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Matches 1 - 50 out of 5,750

Document Document Title
WO/2019/162313A1
The invention relates to a process for producing a contrast agent-containing pharmaceutical preparation, which contains as the contrast agent a complex of a lanthanide, in particular gadolinium, and a macrocyclic chelate, in particular D...  
WO/2019/162309A1
The present invention relates to benzamide compounds of formula I (I) wherein the variables are defined as in the claims and the description, the N-oxides and salts thereof,and to compositions comprising the same. The invention also rela...  
WO/2019/157037A1
Small molecule radiohalogenated PSMA inhibitors and metal complexes thereof and their use in radioimaging and radiotherapy for treating PSMA-related diseases, including prostate cancer, are disclosed. The combination of small molecule ra...  
WO/2019/154974A1
The present invention discloses thermally stable free thiophene croconaine dyes of formula (I), where R1-R4 are 1-20C alkyl or alkenyl groups, and their even more thermally stable complexes with anthracenyl-tetralactam macro molecules, w...  
WO/2019/147912A1
The present invention is directed to radiopharmaceuticals with improved stability, a kit, and a method of production thereof.  
WO/2019/143074A1
Disclosed is a method for producing calcobutrol used as an MRI contrast agent. The method for producing calcobutrol comprises the steps of: obtaining butrol represented by chemical formula 2 in the specification by reacting gadobutrol re...  
WO/2019/141740A1
The present invention related to compounds of Formula (I): or an agronomically acceptable salt thereof, wherein Q, X, Z, R2 and R3 are as described herein. The inventions further relates to compositions comprising said compounds, to meth...  
WO/2019/143073A1
Disclosed are an intermediate for gadoteridol used as an MRI contrast agent, and a method for preparing gadoteridol using same. Provided, as a gadoteridol intermediate, is 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane, which is rep...  
WO/2019/142192A1
Novel compounds capable of inhibiting methionine metabolic pathway are provided. These compounds are used in inhibiting cystathionin γ-synthase (CGS) in general, and in plants, fungi and bacteria, in particular. These compounds of the i...  
WO/2019/138323A1
This invention relates to compounds of formula 1, 2 or 3, Formulae (1), (2), (3), a pharmaceutically acceptable salt, or a solvate thereof, wherein X1, Y, R1, R2, R3, R4, and R5 are as defined herein. The compounds are antimicrobial agen...  
WO/2019/134993A1
The present invention relates to benzamide compounds of formula (I), the N-oxides and the salts thereof (I), where the variables are as defined in the claims and the description. The invention also relates to compositions comprising such...  
WO/2019/134765A1
The invention concerns a sartan analogue on basis of a sartan which sartan comprises an alkyl group or an alkoxy group, wherein the sartan analogue only differs from the sartan by a replacement of the alkyl group or the alkoxy group or r...  
WO/2019/127994A1
The present invention relates to a sacubitril sodium salt as represented by formula IV, a eutectic of sacubitril free acid and acetic acid, a crystal form of the eutectic and a preparation method for the crystal form, and a method for us...  
WO/2019/132782A1
A compound of formula (I) or a salt, solvate or prodrug thereof: wherein R1 and R4 are independently selected from C1-C5 alkyl, C1-C5 haloalkyl, C1-C5 alkenyl, C1-C5 haloalkenyl, C1-C5 alkynyl, C1-C5 haloalkynyl, C1-C5 alkoxy or C1-C5 ha...  
WO/2019/122345A1
The present invention relates to benzamide compounds of formula I wherein the variables are defined as in the claims and the description, the N-oxides and salts thereof,and to compositions comprising the same. The invention also relates ...  
WO/2019/105995A1
The present invention relates to benzamide compounds of formula (I), their N-oxides and salts thereof and to compositions comprising the same. The invention also relates to the use of the benzamide compounds or of the compositions compri...  
WO/2019/106182A1
The present invention relates to compounds of general formula (I) for chromatographic separation of rare earth elements and/or s-, p-, d- metals, as well as to the method of the separation of rare earth elements.  
WO/2019/101729A1
The present invention relates to a compound or a pharmaceutically acceptable salt thereof of formula (I) wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of ra...  
WO/2019/096884A1
The invention relates to benzoyl amides of general formula (I), as herbicides. In formula (I), B is N or CH, and X1 and X2 are O or S(O)n. R, Ra and Rb are groups such as hydrogen, halogen, (C1-C6)-alkyl, halogen-(C1-C6)-alkyl, (C1-C6)-a...  
WO/2019/091389A1
Fluorescent probes for silver ion detection include organic, water-soluble compounds having aggregation-induced emission (AIE) characteristics. The probes can sense or detect silver ions through aggregation or a precipitation reaction be...  
WO/2019/092086A1
The present invention relates to tetrazolylpropyl derivatives of formula (I) wherein one of V1 and V2 represents CR3 and the other one of V1 and V2 represents N, Q represents a 6- membered aromatic cycle as defined in the specification, ...  
WO/2019/079485A1
The present disclosure relates to amine-substituted heterocyclic compounds and derivatives thereof. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., c...  
WO/2019/075136A1
The present disclosure provides compounds and methods of use thereof for treating inflammatory diseases or disorders.  
