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Matches 1 - 50 out of 15,660

Document Document Title
WO/2018/070360A1
Provided are a volatile organic substance detection body and a manufacturing method therefor, a volatile organic substance detection method, and a volatile organic substance detection device that have a high selectivity, a low operating ...  
WO/2018/071327A1
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...  
WO/2018/065611A1
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(arylsulfinyl)- acetamide compounds that, inter alia, inhibit (e.g., selectively inhibi...  
WO/2018/065607A1
The invention relates to compounds which are suitable for the treatment of a disease associated with kallikrein related peptidase 6 overexpression and to pharmaceutical compositions containing such compounds. The invention further relate...  
WO/2018/064119A1
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.  
WO/2018/059420A1
The present invention relates to a crystal form of a Sigma-1 receptor antagonist drug, preparation method therefor and use thereof. The crystal form of E52862 hydrochloride salt provided in the present invention, named crystal form H, ca...  
WO/2018/059533A1
Disclosed is a class of pyrazole compounds of formula (I) having a p38α inhibitory effect, and included are uses of the compounds in the field of p38α-related diseases, such as various inflammatory diseases and immunological abnormalit...  
WO/2018/053587A1
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.  
WO/2018/057973A1
Disclosed are compounds of Formula I (a) or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R4, R5, R6, R7, G1, G2 and Ring A are as described in any of the embodiments describ...  
WO/2018/055550A1
The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further prov...  
WO/2018/054807A1
The present invention relates to a novel process for preparing 3-fluoroalkyl-5-pyrazolecarboxylates from ketimines and oxalic acid derivatives which can be further transformed into 3-fluoroalkyl-5- pyrazolecarboxylic acids.  
WO/2018/052772A1
The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these comp...  
WO/2018/051252A2
An object of the present invention is to provide an amide compound or a salt thereof that controls a mite. The present invention provides an amide compound represented by Formula (1) : or a salt thereof, wherein R1 represents C1-6 alkyl ...  
WO/2018/052838A1
Disclosed are compounds of Formula (1), including all geometric and stereoisomers, N oxides, and salts thereof, wherein R1, R2, R3, R4 and X are as defined in the disclosure. Also disclosed are compositions containing the compounds of Fo...  
WO/2018/049781A1
The present invention relates to an alkynyl-substituted heterocyclic compound acting as an FGFR inhibitor, a preparation method therefor and the medical use thereof. In particular, the present invention relates to a compound as shown in ...  
WO/2018/047670A1
An imide compound represented by formula (I) (in the formula, R represents a fluorine atom or hydrogen atom) exhibits excellent plant disease-preventing effects.  
WO/2018/048763A1
The present invention is directed to indazole derivatives of formula (I), pharmaceutical compositions containing them and their use in the treatment and / or prevention of disorders and conditions ameliorated by antagonizing one or more ...  
WO/2018/048762A1
The present invention is directed to indazole derivatives of formula (I), pharmaceutical compositions containing them and their use in the treatment and / or prevention of disorders and conditions ameliorated by antagonizing one or more ...  
WO/2018/044963A1
The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical composit...  
WO/2018/042377A1
The present invention relates to substituted indazole compounds, their pharmaceutically acceptable salts, and their isomers, steroisomers, atropisomers, conformers, tautomers, polymorphs, hydrates or solvates. The present invention also ...  
WO/2018/039378A1
This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and crystalline solid forms and compositions thereof. Also disclosed herein are methods of making crystalline solid forms of the 19-nor C3,3-disub...  
WO/2018/036558A1
Disclosed are a crystal form of an androgen receptor antagonist medication (ODM-201 as presented by formula (I)), a preparation method therefor, and a use. The B crystal form or C crystal form of the ODM-201 provided in the present inven...  
WO/2018/036414A1
Disclosed are a new derivative as shown by general formula (I') or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the derivative or the pharmaceutically acceptable salt thereof, and a method for prepa...  
WO/2018/033642A1
The present invention relates to a compound of formula (I): wherein L is an optionally substituted heterocyclic group excluding unsubstituted monocyclic pyridine groups; wherein a is 0, 1 or 2; wherein R1 is H or with R2 is a bond; where...  
WO/2018/033467A1
The present invention discloses an efficient preparation of 3-amino-1-((2,6-di-substituted)phenyl)pyrazoles.  
