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Matches 751 - 800 out of 26,417

Document Document Title
WO/2017/061532A1
The present invention provides a compound represented by formula (1) (in the formula, X, R1, R2, R3, R4, R5, R6, Y1, Y2, L, and m are as defined in the description) and a pharmaceutically acceptable salt thereof, which are useful as a va...  
WO/2017/060917A1
The present invention relates to an improved process for preparation of methyl (E)-2-{2- [6-(2-cyanophenoxy) pyrimidin-4-yloxy] phenyl}-3-methoxyacrylate of formula (I) in free form or in agro chemically acceptable salt form useful as a ...  
WO/2017/058645A1
Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a...  
WO/2017/058689A1
The invention is directed to novel anhydrous crystalline butenedioate salt form 1 of Compound I, which is a modulator of muscarinic M1 receptors. The novel crystalline forms of compound I are useful in the treatment or prevention of Alzh...  
WO/2017/059080A1
The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's dis...  
WO/2017/057119A1
The pyrimidine compound represented in formula (1) is effective as a pest control agent.  
WO/2017/059280A1
This invention is in the area of improved therapeutic combinations for and methods of treating selected cancers using selected pyrimidine compounds having pan-TAM or Mer/Axl dual receptor tyrosine kinase inhibitory activity in combinatio...  
WO/2017/017631A3
The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens.  
WO/2017/059085A1
The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's dis...  
WO/2017/057120A1
The pyrimidine compound represented in formula (1) is effective as a pest control agent.  
WO/2017/058691A1
This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)met hyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by ...  
WO/2017/057121A1
The pyrimidine compound represented in formula (1) is effective as a pest control agent.  
WO/2017/052308A2
One embodiment of the present invention provides a compound for an organic device, the compound comprising a functional group comprising a pyrimidine ring, and/or a functional group comprising a pyrimidine ring, which is included at a te...  
WO/2017/053391A1
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic port...  
WO/2017/051251A1
Described inter alia are compounds according to formula (I): or a pharmaceutically acceptable salt thereof, and uses in methods for the modulation of flap endonuclease 1 (FENl), Xeroderma Pigmentosum Complementation Group G protein (XPG)...  
WO/2017/050111A1
The invention relates to a crystal form H and a preparation method of a 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)- 2-pyridinamine monohydrochloride. An x-ray powder diffraction pattern of the crystal form H in 25°C com...  
WO/2017/049992A1
The present invention provides an EGFR kinase inhibitor and a preparation method and use thereof. Specifically, the present invention provides a compound as shown in formula (I), the definition of each group therein being as described in...  
WO/2017/049409A1
Disclosed are compounds of general formula (I) that promote readthrough of a premature termination codon (PTC) of an RNA molecule in a translation system, and their use, alone or in combination with other compounds, such as aminoglycosid...  
WO/2017/051354A1
Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of HIV; including the prevention of the p...  
WO/2017/047602A1
Provided is a compound presenting high efficacy in diseases caused by Trichophyton by having excellent antifungal activity against Trichophyton, which is a major causative organism of superficial mycoses. A biaryl derivative represented ...  
WO/2017/049321A1
Described herein are compounds and compositions, and methods of making and their use as effective agents against mycobacterial infections.  
WO/2017/047594A1
Provided is a nucleoside derivative represented by formula (1). (In formula (1), Y represents an unfused aromatic or heterocyclic hydrocarbon group or a fused polycyclic based hydrocarbon group, W1 represents a hydrogen atom, a hydroxyl ...  
WO/2017/049096A1
The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, and/or a compound of 14 or 14*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to prov...  
WO/2017/049080A1
The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compounds 7, 7* and ...  
WO/2017/045931A1
The present invention relates to compounds according to formula (I) and to heat-curable resin compositions based on polymaleimide resin systems comprising such compounds as co-monomers:, (I) wherein Dis an x-functional group; and x is an...  
WO/2017/042828A2
The present invention provides processes for the preparation of Selexipag compound of formula (1). The present invention also provides processes for the preparation of 4-[(5,6-diphenyl-pyrazin-2-yl)-isopropyl -amino]-butan-1-ol (2), and ...  
WO/2017/043886A1
The present specification provides a heterocyclic compound and an organic light emitting element using the same.  
WO/2017/044302A1
Certain aspects of the present invention generally relate to compositions and methods for treating a bone disease, for example a genetic bone disease. In one embodiment the bone disease is fibular hemimelia, proximal femoral focal defici...  
