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Matches 1 - 50 out of 5,558

Document Document Title
WO/2018/005591A1
The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of ...  
WO/2018/004338A1
Disclosed is an advancement in provoked chemical cleavage. Thereby the invention provides the use of a diene as a chemically cleavable group attached to a Construct, and the use of a dienophile to provoke the release of the Construct by ...  
WO/2017/218344A1
Described are methods of treating or reducing the toxic effects of exposure to a nerve agent, comprising administering to a subject in need thereof (i) an AMPA/GluR5(GluK1) kainate receptor antagonist (such as LY293558) and (ii) an NMD A...  
WO/2017/195149A1
Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases.  
WO/2017/192304A1
The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic di...  
WO/2017/191619A2
The present invention provides a process for the preparation of a salt of sacubitril and valsartan. Specifically, the present invention provides a process for the preparation of a sodium salt of sacubitril and valsartan.  
WO/2017/188551A1
The present invention relates to a novel N-acylurea derivative and use thereof in the treatment or prevention of cardiovascular diseases and, more particularly, to a novel N-acylurea derivative, a pharmaceutical composition comprising th...  
WO/2017/189692A1
The invention described herein relates to methods for treating cancer in a subject by administering an effective amount of a CXCL12 signaling inhibitor and a subtherapeutic amount of an anti-cancer agent, e.g., a chemotherapeutic agent.  
WO/2017/180323A1
The present invention relates to phenyl urea derivatives useful for the treatment of inflammatory diseases, pharmaceutical compositions containing them and their use as tools or as pharmaceuticals as modulators of the N-formyl peptide re...  
WO/2017/178301A1
The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, th...  
WO/2017/177004A8
Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation ...  
WO/2017/177004A1
Compunds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation o...  
WO/2017/168451A1
The present invention provides derivatives of imidazole and benzimidazole based thiones and selones used for degrading various toxic heavy metal and salts thereof to a less toxic, stable and insoluble form. The present invention also pro...  
WO/2017/171657A1
A device and a method for detection of an acryloyl group in a sample are provided. The device comprises a first device coupleable to a second device having a transceiver and a camera for detection of an acryloyl group in a sample, the fi...  
WO/2017/168451A4
The present invention provides derivatives of imidazole and benzimidazole based thiones and selones used for degrading various toxic heavy metal and salts thereof to a less toxic, stable and insoluble form. The present invention also pro...  
WO/2017/165473A1
Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer are disclosed.  
WO/2017/165558A1
The invention provides compounds, compositions, and methods for treating pain.  
WO/2017/161356A1
Disclosed are novel compounds, complexes, compositions and methods using Zirconium-89 combined with azamacrocyclic chelators in connection with PET. The compositions and methods should provide better diagnostic, prognostic and therapeuti...  
WO/2017/153235A1
The invention relates to novel substituted N-cyclo-3-aryl-1-naphthamide derivatives, to methods for producing same, to the use thereof, either alone or in combination, for the treatment and/or prevention of diseases, and to their use for...  
WO/2017/154991A1
[Problem] To provide a novel temperature-responsive compound which exhibits a good self-assembling function. [Solution] A temperature-responsive compound represented by formula (1) [wherein R's independently represent a group represented...  
WO/2017/142221A1
The present invention relates to a novel preparation method for tri-tertiary-butyl-2,2',2''-(1,4,7,10-tetraazacyclododecane- 1,4,7-triyl)triacetate and, more particularly, to a method for synthesizing tri-tertiary-butyl-2,2',2''-(1,4,7,1...  
WO/2017/137770A1
According to the invention there is provided acompound of formula I, wherein R1 and R2 have meanings given in the description,which compounds are useful in the treatment of skin disorders and other diseases.  
WO/2017/136589A1
Aspects of the present disclosure include compounds that activate Nrf2. Such compounds find use in the treatment of autoimmune and inflammatory diseases and disorders, such as for example psoriasis and multiple sclerosis. Embodiments of ...  
WO/2017/131213A1
Provided is a method for producing, at a high yield, a 1H-tetrazole derivative using a flow reactor and using an azide compound and a cyanide compound as starting materials. The method of producing a 1H-tetrazole derivative of the presen...  
WO/2017/132661A3
Imipridones has been found to selectively modulate Class A G protein-coupled receptors (GPCRs), such as the D2-like subfamily of dopamine receptors, and to be useful for the treatment of conditions and disorders in need of such modulatio...  
WO/2017/124835A1
The present invention discloses a compound (I) having 1-sulfonamido-4-aryloxy as a basic backbone. A preliminary activity test showed that the compound of the present invention provides excellent interference of a binding of NRF2 by KEAP...  
