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Matches 1 - 50 out of 11,101

Document Document Title
WO/2020/102506A1
The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of cancers, particularly cancers that exhibit elevated expression of FOXA1 and/or FOXA1 gene targets, such as certain breast, liver ...  
WO/2020/099645A1
The present invention relates to new compounds that act as inhibitors of metallo-betalactamases (MBL). The present invention also relates to pharmaceutical compositions comprising such MBL inhibitors, and uses thereof in the treatment of...  
WO/2020/097012A1
Disclosed are compounds of Formula (1), including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein A, Q, R1, R2, R3, R4, W and Y are as defined in the disclosure. Also disclosed are compositions containing...  
WO/2020/092401A1
The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processe...  
WO/2020/083971A2
The present invention relates to novel compounds of general formula (I) with A being A1 or A2, and in which T, X, Y, Ro, R1, R10 and R11 are as defined herein, methods of preparing said compounds, intermediate compounds useful for prepar...  
WO/2020/086728A1
In one aspect, compounds of Formula A, or a pharmaceutically acceptable salt thereof, are featured (Formula A) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.  
WO/2019/152517A3
A new class of bioorthogonal reagents based on the cyclopentadiene scaffold is described. The reagent is both ambiphilic and self-orthogonal with remarkable stability in physiological environments. The diene reacts rapidly with both a tr...  
WO/2020/085373A1
The present invention provides a novel compound which has activating activity selective for ERβ. A compound represented by formula (1) or a salt thereof. (In the formula, R1 represents a cycloalkyl group having 3-8 carbon atoms, an alke...  
WO/2020/080979A1
This disclosure relates to new phthalimide and isoindolinone derivatives and other PFKFB3 inhibitors for use in the treatment of diseases. The invention further relates to pharmaceutical compositions containing such PFKFB3 inhibitors, me...  
WO/2020/077197A1
The instant invention describes pharmaceutical compositions and dosing regimens comprising radiation therapy and seviteronel with or without dexamethasone, and methods of treating diseases, disorders or symptoms thereof.  
WO/2020/072008A1
The object of the present invention is to provide a pharmaceutical composition comprising solid dispersion of selinexor, having enhanced bioavailability and improved dissolution properties. In accordance with the invention, solid dispers...  
WO/2020/063756A1
A novel triazole compound of the formula (IV) is provided, it can be used in agriculture, wherein R1 is cyclopropyl and the like; X is -CH2-and the like; each of R4 and R6 is independently hydrogen, fluorine, chlorine, CH3-, etc.; each o...  
WO/2019/040499A3
Methods of treating vascular leak, vascular inflammation, angiogenesis, ocular disorders, and/or inflammatory disorders in a patient are provided. The methods can include administering an ADP-ribosylation factor 6 (ARF6) inhibitor to the...  
WO/2020/057604A1
A TLR8 (Toll-like receptor 8) agonist, a compound of the structure shown in formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof.  
WO/2020/055507A1
Aprotic-protic ionic salt (APS) compositions and methods of using aprotic-protic ionic salt compositions to stabilize nucleic acids at ambient temperatures are provided. Certain aspects provide aprotic-protic ionic salt compositions for ...  
WO/2019/169333A8
Described herein are compounds of Formula (I), modified polymers and implantable elements comprising compounds of Formula (II), as well as compositions and methods of use thereof. In particular, the compounds, modified polymers, implanta...  
WO/2020/051207A2
The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presenc...  
WO/2020/051260A1
This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treatin...  
WO/2020/043866A1
A compound for use in the treatment of a disease ameliorated by the inhibition of Notum of formula (I): (I)  
WO/2020/046382A1
Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utili...  
WO/2020/043831A1
The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof useful as inhibitors of Cyclophilins and modulators of cyclophilin-like proteins. The invention also relates to uses of said compound...  
WO/2020/041556A1
The present invention relates to the discovery of novel N-(substituted)-1H-1,2,4-triazole-3-carboxamide compounds capable of inhibiting DksA activity in a bacteria cell. In certain embodiments, the compounds are capable of killing or wea...  
WO/2020/036134A1
The present invention provides a 5-(1,2,4-triazole-5-yl) benzoic acid amide derivative with a superior harmful organism control effect or a salt thereof, and a harmful organism control agent and a manufacturing intermediate that include ...  
WO/2020/036133A1
The present invention addresses the problem of providing a superior harmful organism control agent. Provided are the 3-(1H-1,2,4-triazole-1-yl) benzoic acid amide derivative shown in general formula [I] or an agrochemically permissible s...  
