Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 5,623

Document Document Title
WO/2018/158592A1
A process for preparing a tetra-substituted aminobiphenol macrocyclic ligand having the structure (I), comprising the step of treating a precursor compound having the structure (II) with a compound having the structure R6-L where L repre...  
WO/2018/158131A1
The invention relates to a method for the production of fluoroalkyl nitriles and of the corresponding fluoroalkyl tetrazoles, proceeding from fluorinated carboxylic acid amides.  
WO/2018/140339A1
Disclosed are compounds of formula (I) below and pharmaceutically acceptable salts thereof: (I), in which each of variables R1, R2, R3, R4, R5, A1, A2, A3, A4, X and Y is defined herein. Also disclosed are methods for reducing the glycem...  
WO/2018/120923A1
Disclosed is a method for preparing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) of formula (II), comprising the following steps: carrying out an alkylation reaction on cyclen in formula (I) and XCH2COOR in the presenc...  
WO/2018/122325A1
The present invention pertains to a system of collaborative modifiers that are assembled into a multi molecule complex in vivo within a cell using bioorthogonal chemical reactions. The system of the invention is composed of multiple bind...  
WO/2018/114541A2
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.  
WO/2018/114783A1
The present invention relates to tetrazole containing compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufa...  
WO/2018/114541A3
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.  
WO/2018/110669A1
Disclosed is a compound of formula (I): wherein all symbols are defined in the description. Also disclosed are pharmaceutical compositions comprising the compounds, methods of making the compounds, kits comprising the compounds, and meth...  
WO/2018/108780A1
The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for M...  
WO/2018/097318A1
The present invention provides a tetrazolinone represented by formula (I) and a pest control agent comprising the same, and their use thereof. Formula (I) [wherein, W1 represents an oxygen atom or a sulfur atom; W2 represents a hydrogen ...  
WO/2018/096082A1
The present invention relates to a new class of high relaxivity extracellular gadolinium chelate complexes, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.  
WO/2018/097431A1
The present invention provides a composition for protecting the skin from heavy metals and formaldehyde, comprising at least one selected from the group consisting of trientine or trientine derivative of Formula (1), cyclen or cyclen der...  
WO/2018/093447A3
Described are methods for purifying a 5-nitrotetrazolate solution with a copper(II) modified cation exchange resin. The method can be performed as a stand-alone system or as a system integrated into a continuous flow reactor.  
WO/2018/089402A1
There are described RORγ Gamma modulators of the formula (I), (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutic...  
WO/2018/081047A1
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: (Formula (I)) wherein R1, R2, R3, A, W, L, R...  
WO/2018/073157A1
The invention relates to a method for producing 3-alkylsulfanyl-2-chloro-N-(1-alkyl-1H-tetrazol-5-yl)-4-trif luoromethyl-benzamides of formula (I). In said formula, the substituents R1 and R2 represent residues such as alkyl and substitu...  
WO/2018/059914A1
A method is described for production of a high purity compound of the formula (I) in crystalline form of the modification A. In this, starting from high purity gadobutrol, the gadolinium is removed by decomplexation with oxalic acid, and...  
WO/2018/055133A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.  
WO/2018/056546A1
Provided are: a compound represented by a particular chemical formula; a core shell dye which comprises a core comprising the compound, and a shell covering the core; a photosensitive resin composition comprising the core-shell dye; and ...  
WO/2018/051252A2
An object of the present invention is to provide an amide compound or a salt thereof that controls a mite. The present invention provides an amide compound represented by Formula (1) : or a salt thereof, wherein R1 represents C1-6 alkyl ...  
WO/2018/051197A1
The present invention relates to the preparation of a series of chiral DOTA, D03A, D02A, DO1A, cyclen and their metal complexes, which display properties superior to those of previous DOTA- based compounds, and hence are potentially valu...  
WO/2018/051252A3
An object of the present invention is to provide an amide compound or a salt thereof that controls a mite. The present invention provides an amide compound represented by Formula (1) : or a salt thereof, wherein R1 represents C1-6 alkyl ...  
WO/2018/040065A1
Provided are crystal forms A, B, D, E, F, G, and H of valsartan disodium salt, and a preparation method therefor.  
WO/2018/029150A1
The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I). Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GP...  
