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JPH06220025A |
PURPOSE: To provide 4,5-dihydro-1H-2,4-aryl-fused diazepines useful in the treatment of cardiac dysrhythmia, in particular cardiac dysrythmia of patients of ventricular dysfunction or stagnant heart disorder. CONSTITUTION: A compound of ...
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JPH0653746B2 |
@ The present invention is directed to a chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts with bases and acids by submitting a teicoplanin compound or a teicoplanin-like compound to controlled strong a...
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JPH06505989A |
Hydroxamic acid derivatives for use as medicaments, of formula (1), or a salt, solvate or hydrate thereof, in which R1 is hydrogen, C1-6alkyl, or -(CH2)n-A-R4 where n is from 0 to 6, A is a bond or an oxygen or sulphur heteroatom and R4 ...
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JPH06157481A |
PURPOSE: To prepare a novel compound inhibiting the angiotensinogen-cleaving action of renin. CONSTITUTION: The compound has the formula I [wherein A is H, aryl or the like; B is -CH2-, the formula II (wherein R3 is H, 1-4C alkyl or the ...
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JPH0639463B2 |
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JPH06501944A |
Thiol carboxylic acid derivatives, processes for their preparation and their use as collagenase inhibitors are described.
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JPH0625201A |
PURPOSE: To provide a method for preparing the subject compounds under the mild condition of reaction in the absence of toxic reagents using inexpensive staring materials. CONSTITUTION: The compound of formula IV is obtained by reacting ...
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JPH0625191A |
PURPOSE: To obtain easily and economically a cyclic urea compd. from commercially available raw materials by reacting urea and a specified diamine under specific conditions to obtain an intermediate and heating slowly the intermediate wi...
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JPH05339246A |
PURPOSE: To provide a new compd. useful as an antiarrhythmia. CONSTITUTION: The compd. is expressed by formula I. In formula I, A is phenyl, thienyl, furanyl, naphthyl, etc.; R1 is H, lower alkyl, etc.; R2 is H, benzyl, etc.; R3 is Yp-(C...
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JPH0577668B2 |
Novel polysubstituted 2-keto-1,4-diazacycloalkanes are powerful stabilizers for materials subject to ultraviolet (UV) light degradation, particularly for polyolefins. The cyclic 2-keto compounds of this invention have (a) a fixed two-car...
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JPH0563470B2 |
This invention provides a process for preparing a 2-hydrazino-1,3-diazacycloalk-2-ene hydrohalide The process comprises reacting a one molar proportion of either tautomeric isomer of a 2-nitroamino-1,3-diazacycloalk-2-ene represented by ...
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JPH05222005A |
PURPOSE: To provide the subject compound which has the ability to inhibit angiotensinogen-cleaving action of the natural proteolytic enzyme, renin and is useful for preventing and treating renin-associated hypertension, hyperaldosteronis...
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JPH04253968A |
PURPOSE: To provide binuclear metal macrocyclic and macrobicyclic complexes for oxygen separation and transport and a method for extracting oxygen from a gaseous mixture contg. the oxygen. CONSTITUTION: The binuclear metallic complex whi...
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JPH04230654A |
PURPOSE: To obtain a novel guanidine compd. having a strong microbicidal effect, especially effective for ascomycetes and basidiomycetes which are contagion of plants. CONSTITUTION: The compd. is expressed by formula I, wherein each of R...
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JPH04217961A |
PURPOSE: To provide new compounds which inhibit the angiotensinogen-cutting action of the natural proteolytic enzyme, renin. CONSTITUTION: This compound is represented by formula I [A is H, Het (Het is 5-7 membered monocyclic ring having...
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JPH04210970A |
PURPOSE: To obtain a new benzamide derivative and its intermediate having antiemetic action and intermediate thereof. CONSTITUTION: The objective compound expressed by formula I [R1 is H or lower alkyl; R2 is formula II (B is straight-ch...
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JPH0433791B2 |
Disclosed are 7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines of the formula I I in which R1 is a hydrogen atom or a lower alkoxy or alkanoyloxy radical and R2 is a halogen atom. The compounds possess psychopharmacological, a...
