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Matches 1 - 50 out of 12,217

Document Document Title
WO/2018/011746A1
The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their ta...  
WO/2018/011747A1
The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their ta...  
WO/2018/012769A1
Disclosed herein are a compound of chemical formula 1 or 2 and a use thereof. The compound according to the present application can be advantageously used in the prevention or treatment of metabolic diseases including type 2 diabetes, in...  
WO/2018/008718A1
[Problem] To provide an organic compound having excellent characteristics, which exhibits, as a material for organic electroluminescent elements having high efficiency and high durability, excellent electron injection/transport performan...  
WO/2018/009602A2
The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyra...  
WO/2017/219083A1
The present invention relates to novel compounds which active HIV expression in latently infected cells. More particularly, the invention relates to pharmaceutical compositions comprising the novel compounds and their use in activating H...  
WO/2017/223178A1
Methods for treating or reducing the risk or severity of a hemorrhagic virus infection or certain other viral infections in a mammal that include administering a therapeutically effective amount of an IMPDH inhibitor selected from (S)-N-...  
WO/2017/219769A1
Provided are a polymorph of famoxadone, a use thereof and a preparation method therefor. In particular, the present invention relates to a polymorph of 5-methyl-5-(4-phenoxyphenyl)-3-phenylamino-2,4-oxazolidinedi one, and the preparation...  
WO/2017/222361A1
The invention relates to the use of the compound (2,3-dihydro-2-thioxo-3-benzoxazole methylamino)-salicylic acid (4-DTS) derived from 2-mercaptobenzoxazole as an antibiotic agent that specifically inhibits, in the low micromolar range, b...  
WO/2017/215552A1
Compounds, pharmaceutical compositions, and methods for treatment of microbial infections are provided. The compounds can potentiate the therapeutic effects of one or more antimicrobial agents when co-administered. The compounds have ant...  
WO/2017/209294A1
According to the present invention, it is possible to safely and easily obtain sulfonimidized aromatic compounds using various substrates and a novel sulfonimidization agent by irradiating, with light in the presence of an oxidizer, a co...  
WO/2017/208905A1
The present invention addresses the problem of providing a method for producing a polymethine compound with higher yield and higher efficiency compared with the conventional methods by preventing the production of by-products effectively...  
WO/2017/192858A1
The present disclosure is directed to oxazoline mono- and hetero-pseudodimer compounds, such as compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: These compounds are useful for treating pain. The present ...  
WO/2017/191000A1
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...  
WO/2017/193041A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2017/190682A1
The present invention discloses a novel crystalline form E of a tafamidis methylglucamine salt, and a preparation method and application thereof. When compared to other known crystalline forms, the new crystalline form provided in the in...  
WO/2017/192931A1
The invention provides substituted imidazo[1,2-α]pyridine compounds, substituted imidazo[1,2-α]pyrazine compounds, related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compos...  
WO/2017/186624A1
The present invention relates to a process for the preparation of a compound of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification.  
WO/2017/188485A1
Provided is a compound represented by formula (A-V), wherein Y represents a p-valent anion; R1A to R8A each independently represent a hydrogen atom or an alkyl group having 1-10 carbon atoms; R9A and R10A each independently represent a h...  
WO/2017/184624A1
In one aspect, compounds of Formulae (I) and (II), or pharmaceutically acceptable salts thereof, are featured; Formula (I), Formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formulae (I) and (II) ...  
WO/2017/183625A1
[Problem] To provide an organic electroluminescence element comprising, in order to improve the element characteristics of the organic EL element, in particular, so as to absorb 400-410 nm wavelength sunlight and not have effects on an i...  
WO/2017/182853A1
The present invention relates to an improved process for the preparation of Linezolid. More specifically, the present invention relates to an improved process for preparing(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo- 5-oxazolidiny...  
WO/2017/179883A1
The present specification relates to a compound expressed by the first chemical formula, and to an organic electronic element comprising same.  
WO/2017/175986A1
The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. The organic electroluminescent compound of the present disclosure provides an organic electroluminesce...  
