Heterocyclic Compounds

Matches 951 - 1,000 out of 5,013	< 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 >

Document	Document Title
WO/2005/105764A1	BUTANOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THREREOF Compounds of the formula (I): in which R, R1 and R2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and . processes for the...
WO/2005/105100A1	MORPHOLINE COMPOUNDS The present invention provides compounds of Formula I: wherein R1, R2, R3, and n have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of conditions...
WO/2005/103018A1	UREA DERIVATIVES AS ANTAGONISTS OF THE VANILLOID RECEPTOR (VR1) This invention relates to urea derivatives according to general formula I and salts thereof which are useful as active ingredients of pharmaceutical preparations. The urea derivatives of the present invention have an excellent activity a...
WO/2005/100333A1	METHODS AND INTERMEDIATES FOR THE SYNTHESIS OF DELTA-9 TETRAHYDROCANNABINOL Processes are disclosed for the synthesis of Delta-9 tetrahydrocannabinol which result in an improved Y-THC/Y-THC ratio, and intermediates are disclosed that may be used in the synthesis of Delta-9 tetrahydrocannabinol such that improved...
WO/2005/100325A1	ARYL GLYCINAMIDE DERIVATIVES AND THEIR USE AS NK1 ANTAGONISTS AND SEROTONIN REUPTAKE INHIBITHORS Compounds of the following Formula (I) wherein R1 and R2 are independently selected from alkyl or alkenyl or from a heterocyclic ring together with the N to which they are bound, n is 0-2, Ar1 is (substituted) phenyl and Ar1 is (substitu...
WO/2005/099688A2	CYCLIC COMPOUNDS There is provided a CRF receptor antagonist comprising a compound of the formula (I): A-W-Ar wherein, A is a group represented by the formula (A1) or (A2) (wherein, ring Aa is a 5-or 6-membered ring which may be further substituted; ring...
WO2005030794B1	HEMIASTERLIN DERIVATIVES AND USES THEREOF The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
WO/2005/097761A1	HETEROCYCLIC PHENYLAMINOPROPANOL DERIVATIVES AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of con...
WO/2005/097744A1	1-(1H-INDOL-1-YL)-3-(4-METHYLPIPERAZIN-1-YL)-1-PHENYL PROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE NOREPINEPHRINE (NE) AND THE SEROTONINE (5-HT) ACTIVITY AND THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) The present invention is directed to phenylaminopropanol derivatives of formula (I): or a pharmaceutically acceptable salt thereof; wherein: the dotted line between Y and Z represents an optional double bond; the dotted line between the ...
WO/2005/095440A1	BETA-AMINOACID-DERIVATIVES AS FACTOR Xa INHIBITORS The present invention relates to compounds of the Formula (I), in which R°; R1; R2; R3; R4; R5; R6; Q; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds....
WO/2005/095338A1	ALKOXYPHENYLPROPANOIC ACID DERIVATIVES The invention aims at providing novel compounds having regulatory effect on the activity of GPR (G protein-coupled receptor) 40 and being useful as insulin secretagogue or preventive or therapeutic agent for diabetes and so on. Compounds...
WO/2005/092870A1	NOVEL BENZOXAZINONE DERIVATIVES USED AS LONG-ACTING BETAMIMETICS FOR TREATING RESPIRATORY ILLNESSES The invention relates to compounds of general formula (I) in which radicals R, R1, R2, R3 and A can have the meanings as cited in the claims and in the description, to methods for the production thereof, and to their use as medicaments, ...
WO/2005/090282A1	ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also...
WO/2005/087754A1	SUBSTITUTED MORPHOLINE AND THIOMORPHOLINE DERIVATIVES The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.
WO/2005/082869A1	METHOD FOR THE PREPARATION OF ARYL ETHERS The invention provides a method of preparing a compound of formula (I): wherein R, R1, n and m are as defined herein, or a pharmaceutically acceptable salt thereof; comprising the steps: (a) reaction of a compound of formula (II): wherei...
WO/2005/080339A1	SULFONYLOXY DERIVATIVES Compounds useful as intermediates in the synthesis of neurokinin receptor antagonists, that is, compounds represented by the general formula (I): (I) wherein R1 is substituted phenyl; R2 is halogenated phenyl; R3 is substituted phenyl; D...
WO/2005/076747A2	DOUBLE SALTS OF (-)-HYDROXYCITRIC ACID WITH AN AMINE AND A GROUP II A METAL AND A PROCESS FOR PREPARING THE SAME This invention relates to novel double salt of (-)-hydroxycitric acid with an amine and zinc or a group II A metal. These compounds are stable and water soluble and are used as nutraceuticals, weight reducing agents and in beverages. The...
