Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 401 - 450 out of 5,442

Document Document Title
WO/2010/028051A2
The present invention generally relates to substituted heterocyclic mercaptosulfonamide compounds, precursors, and derivatives as well as methods for the preparation of and pharmaceutical compositions comprising these compounds. These co...  
WO/2010/004215A3
The present invention relates to compounds having the formula (I) where: - R1 is: a substituted or non-substituted phenyl; a substituted or non-substituted naphthyl; a substituted or non-substituted pyridyl; a substituted or non-substitu...  
WO/2010/019417A2
Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase (formula I). Also disclosed are pharmaceutical compositions, methods of using and making the same.  
WO/2009/129267A3
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.  
WO/2010/006940A1
Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein A and R1 to R3 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.  
WO/2010/003624A2
Heterocyclic derivatives, processes for their preparation, medicaments comprising these compounds, and the use thereof. The invention relates to compounds of the formula I in which the radicals R1, R2, R3, R4, W, A, B, D, E, G, L, M, R, ...  
WO/2010/004215A2
The present invention relates to compounds having the formula (I) where: - R1 is: a substituted or non-substituted phenyl; a substituted or non-substituted naphthyl; a substituted or non-substituted pyridyl; a substituted or non-substitu...  
WO/2010/000456A1
The present invention is concerned with novel substituted 6-(1-piperazinyl)-pyridazines of Formula (I) wherein R1, R2, R3 and X have the meaning defined in the claims, having 5 -HT6- antagonistic properties. The invention further relates...  
WO/2009/157425A1
Disclosed is a composition comprising a compound having a pyridazine ring structure and a phosphorescent compound.  
WO/2009/146648A1
Amide compounds, preparation methods and uses thereof. The structure of the compounds is represented as the general formula (I), in which the definitions of substituents are illuminated as description. The present amide compounds have br...  
WO/2009/141291A1
The present invention relates to heteroarylylmethyl sulfonamides of formula (I) wherein B, E, Ra, n, R, A, Y and Cy are as defined in the claims, to the N-oxides, and salts thereof and their use for combating harmful fungi, and also to c...  
WO/2009/136191A1
The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof which possess CSF-IR kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of tre...  
WO/2009/131947A2
The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administerin...  
WO/2009/127338A1
The present invention relates to novel carboxylic acid derivates of the formula (I), having an oxo-substituted azaheterocyclic partial structure, method for the production thereof, use thereof for treating and/or preventing illnesses and...  
WO/2009/129267A2
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.  
WO/2009/124903A1
The present invention relates to pyridazinylmethyl sulfonamides of formula (I) wherein Ra, n, R1, R2, R3, A, Y and Het are as defined in the claims, to the N-oxides, and salts thereof and their use for combating harmful fungi, and also t...  
WO/2009/079797A9
The invention relates to a compound of Formula (I) and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, E-isomer, Z-isomer, or combination thereof, wherein X is selected from S or O; R5 is selected from ...  
WO/2009/114994A1
Derivatives of 6-(3-(trifluoromethyl)phenyl)pyridazin-3(2H)-one having the following formula (I) are used for the manufacture of medicament for anti-tumour, particularly anti-liver cancer.  
WO/2009/114993A1
Pyridazinones of formula I, which have a mother nucleus of 6-[3-(trifluoromethyl)phenyl] pyridazin-3(2H)-one, the preparation and the use in manufacturing medicaments of treating tumor thereof. Particularly, the use of such compounds in ...  
WO/2009/112461A1
This invention relates to novel triaryl derivatives derivatives, formula (I), a stereoisomer thereof or a mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein all of X, Y and Z represent CH; or one or two ...  
WO/2009/103478A1
The present invention relates to pyridone and pyridazinone derivatives as listed in claim 1 including their salts. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention....  
WO/2005/122682A3
The present invention provides simple and cost effective processes to prepare esters of piperazic acid, which can be useful as intermediates in synthesizing cilazapril. Key feature is treating 2, 5-dibromovaleric acid with tert-butanol i...  
WO/2009/097306A1
The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.  
WO/2009/054952A3
Componds and pharmaceutical compositions are provided that inhibit the activity of poly ADP-ribose synthetase (PARP). Such componds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infar...  
WO/2009/086041A1
Disclosed are compounds of Formula (1), N-oxides, and salts thereof, wherein W1 is O or S, and R1, R2, R3, G and J are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for ...  
WO/2009/079797A1
The invention relates to a compound of Formula (I) and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, E-isomer, Z-isomer, or combination thereof, wherein X is selected from S or O; R5 is selected from ...  
