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Matches 1 - 50 out of 15,758

Document Document Title
WO/2018/132372A1
Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.  
WO/2018/123918A1
Provided is a compound or a salt thereof, represented by the formula shown, which has a RORγt inhibitory effect and is useful as a preventive or therapeutic agent for autoimmune diseases, allergies, and the like.  
WO/2018/125816A1
This application relates to efficient and economical synthetic chemical processes for the preparation of pesticidal thioethers and pesticidal sulfoxides. Further, the present application relates to certain novel compounds necessary for t...  
WO/2018/124088A1
Provided are novel pest control agents, in particular, a bactericide and a nematicide. An alkylphenyl-substituted amide compound represented by formula (I) [wherein: G1 stands for a structure represented by G1-2, G1-3, G1-4, etc.; X1 sta...  
WO/2018/122212A1
Compounds of Formula (IA), or a pharmaceutically acceptable salt thereof, and methods of use as Janus kinase inhibitors are described herein.  
WO/2018/121689A1
The present invention provides a sulfonamide-aryl amide compound and a use thereof as a drug for treating hepatitis B. Particularly, the present invention provides a compound as an HBV replication inhibitor and having the structure shown...  
WO/2018/125877A1
Stable solid fungicidal compositions containing valifenalate, cymoxanil and mancozeb are disclosed. Also disclosed are methods for curing or preventing a fungal disease, including an Oomycete-related disease, using the solid fungicidal c...  
WO/2018/125817A1
This application relates to efficient and economical synthetic chemical processes for the preparation of pesticidal thioethers. Further, the present application relates to certain novel compounds useful in the preparation of pesticidal t...  
WO/2018/125820A1
The disclosure relates to efficient and economical synthetic chemical processes for the preparation of pesticidal thioethers. Further, the disclosure relates to certain novel compounds useful in the preparation of pesticidal thioethers.  
WO/2018/125815A1
This application relates to efficient and economical synthetic chemical processes for the preparation of pesticidal thioethers and pesticidal sulfoxides. Further, the present application relates to certain novel compounds necessary for t...  
WO/2018/119262A1
Compositions and methods for treating glioblastoma or recurrent glioblastoma and its associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[l,5- a]pyridine) or a pharmaceutically acceptable salt thereof.  
WO/2018/114786A1
The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds...  
WO/2018/116107A1
Provided are IDO inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases ...  
WO/2018/117151A1
The present invention relates to: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitor; a cocrystal of the derivative; a method for producing the cocrystal; and a method for pu...  
WO/2018/108130A1
A process for the preparation of a novel androgen receptor antagonist is provided, comprising essentially conducting cyclization reaction of a compound of formula V to obtain a compound of formula VI. This method has the advantages of ea...  
WO/2018/111663A1
The instant invention provides compounds which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.  
WO/2018/109082A1
The present invention relates to a process for the preparation of 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)eth yl)piperazin-1-yl)ethanone and salts and solvates thereof and to the use of intermediates in the synthesis of ...  
WO/2018/107100A1
Compounds of Formula (I) pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treati...  
WO/2018/104214A1
A method for producing 5-(1-phenyl-1H-pyrazole-4-yl)-nicotinamide derivatives and similar compounds of formula (I) by converting an aniline into a 1-phenyl-1H-pyrazole derivative without isolating or purifying the phenylhydrazine interme...  
WO/2018/104307A1
Substituted aromatic sulfonamides of formula (I), pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a d...  
WO/2018/107056A1
Disclosed are chemical entities which are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Formula (I) has the structure: R1a, R1b, R2, R3, R4a, R4b and Y are as defined herein. These chemical entities are ...  
WO/2018/106459A1
The invention provides novel chemical compounds useful for treating one or more of autoimmune diseases, cancer, cardiovascular diseases, inflammatory diseases and diabetes, or a related disease or disorder thereof, and pharmaceutical com...  
WO/2018/103583A1
Inhibitors with anti-inflammatory agents are provided, as are methods of using the analogs to inhibit inflammation and prevent or treat diseases and conditions associated with inflammation, such as multiple sclerosis and autoinflammatory...  