WO/2020/010309A9
The present invention provides triazole carboxylic acids and related compounds, as well as pharmaceutically acceptable salts thereof, which are useful as glycolate oxidase inhibitors. Pharmaceutical compositions and methods for treating ...  
WO/2020/020851A1
The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.  
WO/2020/020849A1
The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.  
WO/2020/021032A1
The present invention relates to compounds of the generation (n) dendrimer type or the salts thereof, comprising: a central unit of valency 3 having formula (I), (n-1) inner generation layers consisting of repeat units having formula (II...  
WO/2020/020850A1
The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.  
WO/2020/018613A1
Provided herein are compounds of Formula I, Formula II Formula III which are useful in labeling tissues in a subject (e.g., PET imaging of a subject), for treatment of cancer, and/or for preparing a medicament. Also provided are compound...  
WO/2020/018788A1
Disclosed are bifunctional compounds, pharmaceutical compositions containing them, and methods of making and using them to treat diseases and disorders characterized by aberrant protein activity wherein the protein is targeted for degrad...  
WO/2020/011922A1
The present invention relates to certain dithiocarbamate compounds of formula (I) comprising a nitrogen containing heterocyclic ring, and exhibiting strong absorption in the visible range of the light spectrum. The compounds of the inven...  
WO/2020/010309A1
The present invention provides triazole carboxylic acids and related compounds, as well as pharmaceutically acceptable salts thereof, which are useful as glycolate oxidase inhibitors. Pharmaceutical compositions and methods for treating ...  
WO/2020/008391A1
The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)c yclobutyl)propane-1-sulfonamide. The present i...  
WO/2020/002634A1
The present invention relates to specific nitrogen containing compounds of formulas (I), (II) and (IV) of the present invention, which are suitable to be used in a method to detect alkyne group containing organic compounds by mass spectr...  
WO/2020/006336A1
A method of treating or preventing cardiovascular calcification in a subject is described that includes administering to a subject in need thereof a therapeutically effective amount of a nuclear export inhibitor. In particular, the metho...  
WO/2020/006177A1
Disclosed herein are small molecule Vascular Adhesion Protein- 1 (VAP-1) modulator compositions, pharmaceutical compositions, the use and preparation thereof.  
WO/2019/245393A1
The present invention relates to 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamate derivatives and derivatives of 4-(1-phenyl-7H-[1,2,3]triazol-4-yl)- phenol as new compounds. The subject of the invention is the medical use of 4-(l- p...  
WO/2019/246454A1
The present disclosure relates to therapeutic agents that may be useful in treatment and prophylaxis of neurodegenerative disorders and/or neural inflammation.  
WO/2019/238091A1
A compound for improving the gene editing specificity and application thereof. Specifically disclosed is a compound represented by formula I or a use of a pharmaceutically acceptable salt thereof. The compound and the pharmaceutically ac...  
WO/2019/240140A1
Provided are a method for separating a DAPTAD-containing triazolinedione compound in solid form from a reaction solution, a separated solid triazolinedione compound, and a novel method for producing a triazolinedione compound. A triazoli...  
WO/2019/240142A1
Provided is a method for industrially producing a triazolidinedione compound at a high purity and a high yield. A precipitation step for preparing a solution that contains a triazolidinedione compound represented by formula (1) and preci...  
WO/2019/233447A1
Provided are compounds of Formula I'-III', as well as their preparation and uses, and pharmaceutical compositions comprising these compounds and their uses as nuclear transport modulators. Provided are also uses of the compounds or pharm...  
WO/2019/232724A1
The present invention relates compounds of Formula (I) - (V), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as nuclear transport modulators. The present i...  
WO/2019/235501A1
The present invention provides a novel compound which has HDAC2 inhibitory activity. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof. (In the formula, R1 represents a hydrogen atom, a halogen atom, a s...  
WO/2019/234546A1
The present invention relates to antifungal cuticle oil composition comprising Efinaconazole or Tavaborole or Terbinafine or salt thereof in the treatment of onychomycosis. The topical antifungal cuticle oil according to present inventio...  
WO/2019/224667A1
The present invention relates indane compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I) or Formula (II), and p...  
WO/2018/200214A3
The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucle...  
WO/2019/191502A4
This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanod...  
WO/2019/218024A1
The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compoun...  

Matches 1 - 50 out of 11,101