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Matches 651 - 700 out of 5,440

Document Document Title
WO2006050389A3
The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the sam...  
WO/2006/069808A2
The present invention relates to nitro-substituted phenyl-piperazine compounds of general formula I, a process for their preparation, medicaments comprising said nitro-substituted phenyl-piperazine compounds as well as the use of said ni...  
WO/2006/070878A1
It is intended to provide a compound which has an anticoagulant effect based on the inhibition of the activated blood coagulation factor VII and, therefore, is useful as a blood coagulation inhibitor or a preventive/remedy for diseases c...  
WO/2006/060122A2
The present invention provides compounds of formula (I) possessing inhibitory activity against ß adrenergic receptors and phosphodiesterase (PDE), including type 3 phosphodiesterase (PDE-3). The present invention further provides pharma...  
WO/2006/060127A2
This invention provides compounds that possess inhibitory activity against β-adrenergic receptors and phosphodiesterases, including phosphodiesterase 3 (PDE3). This invention further provides pharmaceutical compositions comprising such ...  
WO2006028957A8
The present disclosure relates generally to the field of phosphodiesterase 10 (PDE10) enzyme inhibition by cinnoline compounds of Formulas: (I) and (II); wherein R'-R3 and R15-R18 are as defined herein. Still further, the present inventi...  
WO2005051301A3
Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the tre...  
WO2006034341A3
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, G, J, K, L, M, Q, W, V,...  
WO2005123692A8
The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives of Formula (I) and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodiesterase 4 (PDE4) and ...  
WO2005049581A8
New pyridazin-e-(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of ph...  
WO/2006/041119A1
Compounds represented by the general formula (1) or salts thereof, or hydrates of both, which are safe and have moderate physicochemical stability and which are useful as preventive or therapeutic agents for diseases caused by thrombus f...  
WO/2006/036981A2
The present invention provides compounds having formula (I) or (II): Formula (I), formula (II) and pharmaceutically acceptable derivatives thereof, wherein m, p, R1, R2, R3 and R4 are as described generally and in classes and subclasses ...  
WO/2006/034341A2
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, G, J, K, L, M, Q, W, V,...  
WO/2006/029799A1
The invention relates to novel iodine-phenyl-substituted cyclic cetoenols of formula (I) wherein CKE, J, X and Y have the above-mentioned meanings, several methods and intermediate products for the production thereof and the use thereof ...  
WO/2006/027236A1
The invention relates to alkylidene tetrahydronaphthalene derivatives of general formula (I), to methods for their production and to their use as anti-inflammatory agents.  
WO/2006/028957A1
The present disclosure relates generally to the field of phosphodiesterase 10 (PDE10) enzyme inhibition by cinnoline compounds of Formulas: (I) and (II); wherein R'-R3 and R15-R18 are as defined herein. Still further, the present inventi...  
WO2005075437A8
Compounds of formula (1) are effective PDE4 inhibitors in which R1 is 1-4C-alkyl and R2 is 1-4C-alkyl, R3 represents a phenyl dervative of formulae (a) or (b) wherein R4 is 1-4C-alkoxy or 1-4C-alkoxy which is completely or predominantly ...  
WO/2006/024034A1
Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.  
WO/2006/015828A1
Compounds which potentiate glutamate receptor and uses thereof in medicine Compounds of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, are disclosed: wherein R1 is C1-6alkyl, haloC1-6 alkyl, C2-6alkenyl, a...  
WO/2006/015859A1
The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of phar­maceuticals, particularly as inhibitors of protein kina...  
WO2005080317A3
The present invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: A and B independently represent CH
WO/2006/016194A1
Compounds of Formula (I) wherein R1 is a cycloalkylsulphonyl group, or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.  
WO2005113511A9
The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods fo...  
WO/2006/009134A1
A novel fungicide that exhibits a wide disease control spectrum against pathogenic fungi acting on various crops and helps resolve worsening resistant strain problems. There are provided diamine derivatives of the formula (1), a process ...  
