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Matches 201 - 250 out of 6,616

Document Document Title
WO/2016/145153A1
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associat...  
WO/2016/143652A1
Provided is a compound that exhibits an excellent controlling effect against harmful arthropods. A 3-aminooxalylaminobenzamide compound represented by formula (1) has an excellent controlling effect against harmful arthropods. [In the fo...  
WO/2016/141257A1
The present disclosure provides an organic sulfur acid-free composition containing a benzoxazine, phenolic compound and nitrogen-containing heterocyclic compound. The organic sulfur acid-free composition, upon curing at temperatures as l...  
WO/2016/089758A3
Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical problems associated with OSDA synthesis and subsequent zeolite synthesis. Methods for...  
WO/2016/089182A3
The present invention relates to a polybenzoxazine precursor and a method for preparing the same and, more specifically, to a polybenzoxazine precursor and a method for preparing the same, wherein the polybenzoxazine precursor can be pre...  
WO/2016/127661A1
Provided is a synthesis process for a chiral cyclopropyl ethynyl tertiary alcohol compound. With regard to the process of the present invention, a chiral amino alcohol or a chiral amino diol is reacted as a ligand in the presence of an a...  
WO/2016/123707A1
The present application relates to a novel process for the preparation of difluoromethyl ether-based derivatives from, for example, aliphatic and aromatic hydroxyl precursors, compositions comprising these compounds and their use, in par...  
WO/2016/112513A1
This invention provides compounds and compositions for inducing mesenchymal stem cells into chondrocytes ex vivo and in vivo. The compound could lead to a stem cell-based therapy for osteoarthritis and joint injuries. The present inventi...  
WO/2016/109406A1
A mefa-substituted trifunctional benzoxazine monomer and compositions containing the same, wherein the trifunctional benzoxazine monomer is represented by the following structure.  
WO/2016/109399A1
A curable composition containing more than 80% by weight of a blend of benzoxazines, wherein the blend includes (A) one or more multifunctional benzoxazines and (B) a liquid, non-halogenated monofunctional benzoxazine. This composition h...  
WO/2016/101887A1
The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The ...  
WO/2016/099988A1
A curable benzoxazine composition is described wherein the benzoxazine is derived from an aryl amine having a b.p. > 200°C. The curable compositions are more thermally stable and have reduced weight loss and by-products upon cure.  
WO/2016/097023A1
The invention relates to novel cationic benzoxazine-based compounds of formula (I) below, in which ● R represents a hydrogen atom or a C1-C4 alkyl or C1-C4 hydroxyalkyl radical, ● R2, R3, R4 and R5 independently represent: - a hydrog...  
WO/2016/089735A1
A method for synthesizing a zeolite is described. The method may include the steps of: (a) preparing an aqueous mixture comprising water, a substituted hydrocarbon, and a 1-oxa-4-azacyclohexane derivative; (b) reacting the aqueous mixtur...  
WO/2016/075240A1
The invention relates to morpholine and 1,4-oxazepane amide derivatives of general formula (I), which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4. In addit...  
WO/2016/069358A1
A synthesis process for making a benzoxazine compound containing at least one benzoxazine unit from aromatic amine containing at least one primary amino group, at least one phenolic compound with at least one ortho-hydrogen, and alkyl fo...  
WO/2016/064585A1
Segregated fluorinated esters are described that are useful as dielectric fluids in electrical devices and as heat transfer agents.  
WO/2016/055858A1
The present application relates to compounds of formula (I), (la), or (lb) and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing Αβ-related pathologies such as Down's ...  
WO/2015/171610A3
The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17...  
WO/2016/030790A1
Oxime sulfonate compounds of the formula (I), wherein R 1 is O(CO)R 4, COOR 5 or CONR 6R 7; n is 1 or 2; R 2 for example is C 1-C 8alkyl, C 3-C 6cycloalkyl or benzyl; R 3 is for example C 1-C 8alkyl, C 3-C 6cycloalkyl, C 1-C 8haloalkyl, ...  
WO/2016/030669A1
The present invention relates to an environmentally friendly process for preparing rivaroxaban. The present invention provides a process for preparing rivaroxaban of formula I, the process comprising: reacting a compound of formula VI wi...  
WO/2016/020490A1
The invention relates to the use of a compound of formula (I) below, addition salts thereof, optical isomers, geometrical isomers and tautomers thereof and/or solvates thereof: Formula (I) in which: • R represents a hydrogen atom or a ...  
WO/2016/020732A1
The current application relates to a pharmaceutical composition for the treatment or amelioration of a neurological disease, wherein the composition comprises a therapeutically effective amount of a caspase-6 inhibitor which is an arylpr...  
WO/2016/004899A1
The present invention is directed to a process for making Tetracyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2 and R3 are defined above herein. The present invention is al...  
