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Matches 1 - 50 out of 25,039

Document Document Title
WO/2018/068357A1
Disclosed are a compound as shown in formula I, or a pharmaceutically acceptable salt, a crystal form, a solvate thereof, wherein Z is selected from (II), (III), (IV) or (V); R1 is selected from H or (VI); R2 is selected from (VII) or (V...  
WO/2018/068296A1
Piperidine compounds of the Formular: (I) and pharmaceutically acceptable salts thereof, wherein X, Y, R 1, R 2, R 3, L, R 4, L 1, Q and R 5 are as defined herein. The compounds and pharmaceutically acceptable compositions comprising a c...  
WO/2018/071313A1
In its many embodiments, the present invention provides certain substituted N-aryl and N-heteroaryl piperidine compounds of the Formula (I): (Formula (I)) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, L, R4, L1,Q, R5...  
WO/2018/068739A1
The present invention relates to alkynyl heterocyclic compounds having inhibitory effects on the protein kinase activity, and to the preparation and use thereof. In particular, disclosed are alkynyl heterocyclic compounds as shown in for...  
WO/2018/069863A1
A compound of formula (I), wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Du...  
WO/2018/071327A1
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...  
WO/2018/065809A1
The present invention relates to pharmaceutical compositions that can be used for the treatment of trichomoniasis, which comprise compounds with the chemical structure and which also exhibit a synergic effect and do not have the typical ...  
WO/2018/065808A1
The present invention relates to novel chemical compounds of formula I with a structure different from nitroimidazoles, and to equally novel uses thereof for the treatment of trichomoniasis, making said compounds useful for application b...  
WO/2018/065359A1
The invention relates to the use of barbituric acid derivatives of formula I for use as a self-tanning substance, for increasing melanin synthesis, improving melanin transport and/or improving the distribution of melanin in suprabasal la...  
WO/2018/065611A1
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(arylsulfinyl)- acetamide compounds that, inter alia, inhibit (e.g., selectively inhibi...  
WO/2018/059288A1
Provided is a method for preparing macitentan and an intermediate thereof. The method comprises: dropwise adding a tetrahydrofuran solution containing a compound of formula (II) and 5-bromo-2-chloropyrimidine to tetrahydrofuran containin...  
WO/2018/060317A1
This invention relates to pyrimidine prodrug derivatives, processes for their preparation, phamaceutical compositions, and their use in therapy.  
WO/2018/058091A1
Described herein are divalent nucleobases that each binds two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone, such as in a γ-peptide nucleic acid (γPNA). Also provided ...  
WO/2018/053587A1
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.  
WO/2018/054359A1
A salt of a quinazoline derivative (N-[4-(3-chlorine-fluoanilino)]-7-(3-morpholinepropanol)-6-( 2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the sal...  
WO/2018/041123A1
The present invention discloses a compound with a nucleus of a fluorene and a six-membered nitrogen-containing heterocycle. The compound has a general structural formula (I), wherein R1, R2, and R3 are respectively one of a phenyl, biphe...  
WO/2018/044963A1
The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical composit...  
WO/2018/045144A1
This application relates to toll like receptor modulator (e.g. TLR8) compounds of Formula I and pharmaceutical compositions containing them. The compounds are useful for the treatment of hyperproliferative diseases such as cancer or vira...  
WO/2018/039232A1
Methods of preparing substituted bicyclo[1.1.1]pentane compounds of Formula (I) comprise reacting a compound of Formula (A) with a compound of Formula (B) in the presence of a first transition metal catalyst selected from a palladium cat...  
WO/2018/033642A1
The present invention relates to a compound of formula (I): wherein L is an optionally substituted heterocyclic group excluding unsubstituted monocyclic pyridine groups; wherein a is 0, 1 or 2; wherein R1 is H or with R2 is a bond; where...  
WO/2018/035296A1
Kinases can be engineered to utilize an ATP analog that is not readily utilized by wild-type kinases by introducing a mutation in the ATP-binding pocket. However, application of this method has been limited by the membrane impermeability...  
WO/2018/035061A1
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.  
WO/2018/027892A1
Provided are compounds of the Formula (A) below where n and R1 are defined herein, methods of treating patients for liver disease, and processes for preparing the compounds.  
WO/2018/028517A1
The present invention provides compounds of the Formula (I), or a pharmaceutically acceptable salt thereof, where n and R1 are defined herein, methods of treating patients for liver disease, and processes for preparing the compounds.  
WO/2018/031658A1
Methods are provided for the treatment of relapsed and/or refractory solid tumors (including neuroendocrine carcinomas (NEC) and non-Hodgkin's lymphomas (NHLs) and the like, using substituted heterocyclic derivative compounds and pharmac...  