WO/2017/041771A1
The object of the invention is a preparation method of Ceritinib of formula (I) and its salts wherein 2-isopropylthioaniline is used in the first step. Even under mild conditions, it provides an intermediate, which is further oxidized to...  
WO/2017/041701A1
Provided are compounds that can be used for treating cardiovascular diseases and compositions containing the compounds. The compounds and the compositions can improve lipid metabolism disorders by increasing high-density lipoprotein chol...  
WO/2017/040896A1
The present invention features compounds effective in inhibiting active against Hepatitis C virus ("HCV") polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of ...  
WO/2017/040895A1
The present invention features compounds effective in inhibiting active against Hepatitis C virus ("HCV") polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of ...  
WO/2017/040971A1
This disclosure features methods for treating lysosomal storage disorders (e.g. MPS) and/or neurodegenerative diseases (e.g., Alzheimers disease), which include administering to a subject (e.g., a human patient) in need of such treatment...  
WO/2017/040898A1
The present invention features compounds effective in inhibiting active against Hepatitis C virus ("HCV") polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of ...  
WO/2017/038873A1
The purpose of the present invention is to provide a compound having inhibitory activity with respect to the discoidin domain receptor 1. The present invention provides a urea derivative represented by the formula below or a pharmacologi...  
WO/2017/040892A1
The present invention features compounds effective in inhibiting active against Hepatitis C virus ("HCV") polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of ...  
WO/2017/040889A1
The present invention features compounds effective in inhibiting active against Hepatitis C virus ("HCV") polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of ...  
WO/2017/033115A1
The present invention relates to a solid oral preparations comprising alogliptin and metformin fixed dose combination and to a process for preparation thereof. More particularly, it relates to a solid oral preparation of alogliptin and m...  
WO/2017/033016A1
The present invention relates to a process for preparing macitentan of Formula (I): to macitentan prepared according to such a process and to macitentan in substantially pure form.  
WO/2017/032350A1
The invention relates to crystalline Form A of rilpivirine adipate of formula I, with the systematic name 4-((4-((4-((lE)-2-Cyanoethenyl)-2,6- dimethyIphenyl)amino)-2-pyrimidinyl) amino)benzo- nitrile adipate and a preparation method of ...  
WO/2017/029397A1
This invention provides a process for providing phosphoramidate derivatives, comprising performing a nucleophilic substitution reaction at phosphorous, where a phosphoryl chloride derivative is reacted with an oxime derivative to provide...  
WO/2016/200930A9
The present invention relates to methods and intermediates useful for the synthesis of protein deacetylase inhibitors of formula (Ia) comprising the following step (11a) (3a).  
WO/2017/029498A1
The invention relates to 2-sulfonylpyrimidine compounds and salts and solvates thereof for use in the treatment of a proliferative disease such as cancers. The 2- sulfonyl-primidine compounds may be administered, either simultaneously or...  
WO/2017/011730A3
The present invention provides novel phenazine derivatives, such as compounds of Formula (I') (e.g., Formula (I)), (II), and (III), and pharmaceutically acceptable salts thereof. The compounds of the invention are expected to be antimicr...  
WO/2017/025523A1
The present invention relates to compounds of formula (I) wherein R1' is CH3; R1 is methyl, ethyl, CF3, CH2OH, cyclopropyl or cyano, or R1' and R1 may form together a 1,1-dioxo-tetrahydro-thiophen-3-yl ring; R2 is hydrogen, methyl, ethyl...  
WO/2017/027571A1
The present disclosure provides combination therapy comprising a BET inhibitor and a protein phosphatase 2A (PP2A) activator, a B-cell lymphoma-2 (Bcl-2) inhibitor, a B-cell lymphoma-extra large (Bcl-xl) inhibitor, a casein kinase 2 (CK2...  
WO/2017/023899A1
Described are cancer therapies and anti-cancer compounds. In particular, disclosed are ihibitors of ACK1 tyrosine kinase and their use in the treatment of cancer. Methods of screening for new ACK1 tyrosine kinase inhibitors are also disc...  
WO/2017/021879A1
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of r...  
WO/2017/020428A1
The present invention relates to novel compounds for use as Janus kinase (JAK) inhibitors. The compounds are compounds of Formula I and pharmaceutically acceptable salts, prodrugs, metabolites, isotopic derivatives and solvates thereof, ...  
WO/2017/021382A1
An antibiofilm composition comprising a compound of formula (A1), (A2) or (A3): (A1) (A2) (A3) wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, ni...  

Matches 751 - 800 out of 26,417