WO/2017/170952A1
The present invention relates to: a novel compound that is useful as a ligand in a variety of catalytic organic synthetic reactions; a method for easily and efficiently producing said novel compound; a synthetic intermediate of said nove...  
WO/2017/165256A1
The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly ...  
WO/2017/160922A1
Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.  
WO/2017/157932A1
The invention relates to a new and efficient process for the preparation of a class of molecules, namely bicyclo[1.1.1]pentanes and derivatives thereof by reaction of [1.1.1]propellane with a variety of reagents under irradiation and/or ...  
WO/2017/153952A1
The invention is directed to substituted salicylamide derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof. ...  
WO/2017/147646A1
The invention relates to a dual emission fluorescent compound comprising a chromophore suitable for exhibiting an emission at a first wavelength from an excited state; wherein the compound further comprises one or more groups suitable fo...  
WO/2017/147893A1
The present invention relates to a compound represented by formula (III), R being selected from C1-C4 alkyls, substituted or unsubstituted phenyl or substituted or unsubstituted benzyl, and being preferably selected from isopropyl; and t...  
WO/2017/148226A1
Disclosed are a fluorobenzoxazole compound of the structure as shown in formula I and the use thereof, wherein the compound has an excellent inhibiting and killing effect towards pest mites and mite ova, can be used as an acaricide for p...  
WO/2017/137744A1
This invention relates to antibacterial drug compounds containing a bicyclic core, typically a bicycle in which one of the rings is an oxazolidinone. It also relates to pharmaceutical formulations of antibacterial drug compounds. It also...  
WO/2017/127627A1
The present invention relates to novel compounds that cross the blood-brain barrier and are effective inhibitors of neurological pathogens such as trypanosomes. The invention further relates to the use of these compounds for treating dis...  
WO/2017/115780A1
An ointment is provided. The ointment stably comprises an oxazole compound that has specific inhibitory activity against PDE4 and that is represented by the following formula (11). The ointment can be efficiently absorbed into the skin.  
WO/2017/108282A1
A compound of formula (Ia) or (Ib) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of a histone deacetylase, and as such is useful in terepy, e.g. in the treatment of autoimmune disorders, mental disorders, ne...  
WO/2017/099237A1
A compound represented by formula (I) and having a property of modulating the activity of an androgen receptor, or a pharmaceutically acceptable salt of the compound. X represents S or O; Z represents (Ra)n-A-(CR13R14)0-1-(CR11R12)0-1-; ...  
WO/2017/089389A1
The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used in the treatment of Human African TRypanosomiasis.  
WO/2017/087777A1
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...  
WO/2017/083719A1
The present disclosure provides methods of preparing biaryl compounds which do not require transition metal catalysts. In yet another aspect, the present disclosure provides pharmaceutical compositions comprising compounds as described h...  
WO/2017/083809A1
Described herein are novel compositions, targeted therapeutic methods, and assays for neutralizing and/or inhibiting the activity of "oxazole-containing (OxC) compounds," to prevent or delay the onset of epithelial barrier dysfunction an...  
WO/2017/075694A1
The present invention relates to compounds of formula (I) wherein G1 to G8 are as defined herein. The compounds are PK inhibitors and as such represent a new approach to treating pathogenic infections, including multidrug resistant patho...  
WO/2017/076293A1
The invention relates to a method for preparing an oxazolidinone intermediate. Specifically, a synthesis procedure for the intermediate comprises: directly performing a "one-pot" reaction on a compound I, a compound J or a compound L wit...  
WO/2017/078927A1
Novel compounds having a formula (I), embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a s...  
WO/2017/078403A1
The present disclosure relates to a plurality of host materials and an organic electroluminescent device comprising the same. By using a specific combination of a plurality of host compounds, it is possible to provide the organic electro...  
WO/2017/076982A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, and especially fungicides.  
WO/2017/074053A1
The present application relates to a compound in chemical formula (1) and an organic light-emitting device comprising same.  
WO/2017/074052A1
The present application relates to an organic light-emitting device.  
WO/2017/070024A1
The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at leas...  
WO/2017/066964A1
The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at leas...  

Matches 1 - 50 out of 12,217