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Patent Searching and Data


Matches 51 - 100 out of 331

Document Document Title
WO/2008/117796A1
The invention relates to mutilin derivatives represented by the general formula (I) which are useful as antimicrobial agent against multidrug-resistant bacteria; and intermediates for the production of the same. In the general formula (I...  
WO/2008/116302A1
The present invention relates to novel compounds of the formula (I), wherein R'-R7, X, Y, D and n are as defined in the specification. These compounds are cysteine protease inhibitors which include but are not limited to inhibitors of ca...  
WO/2008/096001A1
Compounds of the Formula (I) including a stereoisomer thereof, or an N-oxide, a pharmaceutically acceptable addition salt, or a pharmaceutically acceptable addition solvate thereof;usefulas HCV inhibitors; processes for preparing these c...  
WO/2008/038964A1
Disclosed are geldanamycin derivatives of Chemical Formula 1, pharmaceutically acceptable salts thereof, a preparation method thereof, and agents for the preparation and treatment of cancerous diseases, comprising the same as an active i...  
WO/2008/021956A2
The present invention discloses compounds of formulae (I) and (II), or pharmaceutically acceptable salts, esters, or prodrugs thereof: Which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A ...  
WO2006136564A9
Compounds of general formula (I): in which: R1, R2, R3, R4, R5 and FG are as defined in the specification and claims, optionally conjugated with a suitable molecule able to interact with physiological systems; and their chelates with bi-...  
WO/2008/009734A1
The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicament...  
WO/2008/009750A2
The invention relates to novel macrocyclic compounds of the Formula (I) in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments...  
WO/2008/002924A2
The present invention relates to compounds, including compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof, which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV)...  
WO/2007/149543A2
A method for treating a scar comprises administering to a scar a pharmaceutically effective amount of one or more blistering agents in a pharmaceutically acceptable carrier.  
WO/2007/117180A1
The invention relates to novel azaheterocycles of interest as potential physiologically active substances (agonists, antagonists, receptor modulators, ferment inhibitors, oncolytics, antibacterial and antiparasitic agent etc.), to combin...  
WO/2007/077004A1
The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicament...  
WO/2007/076431A1
The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, thereof, wherein the variables A, B, L, M, W, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, a...  
WO/2007/055700A1
Lanthanide chelates derived from diazacrown ethers having two ethyliminodiacetic acid side chains have increased ability to bind lanthanide ions.  
WO/2007/047737A1
Disclosed herein is a compound of Formula (I). Also disclosed herein is a method of modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or con...  
WO/2007/014926A1
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is -OR7, -NH-SO2R8; R2 is hydrog...  
WO/2007/014922A1
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, or stereoisomers thereof, wherein each dashed line (represented by ------) represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 i...  
WO/2007/014925A1
Inhibitors of HCV replication of formula (I), and the N-oxides, salts, and stereoisomers thereof, wherein each dashed line represents an optional double bond; X is Ν, CH and where X bears a double bond it is C; R1a and R1b are hydrogen,...  
WO/2006/137769A1
There is provided processes for the preparation of various compounds, including compounds of formulae I, IV and VII, [Chemical formulas should be inserted here. Please see paper copy] or salts and/or solvates thereof, which compounds are...  
WO/2006/103009A1
The invention concerns antibacterial amide macrocycles , methods for producing same, their use for treating and/or preventing diseases, as well as their use for producing drugs for treating and/or preventing diseases, in particular bacte...  
WO/2006/095795A1
A cyclic dinitron compound is produced by stirring a cyclic nitron compound-containing solution in the presence of an acid catalyst to selectively conduct a ring enlarging dimerization reaction. The cyclic nitron compound is more prefera...  
WO/2006/074940A2
The invention relates to novel macrocyclic compounds of the formula in which R1, R3, V1, V2, X1, X2, Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16, 17 o...  
WO/2005/118613A2
The invention relates to antibacterial amide macrocycles and to methods for producing them, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of ...  
WO/2005/117876A1
The present invention provides analogs and derivatives of thalidomide which inhibit cancer and angiogenesis. The present invention further provides compounds which disrupt microtubule polymerization. The present further provides methods ...  
WO/2005/077908A1
