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WO/2017/102883A1 |
The present invention deals with novel bis-triazole compounds (I), compositions comprising said compounds, and their uses as a medicament, an antibacterial agent, an anti-biofilm agent, an anti- fouling agent and/or an anti-corrosion agent.
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WO/2017/102275A1 |
The invention relates to a compound of formula (I), an N-oxide or an agriculturally suitable salt thereof, wherein the variables are as defined in the specification, and their use as herbicides.
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WO/2017/106426A1 |
The present application discloses a nanoparticle composition prepared from a mixture comprising: a) a transition metal salt; b) an iron salt; and c) a reducing agent; and methods for the use of such compositions, including the reduction ...
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WO/2017/102905A1 |
The present invention relates to a method for producing 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-t
riazol-1-yl)propan-2-ol in high purity. Especially it relates to a method in which this compound is effectively separate...
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WO/2017/104741A1 |
Provided is a compound represented by formula (I) or a salt or N-oxide compound thereof. [In formula (I), A1 to A4 groups each independently denote a carbon atom or nitrogen atom, X1 denotes a C1-6 alkyl group or the like, n denotes the ...
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WO/2017/099237A1 |
A compound represented by formula (I) and having a property of modulating the activity of an androgen receptor, or a pharmaceutically acceptable salt of the compound. X represents S or O; Z represents (Ra)n-A-(CR13R14)0-1-(CR11R12)0-1-; ...
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WO/2017/094790A1 |
The present invention provides a 1,2,3-triazole derivative represented by general formula (1) and an insecticide/acaricide having a 1,2,3-triazole derivative as an active ingredient. In general formula (1), R represents a C1-C6 alkyl gro...
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WO/2017/093351A1 |
The invention relates to the provision of novel inhibitors for the cytosolic phospholipases A2, the inhibitors having a special metabolization stability.
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WO/2017/096315A1 |
Provided herein are triazole compounds and pharmaceutical compositions comprising said compounds useful as modulators of DAGL(α) and DAGL(β). In some embodiments, the compounds described herein are selective DAGL(α) inhibitors. Furthe...
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WO/2017/093835A1 |
Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV- absorbing contact lenses capable of blocking ultra-violet ("UV") rad...
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WO/2017/089389A1 |
The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used in the treatment of Human African TRypanosomiasis.
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WO/2017/087643A1 |
Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1, 1- difluoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)pyridin-3
-yl)oxy)benzonitrile.
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WO/2017/087619A1 |
Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1- difluoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)pyridin-3
-yl)oxy)benzonitrile.
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WO/2017/077550A1 |
The present invention discloses a novel metal free process for the regioselective synthesis of α-substituted carbonyl compounds of formula I from alkene, X is selected from the following compounds (A, B).
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WO/2017/069601A1 |
The present invention relates to novel aminoalkylazoles acting as inhibitors of malarial protease plasmepsin II. These can be used as medicines or as constituent of medicines for the treatment of malaria infection.
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WO/2017/070718A1 |
The invention provides compounds for use as medicaments, which act by inhibiting CYP17A1 and CYP19A1 enzymes. The compounds have particular application in the treatment of cancer especially prostate cancer and breast cancer. The compound...
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WO/2017/060202A1 |
The present invention relates to compounds of formula I; wherein R1' is CH3 R1 is methyl, ethyl, CF3, CH2OH, cyclopropyl or cyano, or R1 and R1 may form together a l,l-dioxo-tetrahydro-thiophen-3-yl ring; R is hydrogen, methyl, ethyl, is...
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WO/2017/055146A1 |
Described are acylated N-(1,2,5-oxadiazole-3-yl)-, N-(1,3,4-oxadiazole-2-yl)-, N-(tetrazole-5-yl)- and N-(triazole-5-yl)-aryl carboxamides of formula (I) and the use thereof as herbicides. In said formula (I), R, V, X, Y, and Z are group...
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WO/2017/059120A1 |
Provided are 3-cyano-1H-1,2,4-triazol-1-yl acetamide compounds, compositions, combinations, kits, uses, and methods for treating HIV in a human being using such compounds or combinations with proteasome inhibitors.
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WO/2017/059303A1 |
Provided herein are vinylogous thioester compounds and methods for using the compounds.
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WO/2017/059142A1 |
An ophthalmic lens operable to protect the eye from harmful ultraviolet and high energy visible wavelengths of light and methods for producing the same.
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WO/2017/055286A1 |
The invention relates to a method for improving the stability of a compound having at least one amine function, and the capacity thereof to pass through cell membranes. As a result of said method, the stabilised compounds thus produced h...
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WO/2017/053706A1 |
The present disclosure compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the TEAD transcription factor, and are useful in the treatment of diseases related to the activity of TEAD transcri...
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WO/2017/049245A2 |
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions fu...
