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Matches 1 - 50 out of 16,201

Document Document Title
WO/2019/159596A1
Provided is a method for preparing a coupled body represented by general formula (3), the coupled body being obtained by reacting a compound represented by general formula (1) and a compound represented by general formula (2) in the pres...  
WO/2019/161280A1
The present disclosure relates to methods and intermediates useful for preparing a compound of formula (I): (I) or a co-crystal, solvate, salt or combination thereof.  
WO/2019/161162A1
Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone acetyltransferase (HAT).  
WO/2019/156438A1
The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound...  
WO/2019/156439A1
The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound...  
WO/2019/150383A1
The present invention discloses an improved process for preparation of Luliconazole in high yield and purity involving a novel intermediate i.e., (S)- 2,4-Dichloro-alpha-(chloro methyl)benzene methanol 4-chlorosulfonyl chloride.  
WO/2019/151419A1
Provided are: a polycarbonyl compound, and a derivative of said polycarbonyl compound. The polycarbonyl compound includes a chemical structure represented by formula (1n). Also provided are: a furan compound including a chemical structur...  
WO/2019/152546A2
A salt compound of 4-(2-((4-bromophenyl)thio)acetamido)-1-phenethyl-1H-pyrazole -3- carboxylic acid is disclosed. Also disclosed are methods for making the salt compound and formulations of the salt compound into dosage forms for clinica...  
WO/2019/148136A1
The present invention provides compounds, compositions thereof, and methods of using the same. Compounds of this invention, and pharmaceutically acceptable compositions thereof, are effective as inhibitors of GCN2 kinase.  
WO/2019/144765A1
Provided in the present application are an aromatic heterocyclic substituted olefin compound, a preparation method for same, a pharmaceutical composition of same, and applications thereof. The aromatic heterocyclic substituted olefin com...  
WO/2019/142107A1
The present invention relates to a novel and improved process for preparation of methyl [2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]m ethoxycarbamate (Pyraclostrobin)of formula (I) in free form or in agrochemically accepta...  
WO/2019/113476A3
The disclosure provides processes for preparing a compound of Formula (I).  
WO/2019/144041A1
Provided are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R1, R2, R3, G1, G2, and G3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of ...  
WO/2019/141259A1
Provided are a heterocyclic compound, a preparation method and the use thereof in medicine, and particularly involved are a heterocyclic compound for preventing and/or treating hyperuricemia and gout, a preparation method and the use the...  
WO/2019/142191A1
Novel compounds capable of inhibiting methionine metabolic pathway are provided. These compounds are used in inhibiting cystathionin y-synthase (CGS) in general, and in plants, fungi and bacteria, in particular. These compounds of the in...  
WO/2019/142192A1
Novel compounds capable of inhibiting methionine metabolic pathway are provided. These compounds are used in inhibiting cystathionin γ-synthase (CGS) in general, and in plants, fungi and bacteria, in particular. These compounds of the i...  
WO/2019/136314A1
Provided are compounds having Formula (1), compositions thereof, and methods of modulating CFTR activity. Also provided are methods of treating a condition associated with decreased CFTR activity comprising administering to a subject an ...  
WO/2019/131922A1
The present invention provides a compound that has β2-adrenergic receptor antagonist activity and carbonic anhydrase-inhibitory activity, and that exhibits excellent ocular antihypertensive activity. Specifically provided is a compound ...  
WO/2019/128871A1
Disclosed are an N-alkyl-N-cyanoalkylbenzamide compound: general formula (I), and an intermediate with general formula (II) used for preparing the compound, wherein: R1 is selected from halogen or C1-C3alkyl; R2 is selected from halogen ...  
WO/2019/128918A1
Disclosed in the present invention are an aromatic vinyl or aromatic ethyl derivative, a preparation method therefor, an intermediate, a pharmaceutical composition, and an application. The aromatic vinyl or aromatic ethyl derivative in t...  
WO/2019/119516A1
Disclosed are a tetramethylspiroindene skeleton-based bisoxazoline ligand compound, an intermediate thereof, a preparation method therefor, and a use thereof. The bisoxazoline ligand compound is a compound having a structure as shown in ...  
WO/2019/122204A1
Disclosed are processes for the manufacture of pyrazole compounds of formula (I) and their application in the manufacture of pyrazole derivatives, in particular in processes for the manufacture of pharmaceutically or agrochemically activ...  
