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Matches 1 - 50 out of 10,918

Document Document Title
WO/2019/133770A3
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the en...  
WO/2019/157417A1
Disclosed are compounds of formulas (I)-(IX) for treating or preventing a disease or disorder responsive to antagonism of a P2Y14R receptor agonist in a mammal in need thereof, wherein R1-R8, X, Y, Z, X', Y', Z', and A are as defined her...  
WO/2019/150138A1
The present invention relates to covalently bonded conjugates of cyclodextrins and deferasirox or an analogue thereof, pharmaceutical compositions comprising such conjugates and methods to make such conjugates. The conjugates may be usef...  
WO/2019/149090A1
The present invention provides a crystal form of a urate transporter 1 inhibitor and a preparation method and use thereof. The crystal form is characterized by stable apparent condition, capability of further improving the purity of the ...  
WO/2019/149091A1
The present invention relates to the field of compounds, and in particular to a probucol derivative, a preparation method therefor and use thereof, the probucol derivative having a structure represented by general formula I. The probucol...  
WO/2019/147899A1
A method to induce photo-chemical reactions in a nanoscale space is provided. The method includes fixing cells and incubating the cells with a probe containing a tag for a click reaction. The probe is a psoralen probe that includes an al...  
WO/2019/147987A1
This invention is directed to antimicrobial compositions and methods of using the same to treat or prevent infection. A method of treating microbial infection in a subject, the method comprising administering to the subject a therapeutic...  
WO/2019/141230A1
Disclosed are processes for the synthesis of sulfentrazone, which provide a high conversion of sulfentrazone amine and high yield of the final sulfentrazone product.  
WO/2019/142192A1
Novel compounds capable of inhibiting methionine metabolic pathway are provided. These compounds are used in inhibiting cystathionin γ-synthase (CGS) in general, and in plants, fungi and bacteria, in particular. These compounds of the i...  
WO/2019/139065A1
An organic EL element having at least a positive electrode, a hole transport layer, a light-emitting layer, an electron transport layer, a negative electrode, and a capping layer in the stated order, wherein the capping layer contains an...  
WO/2019/134993A1
The present invention relates to benzamide compounds of formula (I), the N-oxides and the salts thereof (I), where the variables are as defined in the claims and the description. The invention also relates to compositions comprising such...  
WO/2019/135975A1
The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule seque...  
WO/2019/133770A2
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the en...  
WO/2019/126090A1
The present invention provides compounds of Formula (I): Formula (I), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA...  
WO/2019/123368A1
The present invention relates to an improved and efficient process for the synthesis of 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropy l]-2,4-dihydro-3H-1,2,4- triazole-3-thione, compound of formula (I) (Prothioconazole). T...  
WO/2019/121133A1
The present invention relates to a method of preparing 4-aryl-1,2,4- triazolidine-3,5-dione of the formula (I) and 4-aryl-1,2,4-triazole-3,5-dione of the formula (VII). This method is particularly suitable as the synthesis of 4-aryl-1,2,...  
WO/2019/124577A1
The present invention relates to a novel triazole derivative and a salt thereof. A triazole derivative or a salt thereof according to the present invention induces or promotes browning of white adipocytes and differentiates stem cells, e...  
WO/2019/125785A1
A catalytically active substance includes a copper (I) sulfide mineral particle, and an alkyne functionalized molecule bound to a surface of the copper (I) sulfide mineral particle. In an example method, a copper (I) sulfide mineral is r...  
WO/2019/122345A1
The present invention relates to benzamide compounds of formula I wherein the variables are defined as in the claims and the description, the N-oxides and salts thereof,and to compositions comprising the same. The invention also relates ...  
WO/2019/114838A1
Disclosed are a crystal of a 4-(naphthalen-1-yl)-4H-1,2,4-triazole compound (1) and a preparation method therefor, also comprised are applications of the crystal in preparing a medicament for treating an abnormal uric acid level-related ...  
WO/2019/113301A1
The instant invention describes pharmaceutical compositions and dosing regimens comprising seviteronel and/or dexamethasone, and methods of treating diseases, disorders or symptoms thereof.  
WO/2019/109415A1
The present invention provides a compound that is a compound represented by formula I or its stereoisomer, geometric isomer, tautomer, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug: X-Y-Z Formu...  
WO/2019/109099A1
The present disclosure is directed to asymmetric triazole benzamide compounds of formula (I) and formula (II), pharmaceutical compositions thereof and methods for modulating or activating a Parkin ligase The present disclosure is also di...  
WO/2019/106621A1
The present invention provides the process for the preparation of Roxadustat and its intermediates. Another aspect of the present invention provides a process for preparation of ethyl-5-(2-butoxycarbonyl)-4-phenoxyphenyl) oxazole-4-carbo...  
WO/2019/108800A1
The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.  
WO/2019/107386A1
The present invention provides a method for enhancing an antitumor effect by a compound that strongly inhibits ribonucleotide reductase (RNR) or a salt of said compound. A combination formulation in which a sulfonamide compound that has ...  
