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Matches 501 - 550 out of 6,485

Document Document Title
WO/2010/095602A1
Disclosed is a compound represented by general formula (1): (In the formula, L1 represents a substituted or unsubstituted ethenylene group or ethinylene group. R1a‑R1h each independently represent a hydrogen atom or monovalent substitu...  
WO/2010/062536A3
Actinomycin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided.  
WO/2010/023685A3
The present invention relates to a crystalline form of 2-(2-hydroxyphenyl) benz [e] [1, 3] oxazin-4-one, a process for production thereof and its use in the preparation of 4- (3, 5-bis (2-hydroxyphenyl)-1H-1, 2, 4-triazol-1-yl) benzoic a...  
WO/2010/085978A1
The present invention is directed to a process for the preparation of Efavirenz, (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4 -dihydro-2H-3,1-benzoxazin-2-one, of formula (I) comprising reacting the intermediate of formul...  
WO/2010/042867A3
Disclosed are pyruvate kinase M2 activators, which are bis sulfonamide piperazinyl and piperidinyl compounds of Formula (I), 2,4-disubstituted 4H- thieno[3,2-c]pyrrole-2-(substituted benzyl)pyridazin-3(2H)-ones of Formula (II) and 6-(3,4...  
WO/2010/031708A3
The present invention is directed to the compounds of formula (I), wherein R1 to R5 have the significances given herein, to processes for the manufacture of said compounds as well as medicaments containing said compounds. The compounds a...  
WO/2010/087430A1
An N-acyl anthranilic acid derivative represented by general formula (I) or a salt thereof is useful for prevention or treatment of diseases associated with excessive production of collagen. (In the formula, R1 represents a carboxyl grou...  
WO/2010/042925A3
The present invention provides compounds which antagonize epsilon protein kinase C (PKCε). These compounds have a structural formula (Ia), (Ic) or (II). The present invention also provides pharmaceutical compositions containing these co...  
WO/2010/082627A1
A process for producing a 2-hydroxymethylmorpholine salt, which comprises crystallizing the salt from a solution containing 2-hydroxymethylmorpholine, which is represented by formula (1), the 1,4-oxazepane compound represented by formula...  
WO/2010/083441A2
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.  
WO/2010/078103A1
The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invent...  
WO/2010/028051A3
The present invention generally relates to substituted heterocyclic mercaptosulfonamide compounds, precursors, and derivatives as well as methods for the preparation of and pharmaceutical compositions comprising these compounds. These co...  
WO/2010/073254A2
The present invention relates to a process for the preparation of crystalline non-hygroscopic form H1 of efavirenz, and pharmaceutical compositions containing it. In accordance with the present invention efavirenz was dissolved in aceton...  
WO/2010/070365A1
The invention relates to chiral compounds with monoterpene skeleton of general formula (I) - where in the formula X stands for O or H2; W stands for O, S, N-R2 or Ph-R3; Y stands for O or N-R4; R1 stands for H, C1-4Alk or (C2)1-4-Ph; R2 ...  
WO/2010/068881A1
The present invention relates to benzodioxane and benzoxazine derivatives that act as ligands for CC chemokine receptors, such as CCRl. The invention also relates to methods of preparing the compounds, compositions containing the compoun...  
WO/2010/067078A2
This invention pertains generally to processes, uses, methods and materials utilising particular xanthylium compounds, including compounds of formula (I) and (II), as further defined herein. These compounds are useful as drugs, for examp...  
WO/2010/065717A1
The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compoun...  
WO/2010/062536A2
Actinomycin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided.  
WO/2010/019911A3
The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such...  
WO/2010/032259A3
A simple, cost-effective process for preparation of efavirenz of formula (I) comprising reacting a solution of 5-chloro-α-(cyclopropylethynyl)-2-amino-α-trifluoromethyl) benzene methanol of formula (II) in an organic solvent with trip...  
WO/2010/026110A3
The present invention is concerned with 6-substituted benzoxazine derivatives of formula (I), wherein X, Y, R1 and R2 are as described herein, as well as their manufacture, pharmaceutical compositions containing them and their use as med...  
WO/2010/056320A2
6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine and 2-morpholin-4-yl-7H- pyrrolo[2,3-d]pyrimidine derivatives have unexpected drug properties as inhibitors of PI3 and/or mTOR kinases and are useful in treating disorders related to abnormal PI...  
WO/2010/050779A1
Provided are novel organic electroluminescent compounds, and organic electroluminescent devices and organic solar cells comprising the same. The organic electroluminescent compounds according to the present invention exhibit high luminou...  
WO/2010/049302A1
This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula (I) wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. ...  
WO/2010/050781A1
Disclosed Provided are a novel organic electroluminescent compound and an organic electroluminescent device using the same as an electroluminescent material. The disclosed organic electroluminescent compound is represented by Chemical Fo...  
