Methods for producing lactams from oximes by performing a Beckmann rearrangement using a hierarchical porous aluminophosphate catalyst having interconnected microporous and mesoporous networks are provided. Exemplary catalysts include a ...  
WO/2016/100033A2
Methods for producing lactams from oximes by performing a Beckmann rearrangement using a hierarchical porous aluminophosphate catalyst having interconnected microporous and mesoporous networks are provided. Exemplary catalysts include a ...  
WO/2016/100033A3
Methods for producing lactams from oximes by performing a Beckmann rearrangement using a hierarchical porous aluminophosphate catalyst having interconnected microporous and mesoporous networks are provided. Exemplary catalysts include a ...  
WO/2016/059942A1
Provided is a three-phase AC/DC conversion device disposed between a three-phase AC power supply and a light-emitting diode group, the device comprising: a three-phase full-bridge circuit in which pairs of switching elements are connecte...  
WO/2016/056371A1
Provided is a photochemical reaction device characterized in that two partition walls formed from a light-transmitting material are arranged apart from each other between a light source and a reaction liquid. The photochemical reaction d...  
WO/2016/056370A1
Provided is a photoirradiation device equipped with: a first optically transparent container for covering a light-emitting body provided with a light-emitting diode; a liquid phase section positioned to the exterior thereof and formed fr...  
WO/2016/047882A1
The present invention relates to a novel one-photon or two-photon absorbing fluorescent compound, a method for preparing the same, and a cell imaging method using the same and, more specifically, to a novel two-photon absorbing fluoresce...  
WO/2015/134599A3
Reactions of 1,3-dipole-functional (e.g., azide-functional) platinum(IV) compounds with cyclic alkynes under conditions effective for a cycloaddition reaction to form a heterocyclic compound are disclosed herein. In certain embodiments, ...  
WO/2015/134599A8
Reactions of 1,3-dipole-functional (e.g., azide-functional) platinum(IV) compounds with cyclic alkynes under conditions effective for a cycloaddition reaction to form a heterocyclic compound are disclosed herein. In certain embodiments, ...  
WO/2015/112014A1
The present invention relates to a process comprising the step of reacting a (hetero)aryl 1,3-dipole compound with a (hetero)cycloalkyne, wherein: a (hetero)aryl 1,3-dipole compound is defined as a compound comprising a 1,3-dipole functi...  
WO/2015/112016A1
The present invention relates to a cycloaddition process comprising the step of reacting a halogenated aliphatic 1,3-dipole compound with a (hetero)cycloalkyne according to Formula (1): Preferably, the (hetero)cycloalkyne according to Fo...  
WO/2015/100174A1
The application is directed to compounds of Formula (I) or (IA) and pharmaceutically acceptable salts and solvates thereof, wherein R1 R2, R3 and G are defined as set forth in the specification. The invention is also directed to use of c...  
WO/2015/033261A1
The present application provides a catalytic process which involves the cyclization of a novel catalytic intramolecular arylation process that involves boronic acid or ester aldehydes or imines substrates, of formula (I) and (II), to aff...  
WO/2014/189370A1
The invention relates to a substituted azadibenzocyclooctyne compound according to Formula (5): The invention also relates to a conjugate wherein a substituted azadibenzocyclooctyne according to the invention is conjugated to a label, an...  
WO/2014/127315A1
In alternative embodiments, the invention provides nucleophilic hydroxyimino- acetamido alkylamine antidotes that cross the blood-brain barrier (BBB) to catalyze the hydrolysis of organophosphate (OP)-inhibited human acetylcholinesterase...  
WO/2014/123203A1
Provided is a compound having PTP-1B inhibitory activity that is excellent as a drug, or a pharmaceutically acceptable salt thereof. A compound represented by general formula (I) (in the formula, each symbol means the same as in the spec...  
WO/2014/119636A1
Provided are: a novel compound which has an antiviral effect, in particular, HIV replication inhibitory activity; and a pharmaceutical product, in particular, an anti-HIV agent which contains the novel compound. A compound which is repre...  
