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JP2680044B2 |
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JPH09221479A |
To produce a new aminobenzenesulfonic acid derivative monohydrate useful for producing a medicinal composition effective in preventing or treating ischemic cardiopathy, cardiac failure and hypertension, etc. This new aminobenzenesulfonic...
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JP2589702B2 |
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JPH08512313A |
(57) X in a formula (1) type in which summary book invention has therapeutic activity O, It is S, Se, or NR and; and A are (a) or (b), Although it is O, S, NH, or N* low-grade アルキル, when;, however X are N-H or N* (アリール * ...
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JPH08509700A |
(57) Summary book invention relates to the medical treatment method of HIV infection using a substitution annular carbonyl compound useful as human immunodeficiency virus (HIV) protease inhibitor and its derivative, the medicine composit...
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JPH08269016A |
To obtain the subject compound at extremely high reaction rate because of remarkably high catalytic activity by reacting a (meth)acrylate compound with a heterocyclic alcohol in the presence of a specific catalyst. This compound of formu...
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JPH08183770A |
PURPOSE: To obtain a new heterocyclic compound containing nitrogen capable of irreversively generating red color by the irradiation of a light having a specific wave length, especially of an ultraviolet radiation, excellent in color stab...
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JPH08157453A |
PURPOSE: To obtain the subject composition reduced in the discoloration due to solar light, fluorescent lamp light, etc., and useful as a raw material for heat-resistant pigments, a heat-sensitive coloring agent, etc., by reducing a spec...
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JPH08503693A |
(57) Summary book invention is among a lower type I type, and R is (C*C) -Al Killen or 1, and 2- or 1, and 3-cyclo (C*C) Al Killen, and and R and R, It differs and both R and R are related with the addition compound obtained by making ...
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JPH0859574A |
PURPOSE: To prepare a new compound which is an important intermediate for a bistertiary phosphine useful as a bidentate ligand of a complex used for a hydrogenating catalyst, etc. CONSTITUTION: This compound is represented by formula I (...
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JPH07258224A |
PURPOSE: To provide a new bicyclic compound useful as a causal treatment antirheumatic agent for the prevention and treatment of autoimmune diseases and inflammatory diseases and exhibiting strong effect and high safety. CONSTITUTION: Th...
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JPH07247273A |
PURPOSE: To obtain a new fullerene derivative useful as a physiologically active substance such as an anti-HIV active substance, and improved in hydrophilicity owing to adding pyrazoline ring thereto. CONSTITUTION: This new fullerene der...
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JPH0776214B2 |
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JPH07206827A |
PURPOSE: To obtain a process for producing a cyclic amidine compound in high yield at a low cost. CONSTITUTION: This process for the production of a cyclic amidine compound by reacting a nitrile compound with a polyamino compound in liqu...
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JPH07188179A |
PURPOSE: To obtain the subject compound for providing a catalyst exhibiting excellent productivity and selectivity at a lower temperature, by reacting (meth) acrylate and a heterocyclic alcohol in the presence of a magnesium alkoxide. CO...
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JPH07179430A |
PURPOSE: To obtain a novel tricyclic compound which has antagonist activity at V1 and/or V2 receptors and exhibits in vivo vasopressin antagonist activity and is useful for treatment of diseases characterized by excess renal reabsorption...
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JPH07173142A |
PURPOSE: To obtain the subject novel inhibitor which inhibits the angiotensinogen-cleaving action of a natural proteolytic enzyme, renin, and is useful in treating or preventing renin-associated hypertension, hyperaldosteronism, glaucoma...
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JPH07157486A |
PURPOSE: To provide novel compounds having vasopressin and oxytocin antagonistic activity and useful in the treatment of diseases accompanied by excess water reabsorption by kidneys, diseases accompanied by increased vascular resistance ...
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JPH0749421B2 |
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JPH07501057A |
(57)【要約】 本公報は電子出願前の出願データであるため
要約のデータは記録されません。
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JPH07500324A |
(57)【要約】 本公報は電子出願前の出願データであるため
要約のデータは記録されません。
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JPH06511306A |
(57)【要約】 本公報は電子出願前の出願データであるため
要約のデータは記録されません。
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JPH06321909A |
PURPOSE: To prepare an alkylimidazolidone(meth)acrylate under mild conditions by using a novel catalyst chosen from the chelates of calcium with 1,3-dicarbonyl compounds and reacting (meth)acrylate with heterocyclic alcohol. CONSTITUTION...
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JPH06507176A |
(57)【要約】 本公報は電子出願前の出願データであるため
要約のデータは記録されません。
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JPH06220025A |
PURPOSE: To provide 4,5-dihydro-1H-2,4-aryl-fused diazepines useful in the treatment of cardiac dysrhythmia, in particular cardiac dysrythmia of patients of ventricular dysfunction or stagnant heart disorder. CONSTITUTION: A compound of ...