WO/2009/080314A1
The present invention relates to novel pyridazine derivatives of formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity: formula (I) wherein R1 is C1-C6alkyl, C1-C6haloalkyl or C3-C6cycloal...  
WO/2009/007856A3
The present invention provides a novel polymorphic form of atorvastatin calcium, designated as form Al, process for preparation, pharmaceutical compositions, and method of treating thereof. The present invention further provides a proces...  
WO/2009/071448A1
The present invention relates to novel pyridylmethyl-sulfonamide compounds of formula (I) where: n is 0 to 4; m is 0 to 4; R1 is halogen, CN, NO2, OH, SH, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, etc.; and/or two rad...  
WO/2009/071449A1
The present invention relates to novel pyridylmethyl-sulfonamide compounds of formula (I): where: n is 0 to 4; m is 0 to 4; R1 is halogen, CN, NO2, OH, SH, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, etc.; and/or two ra...  
WO/2009/035150A3
There is provided a compound represented by the formula (I): wherein R1 is a C1-6 alkyl group or a (C1-6 alkyloxy)C1-6 alkyl group; R2 is a hydrogen atom or a C1-6 alkyl group; G is a hydrogen atom etc.; Z1 is a C1-6 alkyl group or a C1-...  
WO/2008/074803A8
The present invention relates to compounds of formula (I) and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various diseases, such as allergic rhinitis.  
WO/2009/056692A2
The invention relates to novel products of formula (I): where ---- is a single or double bond, Ra = H, HaI, alkoxy, O-cycloalkyl, heteroaryl,.phenyl, NHCOaIk, NHCOcycloalk or NR1 R2; X = S, SO or SO2; A = NH or S; W = H, alkyl or COR wit...  
WO/2009/057827A1
Novel pyridazinone compounds of formula (I), which inhibit the purinergic P2X7 receptor and are useful for prevention, therapy and improvement of inflammatory and immunological diseases.  
WO/2009/053799A1
The present invention relates to compounds of f formula (I) as cannabinoid receptor modulators, in particular cannabinoid 1 (CB1) or cannabinoid 2 (CB2 ) receptor modulators, and uses thereof f or treating diseases, conditions and/or dis...  
WO/2009/050469A1
4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro -benzyl]-2H-phthalazin-1-one as crystalline Form L, methods of obtaining form L, pharmaceutical compositions comprising Form L and methods of using Form L and compositions comp...  
WO/2009/048864A1
Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-metho xybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid and salts thereof are disclosed.  
WO/2007/044084A3
Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperpr...  
WO/2007/005058A3
Disclosed herein are novel platinum-based analogs with a single substituted azole ligand: RN=NR7, wherein the RN=NR7 functional group is covalently bonded to the platinum through nitrogen of NR7. The analogs also have nitrogen donor liga...  
WO/2009/048101A1
Disclosed is a novel fused ring compound, which has FAAH inhibitory activity and is useful as an analgesic. Specifically disclosed is a compound represented by the formula (I) below or a salt thereof. (In the formula, the symbols are as ...  
WO/2008/103277A3
Selected compounds defined by Formula I, II, III, IV or V are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases.  
WO/2008/058285A3
This application concerns certain 4-cyanophenylamino-substituted bicyclic heterocycles of formula (I) where the dashed line represents a double bond that may be located either between A and C(V) or between C(V) and D, where A is S or C(Z...  
WO/2009/040288A1
The present invention relates to compounds of formula (1), wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antag...  
WO/2009/037394A2
The invention relates to 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine derivatives of general formula (I) where R2 = an optionally substituted aryl, A = optionally substituted C1-7 alkylene, B = optionally substituted C1-7 alky...  
WO/2005/076861A3
The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and compounds for inhibiting HIV particle formation...  
WO/2009/035150A2
There is provided a compound represented by the formula (I): wherein R1 is a C1-6 alkyl group or a (C1-6 alkyloxy)C1-6 alkyl group; R2 is a hydrogen atom or a C1-6 alkyl group; G is a hydrogen atom etc.; Z1 is a C1-6 alkyl group or a C1-...  
WO/2009/030715A1
The invention relates tosubstitutedarylsulphonylaminomethylphosphonic acid derivativesof general formula (I) wherein the groups Ra to Rf, A and Z are defined as mentioned in the specification and claims, which are suitable for preparinga...  
WO/2009/032277A1
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the c...  
WO/2009/027450A1
The invention relates to compounds of general formula (I), in which n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined as cited in the description, to the enantiomers, diastereomers, mixtures and salts of said compounds, in particular to t...  
WO/2008/062276A3
The present invention provides Stearoyl CoA Desaturase (SCD) inhibitors, hi particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase 1 (SCD 1)...  

Matches 401 - 450 out of 5,442