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JP2011515346T |
A following formula, i. e., [L3MO3]nIt is how to compound a complex which を有 and they are inside of a formula, and L.3At least は三座配 expresses a child, M expresses metal chosen from Tc and Re, n is an electric charge of*2 to 1...
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JP4628366B2 |
The present invention relates to novel macrocyclic compounds of the formula wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17,...
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JP2010531976A |
The present invention relates to ruthenium and osmium complexes of Formula I per se , where A is isoquinoline, guanine or adenine, and the use of ruthenium and osmium complexes as redox mediators in electrochemical biosensors. ...
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JP4543151B2 |
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JP4511030B2 |
Described are compound of the formula (I) defined herein which are useful, for example, in the treatment of diabetes. Also described is a method for preparing the compounds.
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JP4470394B2 |
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JP2010511058A |
Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or condit...
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JP4446736B2 |
A compound of the formula (I): wherein A is an aromatic or heteroaromatic ring system or partially or fully reduced derivatives thereof; Q is hydrogen, C 1 -C 12 straight chain, branched or cyclic alkyl substituted with one or more hydro...
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JP4415148B2 |
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JP4386471B2 |
The present invention relates to the novel compound, 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one of formula (I), its preparation and the use thereof for the preparation of tetraazamacrocycles.
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JP4344779B2 |
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JP2009522236A |
Methods for the synthesis of various novel substituted dipeptide derived nitrogen-containing heterocyclic compounds (I) and their pharmaceutically acceptable salt derivatives are provided. The compounds of the invention are claimed and a...
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JP2009522234A |
The present invention relates to various novel substituted dipeptide derived nitrogen-containing heterocyclic compounds, their pharmaceutically acceptable salt derivatives, and their methods of use.
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JP2009108054A |
To provide a new compound useful for treating infection with vancomycin-resistant bacteria.The new peptoid compound is useful especially against infection with gram-positive bacteria including the vancomycin-resistant and methicillin-res...
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JP4200466B2 |
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JP4056088B2 |
PCT No. PCT/GB98/00678 Sec. 371 Date Dec. 27, 1999 Sec. 102(e) Date Dec. 27, 1999 PCT Filed Mar. 6, 1998 PCT Pub. No. WO98/39288 PCT Pub. Date Sep. 11, 1998Tripodal chelating agents incorporating imine C=N bonds are disclosed for the for...
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JP4024309B2 |
Novel compounds having three substituents in the cyclic partial structure thereof, such as a pyrrolidine or a benzene ring, for example, homophenylalanyl-trans-4-((S)-3-amino-2-hydroxypropionylamin
o)proline 5-indanylamide and N-(3-pheny...
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JP4011215B2 |
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JP3935071B2 |
Compounds according to general formulae (1 and 2), wherein G1 is an azepine derivative and G2 is a group according to general formulae (9-11) are new. Compounds according to the invention are vasopressin V2 receptor agonists. Pharmaceuti...
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JP2007039443A |
To provide a new method for producing 1.3-dimethyl-2-imidazolidinone.This method of production is provided by reacting a compound expressed by general formula (1) [wherein, R is ≥1 and ≤4C alkyl] with a burette in the presence of apr...
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JP3810450B2 |
PURPOSE: To obtain a new condensed ring compound which is useful in the prophylaxis and therapy for hypercholesterolemia and coronary ayteriosclerosis because it has excellent inhibitory action against squalene synthase. CONSTITUTION: A ...
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JP2006516133A |
The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention ...
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JP2005513013A |
This invention relates to a compound of formula (I) wherein: W is N or N+-O-; and R1 to R5 are as defined in the description, for use for the treatment of gastrin related disorders.
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JP2005104990A |
To obtain a new agonist of a peptide hormone, vasopressin.A compound represented by formulae 1 or formula 2 is provided. The compound has antidiuretic action and is useful for treating polyuria, incontinentia urinae, and the like.
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JP3541951B2 |
This invention relates to dichelants, in particular compounds having two macrocyclic chelant groups linked by a bridge containing an ester or amide bond, especially compounds of formula (V) (wherein each X which may be the same or differ...
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JP2004518678A |
This invention relates to a class of heterocycles and their metal complexes, and is particularly concerned with the use of these compounds in the preparation of prodrugs or as prodrugs that may be activated under hypoxic conditions by en...
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JP3522578B2 |
To obtain a new triazacyclononane compound having a high water solubility having a substituted hydrocarbon group containing a hetero atom, and useful as an intermediate or the like for the synthesis of fine chemicals, high functional cat...
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JP3510955B2 |
To obtain a macrocyclic polyamine compound presenting good selectivity to HIV-1 and HIV-2 in vitro tests. This improved antiviral compound is a macrocyclic compound (acid-added salt, metal complex salt thereof) expressed by the formula, ...