WO/2018/099952A1
The present invention relates to 3-amino-pyrazolo[3,4-d]pyrimidin-4-ones particularly useful as cyclin dependent kinase (CDK) inhibitors, pharmaceutical compositions comprising the same and the use thereof in particular in the prophylaxi...  
WO/2018/102325A1
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This inve...  
WO/2018/102419A1
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.  
WO/2018/098305A1
Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compound...  
WO/2018/097225A1
Provided are a preservation solution for live cells or a composition comprising live cells and a method for using the preservation solution to preserve live cells or a composition comprising live cells, the preservative solution being ea...  
WO/2018/090979A1
The present invention provides a compound of a formula I structure, a preparation method therefor, and applications thereof in treatment of cancers. The compound in the present invention has inhibitory effects on multiple types of cancer...  
WO/2018/093696A1
The present invention relates to a compound represented by formula I': and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 ("DGAT2") and may be useful in the tre...  
WO/2018/091338A1
The present invention relates to a process to produce highly purified crystalline 1-(4-chlorophenyl)pyrazol-3-ol (I).  
WO/2018/093107A1
The present invention relates to a novel compound and an organic electroluminescent element comprising the same. The compound according to the present invention is used in an organic compound layer of an organic electroluminescent elemen...  
WO/2018/090975A1
A compound represented by a formula I structure, and a preparation method and application in the treatment of cancer thereof are disclosed. The compound has an inhibitory effect on a plurality of cancer cells, and may be biologically tra...  
WO/2018/090976A1
Provided are a compound of a formula I structure, a preparation method therefor, and applications thereof in treatment of cancers. The compound has inhibitory effects on multiple types of cancer cells, and can be converted into an active...  
WO/2018/090137A1
The invention features methods for inhibiting the formation, reducing the size, and slowing the growth of an osteochondroma in a subject with multiple osteochondroma (MO) by administering to the subject palovarotene (also known as R667),...  
WO/2018/089402A1
There are described RORγ Gamma modulators of the formula (I), (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutic...  
WO/2018/089546A1
Isoquinoline ether compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions co...  
WO/2018/087126A1
The present invention relates to amido-substituted cyclohexane compounds of general formula (I), in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful ...  
WO/2018/086530A1
Provided is a series of sulfonamide compounds as a cccDNA inhibitor. Particularly, the present invention relates to a compound represented by formula (I) as a cccDNA inhibitor or a pharmaceutically acceptable salt thereof.  
WO/2018/089695A1
The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such ...  
WO/2018/089374A1
Compositions and methods for preventing and treating a host infected with Francisella by treating the host with AR-13 alone or in combination with antibiotics are provided.  
WO/2018/083281A1
This invention concerns a process for the manufacture of carboxylic acids or carboxylic acid derivatives and a process for the manufacture of agrochemically and pharmaceutically active compounds comprising the process for the manufacture...  
WO/2018/078097A1
A crystalline form of (1R,2R)-2-[4-(3-Methyl-1H-pyrazol-5-yl)benzoyl]-N-(4-oxo-4,5 ,6,7-tetrahydropyrazolo[1,5-α]pyrazin-3-yl)cyclohexanecarbo xamide, pharmaceutical compositions containing it and its use in therapy.  
WO/2018/078009A1
The present invention relates to amido-substituted cyclohexane compounds of general formula (I) : in which m, A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds use...  
WO/2018/079759A1
The present invention provides a compound having a TrkA inhibitory activity or a pharmaceutically acceptable salt of the compound. The present invention relates to: a compound represented by formula (I) or a pharmaceutically acceptable s...  
WO/2018/070360A1
Provided are a volatile organic substance detection body and a manufacturing method therefor, a volatile organic substance detection method, and a volatile organic substance detection device that have a high selectivity, a low operating ...  
WO/2018/071327A1
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...  
WO/2018/065611A1
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(arylsulfinyl)- acetamide compounds that, inter alia, inhibit (e.g., selectively inhibi...  
WO/2018/065607A1
The invention relates to compounds which are suitable for the treatment of a disease associated with kallikrein related peptidase 6 overexpression and to pharmaceutical compositions containing such compounds. The invention further relate...  
WO/2018/064119A1
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.  

Matches 1 - 50 out of 15,758