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WO/2024/079733A1 |
The present invention provides a process for the preparation of aminopyridazine derivatives, and novel pyridazine-based and pyrazole-based compounds which are useful as either starting materials or intermediates in said process.
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WO/2024/079072A1 |
The present invention relates to a compound of formula (I) or any of its acceptable salts (I) wherein W, X, Y and Z each independently represents =CH- or -N=, provided that at most two of W, X, Y and Z both represent a -N= group, R1 repr...
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WO/2024/067676A1 |
Provided are a compound represented by general formula (1), a preparation method therefor, and use of the compound represented by general formula (1) and isomers, crystal forms, pharmaceutically acceptable salts, hydrates or solvates the...
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WO/2024/040350A1 |
The present disclosure relates to pyridazinone compound of the Formula (I) for the treatment of respiratory diseases, such as, chronic obstructive pulmonary disease (COPD), cystic fibrosis, cancer, Long QT syndrome or Dravet syndrome, wh...
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WO/2024/037558A1 |
The present invention relates to novel forms of Compound I, preparation thereof, pharmaceutical composition containing the same and use thereof, wherein, the compound is (S) -5- ( (1- (3- (5-methyl-3- (trifluoromethyl) -8, 9-dihydropyrid...
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WO/2024/028782A1 |
The present invention relates to novel pyridazin-3-yl phenol compounds of formula (I): wherein R1, R2, R3, R4 and R5 are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relat...
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WO/2024/022186A1 |
The present invention relates to a methylpyrazole compound, a pharmaceutical composition comprising same, a preparation method therefor, and use thereof. In particular, the present invention relates to a compound represented by formula (...
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WO/2024/008176A1 |
A nitrogen-containing heterocyclic compound represented by formula (I-a), or a stereoisomer, a deuterated compound, a solvate, a pharmaceutically acceptable salt or a eutectic crystal thereof, a pharmaceutical composition comprising same...
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WO/2024/010963A1 |
The present disclosure provides phosphonate-containing heterocycle compounds with TYK2/JAK1 inhibitory activities, pharmaceutical compositions comprising the same, and applications thereof. The present disclosure provides compounds of Fo...
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WO/2024/002318A1 |
The present invention relates to the technical field of medicines, and in particular to a pyridazopyridone derivative used as an SOS1 protein inhibitor and a use thereof. The provided compound has an obvious inhibition effect on the acti...
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WO/2024/002375A1 |
Disclosed are a compound or a pharmaceutically acceptable salt thereof which function as a SMARCA2/4 inhibitor, said compound having the structural formula shown in formula I. Further disclosed are a pharmaceutical composition containing...
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WO/2023/246867A1 |
The present invention provides a Nav1.8 inhibitor. Specifically, the present invention provides a compound represented by formula I, a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug thereo...
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WO/2023/243677A1 |
The present invention provides a plant disease control method having an excellent efficacy for controlling plant diseases, the method comprising treating plants or soil used for plant cultivation with a compound represented by formula (I...
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WO/2023/239675A1 |
The present disclosure is related to STING agonists, pharmaceutical compositions thereof, and the use of the agonists and pharmaceutical compositions to induce a STING-mediated immune response and/or to treat diseases and disorders media...
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WO/2023/231997A1 |
Provided in the present invention are a pyridazine compound represented by formula (II), and a preparation method therefor and the use thereof. Further disclosed in the present invention is the use of the compound of the present inventio...
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WO/2023/223055A1 |
This invention relates to compounds that can be used to treat viral infections. The compounds of the present invention are papain-like protease (PLpro) inhibitors.
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WO/2023/217989A1 |
Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.
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WO/2023/220741A1 |
The present disclosure provides small molecule compounds and pharmaceutical compositions for the modulation of alpha 4 beta 7 integrin, useful for the treatment of inflammatory conditions such as inflammatory bowel disease, including ulc...
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WO/2023/213626A1 |
The present invention relates to the use of (5S)-3-[3-( -chloro-2-fluorophenoxy)-6-methylpyridazin-4-yl] 5-(2-chloro-4-methylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine according to formula (I) for controlling unwanted microorganisms causing...
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WO/2023/209086A1 |
The specification relates to compounds of Formula (I): (I) and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in th...
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WO/2023/209090A1 |
The specification relates to compounds of Formula (I): (I) and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in th...
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WO/2023/204124A1 |
The present invention addresses the problem of providing: a pyridazinone compound having excellent bactericidal/antibacterial activities and excellent safety and capable of being synthesized industrially advantageously; an agricultural a...
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WO/2023/202626A1 |
The present invention provides a PRMT5 inhibitor as shown in formula (I), or a pharmaceutically acceptable salt, an isotopic variant, a tautomer, a stereoisomer, a prodrug, a polymorph, a hydrate or a solvate thereof. The present inventi...
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WO/2023/193759A1 |
Described herein are HPK1inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with HPK1.
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WO/2023/194496A1 |
A process for the preparation of compound of formula (I) is provided: where R, R1, R2, R3 and R4 are as defined in the description.
