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Matches 1 - 50 out of 25,569

Document Document Title
WO/2019/072785A1
The invention provides new heterocyclic compounds having general Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, X, Y1 and Y2 are as described herein, compositions including the compounds, processes of manufac...  
WO/2019/071351A1
A novel class of fluorinated derivatives of Formula I have been prepared and found to be useful in the treatment of cancers and other EGFR related disorders. The compounds of Formula I display excellent brain penetration and an improved ...  
WO/2019/068726A1
The present invention relates to a cellular transport system for bringing a sulfonic acid construct which carries a cargo into a cell and releasing the cargo in the cell's cytoplasm, the cellular transport system comprising: (i) a sulfon...  
WO/2019/070169A1
The invention relates to a water-soluble liophilised form of (bis(2-thio-4,6-dioxo-1,2,3,4,5,6-hexahydropyrimidine-5-yl)- (4-nitrophenyl)methane) which has hepatoprotective activity and is designed to be used in medicine for the treatmen...  
WO/2019/070709A1
The present invention provides compounds, compositions and methods for treating and/or preventing a flavivirus infection by administering such compounds and compositions.  
WO/2019/070167A1
The present group of inventions relates to novel compounds having formula (I), and to the salts, solvates or stereoisomers thereof, as well as to a pharmaceutical composition, a method of inhibiting the biological activity of epidermal g...  
WO/2019/066340A1
The present invention relates to an organic compound represented by formula 1, an organic optoelectronic device comprising the same, and a display device.  
WO/2019/062876A1
Provided are a fluorescent probe, a preparation method therefor and a use thereof. The fluorescent probe responds to viscosity sensitively and specifically, can be used for the specific fluorescence label of proteins, and can also be use...  
WO/2019/063634A1
The present inventors have developed new radiolabeled Darapladib and analogs thereof which can be used for the specific detection of vulnerable atherosclerotic plaques by targeting lipoprotein-associated phospholipase A2 (Lp-PLA2) which ...  
WO/2019/063704A1
The present invention covers substituted 3-Phenylquinazolin-4(3H)-one compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, phar...  
WO/2019/063708A1
The present invention covers substituted 3-Phenylquinazolin-4(3H)-one compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, phar...  
WO/2019/067543A1
The present disclosure relates to compounds that are capable penetrating to the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating Glioblastoma and other EGFR media...  
WO/2019/058289A1
The invention relates to peptide conjugates of Formula (I). The peptide conjugates of the invention have activity as MAIT agonists. The peptide conjugates of the invention also enhance immune responses and therefore are effective vaccine...  
WO/2019/057720A1
The present invention relates to herbicidally active pyridyl-/pyrimidyl-pyridine derivatives, as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal composition...  
WO/2019/057721A1
The present invention relates to herbicidally active pyridyl-/pyrimidyl-pyrimidine derivatives. The invention further provides processes and intermediates used for the preparation of such derivatives. The invention further extends to her...  
WO/2019/055528A1
The present invention relates to compositions and methods for the treatment of cancer and other diseases associated with mitochondrial dysfunction, including but not limited to, neurodegenerative disease, brain injuries, and certain non-...  
WO/2019/055832A1
Provided herein are compounds of Formula (I) and (II) and their salts, and compositions comprising such compounds that are useful for useful for modulating neutral sphingomyelinase 2 (n-SMase2) in cells. Also disclosed herein are methods...  
WO/2019/053427A1
There is herein provided a compound of formula (I) or a pharmaceutically acceptable salt thereof,wherein the ring containing Q1to Q5, and the groups R1, R2 and R3, have meanings as provided in the description.  
WO/2019/052519A1
Disclosed is a BRD4 inhibitor as shown in formula I, belonging to the field of compound drugs. The compound provided has a good inhibitory effect on prostate cancer cell proliferation, and can be used for preparing a drug combatting tumo...  
WO/2019/049049A1
The invention provides certain nicotine salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, certain nicotine salt-co-crystals are described, including nicotine and two different coformers. The ...  
WO/2019/051396A1
Disclosed herein are compounds having a structure of formula (I), compositions and methods useful for the treatment of a disease or infection, such as a viral infection (e.g., Ebola), cancer and obesity: formula (I), wherein A is N or CR...  
WO/2019/049174A1
The present invention relates to solid state forms of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1 H,3H)-dione hydrochloride compound of formula-1a and their processes for the preparation thereof and an improved process f...  
WO/2019/047909A1
Compounds of formula (I) or a pharmaceutically acceptable salt thereof, and/or solvates, racemic mixtures, enantiomers, diasteromers, and tautomers thereof, wherein A, R1, R2, R3, R3', R4, R4', R5, R6, R7, R8, m, and n are as defined in ...  
WO/2019/045035A1
The present invention relates to biaryloxy derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage ...  
