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Matches 1 - 50 out of 12,569

Document Document Title
WO/2019/195972A1
The present invention relates to 1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives and a preparation method therefor and the use thereof. Their structures are as shown in formula (I), wherein R 1 is any one of H, OH, and OCH...  
WO/2019/195751A1
Compounds of formula (I) wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as...  
WO/2019/194220A1
Provided are compounds represented by formula (1) or salts thereof, and a pest control agent, an insecticide or miticide, a nematicide, and an endoparasite control or eliminating agent, which contain, as an active ingredient, at least on...  
WO/2019/194211A1
Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5) wherein th...  
WO/2019/190999A1
Disclosed herein are methods of treating fibrotic disorders by administering compounds selective for CAPN1, CAPN2, and/or CAPN9 such that side effects, off pathway interactions, and/or toxicities are minimized. Such methods may, for exam...  
WO/2019/190885A1
Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by...  
WO/2018/213150A8
The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mi...  
WO/2019/180445A1
Polycyclic aromatic hydrocarbon derivatives represented by the following general formula: (I) wherein R independently represents an aromatic group and/or an aliphatic group; Q is one of a cyclic aliphatic hydrocarbon, a cyclic aromatic h...  
WO/2019/175464A1
The present invention related to compounds of formula (I) wherein R1, R2, ring A and ring Bare as defined in the claims. The compounds are potent inhibitors of the sodium-calcium exchanger (NCX) and are useful in the treatment or prevent...  
WO/2019/175263A1
The present invention relates to a new path to synthesize crystalline Tafamidis polymorphs starting from a Tafamidis acetic acid adduct. In addition, this invention relates to a process to synthesize Tafamidis (2-(3,5-dichlorophenyl)-1,3...  
WO/2019/170055A1
The present invention relates to compounds having CDK4/6 kinase inhibitory activity, a pharmaceutical composition thereof and a use thereof. The present invention relates in particular to compounds represented by formula I, and further r...  
WO/2019/171234A1
The present invention relates to novel heterocyclic compound of Formula (I), (I) wherein, Het, L1, A, L2 and R12 are as defined in the detailed description, for use as fungicides.  
WO/2019/166270A1
The invention relates to an organic electronic device comprising at least one electron transport, electron injection or electron generation layer comprising a compound of Formula (I) wherein all positions which are not linked to a -(A)a-...  
WO/2019/166269A1
The present invention relates to an organic electronic device comprising, between an anode and a cathode, at least one layer selected from an electron injection layer, an electron transport layer or an electron generation layer, the laye...  
WO/2019/166206A1
The present invention relates to an organic material and to an electronic device comprising the organic material, particularly to an electroluminescent device, particularly to an organic light emitting diode (OLED), wherein the semicondu...  
WO/2019/070709A8
The present invention provides compounds, compositions and methods for treating and/or preventing a flavivirus infection by administering such compounds and compositions.  
WO/2019/164996A1
The present disclosure is concerned with 2-aminoaryl-5-aryloxazole compounds that are capable of activating NF-κΒ signaling. The present disclosure is also concerned with methods of using these compounds for the treatment of neurologic...  
WO/2019/162911A1
This invention describes a class of compounds able to activate the human SIRT1 enzyme and regulate many metabolic functions. This invention relates to compounds that can be employed in medical applications, specifically for the treatment...  
WO/2019/161534A1
The present disclosure provides novel processes for the preparation of compounds of Formula (I). Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparatio...  
WO/2019/152731A1
Compounds that inhibit the androgen receptor, pharmaceutical compositions comprising one or more of the compounds, as well as methods of treating cancer using such compounds are described.  
WO/2019/142191A1
Novel compounds capable of inhibiting methionine metabolic pathway are provided. These compounds are used in inhibiting cystathionin y-synthase (CGS) in general, and in plants, fungi and bacteria, in particular. These compounds of the in...  
WO/2019/139365A1
The present invention relates to a novel phenylsulfonyl oxazole derivative and a use thereof and, specifically, to a compound represented by chemical formula 1 in the present specification or a pharmaceutically acceptable salt thereof, a...  
WO/2019/140095A1
The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparatio...  
WO/2019/136147A1
Di- and triaryl-substituted heteroaromatic compounds have Toll-like receptor inhibitory activity, including at TLR2, TLR4, TLR7, and/or TLR9. Compounds and compositions have applications in the treatment of diseases and conditions mediat...  
