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Matches 1 - 50 out of 12,270

Document Document Title
WO/2018/071535A1
The present invention relates to pesticidal and parasiticidal isoxazoline of formula (I) and salts thereof: Formula (I) wherein variables B1, B2, B3, R1, P1, P2, Y and Q are described herein are as defined in the description. The inventi...  
WO/2018/064119A1
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.  
WO/2018/053587A1
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.  
WO/2018/051360A1
The invention relates to a novel process for preparation of crystalline Linezolid Form-III. The crystalline Linezolid Form-III obtained by the process is highly pure with HPLC purity equal to or greater than 99.9% with single un-known im...  
WO/2018/050489A1
The invention relates to a method for producing a polybenzazol polymer (P) by reacting a reaction mixture (RG) which contains at least one aromatic dicarboxylic compound of general formula (I), at least one aromatic diamino compound of g...  
WO/2018/047983A1
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein n, X, Y, Z, D, R1, R2, R3, R4, R12, R15nd R16 are as defined in the specification, a process for their preparation, pharmaceut...  
WO/2018/044783A1
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...  
WO/2018/043913A1
The present invention relates to a novel compound and an organic electroluminescent device comprising the same. The compound according to the present invention is used for organic material layers of the organic electroluminescent device,...  
WO/2018/039232A1
Methods of preparing substituted bicyclo[1.1.1]pentane compounds of Formula (I) comprise reacting a compound of Formula (A) with a compound of Formula (B) in the presence of a first transition metal catalyst selected from a palladium cat...  
WO/2018/039242A1
Provided herein are oxazolidinone derivatives that can exhibit anti-microbial activity and/or activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exh...  
WO/2018/039244A1
Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biof...  
WO/2018/036470A1
Provided are a phosphodiesterase-4 (PDE4) inhibitor and application thereof in preparation of a medication for treating a disease related to PDE4. Specifically disclosed is a compound as shown in formula (I) and a pharmaceutically accept...  
WO/2018/033525A1
This invention relates to compounds that are agonists or partial agonists of the histamine site of the NMDA receptor, the method of preparation thereof and applications thereof.  
WO/2018/032356A1
A novel process for the preparation of lactone derivatives, and intermediates thereof is described. The lactone derivatives are important precursors for the synthesis of anti-hepatitis C virus agents, including sofosbuvir.  
WO/2018/029150A1
The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I). Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GP...  
WO/2018/028557A1
The present invention relates to a series of tricyclic compounds and the use thereof as receptor agonists of 1-phosphate sphingosine 1 subtype (S1P1), and in particular to the compounds shown in formula (I), and tautomers or pharmaceutic...  
WO/2018/029137A1
The present invention concerns heterocyclic naphthoquinones derivatives for use in the treatment of Cushing disease and other cancers, in particular via the inhibition of Ubiquitin Specific Proteases (USP) 8 and/or 2.  
WO/2018/031886A1
Disclosed are optical compensation films with exceptionally high positive out-of-plane birefringence. The optical compensation films are based on substituted styrenic fluoropolymers and have positive out-of-plane birefringence greater th...  
WO/2018/018863A1
Disclosed are a mild and efficient preparation method for an α-acyloxy alkenyl amide compound and a use thereof in the synthesis of an amide and a polypeptide. The α-acyloxy alkenyl amide compound is obtained by an addition reaction of...  
WO/2018/019527A1
The present invention relates to polyfunctional compounds of formula (I), (I) the methods for preparing same and the uses thereof, in particular in orthogonal or bioorthogonal processes.  
WO/2018/018091A1
The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.  
WO/2018/016376A1
The present disclosure provides a reaction of a chlorine-containing compound with use of a flow reactor that has few limits on a solvent to be used therein. According to the present disclosure, a chlorine-containing compound and a reacti...  
WO/2018/016743A1
The present invention provides an oxazolidinone derivative compound represented by chemical formula I, an optical isomer thereof, or pharmaceutically acceptable salts thereof. The compound represented by chemical formula I according to t...  
WO/2018/011746A1
The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their ta...  
WO/2018/011747A1
The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their ta...  
