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WO/2010/019098A1 |
The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a selected muscarinic receptor antagonist selected, and a second active ingredient which is a β2-adrenoceptor agonist, of ...
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WO/2010/019547A1 |
Disclosed herein are cannabinoid receptor ligands of formula (I), wherein Y, X1, X2, X3, R1, and R2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such...
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WO/2010/019100A1 |
The present invention relates to a novel crystalline form of 4- (5-{ (IR) -1- [5- (3-chlorophenyl) isoxazol-3-yl] ethoxy } -4- methyl-4H-l, 2, 4-triazol-3-yl) pyridine. Further, the present invention also relates to the use of the novel ...
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WO/2010/015613A1 |
The present invention relates to compounds of Formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain ...
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WO/2010/012442A2 |
The present invention relates to a novel benzenedicarboxamide derivative and the use thereof as an insecticide having the formula (I) wherein the chemical groups W1 to W9, and R1 to R3 are as defined herein.
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WO/2010/012795A1 |
The present invention relates to fungicide N-(2-phenoxyethyl)carboxamide derivatives of formula (I), their aza, thia and sila analogues, their process of preparation, their use as fungicides, particularly in the form of fungicidal compos...
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WO/2010/009847A1 |
The invention relates to heterocyclically substituted amides, a method for the production thereof, and the use thereof as herbicides, compounds of the general formula (I) and the Λ/-oxide and salts thereof. The invention describes compo...
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WO/2010/008734A2 |
Methods of preparing compounds of formula I are disclosed: (Formula should be inserted here)
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WO/2010/005782A1 |
Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally use...
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WO/2010/005048A1 |
Disclosed is a process for producing an isoxazoline-substituted benzoic acid amide compound represented by general formula (1) [wherein X represents a halogen atom, a C1-C6 haloalkyl, or the like; Y represents a halogen atom, a C1-C6 alk...
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WO/2010/001821A1 |
Disclosed are a compound represented by general formula (I) (wherein R1 and R2 each represents a hydrogen, a lower acyl, a lower alkoxycarbonyl or the like; R3 represents a lower alkyl, a halogenated lower alkyl, a cycloalkyl, a heterocy...
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WO/2010/000748A1 |
The present invention relates to formula I compounds having antitumoural activities through, as one possible biological target, the molecular chaperone heat shock protein 90 (Hsp90) inhibition. The invention includes the use of such comp...
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WO/2010/000372A2 |
The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/...
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WO/2009/153180A1 |
The present invention is concerned with novel sulfonamides of formula I wherein R1, R2, R3, R4, R5, Ar, Ar1, Ar2, n, o and p are as described in the description and claims. The compounds are orexin receptor antagonists may be useful in t...
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WO/2009/147990A1 |
Disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which has an agonistic activity on GPR120 and is therefore useful for the treatment of diabetes, obesity or hyperlipemia. [In formula (I), ...
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WO/2009/101082A9 |
The present invention relates to the use of substituted sulfonic acid amide compounds of formula I, wherein Ra, n, Het, A, Y and D are as defined in the claims and the N-oxides and the salts thereof for combating phytopathogenic harmful ...
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WO/2009/141096A1 |
The invention relates to spiro-isoxazolines of the formula (I), to the agriculturally and/or physiologically acceptable salts thereof, and to the use thereof for combating animal pests, wherein the variables and substituents have the mea...
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WO/2009/132453A1 |
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds of subs...
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WO/2009/132452A1 |
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds of subs...
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WO/2009/133687A1 |
Disclosed is a compound having an anti-hyperglycemic activity, which is useful for the treatment or prevention of diabetes, obesity and others. Specifically disclosed is a compound represented by general formula (1) [wherein R1 and R2 in...
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WO/2009/130263A1 |
A process for preparing a crystalline form compound of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazo
l-4-one is described, comprising the step of reacting 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazo
l-4-on...
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WO/2009/130264A1 |
A process for preparing a crystalline form compound of 3-benzyl-2-methyl- 2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one is described, comprising the step of reacting 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazo
l-4- o...
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WO/2009/131951A2 |
The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administerin...
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WO/2009/127338A1 |
The present invention relates to novel carboxylic acid derivates of the formula (I), having an oxo-substituted azaheterocyclic partial structure, method for the production thereof, use thereof for treating and/or preventing illnesses and...
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WO/2009/126668A2 |
Disclosed is a method for preparing a compound of Formula (1) wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula (2), a compound of Formula (3), a base comprising ...
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WO/2008/115149A9 |
A process for preparing a N-phenylisoxazolidin-5-one derivative is provided. The process for preparing the N-phenylisoxazolidin-5-one derivative comprises reacting an α, β-unsaturated aldehyde with nitrosobenzene in the presence of a N...
