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Matches 501 - 550 out of 6,605

Document Document Title
WO/2011/012883A1
Compounds of formula (I): wherein: W is O, N-H, N-alky!, N-alkenyl, N-alkynyl, N-aryl, N-heteroaryl or S; each X is independently CH or N; R1 is formula (b) or R3 is H, alkyl, NH2, OH, =0 or halogen; each A and B are independently CH or ...  
WO/2011/011123A1
This invention relates to substitued 1, 3-oxazin-2-one compounds of the Formula (I), (II), (IIA), (IIB), (IIC), (II D), (IIE), (III), (III A), (III B), (IV), (IV A), (IV B), (IV C), (IV D), (V), (V A), (V B), (VI), (VI A), (VI B), (VII),...  
WO/2011/009943A1
The invention relates to novel heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use as BACE inhibitors for t...  
WO/2011/009203A1
The present invention is directed to methods of preparation of Efavirenz ( 1 ),various intermediates useful in the preparation of Efavirenz and methods of preparation of such intermediates hi some embodiments, a stereoselective cycloprop...  
WO/2011/007367A1
An improved process for Efavirenz, which has several advantages over reported methods like low cost, high yield, better optical purity and industrial feasibility (A).  
WO/2009/116081A3
The present invention relates to an improved process for the preparation of aprepitant compound of formula- (I) as well as novel polymorphs of its intermediates.  
WO/2011/002910A1
This invention relates to novel compounds of the Formula (I), (II), (II-A), (Il-B), (ll-C), (ll-D), (III). (III-A). (IIIl-B). (IIl-C). (IIl-D), (III-E) (IV), (IV-A), (IV-B). (IV-C), (IV-D). (V), (V-A), (V-B), (V-C), (V-D), pharmaceutical...  
WO/2010/148397A1
This invention describes the identification of novel organic dye chemistries that can be used as affinity baits to capture proteins and other biomolecules useful in the fields of medical diagnostics, environmental science, toxicology, an...  
WO/2010/145992A1
The present invention relates to benzoxazinones of the general formula (I) wherein the variables are defined according to the description, processes and intermediates for preparing the benzoxazinones of the formula (I), compositions comp...  
WO/2010/142650A1
The invention relates to compounds of formula (I) wherein A1, R1, R2, R3, R4 and R5 are defined in the description and in the claims, which are preferential inhibitors of the cysteine protease cathepsin, in particular of the cysteine pro...  
WO/2010/139673A1
This invention relates to novel compounds of the Formula (I), dependent compounds of Formula (II), (II-A), (II-B), (II-C), (II-D), (II-E), (II-F), (II-G), (II-H), (III), (III-A), (III-B), (III-C), (IV), (IV-A), (IV-B), pharmaceutically a...  
WO/2010/139758A1
The present invention concerns compounds of general formula (1) (I) wherein R1 is: - a hydrogen atom, or a halogen, - a straight or branched C1-C6 alkyl group or a C1-C3 fluoroalkyl group, - a straight or branched C1-C6 alcoxy group, a c...  
WO/2010/136037A1
The invention relates to novel calcium-sensing receptor (CaSR) modulating substituted cyclopentylene compounds represented in formula I and derivatives thereof, to said compounds for use as a medicament, to said compounds for use in ther...  
WO/2010/133180A1
Disclosed is a kind of poly-iodo benzene compound shown by general formula (I). The poly-iodo benzene compounds have low toxicity, high chemical stability, and are easy to be chemically synthesized. The concentrated aqueous solutions of ...  
WO/2010/130627A1
The invention relates to polymerizable benzoxazine compounds with interfacial active or surface active properties, having at least one polyalkylene oxide structural element, and to a method for producing said compounds. The invention als...  
WO/2010/111626A3
Compounds of the following formula are provided for use in inhibiting Poly (ADP-ribose) Polymerase (PARP): wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprisi...  
WO/2010/067078A3
This invention pertains generally to processes, uses, methods and materials utilising particular xanthylium compounds, including compounds of formula (I) and (II), as further defined herein. These compounds are useful as drugs, for examp...  
WO/2010/124385A1
This invention provides a process for the preparation of S-Rivaroxaban and/or R- Rivaroxaban comprising reacting, in the presence of a first base, a compound of Formula (9): with a compound of Formula (8).  
WO/2010/124521A1
Provided are derivatives of rhein having the structure of general formula (I), their preparation methods and uses in the preparation of medicaments for treating metabolic diseases.  
WO/2010/123870A1
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.  
WO/2010/123139A1
Disclosed is a long-chain fatty acid elongase (Elovl6) inhibitor, which is characterized by comprising at least one of a compound represented by formula (I), a pharmaceutically acceptable salt of the compound, and a solvate of the compou...  
WO/2010/123047A1
Disclosed is a crystal of 2-hexadecyloxy-6-methyl-4H-3,1-benzoxazin-4-one useful as a preventive or therapeutic agent for obesity and the like. Specifically disclosed is a crystal of 2-hexadecyloxy-6-methyl-4H-3,1-benzoxazin-4-one having...  
WO/2010/119906A1
Disclosed is a novel herbicide. A haloalkylsulfonanilide derivative represented by formula (1) or an agrochemically acceptable salt thereof. In formula (1), Z represents –C(R9)(R10)- or –N(R11)-; A represents an oxygen atom, a sulfur...  