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JPH0433795B2 |
New 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine compounds are described having the general formula I I wherein R1 is a hydrogen atom or a lower alkyl or alkenyl radical or the cyclopropylmethyl radical, R2 is a hydrogen atom, n i...
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JPH0419991B2 |
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JPH0429721A |
PURPOSE: To efficiently catch carbon dioxide by absorbing and desorbing a larger amount of carbon dioxide in small temp. difference using a carbon dioxide absorbent containing macrocyclic polyamine represented by a specific formula. CONS...
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JPH03223265A |
NEW MATERIAL:A compound of formula I {R1 is lower alkyl; R2 is aryl(lower) alkyl; (n) is 2 or 3; A is formula II (X is CO, CH2; R3 is H, lower alkyl), formula III [Y is CO, CH(OH), CH2O, etc.; Z is N, CN], formula IV (R4 is R3, halogen, ...
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JPH03209397A |
NEW MATERIAL: A compound of the formula. USE: An antitumor agent. PROCESS: Prepared by cultivation of Polyangium brackhysporum Sp. Nov. K-481-B101 (ATCC53080) in a nutrient medium containing a suitable fatty acid (pref. linolenate, eicos...
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JPH0357897B2 |
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JPH03188048A |
NEW MATERIAL: Compounds of formula I [R1, R2 and R5 are each H, alkyl; R3 and R4 are each H, alkyl, aminoalkyl, carboxymethyl, alkoxycarbonylbenzyl, etc.; R6 is alkylene; R7 and R8 are each H, alkyl; B and B' are each phenyl substituted ...
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JPH0330583B2 |
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JPH0386867A |
NEW MATERIAL:The nitrogen-containing heterocyclic compound of formula I or formula II (R1 is B, 1-18C alkyl, aryl, aralkyl or heterocyclic group; R2 is H or 1-6C alkyl; (n) is 0-3; when (n) is 1 and R1 is H or methyl, R2 is 1-6C alkyl) o...
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JPH02300119A |
PURPOSE: To obtain the subject agent free from side effects, effective in suppressing the formation of lipid peroxide and useful for the prevention and remedy of cerebral diseases, cardiac diseases, circulation disorder, hepatic diseases...
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JPH02166166A |
NEW MATERIAL: A compound of the formula [R1, R4-R5, and R8 are each H, a 1-12C (hetero)aryl, or an alkyl; R2-R3 and R6-R7 are each a 1-12C alkyl(thio), an aryl(thio), an alkylseleno, an arylseleno, an alkyltelluro, an aryltelluro, H, a h...
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JPH0214350B2 |
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JPH01131145A |
NEW MATERIAL: A compd. of formula I [R is H, an alkyl or amine capable of contg. a substituent (aryl or 1 or 2 alkyl); R1 is H, an alkyl or aralkyl; A is an aryl, substituted (cycloalkyl or carboxamide)alkyl, a saturated 6-membered heter...
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JPH0122294B2 |
Novel polysubstituted 2-keto-1,4-diazacycloalkanes are powerful stabilizers for materials subject to ultraviolet (UV) light degradation, particularly for polyolefins. The cyclic 2-keto compounds of this invention have (a) a fixed two-car...
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JPS6346064B2 |
Novel anthracence-9,10-bis carbonyl hydrazones of formula: (I) and the pharmaceutically aceptable acid addition salts thereof, useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the r...
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JPS6345670B2 |
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JPS6344750B2 |
1. Process for the production of 3-hydroxy-6-phenyl-1,2,3,4-tetrahydro-1,5-benzodiazoci- nes of the general Formula I see diagramm : EP0004024,P13,F1 as well as their acid addition salts, in which R is a hydrogen atom or a methyl group, ...
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JPS63205651A |
PURPOSE: To prevent fading of an org. coloring material to light by allowing the org. coloring material and at least one kind selected from specific compds. to co-exist. CONSTITUTION: The org. coloring material and at least one kind sele...
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JPS6332072B2 |
Novel 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine derivatives are disclosed which possess the Formula I (I) wherein R1 represents hydrogen, lower alkyl, lower alkenyl or cyclopropylmethyl; R2 represents hydrogen, lower alkyl or l...
