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Matches 1 - 50 out of 25,385

Document Document Title
WO/2018/224063A2
The invention provides novel solid forms of elagolix and its esters, optionally with acids or with polymers, method of preparation and use thereof. These solid forms are particularly suitable as intermediates of synthesis of elagolix or ...  
WO/2018/223876A1
Provided are a fluorescent probe, a preparation method and application thereof. The fluorescent probe is an addition-activation probe and can be used for specific fluorescent protein labeling, and can also be used for protein quantificat...  
WO/2018/226837A1
We describe the use of comparative structural analysis and structure-guided molecular design to develop potent and selective inhibitors (10d and (S)-17b) of matrix metalloproteinase 13 (MMP-13). We applied a three-step process, starting ...  
WO/2018/225816A1
Provided is a novel compound which has pest control activity for agricultural and horticultural use. The present invention provides: a nitrogen-containing heterocyclic compound represented by formula (1) or a salt thereof; and a bacteric...  
WO/2018/226230A1
The present invention relates generally to methods for treatment of ribosomal disorders and ribosomopathy, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to methods for the use of a small-molecule autophag...  
WO/2018/226622A1
The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the presen...  
WO/2018/224060A1
The present invention relates to solid forms with an antimicrobial activity comprising a polysaccharide and triiodide, where the triiodide decomposition to iodide and volatile iodine is significantly suppressed by the presence of a stabi...  
WO/2018/221720A1
The present invention provides: a heterocyclic compound and an intermediate thereof, the compound having an excellent controlling effect against harmful arthropods and being represented by formula (I) (in the formula, R2 represents a C1-...  
WO/2018/221985A1
The present invention provides a novel heterocyclic compound and an organic light emitting element using the same.  
WO/2018/221433A1
Provided is a novel compound, and a pharmaceutically acceptable salt thereof, that has an action of reducing blood sugar and the like, and that is useful as a therapeutic and/or preventive medicine for diseases such as diabetes. Provided...  
WO/2018/219281A1
Disclosed is a class of 4-pyrimidinediamine small molecular organic compounds or related analogues or pharmaceutically acceptable salts thereof, with the structures thereof as shown in formulae (I)-(VI). Also disclosed are the use of the...  
WO/2018/221604A1
The present invention provides a method for industrially producing: a pyrimidine compound having pest control efficacy; 2-[4-(trifluoromethyl)phenyl]ethylamine, which is a production intermediate of the pyrimidine compound; a phenylethyl...  
WO/2018/222918A1
Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or amelior...  
WO/2018/221667A1
The present invention provides a novel pyrimidine compound represented by Formula [I] and a salt thereof: [in the formula, the symbols are as defined in the specification], which is useful for treating, preventing and/or diagnosing seizu...  
WO/2018/215003A1
The invention describes the pyrimidine-based compounds of the general formula I. Described compounds lower the production of the prostaglandin E2. In concentrations lowering production of this factor by 50%, these compounds have no negat...  
WO/2018/216887A1
The present invention provides a novel compound and an organic light-emitting device using same.  
WO/2018/215557A1
The present invention relates to a compound of the following general formula (I): (I) in which: - either R represents a group Ri and R' represents a group -ArCy1, or R represents a group -ArCy1 and R' represents a group R1; R1 especially...  
WO/2018/215348A1
The present invention relates to a compound of formula 1 and an organic electronic device comprising an organic semiconductor layer, wherein at least one organic semiconductor layer comprises a compound of formula (1), wherein L1 has the...  
WO/2018/214872A1
The present invention provides a substituted pyrimidinetrione compound, a composition comprising the compound, and a use thereof. The present invention provides a pyrimidinetrione compound as shown in formula (I) or a crystal form, pharm...  
WO/2018/213258A1
The present disclosure provides a method of treating a Merlin-deficient tumor using particular sulfamate inhibitors of Nedd8-activating enzyme. The present disclosure also provides a method of treating Merlin-deficient tumors using parti...  
WO/2018/210992A1
The present invention relates to pyrimidine derivatives of formula (I) wherein (R1)n, R3, R4a, R5b, and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reacti...  
WO/2018/213140A1
Disclosed herein are compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (...  
WO/2018/213150A1
The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mi...  
WO/2018/213364A1
Histone deacetylases (HDACs) inhibitors are disclosed. The HDACs inhibitors possess cytotoxicities to various cancer cell lines. They are useful for treating a tumor associated with deregulation of the activity of histone deacetylases in...  
WO/2018/210994A1
The present invention relates to phenyl derivatives of formula (I) Formula (I) wherein (R1)n, R3, R4 a, R4b, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response compri...  
