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Matches 551 - 600 out of 6,485

Document Document Title
WO/2010/010150A1
Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance,...  
WO/2009/124962A3
The invention relates to compounds of formula (I) wherein R1, R2, R4, Ra, Rb, Rc, Re, A*, W1, W2 and W3 are as defined in claim 1, for the treatment of CXCR3 related diseases.  
WO/2009/137144A3
The present invention provides a halogen-free curable composition including a benzoxazine monomer, at least one epoxy resin, a catalyst, a toughening agent and a solvent. The halogen-free curable composition is especially suited for use ...  
WO/2009/087679A3
Disclosed herein is a novel process for preparing polymorphic Forms of (S)-6- chloro-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)- 2H-3,1-benzoxazin-2- one referred as M1, I, II, β, and ω.  
WO/2010/003197A1
The present invention relates to a series of novel compounds (I) which have been shown to possess antifungal activity. The invention therefore relates to the new compounds, methods for their preparation, pharmaceutical compositions compr...  
WO/2010/001982A1
A polymeric compound containing a residue of a compound represented by formula (O). [In formula, Ar0's independently represent a substituent such as a hydrogen atom, an alkyl group, an alkoxy group and an aryl group, or a group represent...  
WO/2009/156889A1
The invention relates to derivatives of a compound of formula I: wherein R1 to R7 and X1 to X7 are as defined herein The invention relates to the uses thereof for treating diseases, conditions and/or disorders mediated by kappa opioid re...  
WO/2009/156458A1
The present invention relates to novel phenolic and catecholic amines of Formula 1, to processes for their preparation, pharmaceutical compositions containing them, to their use in therapy and to their use in radiolabeled form as PET- or...  
WO/2009/157196A1
Disclosed is a compound having GPR52 agonist activity and serving as an agent for preventing or treating schizophrenia or the like. Specifically disclosed is a compound represented by formula (I) or a salt thereof. In the formula, A repr...  
WO/2009/104053A3
A composition and method is provided for modifying sperm fertility in mammals for the purpose of biasing the gender in favor of male offspring. The composition includes an amount of a class of compounds of phenoxazine or phenothiazine, h...  
WO/2009/114950A8
The present application relates to pyrrolidine, piperidine, and other nitrogen-containing heterocyclic derivatives and the use of these compounds for treating and preventing pam or inflammation. The analgesic compounds demonstrate effica...  
WO/2009/132093A3
Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein G, B, Y, and A are as described, in claims 1-13 Methods, compositions, and medicaments related thereto are also disclosed, for treatin...  
WO/2009/152024A1
The present invention provides oxazine dyes, processes for preparing the oxazine dyes, intermediates that may be utilized in the processes for preparing the oxazine dyes, and methods for using the oxazine dyes.  
WO/2009/103479A3
The invention relates to a crystalline, enantiomerically pure hydrochloride salt of N-(5-{2-[3-(4,4-diethyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-1 ,1-dimethyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)- methane sulfonamide, preferably...  
WO/2009/146539A1
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing 4-(aminome...  
WO/2009/145360A1
The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by...  
WO/2009/105218A3
This invention relates to novel compounds that are deuterated propiophenones derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel propiophenones derivatives that are derivatives of...  
WO/2009/117467A3
Compounds comprising or a pharmaceutically acceptable salt thereof, are disclosed, wherein Y, A, R1, R2, Z and G as described in claims 1-12. Methods, compositions and medicaments related thereto are also disclosed, for treating gloucoma...  
WO/2009/137413A1
Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein B, Y, and A are as described in claims 1-10. Methods, compositions, and medicaments related thereto are also disclosed, for treating b...  
WO/2009/137411A1
Compounds comprising Formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein J1, J2, U1, B, Y, and A are as described in claims 1-16. Methods, compositions, and medicaments related thereto are also disclosed, fo...  
WO/2009/137412A1
Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, a dashed line represent the presence or absence of a double bond, are disclosed, wherein J1, J2, U1, B, Y, and A are as described in claims 1-12. Methods, co...  
WO/2009/133538A1
The present invention relates to a process for the preparation of Efavirenz (Formula I), wherein triphosgene is used as a cyclizing agent.  
WO/2009/102460A3
This invention relates to novel compounds of the Formula (I), any of the formulas I1-I26 la1-3-lj1-3 or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of...  
WO/2009/006243A8
The invention relates to processes for the preparation of the bicyclic oxazine carboxaldehyde Compound 1: (I) The invention also relates to the use of Compound 1 in the preparation of β-lactamase inhibitors.  
WO/2009/131977A1
Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein J, B, Y, and A are as described in claims 1-13. Methods, compositions, and medicaments related thereto are also disclosed, for treatin...  
WO/2009/129726A1
The present invention provides novel nitrones, their preparation and use. The novel compounds have the following formula: I The compounds of the present invention have strong antioxidative activity, and are thrombolytic. These compounds ...  
