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Matches 651 - 700 out of 5,550

Document Document Title
WO/2007/021858A2
The present disclosure relates to a solid-phase process for the production of radiolabeled tracers, in particular for the production of 18F-labeled compounds which may be used as Positron Emission Tomography (PET) radiolabeled tracers. T...  
WO/2006/127379A3
The present invention relates to compounds, and uses thereof, having the chemical formula: or a pharmaceutically acceptable salt or prodrug thereof, wherein the compound modulates the activity of PAR2 or a PAR2 subtype and thereby may be...  
WO/2007/014607A1
The invention relates to compounds of formula (I), wherein R, X, R 1, R2,R3, R4 and R5 have the significances specified in claim 1, wherein said compounds are embodied in the form of CHK1- CHK2- and SGK kinase inhibitors and can be used,...  
WO/2006/132811A3
The present invention relates to AMPA receptor potentiators of Formula (I), formulations comprising them, methods for their use, and intermediates useful for their preparation.  
WO/2007/014226A2
Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are rel...  
WO/2007/009913A1
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing...  
WO/2007/003521A2
Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4 have the significance given in claim 1 can be used in the form of pharmaceutical compositions, as 11 beta-hydroxysteroid dehydroge...  
WO/2007/003077A1
A substituted pyridazinyl amine derivatives of fomula I, and pharmceutical acceptalbe salts or hydrates thereof, preparation method, pharmaceutical compositions containing said compounds, and their use as picorna virus inhibitors in the ...  
WO/2006/108714A3
The invention relates to poly-substituted tetrahydronaphtalene derivatives of formula (I) and to a method for the production and the use thereof in the form of antiphlogistics.  
WO/2006/124996A3
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: (I) including steroisomers, prodrug...  
WO/2006/039325A3
The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipepti...  
WO/2006/125194A3
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where p, K, W, V, R2, R3, R4, R4a,...  
WO/2007/002313A2
The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables W, W1, Y, Z, R7, R8, R9, and R11...  
WO/2006/136304A1
The invention relates to compounds of the formula (I), in which R1 , R2, R3, R4, R5, R6 and X have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for the tre...  
WO2006101521A3
Methods of treating an SCD-mediated disease or condition in a mammal, preferebly a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, R2, ...  
WO/2006/132442A1
Disclosed are a compound represented by the general formula (I): (I) or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising the compound or the like; and others. The compound or pharmaceutically acceptable...  
WO/2006/132811A2
The present invention relates to AMPA receptor potentiators of Formula (I), formulations comprising them, methods for their use, and intermediates useful for their preparation.  
WO/2006/127379A2
The present invention relates to compounds, and uses thereof, having the chemical formula: or a pharmaceutically acceptable salt or prodrug thereof, wherein the compound modulates the activity of PAR2 or a PAR2 subtype and thereby may be...  
WO/2006/124996A2
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: (I) including steroisomers, prodrug...  
WO/2006/115221A1
It is intended to provide a novel compound having an excellent PDE4 inhibitory activity and TNF-&agr production-suppressing activity. It is also intended to provide a preventive and therapeutic agent for atopic dermatitis or the like. Th...  
WO2006069808A3
The present invention relates to nitro-substituted phenyl-piperazine compounds of general formula I, a process for their preparation, medicaments comprising said nitro-substituted phenyl-piperazine compounds as well as the use of said ni...  
WO/2006/113650A1
A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to compound 1, against cancer cell ...  
WO2006065448A3
Compositions and methods for treating cancer and other hyperproliferatice disease conditions with topoisomerase inhibitors and their prodrugs are disclosed.  
WO2006083271A3
The invention provides certain acylthiourea derivatives and pharmaceutically acceptable salts thereof. These compounds possess potent antiviral activity. The invention particularly provides compounds that are potent and/or selective inhi...  
WO/2006/108714A2
The invention relates to poly-substituted tetrahydronaphtalene derivatives of formula (I) and to a method for the production and the use thereof in the form of antiphlogistics.  