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JPH06206875A |
PURPOSE: To obtain a new heterocyclic compound, having excellent choline esterase inhibiting activity and antidepressant action and useful as a therapeutic or a preventing agent for senile dementia. CONSTITUTION: The compound of formula ...
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JPH0653746B2 |
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JPH06505989A |
(57)【要約】 本公報は電子出願前の出願データであるため
要約のデータは記録されません。
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JPH06157481A |
PURPOSE: To prepare a novel compound inhibiting the angiotensinogen-cleaving action of renin. CONSTITUTION: The compound has the formula I [wherein A is H, aryl or the like; B is -CH2-, the formula II (wherein R3 is H, 1-4C alkyl or the ...
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JPH0639463B2 |
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JPH06501944A |
(57)【要約】 本公報は電子出願前の出願データであるため
要約のデータは記録されません。
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JPH0625201A |
PURPOSE: To provide a method for preparing the subject compounds under the mild condition of reaction in the absence of toxic reagents using inexpensive staring materials. CONSTITUTION: The compound of formula IV is obtained by reacting ...
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JPH0625191A |
PURPOSE: To obtain easily and economically a cyclic urea compd. from commercially available raw materials by reacting urea and a specified diamine under specific conditions to obtain an intermediate and heating slowly the intermediate wi...
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JPH05339246A |
PURPOSE: To provide a new compd. useful as an antiarrhythmia. CONSTITUTION: The compd. is expressed by formula I. In formula I, A is phenyl, thienyl, furanyl, naphthyl, etc.; R1 is H, lower alkyl, etc.; R2 is H, benzyl, etc.; R3 is Yp-(C...
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JPH0577668B2 |
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JPH0563470B2 |
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JPH05222005A |
PURPOSE: To provide the subject compound which has the ability to inhibit angiotensinogen-cleaving action of the natural proteolytic enzyme, renin and is useful for preventing and treating renin-associated hypertension, hyperaldosteronis...
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JPH04330063A |
PURPOSE: To obtain the subject compd. with high purity and in high yield which is useful for treatment of synthetic paper, woven fabric and leather with a polymer used as a coating adhesive by the reaction of (meth)acrylate and a heteroc...
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JPH04321669A |
PURPOSE: To obtain a vasopressin antagonistic agent useful as a vasodilator, hypotensor, diuretic, antithrombotic agent, etc., by using a new benzoheterocyclic compound as an active component. CONSTITUTION: The compound of formula I [R1 ...
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JPH04253968A |
PURPOSE: To provide binuclear metal macrocyclic and macrobicyclic complexes for oxygen separation and transport and a method for extracting oxygen from a gaseous mixture contg. the oxygen. CONSTITUTION: The binuclear metallic complex whi...
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JPH04230654A |
PURPOSE: To obtain a novel guanidine compd. having a strong microbicidal effect, especially effective for ascomycetes and basidiomycetes which are contagion of plants. CONSTITUTION: The compd. is expressed by formula I, wherein each of R...
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JPH04217961A |
PURPOSE: To provide new compounds which inhibit the angiotensinogen-cutting action of the natural proteolytic enzyme, renin. CONSTITUTION: This compound is represented by formula I [A is H, Het (Het is 5-7 membered monocyclic ring having...
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JPH04210970A |
PURPOSE: To obtain a new benzamide derivative and its intermediate having antiemetic action and intermediate thereof. CONSTITUTION: The objective compound expressed by formula I [R1 is H or lower alkyl; R2 is formula II (B is straight-ch...
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JPH0433791B2 |
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JPH0433795B2 |
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JPH04154765A |
NEW MATERIAL:A compound expressed by formula I {R1 us H, halogen, alkyl, NH2 or alkoxy; R3 is H, halogen, alkoxy, OH, alkyl, NH2, etc.; R3 is NR4R5 [R4 is H, benzoyl, etc.; R5 is formula II (R10 is halogen, alkyl, OH, CN, NO2, etc.; (m) ...
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JPH0419991B2 |
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JPH0429721A |
PURPOSE: To efficiently catch carbon dioxide by absorbing and desorbing a larger amount of carbon dioxide in small temp. difference using a carbon dioxide absorbent containing macrocyclic polyamine represented by a specific formula. CONS...
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JPH03223265A |
NEW MATERIAL:A compound of formula I {R1 is lower alkyl; R2 is aryl(lower) alkyl; (n) is 2 or 3; A is formula II (X is CO, CH2; R3 is H, lower alkyl), formula III [Y is CO, CH(OH), CH2O, etc.; Z is N, CN], formula IV (R4 is R3, halogen, ...
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JPH03209397A |
NEW MATERIAL: A compound of the formula. USE: An antitumor agent. PROCESS: Prepared by cultivation of Polyangium brackhysporum Sp. Nov. K-481-B101 (ATCC53080) in a nutrient medium containing a suitable fatty acid (pref. linolenate, eicos...
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