WO/2019/123375A1
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use therof for treatment of a neurological disorder.  
WO/2019/121159A1
The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description, formula...  
WO/2019/126613A1
Provides herein are novel compounds, compositions, and methods useful for inhibiting bacteria, such as Mycobacterium tuberculosis. These compositions and methods find many uses in medicine and research, e.g., treating subjects afflicted ...  
WO/2019/123368A1
The present invention relates to an improved and efficient process for the synthesis of 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropy l]-2,4-dihydro-3H-1,2,4- triazole-3-thione, compound of formula (I) (Prothioconazole). T...  
WO/2019/126431A1
The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the tr...  
WO/2019/126424A1
The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the tr...  
WO/2019/124537A1
Provided is an agricultural and horticultural fungicide manifesting a high control effect against a wide range of plant pathogens. The compound represented by formula (1): (in the formula, each symbol is as described in the specification...  
WO/2019/119481A1
Provided is a kinase inhibitor, comprising a compound of formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite, or a prodrug thereof. Further provided are a pharmaceutical composition comprising t...  
WO/2019/120218A1
A pyrazole amide microbicide, having a structural formula of N-[2-[2-bromo-4-(trifluoromethyl)phenoxy]phenyl]-1-methyl-3- difluoromethyl-1H-pyrazole-4-carboxamide. The microbicide has significant control effect against soybean rust, corn...  
WO/2019/124538A1
Provided is an agricultural and horticultural fungicide exhibiting a high control effect against a wide range of plant pathogens. A compound represented by formula (1) or a salt thereof (in the formula, each symbol is as defined in the d...  
WO/2019/126098A1
The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhi...  
WO/2019/123378A1
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use therof for treatment of a neurological disorder.  
WO/2019/122194A1
Process for the manufacture of iminium compounds and their application in the manufacture of pyrazole derivatives The present invention concerns processes for the manufacture of iminium compounds and their application in the manufacture ...  
WO/2019/122164A1
The present invention concerns processes for the manufacture of pyrazole carboxylic derivatives and precursors thereof.  
WO/2019/115404A1
A compound of formula I, (I), wherein the substituents are as defined in claim (1), and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.  
WO/2019/118648A1
This disclosure concerns electrically conducting poly(pyrazoles). The concept of oligomerizing and polymerizing substituted aminopyrazole derivatives combined with a monomer activation procedure involving base-mediated conversion of the ...  
WO/2019/114526A1
The present invention relates to the field of pesticides. Disclosed are a pyrazole amide compound and an application thereof, and a fungicide. The pyrazole amide compound has a structure as represented by the following formula (I). The p...  
WO/2019/115781A1
The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit t...  
WO/2019/110795A1
This invention concerns a process for the manufacture of carboxylic acids or carboxylic acid derivatives and a process for the manufacture of agrochemically and pharmaceutically active compounds comprising the process for the manufacture...  
WO/2019/108800A1
The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.  
WO/2019/108565A1
Pyranoyrazoles and pyrazolopyridines of formula I or formula II are disclosed: (I), (II) These compounds inhibit Coagulation Factor Xlla in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune disea...  
WO/2019/104067A1
Provided are methods of increasing a response to a chemotherapeutic agent or an immunotherapeutic agent in a patient in need thereof, and methods of treating cancer in a patient in need thereof, comprising administering to the patient a ...  
WO/2019/097515A1
The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral...  
WO/2019/099314A1
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder...  
WO/2019/092171A1
The present invention relates to sulfonylureas and sulfonylthioureas comprising a5-membered heteroaryl group substituted with a monovalent heteroaryl-containing group. The present invention further relates to salts, solvates and prodrugs...  
WO/2019/092172A1
The present invention relates to sulfonylureas and sulfonylthioureas comprising a 5-membered nitrogen-containing heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is substituted with at least one monovalent grou...  
WO/2019/091277A1
Provided are a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, ether, ester, prodrug and solvate thereof. The compound can be used for preventing and/or treating cancers.  
WO/2019/092170A1
The present invention relates to sulfonylureas and sulfonylthioureas comprising as-membered nitrogen-containing heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is substituted with at least one group containing...  

Matches 1 - 50 out of 16,201