Heterocyclic Compounds

Matches 901 - 950 out of 5,013	< 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 >

Document	Document Title
WO/2006/066044A2	PROCESSES FOR PRODUCING 4-AMINOQUINAZOLINES The present invention relates to methods for preparing compounds of formula (I): or suitable salts thereof useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also relates to methods for preparing in...
WO/2006/061372A2	PHENYLPIPERAZINES WITH A COMBINATION OF AFFINITY FOR DOPAMINE -D2 RECEPTORS AND SEROTONIN REUPTAKE SITES The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine -D2 receptors and to methods for the preparation of these compounds. The invention...
WO/2006/057460A1	NITROGEN-CONTAINING FUSED RING COMPOUND AND USE THEREOF An URAT1 activity inhibitor which contains a nitrogen-containing fused ring compound represented by the following general formula [1]: [1] wherein each symbol is as defined in the description. This URAT1 activity inhibitor is useful in, ...
WO/2006/050054A2	COMPOUNDS AND METHODS OF USE THEREOF Benzolactam boronic acid compounds and pharmaceutical formulations are described along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-&agr ) in a subject in need thereof.
WO/2006/049038A1	PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-(HYDROXYMETHYL)MORPHOLINE DERIVATIVE A process by which an optically active 3-(hydroxymethyl)morpholine derivative useful as an intermediate for medicines can be easily produced from an inexpensive, easily available raw material and which is practical for industrial product...
WO/2006/045505A1	MIF-INHIBITORS 3,4-dihydro-benzo[e][1,3]oxazin-2-ones which are substituted at the nitrogen atom by unsubstituted or substituted (C3-8)cycloalkyl, (C1-4)alkyl(C3-8)cycloalkyl, (C6-18)aryl or (C6-18)aryl(C1-4)alkyl and their use as pharmaceuticals.
WO/2006/047479A2	C-FMS KINASE INHIBITORS The invention is directed to compounds of Formula (I) wherein A, R1, R2, R3, R4, X, and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyr...
WO/2006/047503A2	INHIBITORS OF C-FMS KINASE The invention relates to compounds of Formula (I) wherein A, R1, R2, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kina...
WO/2006/043950A1	IL-8 RECEPTOR ANTAGONISTS This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
WO/2006/042150A1	DIAMINOALKANE ASPARTIC PROTEASE INHIBITORS Diaminoalkanes of Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with elevated levels of aspartic pr...
WO/2006/040643A2	POLYMORPHIC FORMS OF EFAVIRENZ AND PROCESSES FOR THEIR PREPARATION The present invention relates to novel polymorphic forms of efavirenz. The novel polymorphic forms are designated as Forms &agr , β, &gammad , &gammad 1, &gammad 2, &ohgr ,&dgr , N, O and P of efavirenz. The present invention further re...
WO/2006/037481A1	BENZOXAZINE AND QUINOXALINE DERIVATIVES AND USES Compounds of the formula (I); or a pharmaceutically acceptable salt, thereof, wherein k, m, n, p, q, X, Y, Z, Ar, R1, R2, R3 and R4 are as defined herein as well as methods for the preparation thereof, pharmaceutical compositions contain...
WO/2006/037775A1	ENANTIOPURE HETEROCYCLIC COMPOUND USEFUL FOR THE PREPARATION OF PEPTIDES WHICH CAN BE POTENTIALLY USED AS MEDICAMENTS Enantiopure heterocyclic compound Enantiopure heterocyclic compound of formula (I) in which J is chosen from C, N, O and S; Z is H or a group for protecting the amino functional group, R3 denotes H or an organic residue, m is 0, 1 or 2 a...
WO/2006/036790A1	ARYL-UREIDO BENZOXAZINONE COMPOUNDS Fluorescent pigment compounds comprising aryl-ureido benzoxazinone compounds of the general formula (I): wherein R1 is an substituted or unsubstituted aryl group, R2 and R3 are each independently selected from an H atom, an alkyl group, ...
WO/2006/034583A1	ALKYNYL BASED DERVATIVES OF BENZOPHENONE AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS Compounds of formula (I) wherein Q, R1, R2, R3, R4, R6 and R7 are as defined herein. The compounds are useful as reverse transcriptase inhibitors against HIV. In particular, the compounds are active against wild type and single or double...
WO/2006/034093A2	3- (2-ACYLAMINO-1-HYDROXYETHYL)- MORPHOLINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.
WO/2006/029623A1	SUBSTITUTED ANILINE DERIVATIVES The present invention relates to aniline derivatives of the general formula (I) or salts thereof and their use, related to their KCNQ potassium ion channel opening activity.
