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WO/1989/001934A1 |
The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel ...
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WO/1989/001475A1 |
Tri-aza macrocycles of formula (1), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R1, R2 and R3, which may be th...
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WO/1986/002352A1 |
Chelates of gadolinium with 1, 4, 7-triazacyclononane-N, N', N''-triacetate; 1, 4, 7, 10-tetrazacyclododecane-N, N', N'', N'''-tetraacetate; and 1, 5, 9-triazacyclododecane-N, N', N''-triacetate are useful as NMR contrast agents.
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JP2024511235A |
This application describes novel Fe(III) macrocycle complexes with a hydroxy pendant with a third anionic auxiliary group for improving in vivo MR imaging. This complex has the following general structure: Here, high spin Fe(III) is chel...
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JP2024502994A |
Molybdenum(0) coordination complexes are described, each containing a ligand coordinated to a metal center by nitrogen or phosphorus. A method of depositing a molybdenum-containing film on a substrate is described. The substrate is expos...
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JP2023554079A |
The present disclosure discloses that by linker group89bound to a second chelating ligand selective for radionuclides other than Zr.89The present invention relates to a compound comprising a first chelating ligand selective for Zr. Also ...
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JP7390284B2 |
Provided are macrocyclic compounds and compounds with two or more macrocyclic groups, iron coordinated macrocyclic compounds, and iron coordinated compounds with two or more macrocyclic groups. The iron is high-spin iron(III). The iron c...
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JP2023547954A |
In the present invention, A is -As(OH)2or a group equivalent to arsenoxide, R1,R2,R3and R4each independently H, X, OH, NH2, CO, SCN, -CH2NH, -NHCOCH3,-NHCOCH2selected from X or NO, where X is halogen and R5-NHCH2COOH, OH or OR6and R6is C...
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JP7315004B2 |
An object is to synthesize a zirconium complex by reacting 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), even with a small concentration, and radioactive zirconium...
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JP2023099047A |
To provide methods of treating diseases and targeting conjugates of carbonic anhydrase IX inhibitors for imaging of disease.For example, a conjugate of the following formula is illustrated.SELECTED DRAWING: None
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JP7299285B2 |
Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting a...
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JP2023517850A |
The present invention relates to a method of degrading a biofilm by contacting the biofilm with an aqueous mixture comprising a peroxide-type compound and a manganese complex, wherein the aqueous mixture comprises a macrocyclic ligand. ....
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JP2022509385A |
The present invention44Sc,47Sc,55Co,62Cu,64Cu,67Cu,66Ga,67Ga,68Ga,89Zr,8
6Y,90Y,90Nb,99mTc,111ln,135Sm,140Pr,159Gd,149Tb,160Tb,161Tb,
165Er,166Dy,166Ho,175Yb,177Lu,186Re,188Re,213Bi and225Ac, or18F,131I or211A chelating agent or fluorina...
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JP2022507519A |
Macrocyclic complexes and macrocyclic compounds. The macrocyclic complex or macrocyclic compound has a TACN moiety having one or more amine groups, or an O- or S-substituted TACN moiety. The macrocyclic complex has a high spin Fe (III) a...
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JP2021518337A |
Provided herein are triazacyclododecane sulfonamide (TCD)-based protein secretion inhibitors, such as inhibitors of Sec61, methods of their preparation, related pharmaceutical compositions, and the use thereof. How to do it. For example,...
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JP2021042187A |
To provide a dinuclear metal complex that can be synthesized simply and easily and has a proper anticancer action.The present disclosure provides a dinucleating ligand represented by the following formula (I) and a dinuclear metal comple...
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JP6574997B2 |
A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bondi...
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JP2019522625A |
The present invention is a polyvalent compound for target molecule imaging and / or target drug delivery, in which two components or target directional molecules each interact with one or more biomarkers on the cell. , Provide polyvalent...
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JP6386026B2 |
The present invention relates to a compound, comprising a pyrene skeleton and arylamino groups, according to formula (I). The compound is suitable for use as a functional material in electronic devices.
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JP2017081969A |
To provide a novel compound having P2Xand/or P2Xreceptor antagonistic effect.The present invention relates to a compound represented by the formula and having an amino pyrimidine skeleton, amino pyridazine skeleton, amino pyrazine skelet...
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JPWO2014157207A1 |
Provided is a room temperature phosphorescent material that responds to external stimuli. The luminescent metal complex that responds to the external stimulus of the present invention has the general formula (I). [Chemical 1](In the form...
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JP6051444B2 |
Compounds of formula (I) wherein the substituents are as defined in claim 1, are useful as a pesticides and herbicides.
