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Matches 1 - 50 out of 5,881

Document Document Title
WO/2020/181165A1
Provided herein are compounds of formula (I), compositions comprising the compounds and method of treating various diseases with the compounds and compositions.  
WO/2020/051207A3
The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presenc...  
WO/2020/154892A1
Provided are a preparation method and application of a gadolinium ionic contrast agent intermediate. The method for preparation comprises the following steps: a substance represented by the general formula (II) and a substance represente...  
WO/2020/148175A1
The invention relates to acryl carboxamides of the general formula (I) as herbicides. In formula (I) RX, X, Y and Z represent radicals such as alkyl and halogen.  
WO/2019/240884A3
A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(=O)NHRa;...  
WO/2020/150210A1
The present disclosure relates to compounds of formula (AI), (I), (AII), and (II), or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof, a pharmaceutical composition comprising a compound of formula (AI), (I)...  
WO/2020/141723A1
The present invention relates to a preparation method for synthesizing highly pure calcobutrol without using highly pure gadobutrol, via the preparation of highly pure butrol through a purification step of butrol which is an intermediate...  
WO/2020/127644A1
Bi-functional nanohybridscomprising a nanoparticle to the surface of which are covalently coupledchemical functions, one of which being biorthogonal, and their use as support for catalysts.  
WO/2020/097400A8
The present disclosure provides compounds of Formula (I´) (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, cocrystals, tautomers, stereoisomers, isotopically labeled derivatives, a...  
WO/2020/108720A1
The present invention relates to novel tetrazine compounds of formula I, wherein one of R1-R5 is 18F, for use in pretargeted in vivo imaging. The compounds are suitable for use in click chemistry, i.e. reactions that join a targeting mol...  
WO/2020/104822A1
The present invention relates to a compound of formula (Ia), or a pharmaceutically acceptable salt or hydrate thereof, wherein: the group X-Y is -NHSO2- or -SO2NH-; R1 is H or alkyl; R2 is selected from COOH and a tetrazolyl group; R3 is...  
WO/2020/094999A1
The present invention concerns a product characterised in that it has the structure of the following general formula (I): in which R1, R2, R3, R4, Mn+, "Solid support", the bond "~~~" and the bond "¯¯¯¯" between the carbon of the C6H...  
WO/2020/097400A1
The present disclosure provides compounds of Formula (I´) (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, cocrystals, tautomers, stereoisomers, isotopically labeled derivatives, a...  
WO/2020/084504A1
The present invention relates to an improved process for the preparation of macrocyclic chelant 2,2',2''-(10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecan e-1,4,7-triyl) triacetic acid of formula (1). The present invention further rela...  
WO/2020/079078A1
The present invention relates to compounds Formula (I): wherein R1, R2, R3, R4, R5 and R6 are as defined herein. The invention further relates to compositions comprising said compounds, and methods of controlling weeds using said compoun...  
WO/2020/059841A1
The purpose of the invention is to provide a compound which has the effect of suppressing abnormal prion production and is useful as a therapeutic agent for prion diseases. Provided are a compound represented by formula (I) (the symbols ...  
WO/2020/049436A1
The present invention relates to a method for the preparation of fluoroalkyl nitrile of Formula I and their use to prepare related fluoroalkyl tetrazole of Formula II in the presence of the dehydrating agent, wherein, x1 and x2 have the ...  
WO/2020/051207A2
The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presenc...  
WO/2020/051206A1
Stress responses involve corticotropin releasing factor (CRF), the two cognate receptors (CRFi and CRF 2 ) and the CRF-binding protein (CRFBP). Utilizing a novel cell-based assay, a C-terminal CRFBP fragment [CRFBP(IOkD)] was found to po...  
WO/2020/043866A1
A compound for use in the treatment of a disease ameliorated by the inhibition of Notum of formula (I): (I)  
WO/2020/043831A1
The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof useful as inhibitors of Cyclophilins and modulators of cyclophilin-like proteins. The invention also relates to uses of said compound...  
WO/2020/043087A1
A method for human serum albumin (HSA) detection in a biological fluid using small molecule, fluorescent compounds having aggregation-induced emission (AIE) characteristics includes contacting the biological fluid with a fluorescent comp...  
WO/2020/040617A1
The present invention provides a novel method for producing gadobutrol of high purity or a hydrate thereof. Unlike the conventional method for synthesizing gadobutrol, the production method of the present invention can simplify the proce...  
WO/2020/040448A1
The present invention relates to a method for synthesis of TKX-50 using an insensitive intermediate and, more specifically, to a method for producing TKX-50, the method comprising the steps of: preparing DCG as a starting material; formi...  
