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Matches 401 - 450 out of 4,492

Document Document Title
WO/2015/143192A1
Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin -2- yl)-3-(1H-tetrazol-1-yl)propan-2-ols and 1-(2,4-difluorophenyl)-2,2-difluoro-2-(5-substituted-pyridin -2-yl)ethanones and processes for their preparation.  
WO/2015/143142A1
The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.  
WO/2015/143180A1
The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.  
WO/2015/143188A1
Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin -2- yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation.  
WO/2015/138986A1
Novel FXR agonists are disclosed, embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subje...  
WO/2015/139025A1
The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and admin...  
WO/2015/132313A1
The invention relates to novel heterocyclic compounds, to their use for controlling animal pests, which include arthropods, insects and nematodes, and to methods and intermediate products for producing said novel compounds.  
WO/2015/124102A1
The present invention relates to a method of refining valsartan comprising more than 10% D-isomers, the method comprising: adding a solvent to valsartan comprising more than 10% D-isomers and dissolving, adding a certain amount of inorga...  
WO/2015/117911A1
A process for purifying a compound of formula (1), comprising the following steps: a) adding an acid to an aqueous solution of the compound of formula 1, including salts thereof so as to obtain a pH ≤ 3 whereby a slurry is obtained; an...  
WO/2015/117626A1
The invention relates to polyaminotetrazoles of general formula (I), to a method for their preparation and to the use of this novel class of substances.  
WO/2015/117146A1
β-Substituted -amino acids, β-substituted γ-amino acid derivatives, and β-substituted γ-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted γ-amino acid derivatives and Î...  
WO/2015/112441A1
The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.  
WO/2015/107541A1
The present invention relates to compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use ...  
WO/2015/106108A2
Pharmaceutical compositions of the invention include novel functionalized 1,3-benzenediols having a disease-modifying action in the treatment of hepatic encephalopathy and related conditions. Pharmaceutical compositions of the invention ...  
WO/2015/105352A1
The present invention relates to a magnetic resonance imaging (MRI) contrast medium containing a gadolinium complex, and more specifically, to a DO3A-tranexamic acid compound having a structure of chemical formula 1, or an ester compound...  
WO/2015/100267A1
Embodiments provided herein relate to methods and compositions for treating cancer. Some embodiments relate to certain compounds having activity against retinoid X receptor-alpha (RXRa). Some embodiments included designing or identifying...  
WO/2015/090635A1
The present invention discloses the process for the preparation of candesartan cilexetil comprising the steps of hydrogenation of N02group of 1-(((cyclohexyloxy)carbonyl)oxy)ethyl 2-((tert-butoxycarbonyl)((2'-(1-tntyl-1H-tetrazol-5-yl)-[...  
WO/2015/092740A1
The present invention describes novel heteroaryl butanoic acid derivatives that are good drug candidates especially with regard to leukotriene A4 hydrolase (LTA4H). The present invention also relates to pharmaceutical compositions compri...  
WO/2015/089639A1
The present application is directed to excimer forming compounds of Formula I: W-V-[Y]n wherein W is an excimer forming fluorophore, V is a linker moiety, Y is a metal ion coordinating moiety and n is 1, 2 or 3. In particular, the applic...  
WO/2015/091463A1
A compound of Formula (1) wherein R1 represents hydrogen, halo, a C1-C4 alkyl group, a C1-C4 alkylhalide group, a C1-C4 alkoxy-C2-C4 alkyl group, a C2-C4 alkenyl group, a C2-C4 alkynyl group or a C3- C7 cyclo alkyl group; R2 represents F...  
WO/2015/078802A1
The present invention relates to compounds of general formula (I), wherein the groups R1, R2, R3, X, m and n are defined as in claim 1, wich have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate ...  
WO/2015/077451A1
The present invention relates to N-phenyl carbamate derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide 2 receptor.  
WO/2015/064727A1
The tetrazolinone compound of the present invention, represented by formula (1) [In the formula, R1 represents a C1-6 alkyl group or the like; R2, R3, and R4 are the same or different and represent hydrogen atoms or the like; R5 represen...  
WO/2015/061515A1
The present invention is directed to crystalline forms of a compound which has retinoid-related orphan receptor gamma (RORy) modulator activity, processes for their preparation, pharmaceutical compositions containing the same and their u...  