WO/2006/030299A1	PROCESSES FOR THE PREPARATION OF POLYMORPHS OF EFAVIRENZ The invention relates to processes for the preparation of polymorphic forms of efavirenz. More particularly, it relates to the preparation of Form I and Form II of efavirenz. The invention also relates to pharmaceutical compositions that...
WO/2006/028284A1	MORPHOLINE COMPOUND A compound represented by the general formula (1): [wherein ring A represents optionally substituted aryl, etc.; ring B represents optionally substituted arylene, etc.; m is 0 to 2; n is 1 to 5; X represents a bond, etc.; Y represents a ...
WO/2006/029079A2	SYNTHESIS OF A BENZOXAZINONE The present invention provides novel methods for the synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihy dro-2H-3,1-benzoxazin-2-one of formula (III) which is useful as a human immunodeficiency virus (HIV) reverse t...
WO/2006/024217A1	ARYLAMINE KETONES, THEIR PREPARATION METHODS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE Disclosed Arylamine ketones of formula (I), their preparation methods, the pharmaceutical compositions containing them and their use in preventing and/or treating the diseases related to the plaque-activating factors, especially in anti-...
WO/2006/023158A2	MINERALOCORTICOID RECEPTOR MODULATOR COMPOUNDS AND METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds.
WO/2006/021654A1	4-ARYLMORPHOLIN-3-ONE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF The invention concerns compounds of formula (I) wherein: Ar represents a mono- or disubstituted phenyl; R1 represents an unsubstituted or substituted phenyl; R2 represents a pyridyl, an unsubstituted or substituted phenyl, an unsubstitut...
WO/2006/023381A1	PYRIMIDINONE COMPOUNDS This invention relates to treating inflammatory and immune diseases with certain pyrimidinone compounds that bind to CXCR3 receptors. The pyrimidinone compounds are covered by the formula (I) shown below. Each variable is defined in the ...
WO/2006/021213A2	VASOPRESSIN V1A ANTAGONISTS The present invention concerns compounds inter alia according to general formula: (1a). Compounds according to the invention are vasopressin V1a receptor antagonists. Pharmaceutical compositions of the compounds are useful as treatment o...
WO/2006/018853A2	NOVEL POLYMORPHS OF EFAVIRENZ The present invention relates to novel amorphous and crystalline forms of efavirenz, processes for their preparation and pharmaceutical compositions containing them. In accordance with the present invention efavirenz crude is dissolved i...
WO/2006/017326A1	ANTIBACTERIAL AGENTS Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
WO/2006/015259A2	COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activation of steroid hormone nuclear receptors.
WO/2006/012725A1	LYSINE BASED COMPOUNDS The present invention provides lysine based compounds of the formula (I); and when the compound of formula (I) comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein Rl may be, for example, (HO)2P(O)-, (NaO...
WO/2006/014207A1	PROSTAGLANDIN ANALOGS Compounds comprising formula (I): or a pharmaceutically acceptable salt or a produg thereof is disclosed herein. A, X, J, E, and Z are as described herein. These compounds are useful for treating glaucoma or ocular hypertension.
WO/2006/011466A1	5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR Disclosed are a compound and pharmaceutically acceptable salts thereof represented by the general formula (1) below. (In the formula (1), R1, R2, R3, R4 and X are the same as R1, R2, R3, R4 and X defined in the description.)
WO/2006/010142A2	MINERALOCORTICOID RECEPTOR MODULATOR COMPOUNDS, PROCESSES FOR THEIR PREPARATION, AND THEIR USE This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds.
WO/2006/006617A1	AGENT FOR PROMOTING THE RECOVERY FROM DYSFUNCTION AFTER THE ONSET OF CENTRAL NEUROLOGICAL DISEASE It is intended to provide a novel agent for promoting the recovery from dysfunction after the onset of a central neurological disease or an agent for enhancing and/or promoting the effect of rehabilitation for functional recovery. Namely...
WO/2006/002810A1	PHENYL SUBSTITUTED [1.2]-OXAZINE-3,5-DIONE AND DIHYDROPYRONE DERIVATIVES The invention relates to novel phenyl substituted [1.2] oxazine-3,5-dione and dihydropyrone derivatives of formula (I), wherein A, B, U, V, W, X, Y and Z have the above-mentioned meaning. The invention also relates to several methods for...
