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Matches 201 - 250 out of 5,882

Document Document Title
WO/2016/189877A1
The present invention provides a urea compound or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be abbreviated as FPRL1) agonist effect, a pharmaceutical composition containing the...  
WO/2016/185200A1
The invention provides a compound which is a peptide derivative of formula (1) as defined in the claims or a salt thereof: RG is H, -CH2-RGA or C1-12 hydrocarbyl optionally substituted with 1 to 4 substituents selected from -OR', -NO2, -...  
WO/2016/187521A1
A pharmaceutical formulation includes an antibiotic 5-substituted 1H-tetrazole compound in an amount sufficient to treat a bacterial infection, the antibiotic 5-substituted 1H-tetrazole compound being selected from the group consisting o...  
WO/2016/176689A1
Tetrazine non-canonical amino acids, methods for genetic encoding proteins and polypeptides using the tetrazine amino acids, proteins and polypeptides comprising the tetrazine amino acids, and compositions comprising the proteins and pol...  
WO/2016/169902A1
The present invention relates to compounds of formula (I), wherein R1' is CH3 R1' is methyl, ethyl, CF3, CH2OH, cyclopropyl or cyano, or R1, and R1 may form together a 1,1-dioxo-tetrahydro-thiophen-3-yl ring; R2 is hydrogen, methyl, ethy...  
WO/2016/114634A3
The present invention relates to a cyclam derivative compound and a pharmaceutical use thereof. The cyclam derivative compound can alleviate side effects of a drug since the compound enables an efficient drug delivery by selectively reco...  
WO/2016/153054A1
Provided are an efficient method for producing a nitrogen-containing compound or salt thereof to be used in the production of a treatment agent for diseases involving an integrin. Also provided is a production intermediate of the same. A...  
WO/2015/143188A8
Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin -2- yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation.  
WO/2016/150337A1
The present invention relates to a new crystal form of a compound of formula (I), a preparation method and a use thereof. The new crystal form provided in the present invention is stable and has a low hygroscopicity, and a purification p...  
WO/2016/146299A1
A process to isolate a compound of Formula (2a) or a salt or solvate thereof, comprising a) reacting a mixture of diastereoisomers of Formulae (2a, 2b) with a basic heterocyclic-aldehyde compound and an optically active amine in the pres...  
WO/2016/149486A1
The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for p...  
WO/2016/142364A1
The invention discloses a method for the preparation of certain 1,5 disubstituted tetrazole and similar compounds starting from certain thioacetamides, which ultimately allows the preparation of these certain 1,5 disubstituted tetrazoles...  
WO/2016/089208A3
The present invention is directed to compounds having formula (I): A-L-R1, wherein A is an anticancer agent comprising at least one group selected from the group comprising OH, NH and NH2 and L is a direct bond or L is a linker and R1 is...  
WO/2016/127873A1
The present invention provides an isothiocyanate compound and an application thereof. The compound is an aryl substituted isothiocyanate compound that has a structure in the general formula I. The isothiocyanate compound in the present i...  
WO/2016/128541A1
The present invention refers to compounds endowed with RNA helicase DDX3 inhibitory activity of formula I and II and their therapeutic use, in particular for the treatment of viral diseases.  
WO/2016/105172A3
The present disclosure relates to a novel method for preparing high-purity gadobutrol. The present disclosure can be easily applied to a large scale production because purity of intermediate can be managed via simple and mild process and...  
WO/2016/125123A1
The amorphous form of trisodium sacubitril valsartan and methods for the preparation thereof are disclosed herein.  
WO/2016/123028A1
The present disclosure provides compounds that include a tetrazolone derivative of a carboxyl group of an active agent. This disclosure also relates to pharmaceutical compositions that include these compounds, methods of using these comp...  
WO/2016/043462A3
The present invention provides a novel method for preparing highly pure calcobutrol using an intermediate (butrol) of gadobutrol without using highly pure gadobutrol. The present invention is capable of obtaining highly pure calcobutrol ...  
WO/2016/115564A1
Described are methods for preparing salts of 5-nitrotetrazolate that include reacting aqueous solutions of 5-aminotetrazole, an acid, and sodium nitrite in a continuous flow system at an ambient temperature.  
WO/2016/114634A2
The present invention relates to a cyclam derivative compound and a pharmaceutical use thereof. The cyclam derivative compound can alleviate side effects of a drug since the compound enables an efficient drug delivery by selectively reco...  
WO/2016/105172A2
The present disclosure relates to a novel method for preparing high-purity gadobutrol. The present disclosure can be easily applied to a large scale production because purity of intermediate can be managed via simple and mild process and...  
WO/2016/091228A1
A nitro group-substituted phenyltetrazole of general formula (I) wherein R is selected from the group consisting of: H, C1-C11 alkyl, phenyl- or phenyl- substituted in positions 2, 3, 4 or 5 by one or more electron-acceptor groups and/or...  
WO/2016/051393A3
A novel crystalline Form of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3- ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3'-methyl-2'- (pentanoyl{2''-(tetrazol-5- ylate)biphenyl-4'-ylmethyl}amino)butyrate] hydrate, process for its prepa...  
WO/2016/088747A1
Provided is a novel bactericide, especially a bactericide for agricultural and horticultural use. A hydrazone derivative represented by formula (I), a salt thereof, and a bactericide for agricultural and horticultural use, which contains...  