WO/2015/060461A1
A tetrazolinone compound represented by formula (1) (1) [In the formula, R1 and R2 are each a hydrogen atom, halogen atom, C1-C3 alkyl group, etc., R3 is a C1-C3 alkyl group which may have one or more halogen atoms, etc., R4, R5 and R6 a...  
WO/2015/056219A1
The present invention provides a process for the preparation of micronized valsartan, wherein the process involves simultaneous drying and micronization steps. The invention also provides micronized valsartan substantially free of ethyl ...  
WO/2015/054658A1
Provided herein are modified amino acids comprising a tetrazine groups according to Formula I: polypeptides, antibodies, payloads and conjugates comprising these modified amino acid residues derived from the modified amino acids, and met...  
WO/2015/046480A1
A tetrazolinone compound represented by formula (1) (In the formula: Q is (In the formula, R21, R22, R23, R24, and R27 are a hydrogen atom, etc.), etc.; R1 and R2 are each a hydrogen atom, etc.; R3 is a C1 to C6 alkyl group, etc. which m...  
WO/2015/044173A1
The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing medicaments for the treatment and/or prophylaxis of diseases, in particula...  
WO/2015/044170A1
The invention relates to substituted phenylalanine derivatives of formula (I), in which R1 stands for a group of formula (II) or formula (III), R2 stands for hydrogen, fluorine, chlorine, methyl, or methoxy, R3 stands for hydrogen, fluor...  
WO/2015/044163A1
The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing drugs for the treatment and/or prophylaxis of diseases, in particular card...  
WO/2015/044169A1
The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing drugs for the treatment and/or prophylaxis of diseases, in particular card...  
WO/2015/044167A1
The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing medicaments for the treatment and/or prophylaxis of diseases, in particula...  
WO/2015/030217A1
A tetrazolinone compound shown by formula (1) [in the formula, R1, R2, R3, R6, R7, R8, R9, R10, and R11 each independently represent a C1-C6 alkyl group, etc., optionally having one or more halogen atoms; R4 and R5 each independently rep...  
WO/2015/031295A1
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, vi...  
WO/2015/028669A1
The present invention relates to compounds of formula (I), their method of preparation and use thereof in particular in the fields of optoelectronic, photonic, photovoltaics and biology. (I)  
WO/2015/016373A1
A tetrazolinone compound represented by formula (1) (in the formula, R1, R2, R3, and R11 each represent a halogen atom, a C1-C6 alkyl group, or the like; R4 and R5 each represent a hydrogen atom, a halogen atom, a C1-C3 alkyl group, or t...  
WO/2015/008229A1
The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.  
WO/2015/006520A1
There are disclosed compounds of Formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, suc...  
WO/2015/005499A1
A tetrazolinone compound represented by formula (1) has excellent control efficacy on pests. (1) [In the formula: Q is a 6-membered aromatic heterocyclic group which may have one or more atoms or groups selected from group P1 (provided t...  
WO/2015/002918A1
There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, suc...  
WO/2014/207206A1
The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium p...  
WO/2014/202510A1
The invention relates to aryl sulfide derivatives and aryl sulfoxide derivatives, use thereof as acaricides and insecticides for controlling animal pests, and methods and intermediate products for the production thereof. The aryl sulfide...  
WO/2014/202827A1
Compounds of formula (I), wherein R1 to R8 A, B, Z1 and Z2 are as defined in the claims and pharmaceutically acceptable salts and esters thereof are disclosed. The compounds of formula (I) possess utility as androgen receptor antagonists...  
WO/2014/198592A1
The invention relates to a compound of formula (I), wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.  
WO/2014/201161A1
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.  
WO/2014/193974A1
The instant invention describes tetrazole compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.  
WO/2014/184016A1
The invention relates to N-(tetrazol-5-yl)-and N-(triazol-5-yl)arylcarboxamides of formula I and their use as herbicides. In said formula I, B represents N or CH, R2 represents alkoxy, haloalkoxy, alkoxyalkoxy and R2b-S(O)k, whereas R, R...  
WO/2014/184015A1
N-(tetrazol-5-yl)-and N-(triazol-5-yl)arylcarboxamides of formula (I) and their use as herbicides. The invention relates to N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of formula (I) and their use as herbicides. In said formu...  
WO/2014/184503A1
The invention relates to dendritic compounds including a chelating, fluorochrome or recognition agent of formula (I), to compositions including same, and to the uses thereof, wherein in said formula (I): T, L1, D, R, L2, V and n are such...  

Matches 401 - 450 out of 4,492