WO/2019/070236A1
The present invention is directed to a compound of Formula III or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt: Formula III wherein ...  
WO/2019/068177A1
This application relates to a method of detecting negatively charged phosphate- containing membranes and membrane components, such as in cell membranes or artificial lipid vesicles, and its use, for example, in detecting apoptosis and ba...  
WO/2019/046931A1
Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions invol...  
WO/2019/040992A1
The invention relates to oleoyl-lysophosphatidylinositol (oleoyl-LPI) and new synthetic derivatives thereof and uses thereof, and to pharmaceutical compositions comprising such compounds. The invention provides activators and/or up-regul...  
WO/2019/045436A1
Disclosed are: an intermediate capable of high-purity synthesis of gadobutrol which can be used as an MRI contrast agent; and a gadobutrol production method using same. The gadobutrol intermediate is represented by Chemical Formula 2 in ...  
WO/2019/045581A1
New 5-aminotetrazole derivatives with antimicrobial and antifungal activity are disclosed.  
WO/2019/040585A1
Provided herein are improved methods of producing a derivative of PF1022A, for example a compound of Formula I: Formula I wherein R1 and R2 are each independently hydrogen or nitro, and at least one of R1 and R2 is nitro. In some embodim...  
WO/2019/034729A1
The invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, ...  
WO/2019/025540A1
The invention relates to 3-acyl-benzamides of formula (I) as herbicides. In formula (I) X, Y, Z and Rx represent radicals such as alkyl, cycloalkyl and halogen.  
WO/2018/203864A3
The invention relates to green primary explosive that can be used particularly at the defense industry developed for the purpose of eliminating the environmental pollution and negative impact on the human health caused by lead containing...  
WO/2019/018186A1
The present invention relates to metallo-β-lactamase inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to composition...  
WO/2019/016377A1
The present invention relates to novel lipophilic macrocyclic ligands, the complexes thereof, in particular radioactive complexes, and the uses of same in medical imaging and/or in therapy, in particular in interventional radiology.  
WO/2019/016385A1
The present invention relates to benzamide compounds of the formula (I) and the N-oxides and salts thereof and to compositions comprising the same. The variables are as defined in the claims and the description. The invention also relate...  
WO/2018/234371A1
The invention relates to benzamides of formula (I), wherein Q is Q1 or Q2 or Q3 or Q4, and the other variables are as defined in the claims and the description. The invention further relates to a composition comprising such compound and ...  
WO/2018/209366A3
A method of producing K2DNABT wherein a biztetrazole intermediate is nitrated using a nitrating agent selected from the following: dinitronium disulphate; a mixture of nitric acid and sulfuric acid; a mixture of nitric acid and phosphoro...  
WO/2018/230528A1
Provided are a novel nitrocatechol derivative having COMT inhibitory effect and DDC inhibitory effect or a salt thereof and a medicinal composition comprising the same. A compound represented by general formula (1) or a pharmaceutically ...  
WO/2018/228857A1
The invention relates to novel laser markable compositions comprising developing agent precursors according to formula (I).  
WO/2018/191707A3
Provided herein, are compositions and methods of treatment for neurodegenerative diseases, such as neurodegenerative diseases associated with aging and methods for increasing longevity by inhibiting the expression of the protein exportin...  
WO/2018/222778A1
Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer are disclosed.  
WO/2018/219935A1
The invention relates to benzamides of formula (I), wherein Q is Q1 or Q2 or Q3 or Q4 (formulae (Q1), (Q2), (Q3), (Q4)); and their use as herbicides. In said formula (I), R2 is R2cR2dNC(O)NR2n-Z2, both R4 and R5 are hydrogen, R1, R3 and ...  
WO/2018/219936A1
The invention relates to benzamides of formula (I), wherein Q is Q1 or Q2 or Q3 or Q4, and their use as herbicides. In said formula (I), R2 is R2cR2dNC(O)NR2n-Z2, R5 is hydrogen, R1, R3, R4 and R6 represent groups such as hydrogen, halog...  
WO/2018/215070A1
The present invention pertains to novel dual modulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the invention were designed to provide compounds which harbor a dual activity as agonists of FXR...  
WO/2018/215610A1
The present invention pertains to novel dual modulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the invention were designed to provide compounds which harbor a dual activity as agonists of FXR...  
WO/2018/216823A1
Provided are novel compounds represented by the following general formula [1] or pharmaceutically acceptable salts thereof, that inhibit LpxC, as well as pharmaceutical drugs comprising those compounds or pharmaceutically acceptable salt...  
WO/2018/209366A2
A method of producing K2DNABT wherein a biztetrazole intermediate is nitrated using a nitrating agent selected from the following: dinitronium disulphate; a mixture of nitric acid and sulfuric acid; a mixture of nitric acid and phosphoro...  
WO/2018/202535A1
Substituted benzoyl amides and their use as herbicides. The invention relates to benzoyl amides of general formula (I) as herbicides. In formula (I) X, R and Ra represent radicals such as alkyl, cycloalkyl and halogen. Q is a five-member...  
WO/2018/204532A1
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction betw...  

Matches 1 - 50 out of 5,750