WO/2018/032586A1
The present invention relates to a method for preparing a 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, comprising the following steps: (A) reacting a diethyl ester compound represented by the following formula (IV) under th...  
WO/2018/029150A1
The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I). Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GP...  
WO/2018/024644A1
The present invention concerns the manufacture of hydrazinyl compounds useful in the manufacture of pyrazole carboxylic acid and derivatives thereof and processes for the manufacture of agrochemical or pharmaceutical compounds. The inven...  
WO/2018/018863A1
Disclosed are a mild and efficient preparation method for an α-acyloxy alkenyl amide compound and a use thereof in the synthesis of an amide and a polypeptide. The α-acyloxy alkenyl amide compound is obtained by an addition reaction of...  
WO/2018/021508A1
The present invention is a production method for a compound represented by formula [I] or a pharmaceutically acceptable salt thereof, or a hydrate of said compound or salt.  
WO/2018/022899A1
O-substituted hydroxamic acids with carbon-based leaving groups as HNO donors are disclosed. Pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions also are disc...  
WO/2018/021375A1
The present invention provides a production method that is capable of more simply and efficiently producing a fluorine-containing pyrazole carboxylic acid halide that is useful as a pharmaceutical or agrochemical intermediate. The presen...  
WO/2018/018091A1
The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.  
WO/2018/015445A1
The present invention relates to compounds of Formula (I) and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturati...  
WO/2018/015411A1
The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well a...  
WO/2018/014111A1
There is provided methods, compositions and treatment regimens for treating cancer, or for inhibiting metastasis/recurrence of cancer in a patient using 1) a primary cancer treatment such as chemotherapy, and 2) within 12 to 120 hours po...  
WO/2018/011578A1
This invention relates to a process for the preparation of Form B of 3-[5-amino-4-(3- cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide. Also disclosed herein is Form B of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopro...  
WO/2018/011579A1
This invention relates to a process for the preparation of Form A of 3-[5-amino-4-(3- cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide. Also disclosed herein is Form A of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopro...  
WO/2018/005678A1
The present disclosure provides compounds, pharmaceutical compositions, and methods for the treatment of cancer and fibrosis. The disclosed pharmaceutical compositions may include one or more pyrazolyl-containing compounds, or a derivati...  
WO/2018/001973A1
The present invention relates to pyrazole derivatives of formula (I) having pharmacological activity towards the α2δ subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacolo...  
WO/2017/219083A1
The present invention relates to novel compounds which active HIV expression in latently infected cells. More particularly, the invention relates to pharmaceutical compositions comprising the novel compounds and their use in activating H...  
WO/2017/219805A1
Provided are a compounded weeding composition containing dicarfentrazone-ethyl, and a using method therefor. The compounded weeding composition comprises an active component A and an active component B, the active component A is dicarfen...  
WO/2017/217553A1
[Problem] To provide a novel agricultural chemical, and particularly an herbicide. [Solution] An oxime compound represented by formula (1) and an herbicide containing the same. (In formula (1): B represents B-1 or the like; Q represents ...  
WO/2017/210792A1
The invention features dosing regimens and pharmaceutical formulations for oral administration of palovarotene. The dosing regimens can reduce heterotopic ossification, reduce the number of flare- ups, and/or reduce the severity of flare...  
WO/2017/202884A1
The present invention relates to novel 1-hexyl-1H-pyrazole-4,5-diamine derivative compounds of formula (I), to a composition for oxidation dyeing of the keratin fibres containing same, to a process for preparing the compounds of formula ...  
WO/2017/205296A1
2-Acylindazole compounds of formula I or formula II are disclosed. These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.  
WO/2017/202896A1
The invention provides novel compounds having the general formula (I) wherein R1, R1', R2, R3, R4 are as defined herein, compositions including the compounds and methods of using the compounds.  
WO/2017/205795A1
The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.  
WO/2017/201581A1
The present invention relates to new desferrioxamine B-based compounds that may be useful to treat neurodegenerative diseases, to their preparation, and to compositions including the compounds. The present invention also relates to the u...  
WO/2017/197509A1
The present application is directed to transdermal formulations for the delivery of celecoxib to a subject for the treatment of celecoxib-responsive diseases or conditions. In particular, the transdermal formulation is an emulsion compri...  

Matches 1 - 50 out of 15,660