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WO/2023/186102A1 |
The present invention provides a Nav1.8 inhibitor. Particularly, the present invention provides a compound represented by formula I, or a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug the...
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WO/2023/190015A1 |
In the production of crops in agriculture, horticulture, etc., damages caused by pests, etc., are still significant, and it has been required to develop a new agricultural and horticultural pesticide due to factors such as the emergence ...
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WO/2023/192989A2 |
The present disclosure relates to phthalazinone compounds and related compounds and their use in treating a disease or condition responsive to inhibition of PARP7.
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WO/2023/192864A2 |
This invention provides a PARP16 inhibiting compound of Formula (I): (I) wherein: R1 is selected from the group of H, halo, -OH, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -O-alkyl,-O-alkenyl,-O-alkynyl, -O-cycl...
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WO/2023/178130A1 |
Provided herein are SOS1 protein degraders, e.g., a compound of Formula (I) comprising an E3 ubiquitin ligase binding moiety, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing...
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WO/2023/177568A1 |
The application relates to compounds of the general Formula (I) which act as cannabinoid receptor modulators useful for the treatment of complications arising from metabolic, inflammatory and fibrotic disorders.
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WO/2023/172112A1 |
The present specification relates to a compound represented by chemical formula 1 and an organic light-emitting device comprising the compound.
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WO/2023/166067A1 |
A compound of Formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.
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WO/2023/165574A1 |
Disclosed are a compound used as a TYK2 inhibitor, a preparation method therefor, and pharmaceutical use thereof. Specifically, the compound has a structure represented by formula (I), wherein the definitions of the groups and substituen...
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WO/2023/158602A1 |
Disclosed are compounds of Formula I including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein G, Z, L, J, A and T are as defined in the disclosure. Also disclosed are compositions containing the compound...
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WO/2023/158708A1 |
The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NLRP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodru...
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WO/2023/158795A1 |
Provided are compounds of the Formula (I): or pharmaceutically acceptable salts thereof, which are useful for the inhibition of DHX9 and in the treatment of a variety of DHX9 mediated conditions or diseases, such as cancer.
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WO/2023/152182A1 |
Present invention relates to a compound according to formula (II): and all stereoisomers, racemic mixtures, tautomers, pharmaceutically acceptable salts, prodrugs, hydrates, solvates and polymorphs thereof, as well as pharmaceutical comp...
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WO/2023/150034A2 |
Compounds and methods of inhibiting the expression and/or activity of Replication Factor C40 in cancer cells and of treating cancers expressing Replication Factor C 40 are described herein
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WO/2023/147779A1 |
Provided are a preparation method of a pyridazinone derivative, an intermediate thereof, and a preparation method of the intermediate. The method has the advantages of easily available raw materials, simple steps, low costs, good interme...
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WO/2023/149473A1 |
In the production of crops in agriculture, horticulture, etc., damages caused by pest insects, etc. are still significant, and it has been required to develop a novel agricultural and horticultural insecticide due to factors such as the ...
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WO/2023/143147A1 |
Provided in the present invention are pyridazopyridone compounds, a pharmaceutical composition thereof, and the use thereof. Specifically, the compounds have structures as shown in formula (I). The compounds can interfere with the intera...
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WO/2023/145804A1 |
The purpose of the present invention is to provide a novel B0AT1 inhibitor. The present invention relates to a compound represented by formula (I): (the symbols in the formula are as described in the description) or a salt thereof. The p...
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WO/2023/143496A1 |
The present invention relates to a method for synthesizing an intermediate of an imidazo[1,2-b]pyridazine compound. The present invention belongs to the field of pharmaceutical chemistry. More specifically, the present invention relates ...
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WO/2023/134698A1 |
The present application belongs to the technical field of chemical pharmaceuticals and relates to a compound represented by general formula (I), a racemate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof, a use ...
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WO/2023/132369A1 |
Provided is a compound able to activate Nrf2 and represented by formula (1), a salt thereof, or a solvate of these. Formula (1) (In the formula, Xa1 is CRa1 or N, Xa3 is CRa3 or N, Ra1, Ra2, and Ra3 are each independently selected from...
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WO/2023/131277A1 |
The present application belongs to the technical field of medicines, relates to an NLRP3 inflammasome inhibitor and the uses thereof, and particularly relates to a compound represented by general formula (A) or a pharmaceutically accepta...
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WO/2023/125540A1 |
Provided are a pyrazole-1(2H)-phthalazinone compound and an application thereof as a PRMT5·MTA complex inhibitor in the preparation of a drug for treating related diseases.
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WO/2023/127805A1 |
In the production of crops in agriculture, horticulture, and the like, the occurrence of damage by pests and the like has been still a major issue, and therefore the development of new agricultural/horticultural pesticides has been deman...
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WO/2023/125276A1 |
Provided in the present invention are an organic compound and a use thereof, the molecular bulk density thereof being improved through the design of the molecular structure, and the compound having excellent hole transport properties; th...
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