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JP2004505112A |
Novel cyclic polyamine compounds of the form (I) where A1, each A2 (if present), and A3 are independently selected from C1-C8 alkyl, where each Y is independently selected from H or C1-C4 alkyl, where M is selected from C1-C4 alkyl, wher...
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JP3492724B2 |
PURPOSE: To provide a benzotriazole UV absorber which is liquid at ordinary temp. and having excellent compatibility with, e.g. a synthetic polymer. CONSTITUTION: A UV absorber containing a benzotriazole compound represented by the formu...
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JP2004500321A |
A compound of the formula [Ma(XbL)cYdZe]nt± Formula I wherein: M is a metal ion or a mixture of metal ions; X is a cation or a mixture of cations; L is a ligand, or mixture of ligands each containing at least two different donor atoms s...
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JP3449766B2 |
PURPOSE: To obtain a new compound or its salt which comprises phenylalanine, lysine, tyrosine derivative and β-alanine and has a possibility of a therapeutic agent for hypersensitive intestine syndrome as an antagonist of motilin, one o...
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JP3411919B2 |
A nuclear magnetic resonance contrast composition which comprises a tetraazamacrocyclic compound - paramagnetic lanthanide complex having the formula: where x is 2, 3 or a combination of p 2(s) and q 3(s) where p + q = 4; R is (CH2)zP(=O...
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JP3375961B2 |
Pharmaceutical compsn. comprises a linked cyclic cpd. of formula Z-R-A-R1-Y (I) or an acid addn. salt or metal complex of (I), in admixt. or association with a diluent or carrier. In (I) Z and Y are cyclic polyamine moiety contg. 9-32 ri...
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JP3356289B2 |
The present invention refers to a method for inhibiting bacterial or fungal growth on a surface, including a human body surface, or in a solution comprising administering to said surface or solution a complexing agent having the formula ...
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JP3334717B2 |
The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses. The compound has the formula where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=y; y is 3 or 4; R is (CH2)zP(=0)R1R2; R1 is R...
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JP2002519412A |
This invention relates to novel potassium channel blocking agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation...
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JP2002510669A |
Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to ...
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JP2002012582A |
To obtain a compound which has a chelating affinity for and selectivity of a first transition series element, lowers bioavailability of the first transition series element or removes the first transition series element and an element hav...
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JP2002003408A |
To obtain an agent for increasing contrast in taking s nuclear medicinal images or in magnetic resonance image.This agent contains a compound having a formula expressed by formula I or formula II, a dimmer or an element of a radioactive ...
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JP2001524949A |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
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JP2001316253A |
To obtain a medicinal composition comprising a polyaza compound with chelating affinity and selectivity for first transition elements.This medicinal composition comprises a compound represented by formula I or II, or a dimer or physiolog...
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JP3178667B2 |
To obtain a new transition metal complex useful as a catalyst for oxygen-oxidative polymerization of a phenolic compound, and usable as a catalyst for the production of a poly-1,4-phenylene ether having no C-C bond structure, slight orth...
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JP2001158778A |
To obtain a new polyfunctional cyclic azomethine compound useful for synthesizing a dendriform polymer having characteristics of excellent solubility, processability, high strength, high heat resistance, etc., and to provide a method for...
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JP2001507378A |
The invention provides polymeric polychelants containing polymer repeat units of formula [L-Ch-L-B] (where Ch is a polydentate chelant moiety; L is an amide or ester linkage; B is a hydrophobic group providing a carbon chain of at least ...
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JP2001114793A |
To provide a bleach-activating agent which increases the bleaching power of a peroxide-based compound even at low temperature without affecting fibers or fiber product dyes. A compound of the general formula (D: [LnMmXp]zYq [M is mangane...
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JP2000327667A |
To provide a new azacrown derivative useful as a discotic liquid crystal material. The objective derivative has a structure obtained by substituting 1-8 CH2 groups in a 9-24C cycloalkane with N(-XYR) groups [R is a (substituted)1-20C alk...
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JP3107547B1 |
[wrap up] [Task] Provided are novel triazacyclononane compounds and metal complexes thereof in which the α-carbons of the three supernitrogen substituents are all tertiary. A triazacyclononane compound represented by the following gener...
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JP3107550B1 |
[wrap up] [Task] Provided are a novel triazacyclononane compound having a perfluoroaryl group and a metal complex thereof. A triazacyclononane compound represented by the following general formula (I), and a metal complex composed of the...
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JP3086803B1 |
[wrap up] [Task] Provided are a triazacyclononane compound in which a chiral hydrocarbon group is substituted on nitrogen and a metal complex thereof. It is a triazacyclononane compound represented by the general formula (I) and a metal ...
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