WO/2019/128312A1
A 5-chlorobenzoxazole derivative, a preparation method therefor, a herbicidal composition and use thereof. The 5-chlorobenzoxazole derivative has a chemical structure as shown in general formula I: wherein X represents halogen, cyano, tr...  
WO/2019/133462A1
The present disclosure relates to solid state forms of Pemafibrate processes for preparation thereof and pharmaceutical compositions thereof.  
WO/2019/119516A1
Disclosed are a tetramethylspiroindene skeleton-based bisoxazoline ligand compound, an intermediate thereof, a preparation method therefor, and a use thereof. The bisoxazoline ligand compound is a compound having a structure as shown in ...  
WO/2019/123196A1
The present invention disclosed fluoralkenyl compounds of general formula (I), wherein; R, R1, R2, R3, A and integers n, m and k are as defined in description. The present invention further discloses use of the compounds of general formu...  
WO/2019/124550A1
An organic EL element wherein a capping layer contains a compound represented by formula (A-1). In the formula, A and X are monovalent groups having one site, from among R1 to R6 represented by formula (B-1), serving as a binding site. Z...  
WO/2019/121143A1
The present invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for pro...  
WO/2019/126697A1
Provided herein are methods and compositions related to a method of stimulating the immune system in a subject in need thereof by administering an agent that increases the level or activity of indoleamine 2,3-dioxygenase (IDO1) and/or ar...  
WO/2019/126559A1
Disclosed herein are substituted 2-azaspiro[3.3]heptane compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compo...  
WO/2019/099314A1
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder...  
WO/2019/091179A1
Disclosed is a method for preparing florfenicol intermediate V, which belongs to the technical field of the preparation of veterinary medicines. The method comprises an addition reaction, a ring-closing reaction, a hydrolysis reaction an...  
WO/2019/090081A1
Provided herein are compounds of Formula (I) or Formula (II), compositions, and methods there of useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.  
WO/2019/090074A1
Provided herein are compounds of formula (I) and (II), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2019/090088A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2019/084662A1
Heterocyclic compounds of Formula (I) and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly can...  
WO/2019/080882A1
Disclosed are a compound as shown in formula (I), a pharmaceutical composition comprising the compound of formula (I), and the use of the compound and pharmaceutical composition in the preparation of an HDAC inhibitor drug. The compound ...  
WO/2018/064119A8
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.  
WO/2019/070709A1
The present invention provides compounds, compositions and methods for treating and/or preventing a flavivirus infection by administering such compounds and compositions.  
WO/2019/063710A1
The invention relates to resorcinol-based compounds of formula (I), to the salts, solvates, optical and/or geometrical isomers thereof, to the use thereof as active agents for depigmenting, lightening and/ or bleaching keratin materials,...  
WO/2019/065954A1
The present invention provides: a methyl 1-{2-[(3S, 4R)-1-[(3R, 4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidin-3-c arbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethy l)phenyl}piperidine-4-carboxylate 1/2 ethane-1,2-di...  
WO/2019/066578A1
The present invention relates to a process for preparing a compound of formula 2 that is an intermediate used to synthesize a dipeptidyl peptidase IV enzyme-inhibiting therapeutic agent for treating diabetes mellitus, which (1) can be pr...  
WO/2019/064961A1
Provided are: a photosensitive resin composition having high tolerance for focus depth in the formation of a punched pattern; a resist film which is a solidified product of the photosensitive resin composition; a method for forming a pat...  
WO/2019/057969A1
The present invention relates to small molecule compounds and their use as agonists of farnesoid X receptor (FXR) and/or peroxisome proliferator activated receptor delta (PPARδ). The present invention also relates to the use of said com...  
WO/2019/057946A1
Multi-cyclic aromatic compounds and methods of use as Factor D modulators are described herein.  
WO/2019/054443A1
Provided are: a liquid crystal alignment film which is not susceptible to the occurrence of film separation or scratches during rubbing, and which has high voltage holding ratio and good aging resistance under high temperature high humid...  
WO/2019/051396A1
Disclosed herein are compounds having a structure of formula (I), compositions and methods useful for the treatment of a disease or infection, such as a viral infection (e.g., Ebola), cancer and obesity: formula (I), wherein A is N or CR...  
WO/2019/026004A3
The present invention provides a process of synthesizing 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-( (2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3 yl)amino)ethylidene)amino)oxy)cyclopropanecarboxylic acid (referred to ...  

Matches 1 - 50 out of 12,569