WO/2018/030466A1
The purpose of the present invention is to provide a heterocyclic compound that can have GCN2-inhibiting activity and is expected to be useful in the prevention and treatment of GCN 2-related diseases and the like, including cancer. Prov...  
WO/2018/027044A1
Methods using idelalisib to treat proliferative vitreoretinopathy and intraocular pathological angiogenesis (e.g., proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and wet age-related macular degeneration (AMD)).  
WO/2018/019244A1
The present invention relates to salts of 2,6-dimethylpyrimidone derivative and uses of the salts. The present invention also relates to a pharmaceutical composition comprising the salts or a combination thereof, and uses of the salts or...  
WO/2018/021977A1
The present invention relates to a compound of general formula (I) and/or its solvates, hydrates and pharmaceutically acceptable salts, which are modulators of glycine metabolism. The present invention also relates to the methods for the...  
WO/2018/022899A1
O-substituted hydroxamic acids with carbon-based leaving groups as HNO donors are disclosed. Pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions also are disc...  
WO/2018/018091A1
The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.  
WO/2018/019555A1
The present invention relates to the use of pyrimidine compounds of formula (I), or their agriculturally acceptable salts or derivatives as herbicides, wherein the variables are defined according to the description, specific pyrimidine c...  
WO/2018/021200A1
Provided are: a RUNX inhibitor which binds to a RUNX-binding sequence on DNA and thus inhibits the binding of a RUNX family member to the sequence; an antitumor agent comprising the RUNX inhibitor; and an antiallergic agent comprising th...  
WO/2018/019252A1
This invention relates to certain novel pyrimidine derivatives of the Formula (I). The invention also relates to process for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compoun...  
WO/2018/019554A1
The present invention relates to the pyrimidine compounds of formula (I), or their agriculturally acceptable salts or derivatives as herbicides, wherein the variables are defined according to the description, use of pyrimidine compounds ...  
WO/2018/019166A1
Provided are salts of 2, 6-dimethylpyrimidone derivatives and uses thereof. Also provided are pharmaceutical compositions containing the salts.  
WO/2018/018986A1
The present invention relates to a diphenylaminopyrimidine and a triazine compound represented by formula I, or a pharmaceutically acceptable salt, stereoisomer, hydrate, or solvate (I) thereof, wherein A represents C or N, X and Y are i...  
WO/2018/021520A1
The present invention addresses the problem of providing a compound having a guanidine backbone, which can inhibit the protease activity of MALT1, and can exhibit a therapeutic effect or a prophylactic effect on autoimmune diseases inclu...  
WO/2018/014802A1
The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compoun...  
WO/2018/015797A1
An object of the present invention is to provide a benzylamide compound or a salt thereof that controls a mite. The present invention provides a benzylamide compound represented by Formula (1): or a salt thereof, wherein R1 represents C1...  
WO/2018/015852A1
An object of the present invention is to provide a benzylamide compound or a salt thereof that controls a mite. The present invention provides a benzylamide compound represented by Formula (1): or a salt thereof, wherein R1 represents C1...  
WO/2018/012907A1
The present invention relates to novel quinazolinone derivatives inhibiting PI3K; a method for preparing the derivatives; and a pharmaceutical composition for treating hematologic neoplasms or liver diseases, containing the quinazolinone...  
WO/2018/011376A1
A subject of the present invention is a compound having the general formula (I) a pharmaceutically acceptable salt thereof or a tautomeric form thereof, wherein A, B3, B4, B5, Y, X, B1 and B2 are as defined in any one of claims 1 to 10. ...  
WO/2018/002614A1
The present disclosure relates to de novo synthesized, chemical compounds of the formula (1) or (2) that function as senescent cell detectors wherein R1, R2, R3, R4 and Z are as defined herein. The present invention also relates to proce...  
WO/2018/005533A1
This invention is in the area of pyrimidine-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.  
WO/2018/005660A1
Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or sym...  
WO/2018/005192A1
Bifunctional compounds that increase uric acid excretion and reduce uric acid production, and monofunctional compounds that either increase uric acid excretion or reduce uric acid production. Methods of using these compounds for reducing...  
WO/2018/005356A1
Compounds within the scope of the present invention have a Formula 1 or a salt or produg thereof, where ring A is selected from cycloaliphatic; ring B is aryl; R1 is selected from (C1-C10)alkyl, (C3-C10)cycloalkyl, halo, aryl, and hetero...  
WO/2018/004213A1
The present invention relates to a novel compound having an SMO inhibitory activity, wherein the novel compound exhibits an excellent anticancer effect through abilities of isoindolinone and quinazolinone derivative compounds to modulate...  
WO/2017/223413A1
Disclosed herein are reversibly-switchable surfactants and methods of extracting natural products, coating surfaces, cleaning laundry, and osmotic extraction using same.  

Matches 1 - 50 out of 25,039