Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 15,862

Document Document Title
WO/2018/188590A1
Fluorine-substituted indazole compounds, pharmaceutical compositions containing these compounds and uses thereof. The compounds and pharmaceutical compositions can be used as soluble guanylate cyclase simulators.  
WO/2018/191283A1
Described herein are glucocorticoid receptor modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.  
WO/2018/186365A1
The present invention relates to a novel read-through inducing agent, and also relates to a compound represented by general formula (I) (symbols in the formula are as described in the specification) or a pharmaceutically accepted salt th...  
WO/2018/177781A1
The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description, (I). Th...  
WO/2018/178227A1
Disclosed are intermediates and methods of synthesizing Compound 1.  
WO/2018/180943A1
The present invention provides an industrially excellent production method which can more efficiently and conveniently produce a halogen-containing pyrazol carboxylic acid and an intermediate thereof which are useful as a pharmaceutical ...  
WO/2018/181456A1
Provided is a compound represented by the formula, or a salt thereof, the compound having RORγt-inhibiting activity and being useful as a prophylactic or therapeutic agent for autoimmune or allergic diseases.  
WO/2018/176158A1
There are provided PVP-PLA block copolymers as defined in Formula (I): I wherein, x is an initiator alcohol having a boiling point greater than 145°C, n is, on average, from 20 and 40, and m is, on average, from 10 and 40, wherein the b...  
WO/2018/180944A1
The present invention provides an industrially excellent production method by which a halogenated pyrazolecarboxylic acid useful as an intermediate for medicines and agricultural chemicals can be more easily and efficiently produced. The...  
WO/2018/171602A1
Provided are a urea compound having a dual inhibitory activity against IDO and TDO and being represented by the formula (I) or a pharmaceutically acceptable salt thereof, a preparation method and pharmaceutical composition thereof, and a...  
WO/2018/172423A1
The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p¸ q, L, ׇ, X and m are as defined herein. The compound...  
WO/2018/170166A1
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of condi...  
WO/2018/167695A1
The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular t...  
WO/2018/167468A1
The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the matura...  
WO/2018/167800A1
The present invention relates to fused bicyclic compounds that are inhibitors of GPR91, their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them. T...  
WO/2018/165501A1
The invention provides aryl indolinyl sulfonamide and related compounds, pharmaceutical compositions, methods of promoting RORγ activity and/or increasing the amount of IL-17 in a subject, and therapeutic uses of the indolinyl sulfonami...  
WO/2018/165466A1
Disclosed are Indole and Indazole urea derivative compounds, methods for preparing these compounds, and methods for treating cancer.  
WO/2018/162793A1
The present invention relates to crystalline particles of N-((S)-l-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan -2-yl)-5-(1-hydroxyethyl)-1 H-pyrazole-3-carboxamide (I) having specific surface area (SSA) in the range from about 8 ...  
WO/2018/157842A1
The present invention provides a use of 2-(substituted phenylamino)benzoic acid FTO inhibitor in treating leukemia.  
WO/2018/160618A1
Substituted hydroquinones, 1,4-quinones, catechols, 1,2-quinones, anthraquinones, and anthrahydroquinones are disclosed herein. The substituted hydroquinones and catechols have the formula: while the substituted 1,4-quinones or 1,2-have ...  
WO/2018/157843A1
The preparation method provides 2-(substituted benzene matrix) aromatic formate FTO inhibitor, a preparation method therefor, and applications thereof. Specifically, disclosed in the present invention are a 2-(substituted benzene matrix)...  
WO/2018/158212A1
The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases  
WO/2018/161033A1
Described herein are IRE1-alpha inhibitors, compositions containing such inhibitors, and methods of treatment of cancer that include administration of such compounds. Exemplary compounds are provided throughout the application.  
WO/2018/158620A1
The present invention provides processes for the preparation of active pharmaceutical ingredients and intermediates thereof in an aqueous designer smart surfactant solution.  
WO/2018/159827A1
The present invention provides a novel non-steroid-type compound or a salt thereof, having BR-like activity which is useful for regulating plant growth, an agricultural composition containing the compound or the salt thereof, and uses th...  
WO/2018/157190A1
The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human sub...  
WO/2018/159639A1
Provided is a method for producing a heterocyclic compound which is useful as a prophylactic and/or therapeutic agent for Alzheimer's disease and the like. A method for producing 1,5-anhydro-2,4-dideoxy-2-(4-fluoro-5-methyl-1-oxo-6-(4-(1...  