A guanidine compound which has a bi-aryl skeleton represented by the following general formula (1): [wherein R1, R2 and R3 each independently represents a hydrogen atom, a hydrocarbon group optionally having a substituent or a heterocycl...  
WO/2005/077921A1
A guanidine compound which has a bi-aryl skeleton represented by the following general formula (1): [wherein R1, R2 and R3 each independently represents a hydrogen atom, a hydrocarbon group optionally having a substituent or a heterocycl...  
WO/2005/074598A2
Described herein are nitroxyl progenitor compounds, and compositions including, and methods or generating, the compounds thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions.  
WO/2005/073216A2
Compounds of the formula (F) where the variables are as defined in the specification inhibit the NS3 protease of flavivirus sych as hepatitis C virus (HCV). The compounds comprise a novel linkage between a heterocyclic P2 unit and those ...  
WO/2005/073195A2
Peptidomimetic compounds are described which inhibit the NS3 protease of the hepatitis C virus (HCV). The compounds have the formula where the variable definitions are as provided in the specification. The compounds comprise a carbocycli...  
WO/2005/061467A2
Compounds (I) are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical comp...  
WO/2005/049585A1
The present invention relates to novel macrocyclic compounds of the formula (I) wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or...  
WO/2005/030796A1
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. T...  
WO/2005/017124A2
Novel PDF inhibitors and novel methods for their use are provided.  
WO/2004/099162A1
Compounds of Formula 8 are provided: A and B are each independently selected from the group consisting of -NO-, -SO-, and - NR9-. C is a single bond or a double bond. D is selected from the group consisting of single bond, E is selected ...  
WO/2004/089300A2
The present invention relates to compounds of Formula (I): their pharmaceutical composition and their utility in treating neoplasm.  
WO/2004/084809A2
Embodiments of this invention provide novel peptidomimetics that contain a macrocycle. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterised by ne...  
WO/2004/007445A2
One aspect of the present invention relates to amide-bearing substituted benzolactams, and individual stereoisomers thereof. A second aspect of the present invention relates to combinatorial libraries of the aforementioned amide-bearing ...  
WO/2003/106480A1
The invention relates to antibacterial amide macrocycles, to methods for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of illness, especially bacterial infections.  
WO/2003/074476A1
An arylamidine derivative represented by the general formula (1) (wherein X means optionally substituted lower alkylene or alkenylene; G1 means oxygen, sulfur, or imino; G2 means carbon or nitrogen; Ra means at least one member selected ...  
WO/2003/008390A1
Compounds of general formula (I):in which: R¿1? is hydrogen, C¿1?-C¿2O? alkyl, C¿3?-C¿10? cycloalkyl, C¿4?-C¿2O? cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyclic C¿2?-C¿10? alkylene group or...  
WO/2003/002545A1
The invention relates to new peptoid compounds of formula (I), as well as their use in the treatment of bacterial infections, such as those caused by vancomycin resistant microorganisms, and to compositions thereof.  
WO/2002/088115A1
The present invention relates to a novel sulfonamide derivatives and novel intermediates thereof, preparation thereof, and a pharmaceutical composition comprising the same, and more particularly, to novel sulfonamide derivatives and inte...  
WO/2002/085838A1
The present invention relaters to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the ...  
WO/2002/028864A1
There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R?1¿, R?2¿, R?3¿, R?4¿ and R?41¿ to R?46¿ have meanings given in the description...  
WO/2002/028863A1
There is provided 4-({3-[7-(3,3-dimethyl-2-oxobutyl)-9-oxa-3,7-diazabicyclo[3. 3.1]non-3-yl]propyl}amino)benzonitrile, benzenesulfonic acid salt, which compound is useful in the prophylaxis and in the treatment of arrhythmias, in particu...  
WO/2001/040198A2
The invention concerns macrocyclic hydroxamic acid derivatives of general formula (I) wherein: Y is -CH¿2?-, -CH¿2?-CH¿2?- or -CH=CH- and Z and Z' represent -CH¿2?- or Y-Z or Y-Z' represent -CH=CH- and Z and Z' are defined as above; ...  
WO/2001/016110A1
Formulation components such as bleach boosting compounds selected from the group consisting of bleach boosters comprising quaternary imine cations, zwitterions, polyions having a net charge of from about +3 to about -3 and mixtures there...  
WO/2001/010848A2
Compounds of formula (I) in which M is the following central building block (a) are novel effective trypase-inhibitors.  
WO/2000/069830A1
The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring ca...  
WO/2000/058294A1
Compounds of formula (I) are antibacterial agents wherein: R¿3? and R¿4?, taken together with the carbon atoms to which they are respectively attached, form an optionally substituted saturated carbocyclic or heterocyclic ring of 5 to 1...  

Matches 51 - 100 out of 331