WO/2017/122209A2
Disclosed herein are compounds capable of inhibiting dimerization of NF-κB, for example, p65-p65 homodimerization and/or p50-p65 heterodimerization, the compounds being represented by formula I: X-L2-L1-L'2-Y Formula I wherein X, Y, L1,...  
WO/2017/106427A1
A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein one R group on the dihydrotetrazine 1 is a substituted or unsubstituted aryi, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing ...  
WO/2017/106253A1
Conformationally strained irans-cycloalkenes and derivatives thereof suitable for radiolabeling in a subject in need thereof.  
WO/2017/102275A1
The invention relates to a compound of formula (I), an N-oxide or an agriculturally suitable salt thereof, wherein the variables are as defined in the specification, and their use as herbicides.  
WO/2017/103258A1
The present invention provides methods for the preparation of compounds useful in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,...  
WO/2017/097085A1
Disclosed is a preparation method for a eutectic hydrate crystal form II of AHU-377 and diovan trisodium salt, comprising: firstly, obtaining a clear solution of an AHU-377 and diovan trisodium salt compound, a solvent of the clear solut...  
WO/2017/098038A1
The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Re...  
WO/2017/099530A1
Disclosed is a method of preparing an intermediate for an oxazolidinone derivative, which enables 5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine to be produced at high yield and high purity, thus exhibiting high preparation efficiency und...  
WO/2017/096772A1
Disclosed is a method for preparing an anti-heart-failure medicine LCZ696. The preparing method comprises the following steps (formula (I)): in an organic solvent, a sacubitril dicyclohexylamine salt reacts with valsartan under the effec...  
WO/2017/098044A1
The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance...  
WO/2017/093351A1
The invention relates to the provision of novel inhibitors for the cytosolic phospholipases A2, the inhibitors having a special metabolization stability.  
WO/2017/093263A1
The present invention relates to a process for the synthesis of 3,6 functionalized 1,2,4,5-tetrazine compounds of formula (I); wherein A and B being the same; and wherein at least one of R1, R1', R2 and R2' and at least one of R10 and R1...  
WO/2017/091041A1
The present invention provides: a novel salt of Fimasartan having excellent solubility, bioavailability, and physicochemical properties; a method for preparing the same; and a pharmaceutical composition containing the same.  
WO/2017/080443A1
A class of compounds of monosulfonic phenyltetrazole, with the structure of 2- (R1 phenyl) -5 (2-sulfonic phenyl) -2H-tetrazole. The 2-sulfonic phenyl tetrazolium salt of this invention has advantages of low toxicity, short synthetic rou...  
WO/2017/082620A1
The present invention relates to a peptide thiourea derivative, a pharmaceutically acceptable salt thereof, a radioisotope labeled compound containing the same, and a pharmaceutical composition containing the same as an active ingredient...  
WO/2017/080290A1
Provided a complex of formula is [3-((1S, 3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate- (S)-3'-methyl-2'- (pentanoyl {2''-(tetrazol-5-ylate) biphenyl-4'-ylmethyl}amino) butyrate] 6·XCa2+·YNa+·ZH2O, wherein ...  
WO/2017/055146A1
Described are acylated N-(1,2,5-oxadiazole-3-yl)-, N-(1,3,4-oxadiazole-2-yl)-, N-(tetrazole-5-yl)- and N-(triazole-5-yl)-aryl carboxamides of formula (I) and the use thereof as herbicides. In said formula (I), R, V, X, Y, and Z are group...  
WO/2017/059303A1
Provided herein are vinylogous thioester compounds and methods for using the compounds.  
WO/2017/053564A1
An especially robust compound and its derivative metal complexes that are approximately one hundred-fold superior in catalytic performance to the previously invented TAML analogs is provided having the formula (I) wherein Y1, Y2, Y3 and ...  
WO/2017/049096A1
The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, and/or a compound of 14 or 14*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to prov...  
WO/2017/049080A1
The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compounds 7, 7* and ...  
WO/2017/037596A1
The present application relates to amorphous solid dispersion of LCZ-696 with one or more pharmaceutically acceptable carrier. Specifically, the present application relates to amorphous solid dispersion of LCZ-696 with one or more pharma...  
WO/2017/037639A1
The present invention relates to an improved process for the preparation of xylene linked cyclam compounds. More particularly the invention provides a process for preparation of high purity plerixafor which does not involve the use of ex...  
WO/2017/037591A1
The present invention relates to a process for preparing amorphous form of Sacubitril / Valsartan sodium salt of Formula-II and pharmaceutical composition comprising thereof.  

Matches 1 - 50 out of 5,558