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Matches 1 - 50 out of 12,506

Document Document Title
WO/2019/099314A1
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder...  
WO/2019/091179A1
Disclosed is a method for preparing florfenicol intermediate V, which belongs to the technical field of the preparation of veterinary medicines. The method comprises an addition reaction, a ring-closing reaction, a hydrolysis reaction an...  
WO/2019/090081A1
Provided herein are compounds of Formula (I) or Formula (II), compositions, and methods there of useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.  
WO/2019/090074A1
Provided herein are compounds of formula (I) and (II), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2019/090088A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2019/084662A1
Heterocyclic compounds of Formula (I) and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly can...  
WO/2019/080882A1
Disclosed are a compound as shown in formula (I), a pharmaceutical composition comprising the compound of formula (I), and the use of the compound and pharmaceutical composition in the preparation of an HDAC inhibitor drug. The compound ...  
WO/2018/064119A8
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.  
WO/2019/070709A1
The present invention provides compounds, compositions and methods for treating and/or preventing a flavivirus infection by administering such compounds and compositions.  
WO/2019/063710A1
The invention relates to resorcinol-based compounds of formula (I), to the salts, solvates, optical and/or geometrical isomers thereof, to the use thereof as active agents for depigmenting, lightening and/ or bleaching keratin materials,...  
WO/2019/065954A1
The present invention provides: a methyl 1-{2-[(3S, 4R)-1-[(3R, 4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidin-3-c arbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethy l)phenyl}piperidine-4-carboxylate 1/2 ethane-1,2-di...  
WO/2019/066578A1
The present invention relates to a process for preparing a compound of formula 2 that is an intermediate used to synthesize a dipeptidyl peptidase IV enzyme-inhibiting therapeutic agent for treating diabetes mellitus, which (1) can be pr...  
WO/2019/064961A1
Provided are: a photosensitive resin composition having high tolerance for focus depth in the formation of a punched pattern; a resist film which is a solidified product of the photosensitive resin composition; a method for forming a pat...  
WO/2019/057969A1
The present invention relates to small molecule compounds and their use as agonists of farnesoid X receptor (FXR) and/or peroxisome proliferator activated receptor delta (PPARδ). The present invention also relates to the use of said com...  
WO/2019/057946A1
Multi-cyclic aromatic compounds and methods of use as Factor D modulators are described herein.  
WO/2019/054443A1
Provided are: a liquid crystal alignment film which is not susceptible to the occurrence of film separation or scratches during rubbing, and which has high voltage holding ratio and good aging resistance under high temperature high humid...  
WO/2019/051396A1
Disclosed herein are compounds having a structure of formula (I), compositions and methods useful for the treatment of a disease or infection, such as a viral infection (e.g., Ebola), cancer and obesity: formula (I), wherein A is N or CR...  
WO/2019/026004A3
The present invention provides a process of synthesizing 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-( (2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3 yl)amino)ethylidene)amino)oxy)cyclopropanecarboxylic acid (referred to ...  
WO/2019/042301A1
The present invention provides a new class of (E)-α,β-unsaturated amide compounds represented by formula I, and also relates to methods for preparing such compounds and the pharmaceutical uses thereof. The compounds have the effect of ...  
WO/2019/040706A1
Methods of treating vitiligo using JAK/STAT modulating compounds are provided herein. The JAK/STAT modulating compounds may be selected from 5-((2-((4-fluoro-3-methoxy-5-methylphenyl)amino)-5-methylpyr imidin-4-yl)amino)benzo[d]oxazol-2(...  
WO/2019/034468A1
Process for the preparation of a compound with at least one monothiocarbonate group by reacting: - a compound with at least one mercaptoalcohol group and - a dialkylcarbonate, in the presence of a catalyst wherein the catalyst is a salt ...  
WO/2019/026728A1
[Problem] The purpose of the present invention is to provide an organic EL element in which, as a highly efficient and highly durable organic EL material, various materials excelling in electron injection/transport performance, hole bloc...  
WO/2019/026004A2
The present invention provides a process of synthesizing 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-( (2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3 yl)amino)ethylidene)amino)oxy)cyclopropanecarboxylic acid (referred to ...  
WO/2019/023147A1
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured.The variables shown in Formula AA are as defined in the claims. The compounds of formula AA are NLRP3 activity modulators and, as such, c...  
WO/2019/023145A1
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured. The variables shown in Formula AA are as defined in the claims. The compounds of formula AA are NLRP3 activity modulators and, as such, ...  
WO/2019/012173A1
The present invention relates to piperidine derivatives as inhibitors of the PDE8A enzyme. Therefore, said compounds can be used in the production of a drug for the treatment and/or prevention of diseases involving PDE8A, such as neurode...  