WO/2019/096884A1
The invention relates to benzoyl amides of general formula (I), as herbicides. In formula (I), B is N or CH, and X1 and X2 are O or S(O)n. R, Ra and Rb are groups such as hydrogen, halogen, (C1-C6)-alkyl, halogen-(C1-C6)-alkyl, (C1-C6)-a...  
WO/2019/095891A1
The present invention provides a tebuconazole polymorph and a preparation method therefor. In particular, the present invention relates to a polymorph of (RS)-1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-y lmethyl)pentan-3-ol, a...  
WO/2019/093522A1
Provided is a plant disease control agent which has low toxicity to humans and animals, while having excellent safety in handling, and which exhibits excellent controlling effect on a wide range of plant diseases and high antibacterial a...  
WO/2019/092170A1
The present invention relates to sulfonylureas and sulfonylthioureas comprising as-membered nitrogen-containing heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is substituted with at least one group containing...  
WO/2019/087983A1
Provided is a benzotriazole compound that efficiently absorbs UV rays having a long wavelength of 360-400 nm, and either i) has excellent solubility in a monomer of a resin raw material and can dissolve at a high concentration, polymeriz...  
WO/2019/089724A1
Disclosed in certain embodiments is a lubricating grease composition comprising an antioxidant polymer (e.g., oligomer) composition comprising repeat units of diphenylamine monomers of formula (I) wherein R is H, C1-C18 alkyl, C2-C18 alk...  
WO/2019/086494A1
Provided are compounds having the general formula I: wherein R1, R B1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds. The compound...  
WO/2019/089723A1
Disclosed in certain embodiments is a lubricating oil composition comprising an antioxidant polymer (e.g., oligomer) composition comprising repeat units of diphenylamine monomers of formula (I) wherein R is H, C1-C18 alkyl, C2-C18 alkeny...  
WO/2019/090078A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2019/080926A1
Disclosed are a benzotriazole ultraviolet absorber and a preparation method therefor, a polymer comprising the benzotriazole ultraviolet absorber, and the use thereof. The benzotriazole ultraviolet absorber has an excellent ultraviolet a...  
WO/2019/080868A1
The present subject matter relates to water-soluble, fluorescent compounds that have aggregation-induced emission (AIE) characteristics and exhibit near infrared (NIR) absorption. The compounds can be utilized as plasma-membrane specific...  
WO/2019/069960A1
A compound shown in general formula (I-1). (In the formula, A represents an atom group having ultraviolet light absorption capacity, B represents a photoelimination group, and k represents an integer from 1 to 10). A composition containi...  
WO/2019/069549A1
A liquid-crystal composition which contains a specific ultraviolet absorber as a first additive and which may contain a specific compound having a low viscosity or a high upper-limit temperature as a first ingredient, a specific compound...  
WO/2019/062665A1
The present invention discloses a linker compound, a polyethylene glycol-linker conjugate and a derivative thereof, and a polyethylene glycol-linker drug conjugate. The linker compound and the polyethylene glycol conjugate and a derivati...  
WO/2019/057969A1
The present invention relates to small molecule compounds and their use as agonists of farnesoid X receptor (FXR) and/or peroxisome proliferator activated receptor delta (PPARδ). The present invention also relates to the use of said com...  
WO/2019/059132A1
The purpose of the present invention is to provide a novel NF-κB inhibitor which has a more effective and higher bioavailability and is more suitable for clinical application. More specifically, the purpose of the present invention is t...  
WO/2019/053090A1
The present disclosure provides a compound of formula (I): (I); or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treatin...  
WO/2019/054430A1
The purpose of the present invention is to provide a compound having an anti-inflammatory action, a pharmacologically acceptable salt thereof, etc. A solving means of the present invention is a compound of general formula (1) or a pharma...  
WO/2019/054427A1
The present invention addresses the problem of providing a compound having an anti-inflammatory effect, a pharmacologically acceptable salt thereof, etc. The means for solution according to the present invention is a compound represented...  
WO/2019/051396A1
Disclosed herein are compounds having a structure of formula (I), compositions and methods useful for the treatment of a disease or infection, such as a viral infection (e.g., Ebola), cancer and obesity: formula (I), wherein A is N or CR...  
WO/2019/045085A1
The present invention provides 1-(N,N-disubstituted carbamoyl) 4-(substituted sulfonyl)triazolin-5-one derivatives represented by general formula 1 and 4-(N,N-disubstituted carbamoyl) 1-(substituted sulfonyl)triazolin-5-one derivatives r...  
WO/2019/034729A1
The invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, ...  
WO/2019/034690A1
The present invention relates to sulfonylureas and sulfonylthioureas comprising a 5-membered nitrogen-containing heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is substituted with a nitrogen-containing group ...  
WO/2019/034692A1
The present invention relates to sulfonylureas and sulfonylthioureas comprising a 5-membered heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is di-substituted at the 3- and 4-positions relative to the point of...  

Matches 1 - 50 out of 10,918