WO/2009/131065A1
Disclosed is a compound useful as a prophylactic agent or a therapeutic agent for cardiovascular diseases, nervous system diseases, metabolic diseases, genital diseases, gastrointestinal diseases, neoplasm, infectious diseases and others...  
WO/2009/132093A2
Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein G, B, Y, and A are as described, in claims 1-13 Methods, compositions, and medicaments related thereto are also disclosed, for treatin...  
WO/2009/128262A1
Disclosed is a compound having excellent NK2 receptor binding activity. The compound is satisfactory as a pharmaceutical product. Specifically disclosed is a neurokinin receptor antagonist containing a compound represented by formula (I)...  
WO/2009/101432A3
A route for preparing a compound of formula (I), where X, R1,R2, R7, R8 and R9 are as defined in the specification, is described. Process steps used in the route and novel intermediates prepared during the route are also described and cl...  
WO/2009/128395A1
Disclosed is a bone formation promoter having excellent efficacy and few adverse side effects. The bone formation promoter comprises 2-aminophenol or a derivative thereof as an active ingredient.  
WO/2009/125861A1
Disclosed are a compound having an outstanding cysteine protease inhibiting action, and medicaments for treating or preventing a disorder selected from a set comprising osteoporosis, osteoarthrosis deformans, rheumatoid arthritis, Paget'...  
WO/2009/126527A1
The present invention discloses 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I. The compounds are useful in treating and/or preventing various human disease...  
WO/2009/114950A1
The present application relates to pyrrolidine, piperidine, and other nitrogen-containing heterocyclic derivatives and the use of these compounds for treating and preventing pam or inflammation. The analgesic compounds demonstrate effica...  
WO/2009/117467A2
Compounds comprising or a pharmaceutically acceptable salt thereof, are disclosed, wherein Y, A, R1, R2, Z and G as described in claims 1-12. Methods, compositions and medicaments related thereto are also disclosed, for treating gloucoma...  
WO/2009/113569A1
Provided is a medicinal composition, in particular, a medicinal composition for treatment and/or prevention which has a high therapeutic effect on infection with a parasitic protozoa and a selective toxicity thereto and exhibits a life-p...  
WO/2009/070579A3
A method of inhibiting formation of cancerous metabolites, of inhibiting cytochrome P450 2A13 from forming carcinogen metabolites, and/or inhibiting formation of cancerous lung cells in a subject can include: providing a morpholine compo...  
WO/2009/106486A1
This invention relates to processes and intermediates for the stereoselective morpholine derivatives. The invention in particular allows the stereoselective preparation of the drugs aprepitant and fosaprepitant.  
WO/2009/105906A1
A method of providing a range of flavors to an orally-receivable or ingestible product, the method including adding at least one compound, including salts thereof, of the formula (I) wherein R1 may be selected from H, OH, O(CH2)2OH, OCH2...  
WO/2009/107448A1
Disclosed is a novel thiol detection reagent which can be used in vivo and does not cause such a problem that the background fluorescence induced by hydrolysis may be observed. Also disclosed is a thiol detection method using the reagent...  
WO/2009/075835A8
This invention relates to novel compounds of the Formula (I), (Ia) and (Ib), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, j which are useful for the therapeutic treatment of diseases associated with...  
WO/2009/105218A2
This invention relates to novel compounds that are deuterated propiophenones derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel propiophenones derivatives that are derivatives of...  
WO/2009/103479A2
The invention relates to a crystalline, enantiomerically pure hydrochloride salt of N-(5-{2-[3-(4,4-diethyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-1 ,1-dimethyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)- methane sulfonamide, preferably...  
WO/2009/101432A2
A route for preparing a compound of formula (I), where X, R1,R2, R7, R8 and R9 are as defined in the specification, is described. Process steps used in the route and novel intermediates prepared during the route are also described and cl...  
WO/2009/102460A2
This invention relates to novel compounds of the Formula (I), any of the formulas I1-I26 la1-3-lj1-3 or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of...  
WO/2009/099110A1
Disclosed is an ultraviolet absorbent which is composed of a compound represented by general formula (1). (In the formula, R1a, R1b, R1c, R1d, R1e, R1f, R1g and R1h independently represent a hydrogen atom or a monovalent substituent; and...  
WO/2009/094956A1
A method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid of formula (I) by reaction of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one of formula (II) with 4-hydrazinobenzoic acid of formula (III) in an organic aci...  
WO/2009/093905A1
The present invention relates to a method for analyzing seed viability comprising incubating at least one seed in an aqueous solution comprising resazurin and a respiring or fermenting microorganism, and monitoring in said aqueous soluti...  
WO/2009/094169A1
This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie),(If), (Ig), (Ih), (Ii), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic t...  
WO/2009/087649A1
The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present inventi...  

Matches 551 - 600 out of 6,485