WO/2018/153707A1
The present invention relates to crystalline forms of the strobilurin-type compound (Z,2E)-5-[1-(2,4-dichlorophenyl)pyrazol-3-yl]oxy-2 methoxyimino-N,3-dimethyl-pent-3-enamide and to processes for their preparation and agrochemical compo...  
WO/2018/154097A1
The invention discloses a method for the preparation of 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol with high selectivity with respect to the content of the isomer 1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol, wherein ethyl 4,4,4-triflu...  
WO/2018/154519A1
The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compo...  
WO/2018/151126A1
The present invention addresses the problem of providing: a novel method for producing an indazole compound, which is capable of producing an indazole compound without using a reaction reagent that has high toxicity; and a novel indazole...  
WO/2018/149813A1
The present invention relates to a process for preparing substituted 2-nitrobiphenyls via Suzuki coupling using a palladium catalyst with specific phosphorus ligands and a solvent mixture containing water and an organic solvent which is ...  
WO/2018/150061A1
The invention relates to novel functionalised polymers of formula (I), in which trispyrazolylborate-type ligands attach to the structure of vinyl polynorbornenes. In this way, the novel polymer compound can form coordination compounds wi...  
WO/2018/145653A1
The present invention relates to the technical field of chemical medicine and relates to a compound represented by formula (I) or formula (II) and a preparation method therefor, the compound being a biaryl derivative and having retinoid-...  
WO/2018/148737A1
The present invention is directed to the use of a 5-HT2A serotonin receptor inverse agonist for the prophylaxis and/or treatment of the symptoms of dementia with Lewy bodies, Parkinson's disease, or a combination thereof in an individual...  
WO/2018/141069A1
Methods of detecting an aldehyde-containing compound in a subject or in a sample from a subject are described herein, comprising administering an aldehyde-binding compound of Formula I to the subject, or combining such a compound with th...  
WO/2018/141751A1
The invention relates to an economical, single-stage method for producing n-substituted aromatic hydroxylamine of formula (I) R-N(OH)-C(=O)-(O) R1 (I), using hydrogen, by catalytic hydrogenation using optionally modified hydrogenation ca...  
WO/2018/139174A1
A fluoroether compound represented by formula (1). R1-R2-CH2-R3-CH2-R4-R5 (1) (In formula (1), R1 and R5 may be the same or different and are each a group having a heteroring, R2 and R4 may be the same or different and are each a divalen...  
WO/2018/140512A1
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): (I) or a pharmaceutically acceptable salt, isotopic form, stereoisomer or prodrug thereof, wherein A, B, X,...  
WO/2018/137593A1
Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase a...  
WO/2018/138362A1
The present invention provides e.g. N-{[2-(piperidin-1-yl)phenyl] (phenyl)methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl) acetamide derivatives and related compounds as ROR-gamma modulators for treating e.g. autoimmune diseases, aut...  
WO/2018/137618A1
Compounds of Formula (I) or pharmaceutically acceptable salt thereof, a pharmaceutical compositions comprising these compounds, the use of these compounds and compositions in the treatment of diseases in which LRRK-2 kinase is involved.  
WO/2018/136890A1
The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLR...  
WO/2018/133818A1
Provided are a method for preparing bicyclo-substituted pyrazolone azo derivatives and intermediates thereof.  
WO/2018/133621A1
An edaravone derivative and a use thereof. As compared with edaravone, the derivative has enhanced treatment effects and significantly reduced cytotoxicity.  
WO/2018/133870A1
A compound represented by formula (I), a pharmaceutically acceptable salt or tautomer thereof, and an application of the compound as a caspase inhibitor.  
WO/2018/132372A1
Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.  
WO/2018/123918A1
Provided is a compound or a salt thereof, represented by the formula shown, which has a RORγt inhibitory effect and is useful as a preventive or therapeutic agent for autoimmune diseases, allergies, and the like.  
WO/2018/125816A1
This application relates to efficient and economical synthetic chemical processes for the preparation of pesticidal thioethers and pesticidal sulfoxides. Further, the present application relates to certain novel compounds necessary for t...  
WO/2018/124088A1
Provided are novel pest control agents, in particular, a bactericide and a nematicide. An alkylphenyl-substituted amide compound represented by formula (I) [wherein: G1 stands for a structure represented by G1-2, G1-3, G1-4, etc.; X1 sta...  

Matches 1 - 50 out of 15,862