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Matches 51 - 100 out of 8,683

Document Document Title
WO/2023/179758A1
Disclosed in the present application is a crystal of a fused tricyclic derivative or a pharmaceutically acceptable salt thereof; and specifically disclosed are a crystal of a compound of formula (I), a crystal of a pharmaceutically accep...  
WO/2023/177591A1
Described herein are a haloalkylpyridyl triazole MLL1-WDR5 protein-protein interaction inhibitors, pharmaceutical compositions and methods of use.  
WO/2023/170543A1
The present invention relates to fluorinated amphiphilic dendrimer structures (FJDs) capable of self-assembling into supramolecular systems of different size and shape. A further object is a supramolecular complex comprising at least one...  
WO/2023/166039A1
The present invention relates to compounds of formula (I) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa.  
WO/2023/166303A1
The invention relates to compounds of formula (I): (I) and related aspects.  
WO/2023/165011A1
Disclosed in the present application are a cross-linking agent as well as a preparation method and the use thereof. The structure of the cross-linking agent contains triazolyl, and contains a double bond, amide acid or imide structure at...  
WO/2023/160035A1
A β-elemene vinylation coupled derivative, and a preparation method therefor and the use thereof in the preparation of an antitumor drug. Provided are a β-elemene vinylation coupled derivative having a structure as represented by formu...  
WO/2023/161023A1
The presently claimed invention relates to an ultraviolet absorber compound and a process for the preparation thereof.  
WO/2023/158602A1
Disclosed are compounds of Formula I including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein G, Z, L, J, A and T are as defined in the disclosure. Also disclosed are compositions containing the compound...  
WO/2023/156402A1
The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description. The com...  
WO/2023/157862A1
Provided is a method for producing α-fluoroether starting from an inactivated chloride. Disclosed is a method for producing a compound represented by formula (3), the method comprising step A in which a compound represented by formula (...  
WO/2023/151640A1
Provided herein are compounds having the structure (I), wherein the substituents are as defined herein, compositions comprising an effective amount of a compound, and methods for modulating activity of an immune cell.  
WO/2023/151642A1
Provided herein are compounds having the following structure, wherein the substituents are as defined herein, compositions comprising an effective amount of a compound, and methods for modulating activity of an immune cell.  
WO/2023/144711A1
The present invention provides novel 1,2,3-triazole carbonyl sulfonylamide compounds of formula (I), Formula (I) wherein, R1, R2 and Z are as defined in the detailed description. The present invention further relates to their preparation...  
WO/2023/146812A1
Methods of treating a subject for long-haul COVID are provided. Aspects of the methods include administering to the subject a tropane CCR5/CCL5 interaction inhibitor in combination with a statin to treat the subject for long-haul COVID. ...  
WO/2023/146816A1
The present disclosure provides novel 4-substituted-phenyl acetamide and arylurea derivatives that act as agonists against GPR88. The compounds of the present disclosure are believed to be useful for the treatment of diseases and conditi...  
WO/2023/140252A1
This material for controlling humidity contains a salt composed of specific triazolium cations and phosphate ester anions.  
WO/2023/134629A1
The present disclosure relates to the field of drugs. Specifically, the present disclosure relates to a compound as represented by formula (I), or a stereoisomer, tautomer, metabolite, pharmaceutically acceptable salt or prodrug of the c...  
WO/2023/128786A1
A family of triazole derivatives is described. Also described is the use of these triazole derivatives in treating or preventing viral infections, such as human immunodeficiency virus (HIV) infections, and the diseases caused by these in...  
WO/2023/118434A1
The present invention relates to novel pesticidally active amide compounds and in particular heteroaromatic amide compounds, to compositions comprising those compounds, and to their use in agriculture, for example in controlling insect p...  
WO/2023/122242A1
A method of attaching an azide moiety to a biomolecule. The method entails contacting a biomolecule in a solution with an azide and an oxidizing agent, for a time and at a temperature wherein at least one azide moiety is covalently bonde...  
WO/2023/115203A1
Disclosed are compounds of formula (I), wherein ring A is an 8-10 membered aromatic or partially aromatic bicyclic ring having 1-4 heteroatoms compositions thereof, wherein L1, L2, R1 to R4 and m are as defined in claim 1; and methods of...  
WO/2023/112038A1
The present invention is directed to 1,2,4 triazole derivatives and compositions comprising thereof. Further, methods of use such as for the treatment and prevention of a neutrophil-associated disease or condition in a subject in need th...  
WO/2023/109878A1
A compound effectively antagonizing LPAR1. The compound is a compound represented by the following formula, or is a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt, or a prodrug of the compound represented by the f...  
WO/2023/101463A1
In order to efficiently control microalgae and moss that cause problems in plant factories, intelligent smart farms, fish farms, living spaces, urban agriculture, etc., which are emerging as new industries, new alternative products that ...  
WO/2023/101595A1
The present invention is directed towards compounds of formula (I), capable of binding to sortilin and thereby useful as sortilin inhibitors in the treatment of diseases, disorders and conditions associated with sortilin activity and bin...  
WO/2023/094830A1
Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof wherein Ring A, Ring B, R1, R2, R3 and L are as defined herein. The compounds are antagonists of the resistant (R-type) voltage-gated calcium ion ch...  