WO/2006/009054A1
[PROBLEMS] To provide a compound that is useful as a nitrogen monoxide production accelerator and/or endothelial nitrogen monoxide synthetic enzyme activator. [MEANS FOR SOLVING PROBLEMS] The phenethylnicotinamide compound as an active i...  
WO/2006/003495A1
The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists...  
WO/2006/001175A1
Disclosed is a pyridazine compound represented by the formula (1) below which has an excellent effect on controlling plant diseases.  
WO2004080976A8
Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NR
WO/2006/000333A1
The present invention relates to compounds of the formula (I), wherein the substituents have the meaning given in the description, the use of these compounds as plant treatment agents and pesticides, and different methods for the product...  
WO/2005/123693A1
The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives, to processes for their preparation and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodie...  
WO/2005/122682A2
The present invention provides simple and cost effective processes to prepare esters of piperazic acid, which can be useful as intermediates in synthesizing cilazapril. Key feature is treating 2, 5-dibromovaleric acid with tert-butanol i...  
WO/2005/123692A1
The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives of Formula (I) and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodiesterase 4 (PDE4) and ...  
WO/2005/121105A1
A 3-phenyltetrahydrocinnolin-5-ol derivative represented by the following general formula (1) (wherein Z represents 2-carboxyethyl, 3-dimethylaminopropyl, etc.; X represents trifluoromethyl, etc.; X' represents hydrogen, etc.; and Y and ...  
WO/2005/121104A1
A pyridazine compound represented by the formula (1). (1) It is highly effective in controlling plant diseases.  
WO/2005/117883A1
The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.  
WO/2005/117876A1
The present invention provides analogs and derivatives of thalidomide which inhibit cancer and angiogenesis. The present invention further provides compounds which disrupt microtubule polymerization. The present further provides methods ...  
WO/2005/115992A1
This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variant...  
WO/2005/115972A1
Compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are ...  
WO/2005/115983A1
Aryl sulfonamide and sulfonyl compounds of formula (I) as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.  
WO/2005/113511A1
The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods fo...  
WO/2005/112945A2
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among man...  
WO/2005/108373A1
The invention relates to the novel beta agonists of general formula (I); wherein the groups R1 to R7 are defined as in the claims and the description, and to the tautomers, enantiomers, diastereomers, mixtures, prodrugs and salts thereof...  
WO2005051906A3
Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R<1>, R<2>, R<7>, R<8> and R<9>, W, X, Y and Z are as defined in the specification. Such compounds are MEK inhibitors and are us...  
WO2005016264A3
Diamine derivatives of quinones, and related compounds, including salts thereof, that modulate the levels of gene expression in cellular systems, such as cancer cells, are disclosed, along with methods for preparing such compounds and de...  
WO2005082871A3
The invention relates to guanidine compounds of general formula (I), corresponding enantiomeric, diastereomeric, and/or tautomeric forms thereof, and pharmaceutically acceptable salts thereof. The invention further relates to the use of ...  
WO/2005/103033A1
The invention relates to 1-amino-phthalazine derivatives of general formula (I), wherein A, B = possibly substituted C1-4-alkylene; L = a simple bond or C1-2-alkylene, possibly substituted -CH=CH-, or -C=C- or cycloprop-1,2--diyl; R1 = p...  
WO/2005/100323A1
The present invention provides a process for the preparation 6-[3-(hetero)aryloxy-2-­fluoro-benzyl] -2H-pyridazin-3-one compounds of formula VIII wherein R2 is an optionally substituted aryl or an optionally substituted heteroaryl, X is...  
WO/2005/099688A2
There is provided a CRF receptor antagonist comprising a compound of the formula (I): A-W-Ar wherein, A is a group represented by the formula (A1) or (A2) (wherein, ring Aa is a 5-or 6-membered ring which may be further substituted; ring...  
WO2005055715A3
Certain noel N-(heteroarylalkyl)alkanediamine derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula I: wherein Ar, a, r, R, R, R, R, R, b, c, R, R, R, R, R<5>, d, e, U, V, X...  
WO2005030794B1
The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.  

Matches 651 - 700 out of 5,440