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WO/2022/186617A1 |
The present invention relates to a method for producing carnitine orotate using a novel orotate intermediate, and more specifically, to a method for producing high purity carnitine orotate at high yield, wherein a novel ortic acid tertia...
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WO/2022/184119A1 |
Disclosed are a tyrosine kinase inhibitor and a pharmaceutical use thereof. The tyrosine kinase inhibitor of the present invention is a quinazoline derivative, and has the following structural formula:. In the present invention, a functi...
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WO/2022/181157A1 |
Provided are a compound that improves the performance of an organic EL element, an organic electroluminescent element having improved element performance, and an electronic device including such an organic electroluminescent element, the...
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WO/2022/140293A9 |
The present invention provides methods of preparing 2-amino-6-((1r,4r)-4-phenylcyclohexyl)-5-(3-(trifluoromethyl
)benzyl)pyrimidin-4(3H)-one, and 2-amino-6-((1r,4r)-4-phenylcyclohexyl)-5-(3-(trifluoromethyl
)benzyl)pyrimidin-4(3H)-one mo...
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WO/2022/178283A1 |
Disclosed are compounds and methods for treating tauopathy.
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WO/2022/174085A1 |
The present disclosure provides novel inhibitors of PBRM1, specifically the 2nd bromodomain of PBRM1 (PBRM1-BD2), pharmaceutical compositions and methods of use thereof.
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WO/2022/171018A1 |
The present invention relates to a substituted benzopyrimidine or pyridopyrimidine amine inhibitor, and a preparation method therefor and the use thereof. Specifically, the compound of the present invention has a structure as shown in fo...
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WO/2022/173743A1 |
The β2-adrenergic receptor (β2AR) is a primary target in the treatment of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Since β-agonist treatment of airway disease can have severe side effects, compo...
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WO/2022/171560A1 |
The present invention relates to compounds of the Formula (I) in which X represents Cl or Br. According to the present invention, the compounds have anticholinesterase activity. The present invention also relates to pharmaceutical compos...
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WO/2022/171013A1 |
Disclosed in the present invention is a tetrahydroquinazoline compound. Specifically, disclosed is a compound represented by formula (II) and a pharmacologically acceptable salt thereof.
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WO/2022/169790A1 |
The present invention relates to a method of chemovaccination against Plasmodium infection comprising administering to a patient an effective amount of a selective inhibitor of plasmepsin X, or a pharmaceutically acceptable salt thereof.
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WO/2022/167334A1 |
The invention relates to substituted (2-heteroaryloxyphenyl)sulfonates of general formula (I) and to the use thereof as herbicides, in particular for controlling weeds and/or weed grasses in crops of useful plants and/or as plant growth ...
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WO/2022/167503A1 |
The present invention relates to a compound or a combination of compounds which can be used as anti-fungal agents directed against plant pathogenic basidiomycete fungi, and especially for inhibiting the virulence of corn smut fungus Usti...
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WO/2022/170043A1 |
The invention provides compounds and pharmaceutical compositions thereof, which are useful for inhibiting EGFR, as well as methods for using such compounds to treat cancer associated with an EGFR or HER2 exon 20 insertion mutation.
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WO/2022/166469A1 |
A heterocyclic compound as a fibroblast growth factor receptor (FGFR) inhibitor, a preparation method therefor, and the pharmaceutical use thereof. In particular, the present invention relates to a compound represented by general formula...
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WO/2022/166938A1 |
The present invention relates to the field of herbicides, and in particular, to a uracil compound containing a carboxylate fragment and a preparation method therefor, a herbicidal composition, and a use. The uracil compound containing a ...
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WO/2022/170052A1 |
The present disclosure relates to compounds of Formula (I) or a stereoisomer, polymorph, hydrate, solvate, or pharmaceutically acceptable salt thereof. The present disclosure also relates to uses of the compounds, e.g., in treating or pr...
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WO/2022/162701A1 |
The present application relates to process for preparation of Mavacamten, preparative methods of various crystalline forms of Mavacamten and amorphous form of Mavacamten, its preparative method, and pharmaceutical compositions thereof. T...
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WO/2022/161274A1 |
Disclosed in the present invention are a pyrimidine-2,4-diamine compound, a preparation method therefor and the use thereof, relating to the technical field of pharmaceutical chemistry. The pyrimidine-2,4-diamine compound of the present ...
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WO/2022/157324A1 |
The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2- oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-o
ne or a tautomer thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3...
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WO/2022/152140A1 |
Bridged heterocyclyl-substituted pyrimidine compounds, a preparation method and medical use thereof. The compounds or pharmaceutical compositions comprising same can be used as JAK1 and TYK2 kinase inhibitors for treating JAK1 and TYK2 k...
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WO/2022/153962A1 |
The problem to be solved by the present invention is to provide: a compound useful as a hole transport material for photoelectric conversion elements whereby electric current can be efficiently taken out; and a photoelectric conversion e...
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WO/2022/148879A1 |
The present disclosure relates to compounds of formula (I) comprising a heteroaryl, such as derivatives of quinazolines, which can act as modulators of ACKR3. The present disclosure also relates to the use of these compounds as a drug.
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WO/2022/148243A1 |
Disclosed are a pyrimidine small-molecule compound and an application thereof. The pyrimidine small-molecule compound has efficient inhibitory activity towards PDGFRα and PDGFRβ kinases, but has relatively weak inhibitory activity towa...
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WO/2022/147620A1 |
The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs...