WO/2016/089208A2
The present invention is directed to compounds having formula (I): A-L-R1, wherein A is an anticancer agent comprising at least one group selected from the group comprising OH, NH and NH2 and L is a direct bond or L is a linker and R1 is...  
WO/2016/083605A1
The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by ...  
WO/2016/077859A1
The present disclosure relates to methods and products for labelling, binding and/or detection of lipids. Certain embodiments provide a method of labelling a lipid. The method comprises exposing the lipid to a complex comprising a transi...  
WO/2016/067292A1
Energetic nitrogen-rich monomers represented by the general Formula (I); wherein each of X1 and X2 is independently NR or a covalent bond, R is H or C1-4 alkyl, each of T1 and T2 is independently a moiety selected from the group consisti...  
WO/2016/049663A1
Novel crystalline Forms of trisodium [3-((1S,3R)-l-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butyl carbamoyl) propionate-(S)-3'-methyl-2'-(pentanoyl{2"-(tetrazol-5-ylate) biphenyl-4'-ylmethyl}amino)butyrate] hydrate, methods for their prepa...  
WO/2016/043462A2
The present invention provides a novel method for preparing highly pure calcobutrol using an intermediate (butrol) of gadobutrol without using highly pure gadobutrol. The present invention is capable of obtaining highly pure calcobutrol ...  
WO/2016/037552A1
Disclosed are a crystalline ARB-NEPi compound and a preparation method therefor and an application thereof. The ARB-NEPi compound refers to [3-((1S, 3R)-1-biphenyl-4-ylmethyl-3-ethyloxycarbonyl-1-butylcarbamoy l)propionic acid-(S)-3'-met...  
WO/2016/040179A1
A method of reducing radiation exposure of a non-cancerous tissue of a patient diagnosed with a cancer includes administering to the patient an agent capable of competing for binding sites on a surface of the non-cancerous tissue, provid...  
WO/2016/026841A1
The present invention relates to new compounds comprising a siderophore moiety as well as a core structure able to chelate a metal ion. Optionally, the compounds may have additionally a moiety with a functional element including a marker...  
WO/2016/022434A1
Aspects of the present disclosure include compounds of formula (A) that find use for the treatment of a variety of autoimmune and inflammatory diseases and disorders. Embodiments of the present disclosure also relate to pharmaceutical co...  
WO/2016/015593A1
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or ...  
WO/2016/016272A1
The present invention concerns compounds of formula (I):their process of preparation and compositions thereof. The present invention also concerns their use as diagnostic agent in PET imaging.  
WO/2016/016107A1
The invention relates to bicyclic arylcarboxylic acid amides of general formula (I) as herbicides. In this formula (I), Z1, Z2, Z3, Z4 and Z5 represent a bond O, S(O)n or a substituted carbon atom. X is a radical such as hydrogen, organi...  
WO/2016/010538A1
Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the com...  
WO/2016/005892A1
Process for the preparation of a polyazamacrocycle substituted with at least one aryl or heteroaryl group comprising reacting at least one unsubstituted polyazamacrocycle with at least one halogenated aryl or heteroaryl compound. Said po...  
WO/2016/001073A1
The invention relates to benzoic acid amides of general formula (I) as herbicides. In formula (I) X, Z and R represent radicals such as alkyl and cycloalkyl. Q represents a 5-membered heterocycle.  
WO/2016/001075A1
The invention relates to N-(1-methyltetrazol-5-yl)benzoic acid amides of the general formula (I) as herbicides. In formula (I) X, Z and R represent radicals such as alkyl and cycloalkyl.  
WO/2015/197458A1
The present invention relates to the novel substituted 1-[2-[[[2-alkoxyimino-alkenylidene]amino]- oxymethyl]phenyl]-4-methyl-tetrazol-5-one compounds of formula (I) and the N-oxides and the salts thereof for combating phytopathogenic fun...  
WO/2015/196139A1
Disclosed are certain heterocyclic organic compounds that inhibit mitochondrial respiration and also lead to the maintenance of pluripotency of human embryonic stem cells in culture, even in the presence of oxygen. Exemplified are compou...  
WO/2015/174933A1
There is provided a method for detecting the presence or absence of acrylic acid or its derivatives thereof in a sample, the method comprising the steps of: (a) introducing a probe comprising a diaryltetrazole compound to the sample; (b)...  
WO/2015/112902A3
Described herein are methods for treating chemotherapy-induced peripheral neuropathy, or human immunodeficiency virus-associated sensory neuropathy, or symptoms thereof, comprising administering to an individual in need thereof a therape...  
WO/2015/157187A1
Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the c...  
WO/2015/147337A1
A tetrazolinone compound shown by formula (1) (in the formula, R1 and R2 each independently represent a hydrogen atom, C1-C4 alkyl group optionally having one or more halogen atoms, or the like; R3 represents a hydrogen atom, C1-C4 alkyl...  
WO/2015/146552A1
[Problem] To provide a method for producing a 1-(2-halogenomethylphenyl)-4-methyl-1,4-dihydrotetrazol-5-on e. [Solution] The present invention can obtain a compound represented by formula (3) (in the formula, X2 is a chlorine atom or the...  
WO/2015/095097A3
The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents...  

Matches 201 - 250 out of 5,882