WO/2018/012769A1
Disclosed herein are a compound of chemical formula 1 or 2 and a use thereof. The compound according to the present application can be advantageously used in the prevention or treatment of metabolic diseases including type 2 diabetes, in...  
WO/2018/009602A3
The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyra...  
WO/2018/008718A1
[Problem] To provide an organic compound having excellent characteristics, which exhibits, as a material for organic electroluminescent elements having high efficiency and high durability, excellent electron injection/transport performan...  
WO/2018/009602A2
The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyra...  
WO/2017/219083A1
The present invention relates to novel compounds which active HIV expression in latently infected cells. More particularly, the invention relates to pharmaceutical compositions comprising the novel compounds and their use in activating H...  
WO/2017/223178A1
Methods for treating or reducing the risk or severity of a hemorrhagic virus infection or certain other viral infections in a mammal that include administering a therapeutically effective amount of an IMPDH inhibitor selected from (S)-N-...  
WO/2017/219769A1
Provided are a polymorph of famoxadone, a use thereof and a preparation method therefor. In particular, the present invention relates to a polymorph of 5-methyl-5-(4-phenoxyphenyl)-3-phenylamino-2,4-oxazolidinedi one, and the preparation...  
WO/2017/222361A1
The invention relates to the use of the compound (2,3-dihydro-2-thioxo-3-benzoxazole methylamino)-salicylic acid (4-DTS) derived from 2-mercaptobenzoxazole as an antibiotic agent that specifically inhibits, in the low micromolar range, b...  
WO/2017/215552A1
Compounds, pharmaceutical compositions, and methods for treatment of microbial infections are provided. The compounds can potentiate the therapeutic effects of one or more antimicrobial agents when co-administered. The compounds have ant...  
WO/2017/209294A1
According to the present invention, it is possible to safely and easily obtain sulfonimidized aromatic compounds using various substrates and a novel sulfonimidization agent by irradiating, with light in the presence of an oxidizer, a co...  
WO/2017/208905A1
The present invention addresses the problem of providing a method for producing a polymethine compound with higher yield and higher efficiency compared with the conventional methods by preventing the production of by-products effectively...  
WO/2017/192858A1
The present disclosure is directed to oxazoline mono- and hetero-pseudodimer compounds, such as compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: These compounds are useful for treating pain. The present ...  
WO/2017/191000A1
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...  
WO/2017/193041A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2017/190682A1
The present invention discloses a novel crystalline form E of a tafamidis methylglucamine salt, and a preparation method and application thereof. When compared to other known crystalline forms, the new crystalline form provided in the in...  
WO/2017/192931A1
The invention provides substituted imidazo[1,2-α]pyridine compounds, substituted imidazo[1,2-α]pyrazine compounds, related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compos...  
WO/2017/186624A1
The present invention relates to a process for the preparation of a compound of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification.  
WO/2017/188485A1
Provided is a compound represented by formula (A-V), wherein Y represents a p-valent anion; R1A to R8A each independently represent a hydrogen atom or an alkyl group having 1-10 carbon atoms; R9A and R10A each independently represent a h...  
WO/2017/184624A1
In one aspect, compounds of Formulae (I) and (II), or pharmaceutically acceptable salts thereof, are featured; Formula (I), Formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formulae (I) and (II) ...  
WO/2017/183625A1
[Problem] To provide an organic electroluminescence element comprising, in order to improve the element characteristics of the organic EL element, in particular, so as to absorb 400-410 nm wavelength sunlight and not have effects on an i...  
WO/2017/182853A1
The present invention relates to an improved process for the preparation of Linezolid. More specifically, the present invention relates to an improved process for preparing(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo- 5-oxazolidiny...  
WO/2017/179883A1
The present specification relates to a compound expressed by the first chemical formula, and to an organic electronic element comprising same.  
WO/2017/175986A1
The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. The organic electroluminescent compound of the present disclosure provides an organic electroluminesce...  
WO/2017/170952A1
The present invention relates to: a novel compound that is useful as a ligand in a variety of catalytic organic synthetic reactions; a method for easily and efficiently producing said novel compound; a synthetic intermediate of said nove...  
WO/2017/165256A1
The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly ...  

Matches 1 - 50 out of 12,270