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WO/2022/038365A9 |
The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: wherein R, R1, R2 and RB are as defined herein.
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WO/2022/149618A1 |
The present invention provides a method for producing a compound having alkylated acidic functional groups. The method includes alkylating acidic functional groups by reacting, in a mixture containing a compound having two or more types ...
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WO/2022/148317A1 |
A 2-aminopyrimidine compound having a structure represented by formula (I), or a pharmaceutically acceptable salt thereof, an isotope derivative thereof, a solvate thereof, or a stereoisomer thereof, a geometric isomer thereof, a tautome...
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WO/2022/143771A1 |
Provided are an RORγt modulator, and a preparation method therefor and an application thereof. The RORγt modulator is selected from a compound represented by formula I, and a pharmaceutically acceptable salt, solvate, solvate of the ph...
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WO/2022/139304A1 |
The present invention relates to a novel quinazoline derivative compound that serves as an SOS1 inhibitor, and a use thereof, and more specifically to: a novel quinazoline derivative compound having inhibitory activity against SOS1 bindi...
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WO/2022/140456A1 |
This disclosure is in the field of medicinal chemistry, and relates to a new class of small-molecules having the Formula I, or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer, a mixture of enantiomers, a mixture o...
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WO/2022/134488A1 |
Provided is a related substance 4,4'-(2-methylpropane-1,3-diyl)bis(2-(chloromethyl)quinazoli
ne) of the linagliptin intermediate 2-chloromethyl-4-methylquinazoline. Further provided are a method for synthesizing the related substance (im...
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WO/2022/133551A1 |
The present application is directed towards compounds, pharmaceutically acceptable salts or prodrugs thereof, which are inhibitors of Histone Deacetylase (HDAC) binding or function. The compounds especially may have some selectivity for ...
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WO/2022/140554A1 |
The present invention relates to bifunctional compounds, compositions, and methods for treating diseases or conditions by modulating (e.g., reducing) the level or activity of at least one of PIP4K2A, PIP4K2B, and PIP4K2C.
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WO/2022/135534A1 |
A novel substituted nitrogen-containing bicyclic compound and a pharmaceutical composition containing the compound, capable of being used as chymase inhibitors. Also provided are methods for preparing the compound and pharmaceutical comp...
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WO/2022/138387A1 |
A composition comprising a resin (A) and a compound (B) which comprises a cation and an anion having a partial structure represented by formula (I). [In formula (I), ring W1 represents an optionally substituted ring structure, and ring W...
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WO/2022/131887A1 |
The present invention relates to a novel compound with excellent carrier transport ability, light-emitting ability, and thermal stability, and an organic electroluminescent device that includes the compound in at least one organic materi...
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WO/2022/127518A1 |
Disclosed by the present application are a nitrogen-containing organic compound and an electronic component and electronic apparatus using same; the nitrogen-containing organic compound has an adamantyl-substituted nitrogen-containing he...
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WO/2022/127923A1 |
The present invention relates to a benzene ring compound and a use thereof. In particular, provided is a compound as shown in formula I, or an optical isomer thereof or a racemate thereof, or a solvate thereof, or a pharmaceutically acce...
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WO/2022/129914A1 |
The present invention relates to compounds of Formula (I), in particular of Formulae (II) to (IV), that are inhibitors of c-ABL. The invention also relates to pharmaceutical compositions comprising those compounds, and to their use in th...
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WO/2022/131135A1 |
The purpose of one mode of the present disclosure is to provide: a novel pyrimidine compound for forming an organic electroluminescent element that exerts high electric current efficiency; and an organic electroluminescent element materi...
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WO/2022/133097A1 |
The disclosure provides processes for preparing spiro derivatives, in particular (2R,5S)-7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]p
yrimidin-2-yl]-1,7- diazaspiro[4.4]nonan-6-one, as well as intermediates for use in said proces...
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WO/2022/129933A1 |
Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein Ring A, Ring B, Ring C, R1, R2, R3, R4, R5, L, m, n, and p are as defined herein. The compounds are modulators of G-protein coupled rec...
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WO/2022/129259A1 |
The invention relates to a compound of formula (I) wherein A, L, R1, R2, R3 and R4 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
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WO/2022/129047A2 |
The present invention is directed to novel modulators of the NMDA receptor. Separate aspects of the inventions are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat neurological disorder...
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WO/2022/129041A1 |
The present invention is directed to novel prodrugs of modulators of the NMDA receptor. Separate aspects of the inventions are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat neurologi...
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WO/2022/127909A1 |
A pyrimidine carboxamide compound as shown in formula I, or a tautomer, mesomer, racemate, enantiomer and diastereomer thereof, or a mixture form thereof, or a pharmaceutically acceptable salt thereof, which can be used as a Vanin enzyme...
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WO/2022/132676A1 |
The present invention relates to oral dosage forms comprising letermovir and, in particular, to compressed mini-tablets comprising letermovir. The invention also relates to methods of using the oral dosage forms for the treatment, preven...
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WO/2022/129909A1 |
The present invention relates to a group of novel compounds, methods for their manufacture and the use of these compounds as research tools and as pharmaceuticals. The novel compounds are analogues of cannabidiol (CBD). CBD is a non-psyc...
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WO/2022/125613A1 |
Compounds having activity as inhibitors of ENPP1, CdnP, or both are provided herein. Some embodiments provide compounds having one of the following Structures (I) or (II): or a pharmaceutically acceptable salt, tautomer, stereoisomer, or...
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