WO/2006/001326A1	METHOD FOR PRODUCING N-CARBONYL SATURATED HETEROCYCLIC RINGS AND SYNTHETIC INTERMEDIATE THEREOF Disclosed is a novel method for producing N-carbonyl saturated heterocyclic rings. Also disclosed are an intermediate thereof, a method for producing such an intermediate, and use of the N-carbonyl saturated heterocyclic rings. Specifica...
WO/2006/000398A1	2,3-BENZOXAZIN DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS The present invention provides compounds of formula (I), wherein R1 represents 1-ethylpropyl, 1-methylethyl or 2-methylpropyl; or a physiologically functional derivative thereof; pharmaceutical compositions comprising the compounds, the ...
WO/2006/000401A1	SUBSTITUTED OXAZINES AS GLUCOCORTICOID RECEPTOR MODULATORS The present invention is directed to compounds of formula (I), wherein R1 represents a C3-6cycloalkyl group; or a physiologically functional derivative thereof, pharmaceutical compositions comprising the compounds, the use of the compoun...
WO/2006/001318A1	SULFONAMIDE COMPOUND Disclosed are a compound represented by the formula (I) below, prodrugs thereof, pharmaceutically acceptable salts of those and solvates of those. (I) (In the formula, R1 represents an ethyl which may be substituted by a halogen or an am...
WO/2005/118562A1	NEW ISOBENZOXAZINONES AND THEIR USE AS ULTRAVIOLET LIGHT ABSORBERS The present invention relates to new substituted isobenzoxazinones, in particular of formula (I) as given in claim 1, and their use as ultraviolet light absorbers, in particular for organic polymers.
WO/2005/116027A2	INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS The present invention provides for compounds of formula (I), which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention ...
WO/2005/115972A1	THERAPEUTIC COMPOUNDS Compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are ...
WO/2005/113524A1	FLUORESCENT METHOD AND COMPOUNDS TO MONITOR PROTEIN-LIPID BINDING The invention refers to compounds according to formula (I), wherein Rl is independently in position 2', 3', or in both positions of the A ring and is hydroxyl, linear or branched -0-alkyl, wherein the alkyl group has 1-12 carbon atoms, p...
WO/2005/111005A1	NOVEL ENANTIOMERICALLY PURE BETA-AGONISTS, METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF A DRUG The invention relates to enantiomerically pure compounds of formula (1), wherein the radicals R1, R2, R3, R4 and X are defined as in claims and a description. A method for producing said compounds and the use thereof in the form of a dru...
WO/2005/110990A1	HYDROXY-SUBSTITUTED BENZO-CONDENSED HETEROCYCLES FOR USE AS BETA AGONISTS IN THE TREATMENT OF RESPIRATORY DISEASES The invention relates to the compounds of general formula (1), wherein the groups n, A, B, R1, R2 and R3 are defined as in the claims and in the description, and to methods for producing the same. The invention also relates to the use of...
WO/2005/111002A2	SUBSTITUTED CYCLOALKYL DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY DISEASES The invention relates to the compounds of formula (1), wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X are defined as in the claims and in the description. The invention also relates to the use of these compounds as drugs, ...
WO/2005/111004A1	NOVEL SUSTAINED-ACTION BRONCHODILATING AGENTS FOR USE IN THE TREATMENT OF RESPIRATORY DISEASES The invention relates to the compounds of general formula (1), wherein the groups n, A, B, D, L, R1, R2, R3 and R4 are defined as in the claims and in the description, and to methods for producing the same. The invention also relates to ...
WO/2005/108359A1	NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES The present invention relates to compounds with the formulas (I), (II), and (III), or a pharmaceutically acceptable salt thereof: wherein T is a (4 to 10)-membered heterocyclyl selected from the group consisting of and wherein R1. R2 and...
WO/2005/108381A1	SYNTHESIS AND USES OF SYNEPHRINE DERIVATIVES The present invention discloses a novel syntheses of synephrine, its derivatives, and the salts of the foregoing, including their intermediates. One or more of the substituents of the nitrogen atom of the synephrine is/are modified to pr...
WO/2005/105763A1	SUBSTITUTED MORPHOLINE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS This invention relates to compounds of the formulae (I), (II), (III), wherein R'- Re, A, X, and Z are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system d...
WO/2005/105776A1	ARYLSULFONYL BENZODIOXANES USEFUL FOR MODULATION THE 5-HT6 RECEPTOR, THE 5-HT2ARECEPTOR OR BOTH Compounds of the formula (I) or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, n, p, Ar, X, R1, R2, R3, R4, R5 and R6 are as defined herein as well as compositions comprising these compounds and uses of the s...

Matches 901 - 950 out of 5,013	< 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 >