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Matches 1 - 50 out of 10,696

Document Document Title
WO/2018/129552A1
The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-sta...  
WO/2018/122325A1
The present invention pertains to a system of collaborative modifiers that are assembled into a multi molecule complex in vivo within a cell using bioorthogonal chemical reactions. The system of the invention is composed of multiple bind...  
WO/2018/124172A1
A method is provided by which an alcohol compound having a satisfactory purity is obtained from an ester compound in a simple manner. A high-purity alcohol compound can be obtained by: passing a solution which contains both an ester comp...  
WO/2018/121560A1
The present invention relates to a urea compound and a preparation method and an application thereof. The structure of the present compound is represented by formula (I), the definition of each variable in the formula being as described ...  
WO/2018/117063A1
[Problem] To provide a medicine, in particular, a medicine that is useful for treating agitation. [Solution] The present inventors conducted intensive studies to provide a therapeutic agent for agitation. As a result, they found that 4-{...  
WO/2018/116107A1
Provided are IDO inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases ...  
WO/2018/118736A1
The present invention is directed to 6,5-fused heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described he...  
WO/2018/109649A1
The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I), and...  
WO/2018/108695A1
The present invention relates to phenyltriazolinones of formula (I) (I), or their agriculturally acceptable salts or derivatives,wherein the variables are defined according to the description, processes and intermediates for preparing th...  
WO/2018/106646A1
The invention relates to triazole compounds of formula (I') or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: wherein A is selected from the group consisting of (i), (ii), (iii), (iv), (v), and...  
WO/2018/103757A1
Provided is a CCR2/CCR5 receptor antagonist and the use thereof in the preparation of a drug for treating diseases associated with the CCR2/CCR5. In particular, disclosed are a compound represented by formula (I) and a pharmaceutically a...  
WO/2018/099416A1
Provided in the present invention are an azo-compound, a polymer and a preparation method and a use. The structural formula of the azo-compound is shown in formula (I), wherein R1、R2、R3 and m have meanings as described in the descrip...  
WO/2018/098207A1
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.  
WO/2018/093579A1
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions...  
WO/2018/089402A1
There are described RORγ Gamma modulators of the formula (I), (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutic...  
WO/2018/087019A1
The invention relates to a method for producing amide bonds, particularly peptide bonds, with the aid of new amide coupling reagents containing an anion of formula (I); the invention also relates to these new reagents and to the producti...  
WO/2018/085932A1
The present invention provides novel crystalline forms of Lesinurad, pharmaceutical compositions comprising these crystalline forms, and their use in the treatment of hyperuricemia associated with gout. Specific crystalline forms provide...  
WO/2018/077923A1
The present invention provides triazolone compounds compounds of general formula (I) : in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds,...  
WO/2018/081425A1
Described herein are compounds having a hydrogen-bonding group and optionally a functional group for binding (e.g., covalently binding) the compound to another compound (e.g., hyaluronic acid and/or gelatin). A compound of the present in...  
WO/2018/067764A1
This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containi...  
WO/2018/065341A1
Disclosed is a method for preparing an ultraviolet radiation absorbing polymer composition comprising the polymer compound of formula in an esterification / transesterification which method comprises the steps of reacting a polyglycerol ...  
WO/2018/067615A1
The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are i...  
WO/2018/062978A1
The present invention relates to a novel heteroaryl compound, an enantiomer, a diastereomer or a pharmaceutically acceptable salt thereof, and an antiviral composition comprising the same as an active ingredient. The novel compounds repr...  
WO/2018/060704A1
Compounds of Formula (I), which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) are provided. Methods and uses of these compounds for the treatment or prevention of disorders requiring a reduct...  
WO/2018/060070A1
The present invention relates to novel triazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmf...  
WO/2018/053587A1
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.  
WO/2018/051252A2
An object of the present invention is to provide an amide compound or a salt thereof that controls a mite. The present invention provides an amide compound represented by Formula (1) : or a salt thereof, wherein R1 represents C1-6 alkyl ...  
WO/2018/051278A3
The present invention relates to a compound of formula (I) based on enamine derivatives and used as organic hole conductors or hole transporting material in an optoelectronic or photoelectrochemical device. The present invention relates ...  