WO/2014/083150A1
The present invention relates to the preparation of 3-amino-piperidine compounds via nitro-tetrahydropyridine precursors and salts thereof. These compounds can be used as intermediates in the synthesis of pharmaceutically active agents s...  
WO/2014/048692A1
The present invention relates to a method for producing metathesis products comprising contacting metathesis starting materials under metathesis conditions with a metathesis catalyst, wherein the metathesis catalyst is employed in an amo...  
WO/2014/007398A1
Provided are: a cationic lipid represented by formula (A) or the like, which makes it easier to introduce a nucleic acid into, for example, a cell; a composition which contains the cationic lipid and a nucleic acid; a method for introduc...  
WO/2014/008204A3
Disclosed herein are novel structures of proteasome inhibitors and methods for synthesizing and use thereof, including novel structures of proteasome inhibitors, such as syrbactins and its analogs, and methods for synthesizing them and u...  
WO/2013/060818A1
Disclosed is a direct acid catalyzed intermolecular electrocyclic rearrangement process for the preparation of linear and cyclic homoallylic ester and amides.  
WO/2013/058582A2
The present invention relates to a preparation method for an ansamycin glycoside or a non-benzoquinone geldanamycin glycoside having an ansamycin backbone using a glycosyltransferase, a non-benzoquinone geldanamycin glycoside, and a phar...  
WO/2013/058582A3
The present invention relates to a preparation method for an ansamycin glycoside or a non-benzoquinone geldanamycin glycoside having an ansamycin backbone using a glycosyltransferase, a non-benzoquinone geldanamycin glycoside, and a phar...  
WO/2013/013240A2
Compounds and compositions, which can be use for example, for treating cancer, are described herein.  
WO/2013/013240A3
Compounds and compositions, which can be use for example, for treating cancer, are described herein.  
WO/2012/167171A2
The present invention relates generally to olefin metathesis. In some embodiments, the present invention provides methods for Z-selective ring-closing metathesis.  
WO/2012/134925A1
The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA, wherein the variables R1, R2, R3, Ra and L a...  
WO/2012/082618A3
The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a co...  
WO/2012/047663A2
Methods that include latent 1,3-dipole-functional compounds are disclosed herein. The latent 1,3-dipole-functional compound (e.g., an oxime) can be used to form an active 1,3-dipole-functional compound (e.g., a nitrile oxide) that can be...  
WO/2012/047663A3
Methods that include latent 1,3-dipole-functional compounds are disclosed herein. The latent 1,3-dipole-functional compound (e.g., an oxime) can be used to form an active 1,3-dipole-functional compound (e.g., a nitrile oxide) that can be...  
WO/2011/151436A3
The present invention is directed to novel compounds of formula (I) Ar1__L1__R__Ar2__Ar3 and their use in treating and/or preventing inflammatory, gastrointestinal and/or metabolic disorders.  
WO/2011/151436A2
The present invention is directed to novel compounds of formula (I) Ar1__L1__R__Ar2__Ar3 and their use in treating and/or preventing inflammatory, gastrointestinal and/or metabolic disorders.  
WO/2011/119456A1
Nitrogen-containing fluorochemical ketones are provided that can be useful in apparatuses that includes a device and a mechanism for transferring heat. The provided fluorochemical ketones are stable at temperatures above 170°C, are envi...  
WO/2011/115132A1
Disclosed is a method for producing a high purity, high quality amide compound, specifically, lactam. A first embodiment is characterized in that, in an oximation process, the content for halides, aldehyde compounds, alcohol compounds an...  
WO/2011/082519A1
Geldanamycin derivatives, preparation methods and uses thereof in the manufacture of medicaments of cell killing agents, cell proliferation inhibitors and antitumor agents are disclosed.  
WO/2011/063615A1
Macrocyclic amide WH-21091 with antibacterial and antitumor activities, its analogs, preparation methods and uses thereof. The said macrocyclic amides are prepared by microbes of Xenorhabdus and Photorhabdus, or they can be prepared by o...  

Matches 1 - 50 out of 1,045