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Matches 1 - 50 out of 6,885

Document Document Title
WO/2020/094434A1
The invention relates to a process for preparing optically enriched isoxazoline compounds of formula (I), wherein the variables are as defined in the specification, and the shown enantiomer has at least 80% ee; by oxo-Michael addition of...  
WO/2020/088949A1
The present invention relates to a process for preparing benzylic amidesof formula (I) wherein the variables are as defined in the specification, and the shown enantiomer has at least 50 % ee; by condensation of a ketone o formula (II) w...  
WO/2020/086728A1
In one aspect, compounds of Formula A, or a pharmaceutically acceptable salt thereof, are featured (Formula A) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.  
WO/2020/064569A1
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, and their uses as insecticides.  
WO/2020/064564A1
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, and their uses as insecticides.  
WO/2020/064565A1
The present invention relates to compounds of formula (I) wherein A1, A2, A3, A4, R1, R2, R3, R4 and n are as defined in claim 1; or a tautomer, isomer, enantiomer, salt or N-oxide thereof; to intermediates for preparing compounds of for...  
WO/2020/064560A1
The present invention relates to compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds; to intermediate...  
WO/2020/060915A1
The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhi...  
WO/2020/058913A1
A compound of Formula (I) or or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating hearing loss or balance disorder: Formula (I) wherein R1 and Y are as defined herein.  
WO/2020/060916A1
The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhi...  
WO/2020/048476A1
Provided are isoxazoline derivatives and uses thereof in agriculture; in particular, provided are a compound having formula (I), a stereoisomer, an N-oxide or a salt thereof, preparation methods thereof, and compositions containing these...  
WO/2020/042114A1
Provided herein are methods and compositions for treating liver disorders, including without limitation non-alcoholic steatohepatitis, and symptoms and manifestations thereof, in a patient. Accordingly, utilized herein are compounds of f...  
WO/2020/042841A1
A preparation method for (1R,3S)-3-amino-1-cyclopentanol and salts thereof, relating to the field of organic synthesis, wherein the (1R,3S)-3-amino-1-cyclopentanol undergoes an asymmetric cycloaddition reaction with cyclopentadiene by us...  
WO/2020/040343A1
The present invention relates to an isoxazole derivative compound of Formula (1) useful as a substance for treating respiratory viral infectious disease caused by coronavirus, in particular, Middle East respiratory syndrome-coronavirus (...  
WO/2020/034945A1
The present invention provides a method for preparing a cyclohexane derivative, comprising the following steps: (1) subjecting a compound SM01 and a compound SM02 or a salt thereof to a nucleophilic substitution reaction to obtain a comp...  
WO/2020/034946A1
Provided is a method for preparing a cyclohexane derivative, the method comprising the following steps: subjecting a compound, 2-(4-(3,3-dimethylureido)cyclohexyl)acetaldehyde, represented by formula SM01 and a compound represented by fo...  
WO/2020/033382A1
Provided are compounds that can act as a modulator of a farnesoid X receptor (FXR) and that can be useful in the treatment of diseases and/or disorders associated with the FXR. Compositions including such compounds are also provided alon...  
WO/2020/022350A1
Provided are: an isoxazolin-5-one derivative represented by general formula (1); and a herbicide containing the isoxazolin-5-one derivative as an active ingredient. In the formula, R1 represents a C1-C6 haloalkyl group; Q represents a C3...  
WO/2020/016801A1
The present invention relates to compounds of formula (I), to pharmaceutical compositions thereof and to their uses, in particular in the treatment and/or prevention of FXR mediated diseases.  
WO/2019/171234A9
The present invention relates to novel heterocyclic compound of Formula (I), (I) wherein, Het, L1, A, L2 and R12 are as defined in the detailed description, for use as fungicides.  
WO/2020/010155A1
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes...  
WO/2020/002587A1
A compound of formula (I), or a pharmaceutically acceptable salt thereof.  
WO/2020/006294A1
Disclosed herein are methods of treating liver fibrosis by administering calpain inhibitors to subjects in need thereof.  
WO/2019/246109A1
Heterocyclic compounds are described that are lysophosphatidic acid receptor ligands that are useful in the treatment of lysophosphatidic acid receptor-dependent diseases and conditions.  
WO/2019/243491A1
A compound of formula (I), or a pharmaceutical salt thereof.  
WO/2019/229464A1
There are described compounds of formula (I): (I) and their use as a medicament in the treatment of diseases associated with the abnormal or elevated catabolism of tryptophan, such as, cancer, immunosuppression, viral infection, depressi...  