WO/2018/014140A1
Disclosed herein is a method for multimodal imaging during a medical procedure using magnetic resonance imaging (MRI) and Raman optical imaging which involves administering an MRI imaging contrast agent that a chemical structure having c...  
WO/2018/005591A1
The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of ...  
WO/2018/004338A1
Disclosed is an advancement in provoked chemical cleavage. Thereby the invention provides the use of a diene as a chemically cleavable group attached to a Construct, and the use of a dienophile to provoke the release of the Construct by ...  
WO/2017/218344A1
Described are methods of treating or reducing the toxic effects of exposure to a nerve agent, comprising administering to a subject in need thereof (i) an AMPA/GluR5(GluK1) kainate receptor antagonist (such as LY293558) and (ii) an NMD A...  
WO/2017/195149A1
Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases.  
WO/2017/192304A1
The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic di...  
WO/2017/191619A2
The present invention provides a process for the preparation of a salt of sacubitril and valsartan. Specifically, the present invention provides a process for the preparation of a sodium salt of sacubitril and valsartan.  
WO/2017/188551A1
The present invention relates to a novel N-acylurea derivative and use thereof in the treatment or prevention of cardiovascular diseases and, more particularly, to a novel N-acylurea derivative, a pharmaceutical composition comprising th...  
WO/2017/189692A1
The invention described herein relates to methods for treating cancer in a subject by administering an effective amount of a CXCL12 signaling inhibitor and a subtherapeutic amount of an anti-cancer agent, e.g., a chemotherapeutic agent.  
WO/2017/180323A1
The present invention relates to phenyl urea derivatives useful for the treatment of inflammatory diseases, pharmaceutical compositions containing them and their use as tools or as pharmaceuticals as modulators of the N-formyl peptide re...  
WO/2017/178301A1
The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, th...  
WO/2017/177004A8
Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation ...  
WO/2017/177004A1
Compunds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation o...  
WO/2017/168451A1
The present invention provides derivatives of imidazole and benzimidazole based thiones and selones used for degrading various toxic heavy metal and salts thereof to a less toxic, stable and insoluble form. The present invention also pro...  
WO/2017/171657A1
A device and a method for detection of an acryloyl group in a sample are provided. The device comprises a first device coupleable to a second device having a transceiver and a camera for detection of an acryloyl group in a sample, the fi...  
WO/2017/171657A9
A device and a method for detection of an acryloyl group in a sample are provided. The device comprises a first device coupleable to a second device having a transceiver and a camera for detection of an acryloyl group in a sample, the fi...  
WO/2017/168451A4
The present invention provides derivatives of imidazole and benzimidazole based thiones and selones used for degrading various toxic heavy metal and salts thereof to a less toxic, stable and insoluble form. The present invention also pro...  
WO/2017/165473A1
Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer are disclosed.  
WO/2017/165558A1
The invention provides compounds, compositions, and methods for treating pain.  
WO/2017/161356A1
Disclosed are novel compounds, complexes, compositions and methods using Zirconium-89 combined with azamacrocyclic chelators in connection with PET. The compositions and methods should provide better diagnostic, prognostic and therapeuti...  
WO/2017/153235A1
The invention relates to novel substituted N-cyclo-3-aryl-1-naphthamide derivatives, to methods for producing same, to the use thereof, either alone or in combination, for the treatment and/or prevention of diseases, and to their use for...  
WO/2017/154991A1
[Problem] To provide a novel temperature-responsive compound which exhibits a good self-assembling function. [Solution] A temperature-responsive compound represented by formula (1) [wherein R's independently represent a group represented...  
WO/2017/142221A1
The present invention relates to a novel preparation method for tri-tertiary-butyl-2,2',2''-(1,4,7,10-tetraazacyclododecane- 1,4,7-triyl)triacetate and, more particularly, to a method for synthesizing tri-tertiary-butyl-2,2',2''-(1,4,7,1...  
WO/2017/137770A1
According to the invention there is provided acompound of formula I, wherein R1 and R2 have meanings given in the description,which compounds are useful in the treatment of skin disorders and other diseases.  
WO/2017/136589A1
Aspects of the present disclosure include compounds that activate Nrf2. Such compounds find use in the treatment of autoimmune and inflammatory diseases and disorders, such as for example psoriasis and multiple sclerosis. Embodiments of ...  

Matches 1 - 50 out of 5,623