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JP6054307B2 |
This document discloses pesticidal compostions comprising molecules having the following formulas: and processes related thereto.
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JP5733988B2 |
The present invention relates to linear and cyclic guanidine derivatives, method of preparation and uses thereof, pharmaceutical compositions to be used as antifungal agents, in particular against Candida species.
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JP5688413B2 |
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JP5676600B2 |
The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for det...
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JP2015027951A |
To provide a compound useful as an agricultural and horticultural pesticide and an animal parasite control agent.The present invention relates to a phthalamide derivative represented by general formula (I) or a salt thereof. [In the form...
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JP5608914B2 |
The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or proteins, although other types of molecule...
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JP2014524138A |
The present invention relates to organic electronic devices, in particular organic electroluminescent devices, which comprise organic cyclophanes, in particular as matrix materials for fluorescent or phosphorescent emitter compounds or a...
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JP5581226B2 |
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JP5541738B2 |
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at le...
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JP5451041B2 |
A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a...
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JP2014037410A |
To provide a novel biaryl heterocyclic compound effective in the field of anti-infection drugs, antiproliferation drugs, antiinflammatory drugs and motor function promoting drugs.An oxazolidinone compound represented by the formula, wher...
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JP5411161B2 |
Disclosed are N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-
dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide (which is represented by formula III), its preparation method, intermediates during preparation procedure, prepa...
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JP2013242397A |
To provide a method for forming a negative pattern, in which a pattern excellent in the depth of focus (DOF), uniformity in a local pattern dimension and resolution can be formed even when a pattern having various features including a co...
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JP5335171B2 |
Cyclic polyamines containing N nitrogens on the ring are protected with high yields in a N-1 manner, e.g. all protected but one amino group, by using certain fluoro-containing agents that offer easy deprotection. Preferably, a new proces...
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JP2013525270A |
Conjugates of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes with a variety of conjugating members are used in the formation of dinuclear metal complexes which bind to phosphate esters. By virtue of their conjugated forms, the comp...
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JP2013521235A |
The present invention relates to synthesizing a manganese complex in a substantially water-insoluble solution.
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JP2013519693A |
Compounds of formula (I) wherein m, R1, R2, R3, X and Y are defined herein, are useful as inhibitors of HIV replication.
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JP2013518836A |
The invention relates to a process for the manufacture of an epoxyethyl ether or glycidyl ether by catalytic oxidation of a vinyl or allyl ether using an oxidant, preferably hydrogen peroxide, and a manganese complex wherein the catalyti...
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JP5162460B2 |
The present invention is directed to a novel process for the preparation of benzo[e][1,2,4]triazepin-2-one derivatives, useful in the preparation of gastrin and cholecystokinin receptor ligands.
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JP5139999B2 |
The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, L, M, W, Z, R1, R2, R3, R4, R5, R6, R...
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JP5118648B2 |
The present invention relates to various novel substituted dipeptide derived nitrogen-containing heterocyclic compounds, their pharmaceutically acceptable salt derivatives, and their methods of use. In one aspect the present invention re...
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JP5054877B2 |
Preparation of cyclic urea compounds (I) from activated carbamic acid derivative(s) (II) is new. Preparation of cyclic urea compounds (I) from activated carbamic acid derivative(s) (II) containing a non-protected primary or secondary ami...
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JP5043428B2 |
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at le...
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JP2012067103A |
To provide a new compound which is useful for treatment of Vancomycin-resistant bacteria infection.Following compounds are illustrated as new peptoid compounds, namely, methyl(2S, 5S, 8R/S)-8-acetamide-2-allyl-9-[6-allyl-9-t-butoxycarbon...
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JP2012056967A |
To provide a process for preparation of N-1 protected N ring nitrogen-containing cyclic polyamines, and products thereof.The present invention relates to efficient high yielding N-1 protection of cyclic polyamines containing a total of N...
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JP4848671B2 |
To provide an excellent method for producing decane-1,10-dicarboxylic imide in an industrial scale, from 1,1'-peroxydicyclohexylamine. The invention relates to the method for producing decane-1,10-dicarboxylic imide from 1,1'-peroxydicyc...
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JP4763009B2 |
To provide a CO2absorbent for recovering CO2in a gas by absorption/desorption more efficiently and by a lower energy consumption in comparison with the CO2absorbents used up to now and a method for recovering CO2in the gas efficiently an...
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JP2011518169A |
The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include the following: wherein R1 and R2 are each H or C1-6 alkyl. X is C1-6 alkylene....
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