WO/2019/215427A1
A process for forming a carbon-carbon bond to couple an aryl or heteroaryl group of a first compound with an alkyl or cycloalkyl moietyof a second compound, the process comprising reacting the first compound with the second compound in t...  
WO/2019/217977A1
Disclosed herein are compounds represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Values for the variables in Structural Formula I are described herein. The compounds can be used to modulate (e.g, inhib...  
WO/2019/210397A1
The present application relates to treatments for bacterial infections. For example, the application relates to the use a gallic acid-sulfamethoxazole conjugate for treatment of a Lactobacillales bacterial infection or a disease, disorde...  
WO/2019/208643A1
The objective of the present invention is to provide a production method for a 4,5-dihydroisoxazole represented by formula (3), which is safe, industrially desirable, economical, and environmentally friendly. The present invention causes...  
WO/2019/208812A1
A compound represented by general formula (1), a salt thereof, or a prodrug thereof is provided as a compound effective in the prevention and/or treatment of fibrosis. (In the formula, A is an optionally substituted benzene ring; B is an...  
WO/2018/187623A8
The present invention provides crystalline forms of compound of formula (la) and processes of making the crystalline forms. Also provided are compositions comprising the crystalline forms and crystalline forms for treating or preventing ...  
WO/2019/195751A1
Compounds of formula (I) wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as...  
WO/2019/190999A1
Disclosed herein are methods of treating fibrotic disorders by administering compounds selective for CAPN1, CAPN2, and/or CAPN9 such that side effects, off pathway interactions, and/or toxicities are minimized. Such methods may, for exam...  
WO/2019/174589A1
Disclosed herein a crystal structure of a caspase inhibitor, and more specifically a crystal structure of an (S)-3-((S)-2-(5-(2-chlorobenzyl) isoxazole-3-formyl amide) proponamide)-4-oxo-5-(2,3,5,6-tetraphenoxy)) valeric acid, a preparat...  
WO/2019/171234A1
The present invention relates to novel heterocyclic compound of Formula (I), (I) wherein, Het, L1, A, L2 and R12 are as defined in the detailed description, for use as fungicides.  
WO/2019/165967A1
A compound of formula (II), a tautomer thereof or a pharmaceutically acceptable salt thereof, and use thereof in the preparation of medicaments for treating solid tumor-related diseases.  
WO/2019/160813A1
The present invention provides compounds of Formula (I): pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR. Specifically, the present inv...  
WO/2019/156903A1
Disclosed are compounds of Formula 1, wherein J is and R1a, R1b, R2, R3, R4, R5, R6, R7, R8, R14, R15, R16, Q and X are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for c...  
WO/2019/145245A1
The invention relates to 3-phenylisoxazoline-5-carboxamides of cyclopentenyl carboxylic acid derivatives of the general formula (I) and their agrochemically acceptable salts (I), and to the use thereof in the field of plant protection.  
WO/2019/142191A1
Novel compounds capable of inhibiting methionine metabolic pathway are provided. These compounds are used in inhibiting cystathionin y-synthase (CGS) in general, and in plants, fungi and bacteria, in particular. These compounds of the in...  
WO/2019/136147A1
Di- and triaryl-substituted heteroaromatic compounds have Toll-like receptor inhibitory activity, including at TLR2, TLR4, TLR7, and/or TLR9. Compounds and compositions have applications in the treatment of diseases and conditions mediat...  
WO/2019/131715A1
The present disclosure provides an industrially preferable, economical, and environmentally friendly method for producing a compound (C1) of formula (5), namely, a (4, 5-dihydroisooxazol -3-yl)thiocarboxamidine salt compound. The present...  
WO/2019/121394A1
The present invention relates to solid forms of the insecticide of formula (I): compositions comprising the solid forms and methods of their use as insecticides.  
WO/2019/126084A1
The present invention provides compounds of Formula (Ia) or (Ib) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein wherein X1, X2, X3, and X4 are each independently CR6 or N; provided that no mo...  
WO/2019/123375A1
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use therof for treatment of a neurological disorder.  
WO/2019/126613A1
Provides herein are novel compounds, compositions, and methods useful for inhibiting bacteria, such as Mycobacterium tuberculosis. These compositions and methods find many uses in medicine and research, e.g., treating subjects afflicted ...  
WO/2019/126099A1
The present invention provides compounds of Formula (Ia) and (Ib): (Ia) or (Ib), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are se...  
WO/2019/126086A1
The present invention provides compounds of Formula (Ia) or (Ib): (Ia) or (Ib), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are sel...  
WO/2019/123378A1
This invention, in at least some embodiments, relates to an inventive molecule, compositions comprising same, and methods of use therof for treatment of a neurological disorder.  

Matches 1 - 50 out of 6,885