WO/2010/119275A1
A monomer of formula (III): wherein X is a polymerisable group Ar, Ar1 and Ar2 each independently represent an optionally substituted aryl or heteroaryl group; R1 represents H or a substituent; and Z represents a direct bond or a divalen...  
WO/2010/120889A1
The present application relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables are'as defined in the claims. The present application also relates to the treatment of metabolic syndrome o...  
WO/2010/115641A1
The invention is directed to a process for the preparation of a chiral cyclic carbamate of formula (I) and/or mirror image, and/or a salt thereof, from the corresponding o-aminobenzyl alcohol and/or salts thereof.  
WO/2010/115640A1
The invention is directed to a process for the preparation of cyclic carbamates of formula (I) and/or a salt thereof, from the corresponding o-aminobenzyl alcohol and/or a salt thereof.  
WO/2010/116270A1
EP2/4 compounds having improved dual pharmacological activity are described. The uniqueness of using EP2/4 dual agonists resides in their ability to modify both uveoscleral outflow via the ciliary muscle and conventional outflow via trab...  
WO/2010/108903A1
The present invention relates to compounds of formula (I), wherein R1a to R1e, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically 5 ...  
WO/2010/111626A2
Compounds of the following formula are provided for use in inhibiting Poly (ADP-ribose) Polymerase (PARP): wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprisi...  
WO/2010/107768A1
The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase ("DGAT") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventin...  
WO/2010/056320A3
6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine and 2-morpholin-4-yl-7H- pyrrolo[2,3-d]pyrimidine derivatives have unexpected drug properties as inhibitors of PI3 and/or mTOR kinases and are useful in treating disorders related to abnormal PI...  
WO/2010/103312A1
A compound useful for therapy of a pain or inflammatory condition, is of formula (I): wherein: R1 is aryl or heteroaryl and is optionally substituted with one or more groups selected from alkyl, CF3, OR6, OCOR6, CONH2, CN, Cl, Br, I, N(R...  
WO/2010/103064A1
The present invention encompasses novel 1,4-dihydro-3,1-benzoxazin-2- one derivatives, which are surprisingly found to be efficacious in animal models of CNS disorders and, as such, are valuable candidates for the prevention or treatment...  
WO/2010/083441A3
Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.  
WO/2010/101247A1
Disclosed is a novel cyclohexane derivative having NPY Y5 receptor antagonism. Specifically disclosed is a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate of the same. In formula (I), A repres...  
WO/2010/102212A2
The present application is related to compounds which are novel neurotrophin mimetics. The application also discloses the treatment of disorders associated with p75 expression, such as degradation or dysfunction of cells expressing p75 i...  
WO/2010/067078A8
This invention pertains generally to processes, uses, methods and materials utilising particular xanthylium compounds, including compounds of formula (I) and (II), as further defined herein. These compounds are useful as drugs, for examp...  
WO/2010/095602A1
Disclosed is a compound represented by general formula (1): (In the formula, L1 represents a substituted or unsubstituted ethenylene group or ethinylene group. R1a‑R1h each independently represent a hydrogen atom or monovalent substitu...  
WO/2010/062536A3
Actinomycin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided.  
WO/2010/023685A3
The present invention relates to a crystalline form of 2-(2-hydroxyphenyl) benz [e] [1, 3] oxazin-4-one, a process for production thereof and its use in the preparation of 4- (3, 5-bis (2-hydroxyphenyl)-1H-1, 2, 4-triazol-1-yl) benzoic a...  
WO/2010/085978A1
The present invention is directed to a process for the preparation of Efavirenz, (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4 -dihydro-2H-3,1-benzoxazin-2-one, of formula (I) comprising reacting the intermediate of formul...  
WO/2010/042867A3
Disclosed are pyruvate kinase M2 activators, which are bis sulfonamide piperazinyl and piperidinyl compounds of Formula (I), 2,4-disubstituted 4H- thieno[3,2-c]pyrrole-2-(substituted benzyl)pyridazin-3(2H)-ones of Formula (II) and 6-(3,4...  
WO/2010/031708A3
The present invention is directed to the compounds of formula (I), wherein R1 to R5 have the significances given herein, to processes for the manufacture of said compounds as well as medicaments containing said compounds. The compounds a...  
WO/2010/087430A1
An N-acyl anthranilic acid derivative represented by general formula (I) or a salt thereof is useful for prevention or treatment of diseases associated with excessive production of collagen. (In the formula, R1 represents a carboxyl grou...  
WO/2010/042925A3
The present invention provides compounds which antagonize epsilon protein kinase C (PKCε). These compounds have a structural formula (Ia), (Ic) or (II). The present invention also provides pharmaceutical compositions containing these co...  
WO/2010/082627A1
A process for producing a 2-hydroxymethylmorpholine salt, which comprises crystallizing the salt from a solution containing 2-hydroxymethylmorpholine, which is represented by formula (1), the 1,4-oxazepane compound represented by formula...  
WO/2010/083441A2
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.  
WO/2010/078103A1
The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invent...  
WO/2010/028051A3
The present invention generally relates to substituted heterocyclic mercaptosulfonamide compounds, precursors, and derivatives as well as methods for the preparation of and pharmaceutical compositions comprising these compounds. These co...  

Matches 501 - 550 out of 6,605