WO/2005/077463A2	LIGAND FOR A MONOAMINE RECEPTOR OR TRANSPORTER FOR TREATING ADDICTION OR DEPENDENCE One aspect of the present invention relates to a method of treating of drug addiction or drug dependence in a mammal, comprising the step of administering to a mammal in need thereof a therapeutically effective amount of a heterocyclic c...
WO/2005/073201A1	UREA DERIVATIVES Novel compounds of formula (I), wherein X-Y-D-E, R1, R2 and R3 have the meanings as cited in patent claim 1, are inhibitors of the coagulation factor Xa and can be used for preventing and/or treating thromboembolic diseases and for treat...
WO/2005/070908A1	NOVEL LONG-WORKING BETA-2-AGONISTS AND USE THEREOF AS MEDICAMENTS The invention relates to compounds of formula (1), wherein groups X, Ra, Rb, R1, R1', R2, R2', R2'', R2''', V and n can have the meanings as cited in the claims and in the description, and to the use of these compounds as medicaments, pa...
WO/2005/070872A1	ARYL ANILINE DERIVATIVES AS BETA2 ADRENERGIC RECEPTOR AGONISTS The invention provides novel β2-adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2-adrenergic r...
WO/2005/067502A2	ALKYLAMINO, ARYLAMINO, AND SULFONAMIDO CYCLOPENTYL AMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Compounds of the formula (I) which are modulators of chemokine receptor activity useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including al...
WO/2005/067933A1	1-BENZYL-5-PIPERAZIN-1-YL-3,4 DIHYDRO-1H-QUINAZOLIN-2-ONE DERIVATIVES AND THE RESPECTIVE 1H-BENZO(1,2,6)THIADIAZINE-2,2-DIOXIDE AND 1,4-DIHYDRO-BENZO(D) (1,3)OXAZIN-2-ONE DERIVATIVES AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR (5-HT) FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM The invention relates to substituted quinazolinone compunds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Y is C or S; m is 1 when Y is C and m is 2 when Y is S; n is 1 or 2; p is from 0 to 3; q is from 1 to 3; Z ...
WO/2005/065779A1	CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONISTS The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors ('CGRP-receptor'), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment usin...
WO/2005/066144A1	MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.
WO/2005/063705A1	BENZENE COMPOUNDS DISUBSTITUTED WITH CYCLIC GROUPS AT THE 1- AND 2-POSITIONS Compounds represented by the general formula (1) or (100) have excellent inhibitory activities against cell adhesion and cell infiltration and are useful as therapeutic or preventive agents for various inflammatory and autoimmune disease...
WO/2005/060663A2	DERIVATIVES OF GAMBOGIC ACID AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS The present invention is directed to novel derivatives of gambogic acid and analogs thereof. The present invention also relates to the discovery that novel derivatives of gambogic acid are activators of caspases and inducers of apoptosis...
WO/2005/061491A2	ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS WITH AFFINITY FOR 5-HT1 RECEPTORS The present invention relates to compounds of the formula (I) wherein R1, R2, R3, X, Y and the dashed line are defined in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and to th...
WO/2005/058846A1	PROCESS FOR THE PORDUCTION OF DTPA-BIS ANHYDRIDE Process for the production of DTPA-bis(anhydride) by reacting DTPA with acetic anhydride in pyridine under elevated temperature wherein the molar amount of pyridine is equal to or less than 6 times the molar amount of DTPA.
WO/2005/058884A2	CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane c...
WO/2005/058847A1	BENZOXAZINE DERIVATIVES AND USES THEREOF Compounds of the formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, X, Y and m are as defined herein. Also provided are compositions containing these compounds, the ...
WO/2005/056536A1	ANTIDIABETIC AGENTS WHICH EXHIBIT ACTIVITY AGAINST PPAR The present invention relates to alkanoic acids and their derivatives which exhibit activity against PPARs, and hence can be used as antidiabetic compounds. Compounds disclosed herein can be used as peroxisome proliferation activated rec...
WO/2005/054871A2	ANALYSIS OF MASS SPECTRAL DATA IN THE QUIET ZONES Embodiments of this invention relate to the analysis of mass spectral data in the quiet zones.
WO/2005/053663A2	NOREPINEPHRINE REUPTAKE INHIBITORS USEFUL FOR TREATMENT OF COGNITIVE FAILURE Selective norepinephrine reuptake inhibitors are used to treat cognitive failure.
WO/2005/051934A1	ANTITHROMBOTIC COMPOUNDS WITH DUAL FUNCTION The present invention comprises compounds of the general formula (I) : and pharmaceutically acceptable salts thereof, wherein the substituents have in the description specified meaning. The compounds are used as antithrombotic agents pos...
