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Matches 1 - 50 out of 6,787

Document Document Title
WO/2019/160813A1
The present invention provides compounds of Formula (I): pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR. Specifically, the present inv...  
WO/2019/156903A1
Disclosed are compounds of Formula 1, wherein J is and R1a, R1b, R2, R3, R4, R5, R6, R7, R8, R14, R15, R16, Q and X are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for c...  
WO/2019/145245A1
The invention relates to 3-phenylisoxazoline-5-carboxamides of cyclopentenyl carboxylic acid derivatives of the general formula (I) and their agrochemically acceptable salts (I), and to the use thereof in the field of plant protection.  
WO/2019/142191A1
Novel compounds capable of inhibiting methionine metabolic pathway are provided. These compounds are used in inhibiting cystathionin y-synthase (CGS) in general, and in plants, fungi and bacteria, in particular. These compounds of the in...  
WO/2019/136147A1
Di- and triaryl-substituted heteroaromatic compounds have Toll-like receptor inhibitory activity, including at TLR2, TLR4, TLR7, and/or TLR9. Compounds and compositions have applications in the treatment of diseases and conditions mediat...  
WO/2019/131715A1
The present disclosure provides an industrially preferable, economical, and environmentally friendly method for producing a compound (C1) of formula (5), namely, a (4, 5-dihydroisooxazol -3-yl)thiocarboxamidine salt compound. The present...  
WO/2019/121394A1
The present invention relates to solid forms of the insecticide of formula (I): compositions comprising the solid forms and methods of their use as insecticides.  
WO/2019/126084A1
The present invention provides compounds of Formula (Ia) or (Ib) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein wherein X1, X2, X3, and X4 are each independently CR6 or N; provided that no mo...  
WO/2019/123375A1
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use therof for treatment of a neurological disorder.  
WO/2019/126613A1
Provides herein are novel compounds, compositions, and methods useful for inhibiting bacteria, such as Mycobacterium tuberculosis. These compositions and methods find many uses in medicine and research, e.g., treating subjects afflicted ...  
WO/2019/126099A1
The present invention provides compounds of Formula (Ia) and (Ib): (Ia) or (Ib), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are se...  
WO/2019/126086A1
The present invention provides compounds of Formula (Ia) or (Ib): (Ia) or (Ib), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are sel...  
WO/2019/123378A1
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use therof for treatment of a neurological disorder.  
WO/2019/115781A1
The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit t...  
WO/2019/117255A1
The present invention addresses the problem of providing an industrially preferable, economical, and environmentally friendly method for producing the 4,5-dihydroisoxazole represented by a formula (3). The present invention enables the c...  
WO/2019/109132A1
The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which are useful in relation to the treatment of diseases, disorders or c...  
WO/2019/113542A1
Described herein are heterocycle substituted pyridine derivative antifungal agents and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of fungal diseases and infe...  
WO/2019/106584A1
An object of the present invention is to provide an isoxazole compound or a salt thereof that controls pests. The present invention provides an isoxazole compound represented by Formula (I), or a salt thereof, wherein R represents C1-6 a...  
WO/2019/096241A1
Disclosed are a class of anti-HBV tetrahydroisoxazolo[4,3-c]pyridine compounds and pharmaceutically acceptable salts thereof or isomers thereof, the compounds being represented by the formula (I).  
WO/2019/091940A1
The application relates to a process to produce large isoxazoline compound particles which comprises initiating crystallization and then maintaining the temperature of the crystallization in the metastable region by removing, reheating a...  
WO/2019/091936A1
An injectable pharmaceutical composition comprising an isoxazoline compound of Formula (I) or a salt or N-oxide thereof wherein the isoxazoline compound has a particle size of from about 25 microns to about 250 microns and a method of pr...  
WO/2019/090069A1
Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2019/089672A1
The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farn...  
WO/2019/090074A1
Provided herein are compounds of formula (I) and (II), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2019/089667A1
The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farn...  
WO/2019/090076A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2019/089665A1
The present invention provides compounds of Formula (I), or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of far...  
WO/2018/064119A8
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.  
WO/2019/068947A1
Use of the compound Ki16425 for preventing, relieving, improving and/or treating alcohol-related mental and behavioural disorders, including harmful or high-risk use, alcohol intoxication or pathological drunkenness, alcohol dependence s...  