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JPS6312067B2 |
PCT No. PCT/JP80/00055 Sec. 371 Date Dec. 1, 1980 Sec. 102(e) Date Dec. 1, 1980 PCT Filed Mar. 28, 1980 PCT Pub. No. WO80/02155 PCT Pub. Date Oct. 16, 1980.An antibacterial surface active agent comprising an effective amount of at least ...
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JPS6311928B2 |
Acid gases such as CO2 and H2S are scrubbed from a gas mixture in an absorption zone (2) employing an aqueous solution (22) comprising an alkali metal compound and a sterically hindered amine of formula: R-NH2-(CH2)m-NH2 in which R is a ...
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JPS62209067A |
NEW MATERIAL:A 5,10-disubstituted-1,5-diazacyclodecane derivative expressed by formula I (n is 2 or 3; R1 is alkyl, aralkyl or acyl; R2 is alkyl, alkenyl, benzyl, alkyl having electron attractive group at the β-position, α-hydroxyalkyl...
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JPS6212222B2 |
Compounds of the formula I and their acid addition compounds, where R1 is a hydrogen atom or a halogen atom, R2 is a hydrogen atom, a halogen atom or the trifluoromethyl group and R3 is a hydrogen atom or an alkyl group with 1 to 6 carbo...
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JPS61178970A |
Compounds of the formula I and their acid addition compounds, where R1 is a hydrogen atom or a halogen atom, R2 is a hydrogen atom, a halogen atom or the trifluoromethyl group and R3 is a hydrogen atom or an alkyl group with 1 to 6 carbo...
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JPS61112065A |
1. A process for selective addition of a cyclic secondary amine of general formula : see diagramm : EP0176398,P8,F5 in which R1 and R2 form together with the nitrogen atom to which they are attached a piperidino or phorpholino radical, t...
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JPS60202850A |
Decane-1,10-diisocyanates corresponding to the formula wherein R1 is an alkyl or cycloalkyl radical, and R2 is a hydrogen atom or an alkyl or cycloalkyl radical and the method of making these diisocyanates by the phosgenation of 1,10-dia...
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JPS5998039A |
The invention relates to curable mixtures which contain 1,10-substituted 1,10-diaminodecanes, as the curing agents, new 1,10-substituted 1,10-diaminodecanes and a process for the manufacture of the latter.
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JPS5948462A |
NEW MATERIAL:The N-substituted hydrazine derivative of formula I (R1 is H or halogen; R2 is halogen; R3 is H or 1W8C straight or branched-chain alkyl which may be substituted with lower alkoxy; R4 is lower alkyl; X is O or S; n is 3W6). ...
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JPS595131B2 |
The invention relates to curable mixtures which contain 1,10-substituted 1,10-diaminodecanes, as the curing agents, new 1,10-substituted 1,10-diaminodecanes and a process for the manufacture of the latter.
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JPS5910572A |
NEW MATERIAL:The compound of formula I (R1 is H, Cl, F or OCH3; R2 is H, CH3, cycloalkyl, phenetyl, etc.; R3 is alkyl, cycloalkyl, phenetyl, 2-methylthioethyl, etc.) and its pharmacologically permissible salt. EXAMPLE: 1,2,3,4,5,6-Hexahy...
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JPS58164509A |
NEW MATERIAL:The compound of formula I[R1 is phenyl or p-methoxyphenyl; R2 is H or CH3; R3 is p-methoxyphenetyl, 3-(p-fluorobenzoyl)-propyl, cyclopropylmethyl or group of formula II] or its pharmacologically permissible salt. EXAMPLE: 5-...
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JPS5813535B2 |
Benzodiazocines corresponding to the formula are converted to benzodiazepines corresponding to the formula of claim 1 by subjecting the benzodiazocine (a) if it is halogen-substituted in the 3-position to a thermal treatment which may al...
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JPS589101B2 |
Benzodiazocines corresponding to the formula are converted to benzodiazepines corresponding to the formula of claim 1 by subjecting the benzodiazocine (a) if it is halogen-substituted in the 3-position to a thermal treatment which may al...
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