WO/2005/051869A2	CARBON-CARBON CROSS COUPLING CATALYZED BY TRANSITION METALS ON SOLID SUPPORTS The present invention provides methods of coupling carbon-containing compounds using a transition metal or transition metal complex on a solid support. The solid support can include alkaline earth metal salts, including carbonate and sul...
WO/2005/049589A2	HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA, DIABETES, OBESITY AND SIMILAR DISEASES Disclosed are novel compounds of formula (I), having hypolipidaemic and hypocholesterolemic properties, their tautomeric forms, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acce...
WO/2005/047272A1	MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.
WO/2005/047245A2	FLUORESCENCE ASSAYS WITH IMPROVED BLOCKING GROUPS Latent fluorescent compounds, comprising a fluorescent molecule with one or more blocking groups attached and optionally one or more urea-containing groups are provided. The urea-containing group can be used to further attach one or more...
WO/2005/047230A1	BIS-CATIONIC COMPOUNDS AND USE THEREOF The present invention relates to bis-cationic compounds comprising quaternary ammonium groups and/or quaternary phosphonium groups. The invention also relates to the use of bis-cationic compounds as Phospholipase B inhibitors and the use...
WO/2005/044201A2	PH SENSITIVE PRODRUGS OF 2,6-DIISOPROPYLPHENOL The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-i...
WO/2005/044809A1	DIASTEREOMERIC DYNAMIC KINETIC RESOLUTION PROCESS FOR PREPARING (+)-(2S, 3S)-2-(3-CHLOROPHENYL)-3,5,5-TRIMETHYL-2-MORPHOLINOL, SALTS, AND SOLVATES THEREOF Disclosed is a method for preparing (+)-(2S, 3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol, pharmaceutically acceptable salts, and pharmaceutically acceptable solvates thereof, such as the (+)-(2S, 3S)-2-(3-chlorophenyl)-3,5,5-tri...
WO/2005/042504A1	FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION IN DETECTING HYDROGEN PEROXIDE The invention provides novel fluorinated resorufin compounds having the general in which at least one of Rb, Rc, Re, Rf, Rh et Ri is fluorine; Rd represents Ord1 ou NRd1Rd2; Rg represents ORg1, NRg1Rg2 ou (=O); X is oxygen or sulfur; tha...
WO/2005/042503A1	ENZYME-CATALYZED DYNAMIC KINETIC RESOLUTION PROCESS FOR PREPARING (+)-(2S, 3S)-2-(3-CHLOROPHENYL)-3,5,5-TRIMETHYL-2-MORPHOLINOL, SALTS, AND SOLVATES THEREOF A process for preparing (+)-(2S, 3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol, pharmaceutically acceptable salts and solvates thereof such as the (+)-(2S, 3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride salt vi...
WO/2005/040104A1	NOVEL COMPOUNDS AND THEIR USE IN MEDICINE: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The present invention relates to novel hypolipidemic, antiobesity, hypocholesterolemic and antidiabetic compounds. More particularly, the present invention relates to novel alkyl carboxylic acids of the general formula (I), their stereoi...
WO/2005/040357A2	COMPOUNDS AND METHODS FOR FLUORESCENT LABELING Compounds useful in the fluorescent labeling of biological materials are provided along with methods for their use and preparation.
WO/2005/040141A1	RESOLUTION PROCESS FOR PREPARING (+)-(2S,3S)-2-(3-CHLOROPHENYL)-3,3,3-TRIMETHYL-2-MORPHOLINOL Disclosed is a method for preparing (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts such as the (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride salt via dyna...
WO/2005/040102A2	NOVEL COMPOUNDS AND THEIR USE AS ANTIDIABETIC AND HYPOLIPIDEMIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The present invention relates to novel compounds of formula (I) and their pharmaceutically acceptable salts, wherein ring “Ar1” represents a monocyclic or polycyclic aromatic or partially saturated aromatic polycyclic, which may opti...
WO/2005/040140A1	NEW PROCESS FOR PREPARING AN OPTICALLY PURE 2-MORPHINOL DERIVATIVE The present invention relates to a process for preparing optically pure (+)-(2S, 3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates from a mixture of (+)-(2S, 3S)-2-(3-chlorophenyl)-3,...
WO/2005/037772A2	NOVEL LIGAND ACTIVATING RECEPTORS RARS USED FOR HUMAN MEDICINE AND COSMETICS The invention relates to novel compounds of general formula (I), compositions containing said compounds and to the use thereof for producing pharmaceutical compositions used for human medicine or for veterinary science, and also for cosm...

Matches 951 - 1,000 out of 5,013	< 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 >