WO/2019/046784A1
Disclosed herein, inter alia, are compositions and methods for modulating Adenosine Receptors. In an aspect is provided a method of inhibiting Adenosine A2B Receptor activity and Adenosine A2A Receptor activity, the method including cont...  
WO/2019/046163A1
The invention provide novel pyrimidine derivatives and analogs having inhibitory activities towards certain tyrosine kinases, e.g., Bruton's tyrosine kinase (Btk) and/or Focal adhesion kinase (FAK), extracellular signal-regulated kinase ...  
WO/2019/043706A1
Provided herein are novel barbituric acid derivatives, their synthesis and use thereof in blocking leukocyte transmigration. The novel barbituric acid derivatives are useful for the treatment of disorders associated with leukocyte transm...  
WO/2019/038583A1
The present subject matter provides a crystalline form of the compound having the following structure: Formula (I), wherein the crystalline form is a polymorph, hydrate or solvate.  
WO/2019/040699A1
The present invention is directed to agricultural mixtures comprising a protoporphyrinogen oxidase inhibitor compound of formula (I): (I and a C16 to C18) fatty acid methyl ester adjuvant system, The present invention is further directed...  
WO/2019/034153A1
Provided are a pyrimidinyl amino compound having protein kinase inhibitor activity, and a pharmaceutical composition containing said compound; also provided are a use and application of said compound. What is provided is selected from a ...  
WO/2019/034796A1
This invention relates to pyrimidine derivatives, to compositions comprising the pyrimidine derivatives, to methods of making and using these compositions, and to the use of the pyrimidine derivatives as adjuvants, particularly for agroc...  
WO/2019/034692A1
The present invention relates to sulfonylureas and sulfonylthioureas comprising a 5-membered heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is di-substituted at the 3- and 4-positions relative to the point of...  
WO/2019/034693A1
The present invention relates to sulfonylureas and sulfonylthioureas comprising a monocyclic imidazolyl group. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions compri...  
WO/2019/029295A1
The present invention relates to a pazopanib-based HDAC and VEGFR double-target inhibitor, a preparation method therefor and an application thereof. Said compound has a structure as presented in formula I, II or III. The present inventio...  
WO/2019/027855A1
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (I) Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or d...  
WO/2019/027765A1
Disclosed are new small molecules having a substituted pyrimidine or substituted fused pyrimidine core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising t...  
WO/2019/027856A1
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or ...  
WO/2019/024845A1
A crystal form of a compound Lemborexant, a preparation method therefor, a pharmaceutical composition comprising the crystal form, and use of the crystal form in the preparation of an orexin receptor antagonist and of a pharmaceutical fo...  
WO/2019/025467A1
The present disclosure relates to compounds of Formula (I): (I); and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful fo...  
WO/2019/028055A1
In an aspect, the disclosure provides for compounds (II), compositions, and methods of administering the compounds and compositions to a patient in need thereof. In another aspect, the disclosure relates to compounds and compositions for...  
WO/2019/025275A1
The present invention relates to novel N-[(Pyrimidinylamino)propanyl]-, N-[(Pyridylamino)propanyl]- and N-[(Pyrazinylamino)propanyl]arylcarboxamide derivatives, processes for their preparation, pharmaceutical compositions containing them...  
WO/2019/028008A1
Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular...  
WO/2019/028357A1
Aspects of the invention relate to compounds, pharmaceutical compositions, methods for the manufacturing of compounds and methods for treatment of various disorders mediated at least in part by one or more galectins.  
WO/2019/022455A1
The present specification relates to a fluorene derivative of chemical formula 1 and an organic light emitting device comprising the same.  
WO/2019/022249A1
The purpose of the present invention is to provide a method for easily raising the transdermal absorption properties of minoxidil without forming a prodrug by organic synthesis. The present invention pertains to: a complex formed from mi...  
WO/2019/023350A1
A composite sorbent composition comprising a polymeric adsorbent; and an extractant having the formula (I), or hydrate thereof, wherein X is O or S, A1 and A2 are each independently -C(O)- or -C(R')(R'')- wherein R', and R'' are each ind...  
WO/2019/023553A1
The present disclosure relates to bifunctional compounds, which find utility to degrade (and inhibit) Androgen Receptor. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to ...  
WO/2019/016111A1
The invention discloses a method for preparation of 4,6-dichloro-5-nitro-2- (propylthio)pyrimidine by conversion of 5-nitro-2-propylthiopyrimidine-4,6-diol with phosgene in the presence of DMF.  
WO/2019/016293A1
The present invention relates to certain compounds of formula (I) wherein - Ar is (Ar1) or (Ar2) and to their uses as antibacterial agents. The invention further relates to methods of treatment of bacterial infection with such compounds,...  
WO/2019/018359A1
The present disclosure provides compounds, methods, and compositions which may be used to treat tuberculosis. In some embodiments, these compounds and compositions have a bactericidal property against Mycobacterium tuberculosis (Mtb). Me...  

Matches 1 - 50 out of 25,569