WO/2016/003167A1
The present invention relates to a polybenzoxazine precursor and a method for preparing the same and, more specifically, provides a polybenzoxazine precursor and a method for preparing the same, wherein the polybenzoxazine precursor make...  
WO/2016/001631A1
Disclosed arecertain derivatives of benzoxazinone amidesof formula (I),or pharmaceutically acceptable salts thereof, (Formula (I)) that act as mineralocorticoid (MR) receptor modulatorsthat may reduce oxidative stress in endothelium and ...  
WO/2015/192774A1
The present invention relates to an application of a chiral aminophenol ligand in asymmetric synthesis of efavirenz. A chiral aminophenol ligand compound is used for inducing asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-tr...  
WO/2015/187980A1
Method and apparatus for detecting metals in a liquid are described. The liquid is contacted with a hexahydrotriazine and/or a hemiaminal material, and a UV absorption spectrum of the material before and after exposure to the liquid is e...  
WO/2015/143654A8
The present invention is directed to six membered heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, can...  
WO/2015/181380A1
The present disclosure relates to cyclopropyl compounds of general formula (I), wherein R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to ...  
WO/2015/173106A1
Object of the present invention is an improved process for the preparation of Efavirenz, avoiding the distillations of the solvents.  
WO/2015/162558A1
The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in the treatment of an ATX-dependent or ATX-med...  
WO/2015/163952A1
Isatoic anhydride derivatives having an N-substituent which includes a quaternary ammonium group are useful for labeling and/or functionalizing a target material and/or for coupling materials together. The isatoic anhydride derivatives o...  
WO/2015/158518A1
The present invention relates to for manufacturing benzoxazinones of formula (I), characterized in that amino compounds of formula (II) are added to an acid; wherein the substituents are defined according to the specification.  
WO/2015/152273A1
This fluorine-containing compound is a nitrogen atom-containing perfluoroalkyl (meth)acrylate in which a plurality of straight-chain perfluoroalkyl groups having a carbon number of 6 or less have been bonded via a nitrogen atom, wherein ...  
WO/2015/143654A1
The present invention is directed to six membered heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, can...  
WO/2015/145371A1
The present invention relates to a compound of formula I, or an isotopic form, stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, a polymorph, a prodrug, N-oxide or S-oxide thereof; and processes for their preparati...  
WO/2015/141958A1
The present invention relates to a compound inhibiting CDK5-mediated PPARG phosphorylation and a pharmaceutical composition for treating PPARG-related diseases containing the same as an active ingredient. A compound represented by chemic...  
WO/2015/138969A1
Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subjec...  
WO/2015/138500A1
A genus of arylsulfonamide derivatives of aminocycloalkanols is disclosed. The compounds are of the following genus (I):. The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequen...  
WO/2015/130905A1
The present invention relates to heterocyclic compounds of formula (I) wherein: Z1 is C(R)(R), C(O), C(S), or C(NR); 2 Z is C(R)(R), 0, S, SO, S02, or NR; X is -O-, -S-, -S02-, -SO-, -C(O)-, -C02-, -C(O)N(R)-, -NRC(O)-, -NRC(O) N(R)-, -N...  
WO/2015/129714A1
 A compound represented by general formula (1) is useful as a light-emitting material. R1, R3, and R5 represent fluorine atoms, or R1, R2, R4, and R5 represent fluorine atoms. The remaining R1-R6 represent groups represented by general...  
WO/2015/127549A1
The invention relates to compounds useful in treating conditions associated with voltage- gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic...  
WO/2015/123783A1
Compounds that are cathepsin B substrates and that are useful as imaging probes, for example in positron emission tomography (PET) or fluorescence imaging are described.  
WO/2015/122502A1
The present invention pertains to a method for producing an optically active compound which includes a step for reducing an imino group of an imine compound or a step for reducing an unsaturated bond of a heterocyclic compound, while in ...  
WO/2015/118515A1
The present invention relates to an improved process for the preparation of a non-nucleoside reverse transcriptase inhibitor. Specifically, the present invention relates to an improved process for the preparation of Efavirenz of Formula ...  
WO/2015/120059A1
This disclosure relates to small molecule inhibitors of paxillin and paxillin binding, and related compositions and methods of treatment.  
WO/2015/115021A1
Provided is a method for producing a compound (II) having high purity, which comprises reacting a crude form of the compound (II) with, for example, a ketone compound to produce a reaction mixture containing a compound (I) and then react...  
WO/2015/113192A1
Disclosed are a benzo-lactam compound, a synthesis method and an application thereof, which comprises the following steps: step (a): compound (I) and compound (II) or compound (III) reacting with an action of a catalyst or without the ac...  
WO/2015/112081A1
The present invention relates to methods and compositions for inhibiting the activity of skin proteases, especially human kallikrein 7 (KLK7), human kallikrein 5 (KLK5), and human kallikrein 14 (KLK14). More specifically, the invention r...  

Matches 201 - 250 out of 6,616