WO/2010/043592A1
Specific aromatic compounds of the general formula (I) can be used for the treatment of obesity wherein R1 e. g. denotes -H, -CH3, -F, -Cl, -Br, -I or -OH, -NH2; -X-Y e.g. denotes a group (1), with n being 1, 2, 3; -Y e. g. denotes a gro...  
WO/2010/042867A2
Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16...  
WO/2010/042475A1
In its many embodiments, the present invention provides a novel class of spiroaminooxazoline analogues as modulators of α2C adrenergic receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more suc...  
WO/2010/042925A2
The present invention provides compounds which antagonize epsilon protein kinase C (PKCε). These compounds have a structural formula (Ia), (Ic) or (II). The present invention also provides pharmaceutical compositions containing these co...  
WO/2010/035915A1
A novel sulfur containing heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obes...  
WO/2010/031708A2
The present invention is directed to the compounds of formula (I), wherein R1 to R5 have the significances given herein, to processes for the manufacture of said compounds as well as medicaments containing said compounds. The compounds a...  
WO/2009/146539A8
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing 4-(aminome...  
WO/2010/032259A2
A simple, cost-effective process for preparation of efavirenz of formula (I) comprising reacting a solution of 5-chloro-α-(cyclopropylethynyl)-2-amino-α-trifluoromethyl) benzene methanol of formula (II) in an organic solvent with trip...  
WO/2010/029926A1
A lighting cover composed of a resin composition containing an ultraviolet absorbent (A), wherein the ultraviolet absorbent (A) is composed of a compound represented by general formula (1). (In the formula, Het1 represents a divalent 5- ...  
WO/2010/029959A1
Disclosed is an acid addition salt of (+)-2-[(inden-7-yloxy)methyl]morpholine (compound A), which is intended to be used as a pharmaceutical agent or an active ingredient for a pharmaceutical agent, and has high storage stability, partic...  
WO/2010/029958A1
Disclosed is a novel and excellent pharmaceutical composition for treating nociceptive pain. The pharmaceutical composition for treating nociceptive pain comprises a morpholine derivative or a pharmaceutically acceptable salt thereof as ...  
WO/2010/029927A1
A compound represented by general formula (1) [wherein Ar1 represents a 5- to 20-membered aromatic cyclic residue having a valency of 2 to 10, provided that the aromatic residue may contain a hetero atom and may have a substituent, and t...  
WO/2010/026110A2
The present invention is concerned with 6-substituted benzoxazine derivatives of formula (I), wherein X, Y, R1 and R2 are as described herein, as well as their manufacture, pharmaceutical compositions containing them and their use as med...  
WO/2010/026112A1
The present invention is concerned with 5-substituted benzoxazine derivatives of formula (I), wherein X, R1 and R2 are as described herein, as well as their manufacture, pharmaceutical compositions containing them and their use as medica...  
WO/2010/028051A2
The present invention generally relates to substituted heterocyclic mercaptosulfonamide compounds, precursors, and derivatives as well as methods for the preparation of and pharmaceutical compositions comprising these compounds. These co...  
WO/2010/023448A1
The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives thereof wherein; X1 is selected from a group consisting of CH2, C(=O), C(=NH), NC(=O), R1 is selected from the group consist...  
WO/2010/023445A1
The present invention provides a compound of formula (I):or its salts or pharmaceutically acceptable derivatives wherein; R1 is selected from the group consisting of optionally substituted arylalkyl, optionally substituted aryl, optional...  
WO/2010/023685A2
The present invention relates to a crystalline form of 2-(2-hydroxyphenyl) benz [e] [1, 3] oxazin-4-one, a process for production thereof and its use in the preparation of 4- (3, 5-bis (2-hydroxyphenyl)-1H-1, 2, 4-triazol-1-yl) benzoic a...  
WO/2009/110985A3
Compounds are provided according to formula (1 ) : where A, B, W, X', L, R1, R3, R4b, and m' are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of co...  
WO/2010/021149A1
Disclosed is a novel prophylactic/therapeutic agent for digestive system diseases. The prophylactic/therapeutic agent for digestive system diseases comprises a compound represented by the formula or a salt or prodrug thereof. In the form...  
WO/2004/092124A8
Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula (I): which are used to...  
WO/2010/019911A2
The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such...  
WO/2010/018198A1
The present invention relates to polymerizable compositions, comprising at least two specific benzoxazines and to cured products obtained from the polymerizable compositions. More particularly, the present invention relates to increasing...  
WO/2008/149380A3
This invention relates to a process for solvent less synthesis of benzoxazine which comprises in taking a phenol in molar combination with primary amine and aldehyde so as to form a ring of oxazine, heating said reactants to a temperatur...  
WO/2010/015107A1
The present invention discloses an intermediate compound for preparing valiolamine and a method for stereoselective synthesis of valiolamine. The intermediate compound possesses chemical structure of formula (21). The said method compris...  

Matches 501 - 550 out of 6,485