WO/2019/057969A1
The present invention relates to small molecule compounds and their use as agonists of farnesoid X receptor (FXR) and/or peroxisome proliferator activated receptor delta (PPARĪ“). The present invention also relates to the use of said com...  
WO/2019/054430A1
The purpose of the present invention is to provide a compound having an anti-inflammatory action, a pharmacologically acceptable salt thereof, etc. A solving means of the present invention is a compound of general formula (1) or a pharma...  
WO/2019/051396A1
Disclosed herein are compounds having a structure of formula (I), compositions and methods useful for the treatment of a disease or infection, such as a viral infection (e.g., Ebola), cancer and obesity: formula (I), wherein A is N or CR...  
WO/2019/034059A1
The present invention relates to a compound and the application thereof in treating inflammation or inflammation-related diseases, and more specifically to a compound UTLOH combination. Said compound effectively inhibits the level of LPS...  
WO/2019/034602A1
The invention relates to 3-phenyl-5-trifluoromethylisoxazoline-5-carboxamides of cyclopentylcarboxylic acids and esters of general formula (I) and the agrochemically acceptable salts thereof and to the use thereof in the field of plant p...  
WO/2019/030177A1
The present invention relates to crystal forms of 2-[(2,4-dichlorophenyl)methyl]-4,4-dimefhyl- isoxazolidin-3-one, a method for preparing these crystal forms, use thereof in agrochemical formulations and also particular compositions, mix...  
WO/2019/014748A1
Methods for prevention and treatment of asthma attacks involve the administration of one or more TRPV1 antagonists, one or more LPAr antagonists or preferably a combination of one or more TRPV1 antagonists and one or more LPAr antagonist...  
WO/2019/001361A1
A piperic acid derivative and preparation and an application thereof. The structure of the derivative is as shown in general formula I. The compound of general formula I has excellent pesticidal, miticidal, and bactericidal activities an...  
WO/2018/233728A1
Provided in the present application are benzo[d]isoxazole compounds, a preparation method therefor and an application thereof. The benzo[d]isoxazole compounds are a group of compounds having novel structures and which act as bromodomain ...  
WO/2018/232491A1
There is described herein compound comprising a mitochondrial targeting portion, a cargo portion including a drug unit, and a linker conjugating the mitochondrial targeting portion and the cargo portion, the linker portion cleavable in a...  
WO/2018/230528A1
Provided are a novel nitrocatechol derivative having COMT inhibitory effect and DDC inhibitory effect or a salt thereof and a medicinal composition comprising the same. A compound represented by general formula (1) or a pharmaceutically ...  
WO/2018/219204A1
The present invention relates to a novel phenoxyacetic acid derivative represented by general formula (I), a preparation method for the derivative and uses of drug compositions containing the derivative in drug preparation for treatment ...  
WO/2018/215818A1
The present invention relates to compounds of formula (I): wherein Q is O or S; R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted; X is any group comprising a carbonyl group; and...  
WO/2018/202487A1
The present invention relates to 5-(haloalkyl)-5-hydroxy-isoxazoles of the formula (I), or the N-oxides, or the agriculturally useful salts thereof, and the use thereof for controlling phytopathogenic fungi; to a method for combating phy...  
WO/2018/191871A1
Disclosed in the present invention is a method for use in preparing an isoxazoline derivative: an olefin derivative, a diazo derivative and tert-Butyl nitrite are used as a reaction substrate, while a copper compound is used as a catalys...  
WO/2018/190643A1
The present invention relates to isoxazole derivatives, including pharmaceutical compositions and for the preparation of isoxazole derivatives. And more particularly the present invention provided a pharmaceutical composition of isoxazol...  
WO/2018/187623A1
The present invention provides crystalline forms of compound of formula (la) and processes of making the crystalline forms. Also provided are compositions comprising the crystalline forms and crystalline forms for treating or preventing ...  
WO/2018/186365A1
The present invention relates to a novel read-through inducing agent, and also relates to a compound represented by general formula (I) (symbols in the formula are as described in the specification) or a pharmaceutically accepted salt th...  
WO/2018/178008A1
Described are substituted isoxazoline-5-ones of general formula (I) and the use thereof as herbicides, in particular for controlling weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing th...  
WO/2018/172480A1
Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, and their uses as insecticides.  
WO/2018/172471A1
The present invention relates to compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds; to intermediate...  

Matches 1 - 50 out of 6,787