WO/2006/108591A1
The present invention relates to l H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as AMPA-receptor ligands, in particular for the treatment of epilepsy or schiz...  
WO/2006/109817A1
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R1 represents a branched alkyl group having 3 to 9 carbon atoms or the like; R2 represents a 6-membered heteroaryl group having 1 or 2 n...  
WO/2006/108107A1
Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of steroid hormone nuclear receptors, an...  
WO/2006/104172A1
A preventive and/or therapeutic agent for rheumatoid arthritis. There is provided a preventive and/or therapeutic agent for rheumatoid arthritis, comprising 2-benzyl-5-(4-chlorophenyl)-6-[4-(methylthio)phenyl]-2H-pyri dazin-3-one and a C...  
WO/2006/101521A2
Methods of treating an SCD-mediated disease or condition in a mammal, preferebly a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, R2, ...  
WO/2006/101058A1
Disclosed is a method for producing 3,6-dichloropyridazine-1-oxide which is characterized by reacting 3,6-dichloropyridazine with an acid anhydride and a hydrogen peroxide having a concentration of not more than 60% or a urea hydrogen pe...  
WO2005013914A8
The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and met...  
WO/2006/100100A1
The invention relates to tetrahydronaphthalene derivatives of general formula (I), to a method for their production and to their use as anti-inflammatory agents.  
WO/2006/097176A1
The invention relates to compounds of formula I, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, Z1, Z2, Z3 and Y1 have the meaning cited in claim 1, and which can be used for treating tumours.  
WO2004073634A3
The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.  
WO/2006/094187A2
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula (I), wherein A1, A...  
WO/2006/094034A1
This invention relates to cinnoline-based modulators of Liver X receptors (LXRs) of formula (I) wherein R2 is a ring containing residue, particularly a phenyl residue. These compounds are useful in the treatment of cardiovascular diseases.  
WO/2006/091592A1
The present invention relates to naphthalene derivatives of formula (I) that are modulators of the glucocorticoid receptor, and to processes for the preparation and use of the same.  
WO/2006/090235A1
The present invention relates to C ompounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, arylox...  
WO2006074223A3
Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of ...  
WO2006078891A3
Compounds of Formula I and Formula II are provided, as are methods for their preparation. The variables Y, Z1, Z2, Z3, R4, R5, R6, R7, R8 and Ar in the above formula are defined herein. Such compounds may be used to modulate ligand bindi...  
WO2006060122A9
The present invention provides compounds possessing inhibitory activity against ß adrenergic receptors and phosphodiesterase (PDE), including type 3 phosphodiesterase (PDE-3). The present invention further provides pharmaceutical compos...  
WO/2006/086447A2
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5,...  
WO/2006/083271A2
The invention provides certain acylthiourea derivatives and pharmaceutically acceptable salts thereof. These compounds possess potent antiviral activity. The invention particularly provides compounds that are potent and/or selective inhi...  
WO2006050359A3
The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the sam...  
WO/2006/080323A1
A compound that can be used as a pharmaceutical active ingredient effective in prevention and/or treatment of osteoporosis, a bone disease such as fracture, and further, glaucoma or ulcerative colitis, and is represented by the general f...  
WO/2006/077851A1
Disclosed is a compound having an excellent platelet agglutination inhibitory effect. Specifically disclosed is a quinolone derivative characterized by having an amide group at the 3-position which is substituted with a substituent havin...  
WO2006009937A3
The instant invention relates to the discovery of certain novel herbicidal esters of agriculturally active acids. These esters present agronomical advantages over traditional herbicidal products by presenting multiple herbicidal mechanis...  
WO2006036981A3
The present invention provides compounds having formula (I) or (II): Formula (I), formula (II) and pharmaceutically acceptable derivatives thereof, wherein m, p, R1, R2, R3 and R4 are as described generally and in classes and subclasses ...  
WO/2006/076706A1
The present invention provides novel cinnamide compounds of formula (I) useful as inhibitors of raf -protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and use thereof in th...  

Matches 651 - 700 out of 5,550