WO/2019/011176A1
Disclosed is the use of a 2-trifluoromethylbenzenesulfonamide derivative as shown in formula (I) as a URAT1 inhibitor, in particular as a therapeutic agent for a disorder related to abnormal uric acid levels.  
WO/2019/000494A1
Provided is a fluorene-based organic electroluminescent compound, having the following structure: The compound has good thermal stability, high luminous efficiency, and high luminous purity, and can be used for manufacturing organic elec...  
WO/2018/235926A1
The purpose of the present invention is to provide an α, β-unsaturated amide compound or a pharmaceutically acceptable salt thereof or the like, which has anti-cancer activity or the like. An α, β-unsaturated amide compound represent...  
WO/2018/230528A1
Provided are a novel nitrocatechol derivative having COMT inhibitory effect and DDC inhibitory effect or a salt thereof and a medicinal composition comprising the same. A compound represented by general formula (1) or a pharmaceutically ...  
WO/2018/214932A1
Small molecule compounds having aggregation-induced emission (AIE) characteristics. The compounds include organic, aromatic salts having anion-π+ interactions. In some embodiments, the anion-π+ interactions can include heavy-atom-anion...  
WO/2018/216921A2
The present invention relates to a novel compound and an organic electroluminescent element comprising the same, and as the compound according to the present invention is used in an organic material layer, preferably a light emitting lay...  
WO/2018/216921A3
The present invention relates to a novel compound and an organic electroluminescent element comprising the same, and as the compound according to the present invention is used in an organic material layer, preferably a light emitting lay...  
WO/2018/213140A1
Disclosed herein are compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (...  
WO/2018/213150A1
The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mi...  
WO/2018/204987A1
Compounds are provided which are inhibitors of the CAXII enzyme. Due to the interaction between CAXII and Pgp, such compounds may be useful in lowering the chemoresistance of a cancer allowing for co-administration with existing anti-can...  
WO/2018/205948A1
Provided are benzoxazolinone sulfonamide derivatives that inhibit Na v1.7 activity, pharmaceutical compositions containing them and their use in therapy for the treatment of diseases mediated by Na v1.7 activity.  
WO/2018/187845A1
The present invention relates to certain heterocyclic compounds of formula (1) that have the ability to inhibit lysine biosynthesis via the diaminopimelate biosynthesis pathway in certain organisms. As a result of this activity these com...  
WO/2018/187414A1
The present disclosure provides compounds and methods for inhibiting mTORC2, as well as methods for treating cancers such as glioblastoma.  
WO/2018/187506A1
Described herein are compounds, including pharmaceutically acceptable salts, solvates, metabolites, prodrugs thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such comp...  
WO/2018/187324A1
The subject invention relates to a process of prepating (R)-3-hydroxybutyric acid or a salt thereof by one-step fermentation with a nonpathogenic microorganism. The fermentation of (R)-3-hydroxybutyric acid was performed by supplying wit...  
WO/2018/186365A1
The present invention relates to a novel read-through inducing agent, and also relates to a compound represented by general formula (I) (symbols in the formula are as described in the specification) or a pharmaceutically accepted salt th...  
WO/2018/177865A1
The present invention relates to the use of compounds having an anti- heparanase activity of formu la [R - L1- Ar1- L - Ar]2- X, wherein X is selected from the group consisting of SO2, C1 -C4 a lkylene, linear or branched, and wherein Ζ...  
WO/2018/176343A1
Compounds of Formula (A), where the definition of the variables are as described in the description, as well as their preparation and uses, and pharmaceutical compositions comprising these compounds and their uses as modulators of dysfun...  
WO/2018/177857A1
The present invention relates to symmetrical 2-aminophenyl-benzazolyl-5-acetate compoundsof formula (I). Such compounds are endowed with an anti-heparanase activity. The present invention also relates to the use of such compounds as a me...  
WO/2018/183626A1
Embodiments are directed to a series of novel EPAC antagonists that are designed, synthesized and evaluated in an effort to develop diversified analogues based on the scaffold of the previously identified high-throughput (HTS) hit ESI-09.  
WO/2018/177860A1
The present invention relates to 2-(4-(4-(bromo-methoxybenzamido)benzylamino) phenyl)benzazole derivatives of formula (I) having an anti-heparanase activity. The invention also relates to the use of such compounds as a medicament, in par...  
WO/2018/175185A1
The present invention relates to oxazolidinone Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at ...  
WO/2018/172423A1
The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p¸ q, L, ׇ, X and m are as defined herein. The compound...  
WO/2018/171942A1
It is disclosed a process for obtaining phenolic derivatives with high industrial interest in the pharmaceutical industry by using glycerol carbonate. Specifically, the process provides for a phenol substituted in position 2 to react wit...  

Matches 1 - 50 out of 12,506