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WO/2009/123241A1 |
Disclosed is a novel compound having an inhibitory activity on a plasminogen activator inhibitor-1 (PAI-1). Also disclosed is a PAI-1 inhibitor comprising the compound as an active ingredient. Further disclosed is a pharmaceutical compos...
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WO/2009/122034A2 |
The invention relates to the novel substances in Formula (I): wherein Het is a heterocycle optionally substituted by one or a plurality of radicals R1 or R’1; R is selected from the group comprising Formula (II) with R1 and/or R’1 se...
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WO/2009/119652A1 |
Disclosed are use of a benzophenone derivative represented by general formula (I) or a salt thereof and one or more TNFα inhibitors in combination, and a pharmaceutical composition containing the benzophenone derivative or a salt thereo...
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WO/2009/118125A1 |
The invention relates to 4-(3-aminobenzoyl)-5-cyclopropylisoxazoles of the general formula (I) as herbicides. In said formula (I), A, X, Y, and Z are radicals such as hydrogen, and organic radicals such as alkyl, and other radicals such ...
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WO/2009/112275A1 |
Condensed-ring aryl compounds of formula (I) and use of the same as a agrochemical for controlling noxious organisms wherein (X)mQ, A, R1, (Y)n and the grouping -W1-W2-W3-W4- are as defined herein.
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WO/2009/111447A2 |
The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory ('umami') taste modifiers, savory flavoring agents and savo...
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WO/2009/105906A1 |
A method of providing a range of flavors to an orally-receivable or ingestible product, the method including adding at least one compound, including salts thereof, of the formula (I) wherein R1 may be selected from H, OH, O(CH2)2OH, OCH2...
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WO/2009/105509A1 |
Compounds which modulate the CB2 receptor are disclosed. The compounds are useful for treating CB2 receptor-mediated diseases such as pain.
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WO/2009/081892A1 |
Disclosed is a compound represented by the general formula (I) below which has a strong COMT inhibitory effect, or a pharmacologically acceptable salt thereof. Also disclosed are a pharmaceutical composition containing such a compound or...
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WO/2009/077197A1 |
A compound of formula (I): wherein A1, A2, A3, A4, G1, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of Formul...
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WO/2009/075080A1 |
Disclosed is a fluoroalkylsulfide derivative having excellent pest control activity or a salt thereof. Also disclosed is a pest control agent characterized by containing such a fluoroalkylsulfide derivative or a salt thereof as an active...
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WO/2009/068171A2 |
The invention relates to 3-(benzylsulfinyl)-5,5-dimethyl-4,5-dihydroisoxazole derivatives and 5,5-dimethyl-3-[(1 H-pyrazol-4-ylmethyl)sulfinyl]-4,5-dihydroisoxazole derivatives of general formula (I) and the salts thereof. The invention ...
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WO/2009/068509A1 |
This invention relates to novel benzamide derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive ...
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WO/2009/068557A1 |
This invention relates to novel phenyl-acetamide and phenyl- propionamide derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as divers...
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WO/2009/069643A1 |
Disclosed is a solid dispersion comprising 3-[5-[4- (cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2- benzisoxazol-6-yl)methoxy]phenyl]propionic acid or a salt thereof and polyvinylpyrrolidone, or a composition comprising the solid d...
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WO/2009/066009A1 |
This invention relates to novel 4,5-dihydroisoxazoles of formula (I), to their use as estrogen receptor modulators, and to methods of their preparation.
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WO/2009/063910A1 |
Disclosed is a novel method for asymmetric synthesis of an intermediate of a pest control agent. Specifically disclosed is a method for catalytic asymmetric synthesis of an optically active isoxazoline compound represented by the formula...
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WO/2009/061652A1 |
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating ...
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WO/2009/055514A2 |
Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1 N-oxides, and salts thereof, wherein R1, R2, A, G, W, Z1, X, J, and n are as defined in the disclosure, and (b) at least ...
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WO/2009/049844A1 |
A compound of formula (I) wherein A1, A2, A3, A4, G1, G2, R1, R2, R3, R4, Q1, Y1, Y2, Y3 and Y4 are as defined in claim 1; or a salt or TV-oxide thereof. Furthermore, the present invention relates to processes and intermediates for prepa...
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WO/2009/051718A2 |
The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium se...
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WO/2009/049846A1 |
A compound of formula (I) wherein A1, A2, A3, A4, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I)...
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WO/2009/050197A2 |
The invention relates to compound of the formula (I): wherein the substituents are as defined in the specification; in free base form or in acid addition salt form; to its preparation, to its use as medicament and to medicaments comprisi...
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WO/2009/049180A2 |
The present invention relates to compounds of formula I'' useful as inhibitors of voltage -gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods ...
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