WO/2020/027304A1
Provided are carotenoid derivatives having exceptional hydrophilicity and oral absorptivity. A carotenoid-related compound represented by the formula (in the formula, X represents a carbonyl group or a methylene group, and Z1 and Z2 are ...  
WO/2020/019994A1
Disclosed is a compound having a neuroprotective effect, a preparation method therefor and a use thereof. In particular, disclosed is a compound as shown in general formula A or a pharmaceutically acceptable salt thereof. Also disclosed ...  
WO/2020/020851A1
The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.  
WO/2020/020849A1
The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.  
WO/2020/020850A1
The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.  
WO/2020/012372A1
The present invention relates to an improved process for the preparation of 2,2',2''-(10-((2R,3S)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid, gadolinium (III) with iron metal content less than...  
WO/2020/010643A1
A method for synthesizing valsartan, comprising the steps of: synthesizing a valsartan methyl ester intermediate to obtain a reaction mixture of the valsartan methyl ester intermediate; diluting the reaction mixture by salt water or wate...  
WO/2019/241594A8
Provided herein are DOTA-containing compounds (e.g., compounds of Formula (I)) and complexes that are reactive with an enzyme activator (e.g., a peroxidase) and covalently bind a target analyte (e.g., a protein) in a catalyzed reporter d...  
WO/2020/006177A1
Disclosed herein are small molecule Vascular Adhesion Protein- 1 (VAP-1) modulator compositions, pharmaceutical compositions, the use and preparation thereof.  
WO/2019/243799A1
The present disclosure relates to a hybrid salt/co-crystal of sacubitril. The present disclosure is also related to processes for the preparation of the hybrid salt/co-crystal of sacubitril. In addition, the present disclosure is related...  
WO/2019/243358A1
The present invention relates to compounds Formula (I): wherein Q, R2, R3, R4 and R5 are as defined herein. The invention further relates to compositions comprising said compounds, and methods of controlling weeds using said compounds an...  
WO/2019/246445A1
The present invention provides a compound having the structure: and methods of using the compound in targeted PET imaging.  
WO/2019/241594A1
Provided herein are DOTA-containing compounds (e.g., compounds of Formula (I)) and complexes that are reactive with an enzyme activator (e.g., a peroxidase) and covalently bind a target analyte (e.g., a protein) in a catalyzed reporter d...  
WO/2019/239432A1
The present invention relate to trisodium sacubitril valsartan complex with polymer as an extrudate and to a hot melt extruded pharmaceutical composition comprising, trisodium salt of valsartan sacubitril and at least one pharmaceuticall...  
WO/2019/236988A1
Provided herein are methods, reagents, and kits for isolating polypeptides, such as a proteome. Also provided herein is a modified trypsin polypeptide that is resistant to autolysis, and that can be selectively-separated from a biologica...  
WO/2019/232724A1
The present invention relates compounds of Formula (I) - (V), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as nuclear transport modulators. The present i...  
WO/2019/226490A1
Provided is a compound of Formula (I), wherein the variable groups are defined herein.  
WO/2019/191502A4
This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanod...  
WO/2019/212356A1
Disclosed herein are tetrazines substituted with groups that result in a high click conjugation yield in vivo and high click release yields. In one aspect, the invention relates to kits comprising said tetrazines and a dienophile, prefer...  
WO/2019/213579A1
Disclosed herein are compounds having antiviral activity, and, in particular, an inhibitory activity on the replication of Respiratory Syncytial Virus (RSV). Druggable target sites, including Px, in the RSV N protein are disclosed, as we...  
WO/2019/206695A1
The invention relates to a process for the preparation of 1-(2-methoxymethyl-3- methylphenyl)4H-tetrazolin-5-one, comprising a step of reacting an isocyanate compound with an azide salt in a solvent and in the presence of a silicon deriv...  
WO/2019/206696A1
The invention relates to a process for the preparation of a tetrazolinone compound, comprising a step of reacting an isocyanate compound with an azide salt in a solvent and in the presence of a silicon derivative as a catalyst.  
WO/2019/203191A1
The present invention relates to a labeling technique with which, without deterioration in the function of an antibody, metabolization in the liver after administration to a patient is facilitated and accumulation of radionuclides in org...  
WO/2019/191502A1
This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanod...  
WO/2019/183587A1
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurolo...  
WO/2019/182395A1
In the compound of the present invention and in an anti-inflammatory agent, a cyclooxygenase-2 inhibitor, a therapeutic agent for brain diseases, and an MRI contrast medium, which each comprise the same compound, the compound of the pres...  

Matches 1 - 50 out of 5,881