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WO/2017/044314A1 |
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
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WO/2017/041230A1 |
A new type of herbicidal chloromethyl triazolinones of general formula (III), compositions of them, methods of preparing them, and methods for preventing or destroying undesired plant growth by preemergence or postemergence application o...
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WO/2017/036404A1 |
Carboxy-substituted (hetero)aryl derivatives, pharmaceutical compositions comprising these compounds, and methods of preparing such compounds and compositions are provided. The compounds or compositions are useful in inhibiting xanthine ...
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WO/2017/040060A1 |
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
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WO/2017/037146A1 |
The invention provides novel compounds having the general formula (I), wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.
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WO/2017/036884A1 |
The present disclosure relates to a co-crystal comprising 2-[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol
-3-ylsulfanyl]acetic acid (lesinurad, free form) and ethyl-2-[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-t
riaz...
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WO/2017/032728A1 |
The invention relates to substituted ketoxime benzoylamides of general formula (I) as herbicides. In said formula (I), R1', R2', X, Y and W represent groups such as hydrogen, organic groups such as alkyl, and other groups such as halogen...
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WO/2017/027309A1 |
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I), as follows: wherein R1, R2, R4, W, X, Y, and G, are def...
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WO/2017/027870A1 |
Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radioflu...
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WO/2017/027312A1 |
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (III); wherein R1c, R2C, R4C, Wc, Yc, Zc and Gc, are defined...
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WO/2017/027310A1 |
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula II.
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WO/2017/023739A1 |
The present invention provides compounds of formula I which are capable of inhibition of the activation of hNav1.1 or hNavl.6 sodium channels in neurons. Pharmaceutical compositions comprising these compounds are also provided. Methods f...
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WO/2017/012922A1 |
The invention relates to substituted cyclic aryl and heteroaryl carboxylic acid hydrazides of general formula (I) or salts thereof, wherein the groups of formula (I) have the definitions stated in the description, for increasing the stre...
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WO/2017/013206A1 |
The invention relates to a process for preparing 3,3'-dinitro-5,5'-bis(1H-1,2,4-triazole) (DNBT) from 3,3'-diamino-5,5'-bis(1H-1,2,4-triazole) (DABT), wherein in the presence of nitrite H2SO4 is added to a suspension of DABT in H2O.
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WO/2017/013265A1 |
The present invention relates to compounds according to general formula (I) which are metabolically robust analogues of bioactive lipid mediators derived from omega-3 polyunsaturated fatty acids (n-3 PUFAs).The present invention further ...
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WO/2017/009344A1 |
The invention relates to a method of identifying molecules which inhibit the virulence machinery of Pseudomonas aeruginosa, to a device for identifying a molecule which inhibits the virulence machinery of Pseudomonas aeruginosa, to novel...
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WO/2017/007672A1 |
Benzotriazole phenols with substituents either ortho to the phenol hydroxyl group and/or para to the phenol hydroxyl group can be prepared from the unsubstitued benzotriazole phenol by coupling reactions. The ortho substituent group can ...
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WO/2017/006929A1 |
The present invention makes it easy to obtain, with good yield and stereoselectivity, an optically active α-tetrasubstituted α-amino nitrile derivative, or an intermediate for the synthesis of said derivative, by reacting a cyanometala...
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WO/2017/003685A1 |
Compounds that stabilize ultraviolet (UV) light are generally disclosed herein. Methods of making and using such compounds are also generally disclosed. Compositions, such as sunscreen compositions, containing such UV-stabilizing compoun...
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WO/2017/003894A1 |
The present invention is directed to substituted triazolo bicyclic compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The presen...
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WO/2016/203400A1 |
The present invention relates to aryl analogs Formula (I), pharmaceutical compositions containing them and their use as Nrf2 regulators.
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WO/2016/203436A1 |
The present invention provides amorphous form of lesinurad, amorphous solid dispersion of lesinurad and processes for preparation thereof. The present invention also provides a pharmaceutical composition comprising amorphous or amorphous...
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WO/2016/202935A1 |
The present invention relates to quinoline-4-carboxamide derivatives of Formula (I) that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprisin...
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WO/2016/202807A1 |
The present invention relates to a process for providing substituted phenyl ketones wherein a Grignard reagent which is obtained from a substituted phenyl bromide is reacted with an acyl chloride at a temperature of -20 to 10 °C. Furthe...
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WO/2016/202253A1 |
Provided are aryl analogs，pharmaceutical compositions containing them and their use as NRF2 regulators.
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WO/2016/204270A1 |
The present invention provides a compound represented by formula (I) (in the formula, A1 and A2 each independently indicate a carbon atom or nitrogen atom; X1 indicates a substituted or unsubstituted C1-6 alkyl group or the like; n is an...
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