WO/2023/092175A1
The invention relates generally to a compound of Formula (I), wherein R1 is a bicyclic fused heterocyclic moiety and R2 is H or F. The compound of Formula (I) or a pharmaceutically acceptable salt thereof has potential medical use in the...  
WO/2023/094939A1
A novel dual-acting class of antifungal compound synthesized by linking an azole pharmacophore to a COX inhibitor to form a hybrid molecule. A method of making the antifungal compound by preparing a mixture of an azide-functionalized pha...  
WO/2023/092715A1
Provided are an alanine aggregation-induced emission fluorescent probe (TPAPy-D-Ala) having a structure as represented by formula (I), and a synthesis method therefor and the use thereof. The synthesis method for TPAPy-D-Ala comprises: f...  
WO/2023/087632A1
The present invention belongs to the field of medicinal chemistry, and specifically disclosed are an anti-inflammatory analgesic compound and the use thereof. The compound of the present invention is a compound having a structure shown i...  
WO/2023/088426A1
The present invention relates to the field of herbicides. Disclosed are an oxobutan(-2-enoic acid) acid compound and a preparation method therefor, a herbicidal composition and the use thereof, and a herbicide. The compound has a structu...  
WO/2023/086547A1
Methods of preventing or treating a coronavirus infection or a herpes simplex virus infection in a subject or preventing or treating a disease caused by a coronavirus infection or a herpes simplex virus infection in a subject are disclos...  
WO/2023/083983A1
The present invention thus provides a novel family of liposomal compositions (nanocarriers), hereinafter referred to as Tetra-Acidosomes, comprising natural tetrameric acid (TA) lipids and/or novel chemically functionalized tetrameric ac...  
WO/2023/085246A1
A nonphotosensitive surface modifying agent according to the present invention is for forming a surface modification layer between a metal layer and a resin layer, and contains at least one heterocyclic compound having a structure repres...  
WO/2023/080708A1
The present invention relates to a novel salt of 2-amino-2-(2-(1-decyl-1H-1,2,3-triazol-4-yl)ethyl)propane-1, 3-diol, and a pharmaceutical composition containing same. In the results of a comparison with hydrochloride salt of 2-amino-2-(...  
WO/2023/078337A1
The disclosure provides for compounds and methods for modulating or inhibiting CDK8/19. In one aspect, described herein are compounds of Formula (A'), (A), (A-I), (A-II), (II), (II-I), (II-II), (III), (B), (IV), (V), (VI), and (VII), and...  
WO/2023/078461A1
A heterocyclic compound as shown in formula I, a tautomer, stereoisomer, solvate, pharmaceutically acceptable salt or prodrug thereof, a preparation method therefor, and the use thereof. The heterocyclic compound has a better 15-PGDH inh...  
WO/2023/070700A1
Provided are a compound using fluorene as a core, and a preparation method therefor and the use thereof. By means of changing the types of a donor and an acceptor and bonding positions, an electroluminescent device having a series of blu...  
WO/2023/072248A1
Provided are a pyridyl-containing compound represented by formula I and a preparation method therefor, and the use thereof in the preparation for a drug for treating tumors.  
WO/2023/076626A1
The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such ...  
WO/2023/073115A1
The present invention relates to the use of the compound of the formula (I) and the composition thereof as control agent for plant diseases caused by fungi, oomycetes and bacteria. Plant pathogens produce self-aggregating proteins, like ...  
WO/2023/066348A1
Provided are a new compound as represented by formula (I) having a dual antagonistic effect of an angiotensin II receptor and an endothelin receptor, and the use thereof in the preparation of a drug.  
WO/2023/062627A1
Provided herein are compounds that inhibit the protein-protein interaction of serine acetyltransferase (SAT) with O-acetyl serine sulfhydrylase (OASS), and can therefore be used as herbicides.  
WO/2023/056714A1
The present application relates to an aromatization method for a nitrogen-containing heterocyclic compound. The aromatization method for a nitrogen-containing heterocyclic compound comprises: in a solvent, using a nitrogen-containing het...  
WO/2023/056033A1
Disclosed herein are novel lipids that can be used in combination with other lipid components, such as helper lipids, structural lipids, and cholesterols, to form lipid nanoparticles for delivery of therapeutic agents, such as nucleic ac...  
WO/2023/049438A1
Provided herein are compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, stereoisomers, tautomers, isotopically labeled derivatives, solvates, hydrates, polymorphs, co-crystals, and prodrugs thereof, pharmac...  
WO/2023/045910A1
The present application discloses a small-molecule compound having a naphthol ether structure, and a use thereof. Disclosed in the present application are a compound having a structure represented by general formula (I), a pharmaceutical...  
WO/2023/031375A1
Disclosed herein are compounds of formula (I). In particular, the compounds are metallodrug therapeutic compounds or prodrugs of metallodrug therapeutic compounds. The metallodrug therapeutic compounds and prodrugs of metallodrug therape...  
WO/2023/031319A1
The present invention relates to novel 2,4-dihydro-3H-1,2,4-triazol-3-one compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for prepar...  

Matches 51 - 100 out of 8,683