WO/2018/205916A1
The present invention falls within the field of medical chemistry, and in particular relates to an FGFR4 inhibitor as shown in formula II, a preparation method thereof, a pharmaceutical composition comprising the inhibitor, and the use o...  
WO/2018/208181A1
The invention relates to 2-amino-5-nitropyridine and barbital co-crystals with an X-ray pattern exhibiting the presence of characteristic interplanar distances amounting to: dhkl 2.966x, 3.5823, 2.9972, 2.9302, 3.0772, 5.2652, 5.7601, 4....  
WO/2018/204164A1
Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof (Formula (1)) wherein K, Z, R2, R3 and m are as defined in the disclosure. Also disclosed are compositions containing the compounds, N-oxide...  
WO/2018/203691A1
The present invention relates to a pyrimidine derivative compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a composition for preventing or treating cancer comprising the same as an active ingredient....  
WO/2018/204661A1
Compounds that inhibit at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. Also described are the use of such compounds and compos...  
WO/2018/201006A1
This invention provides methods of treating inflammatory conditions and autoimmune diseases in a mammal, comprising administering to the mammalian subject in need thereof a therapeutically effective amount of a compound, or pro-drug ther...  
WO/2018/198086A1
The present invention relates to a process for the preparation of Elagolix of formula (I) and its pharmaceutically acceptable salts. The present invention also relates to an intermediate of formula (VIII) and its use in preparation of El...  
WO/2018/200833A1
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as products containing such compounds, and methods of their use and synthesis. Such compounds have the structure of Formula (I) below: (I) or phar...  
WO/2018/195439A3
Provided herein, inter alia, are methods and compounds for modulating K-Ras treating cancer.  
WO/2018/194885A1
The present invention provides phenyl-2-hydroxy-acetylamino-2-methyl-phenyl compounds, to pharmaceutical compositions comprising the compounds, to methods of using the compounds to treat physiological disorders such as cancer.  
WO/2018/195439A2
Provided herein, inter alia, are methods and compounds for modulating K-Ras treating cancer.  
WO/2018/189747A1
Present invention relates to an improved process for the preparation of N-(3- ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin-4-amine dihydrochloride of formula-I.  
WO/2018/189212A1
The invention relates to non-deliquescent acid addition salts of elagolix with strong acids, for example selected from the group consisting of sulfuric acid and hydrochloric acid, to processes for their preparation and to a pharmaceutica...  
WO/2018/189213A1
The invention relates to an amorphous solid dispersion comprising elagolix sodium and at least one silicon-based inorganic compound and to a process for preparing the same. Furthermore, it relates to a pharmaceutical composition comprisi...  
WO/2018/191166A1
The present disclosure provides compositions comprising a lyn kinase activator and TRPM8 agonist, and to methods of: reducing blood glucose levels, weight gain, or fat depot levels; treating metabolic syndrome, Syndrome X, obesity, predi...  
WO/2018/184274A1
Provided in the present application are a compound for enhancing the spatial coupling of endothelial ion channel complex TRPV4-KCa2.3 and antihypertensive applications of the compound.  
WO/2018/187652A1
The present invention relates to 2,4-diaminopyrimidines of formula (I) and pharmaceutically acceptable salts thereof, purification methods for the same, pharmaceutical compositions containing them, methods of obtaining and using them for...  
WO/2018/184978A1
The invention relates to compounds of the common formula (I) and to the agrochemically compatible salts thereof, to the production and use thereof in the field of plant protection.  
WO/2018/186365A1
The present invention relates to a novel read-through inducing agent, and also relates to a compound represented by general formula (I) (symbols in the formula are as described in the specification) or a pharmaceutically accepted salt th...  
WO/2018/177899A1
The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of...  
WO/2018/181001A1
Provided are a novel phenyl imidazoline compound having an aminomethyl group, a novel phenyl tetrahydropyrimidine compound having an aminomethyl group, etc. The compound according to the present invention or a salt thereof is represented...  
WO/2018/176150A1
Novel methods for isolating fish roe/egg extracts, notably a coagulum and a sediment extract, enriched in phospholipids and omega-3 fatty acids are described. Novel compositions comprising omega-3 polyunsaturated fatty acids and micronut...  
WO/2018/176134A1
The present disclosure relates to compounds for use as electrode additives or as salts in electrolyte compositions, and their methods of preparation. The majority of compounds are anions of imidazoles bearing a sulphonyl or a carbonyl gr...  
WO/2018/183112A1
The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycar...  
WO/2018/177889A1
The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of...  

Matches 1 - 50 out of 25,385