WO/2018/051278A4
The present invention relates to a compound of formula (I) based on enamine derivatives and used as organic hole conductors or hole transporting material in an optoelectronic or photoelectrochemical device. The present invention relates ...  
WO/2018/051252A3
An object of the present invention is to provide an amide compound or a salt thereof that controls a mite. The present invention provides an amide compound represented by Formula (1) : or a salt thereof, wherein R1 represents C1-6 alkyl ...  
WO/2018/051278A2
The present invention relates to a compound of formula (I) based on enamine derivatives and used as organic hole conductors or hole transporting material in an optoelectronic or photoelectrochemical device. The present invention relates ...  
WO/2018/045182A1
The present disclosure provides compounds that may be useful for inhibiting Wnt pathway comprising compounds of the formula: (Ia) or (Ib) wherein the variables are as defined herein. In some aspects, the compounds may be used to inhibit ...  
WO/2018/045182A8
The present disclosure provides compounds that may be useful for inhibiting Wnt pathway comprising compounds of the formula: (Ia) or (Ib) wherein the variables are as defined herein. In some aspects, the compounds may be used to inhibit ...  
WO/2018/042342A1
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, G, L, R1, Rx, Ry, X1, X2, X3, X4, n, p, q and t are as defined herein, which are active as modulators of retino...  
WO/2018/035291A1
The present invention relates to 1,2,4-triazolidine-3-thione compounds, compositions, and methods for the treatment or prevention of bacterial infections (for example, bacterial infections due to Acinetobacter).  
WO/2018/029150A1
The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I). Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GP...  
WO/2018/024188A1
Provided are a polycyclic compound and a manufacturing method, pharmaceutical composition, and application thereof. The structure of the polycyclic compound and an isomer, prodrug, solvate, hydrate, stable isotopic derivative, or pharmac...  
WO/2018/024224A1
A nitrogen-containing tricyclic compound which acts as modulator of FXR, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the ...  
WO/2018/018091A1
The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.  
WO/2018/014800A1
A compound of the Formula (1) is below provided where R1-R5 are as described in the description and each "*" represents a chiral center.  
WO/2018/010539A1
A synthesis method and intermediate for prothioconazole and enantiomer thereof. The method comprises: reacting a hydrazine with a glyoxylic acid to obtain a hydrazono-acetic acid intermediate, and reacting the intermediate with a thiocya...  
WO/2018/010163A1
Provided are a synthetic method for a 1,2,4-triazole-3-thione compound and an intermediate thereof. The method comprises reacting hydrazine as a raw material with glyoxylic acid to obtain a hydrazono acetic acid intermediate, and then re...  
WO/2018/001084A1
The present invention relates to the field of pharmaceutical chemistry. Disclosed are a heat shock protein inhibitor, and a manufacturing method and application thereof. The heat shock protein inhibitor has a characteristic structure rep...  
WO/2018/001197A1
Provided is a method for preparing an URAT1 inhibitor 2-((5-bromo-4-((4-bromonaphthalen-1-yl)methyl)-4H-1,2,4-tria zol-3-yl)thio)acetic acid as represented by the following formula ZXS-BR, the reaction equation thereof being as follows. ...  
WO/2018/005914A1
Methods for treating HIV or AIDS in a human are provided using two drug regimens comprising a bictegravir and rilpivirine, as well as compositions containing such compounds.  
WO/2017/223016A1
The present invention provides compounds of Formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA rec...  
WO/2017/219083A1
The present invention relates to novel compounds which active HIV expression in latently infected cells. More particularly, the invention relates to pharmaceutical compositions comprising the novel compounds and their use in activating H...  
WO/2017/221083A1
The compositions and compounds of formula I which includes ribavirin conjugates or its polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These conjugates may be formulated as pharmaceutical compositions. The pharmac...  
WO/2017/220467A1
The invention relates to compounds of general formula (I), to the agrochemically compatible salts thereof, to a method for the production thereof and to the use thereof in the field of plant protection.  
WO/2017/217553A1
[Problem] To provide a novel agricultural chemical, and particularly an herbicide. [Solution] An oxime compound represented by formula (1) and an herbicide containing the same. (In formula (1): B represents B-1 or the like; Q represents ...  

Matches 1 - 50 out of 10,696