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Matches 301 - 350 out of 6,616

Document Document Title
WO/2014/107622A1
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.  
WO/2014/096407A1
The present invention relates to test devices for determining the presence of one or more analytes in a sample, methods for using such test devices and methods of manufacturing such test devices. The test devices comprise a substrate hav...  
WO/2014/097188A1
The present invention concerns new compounds of 2,3-dihydro-4H-1,3- benzoxazine-4-one, a method for preparing the said compounds, a pharmaceutical form that contains the said compounds, and their use. In particular, the present invention...  
WO/2014/096377A1
New hydroxy aliphatic substituted phenyl aminoalkyi ether compounds of formula (I), compositions thereof and their use as a medicament in the treatment of nervous system diseases and/or the treatment of developmental, behavioral and/or m...  
WO/2014/081024A1
The present invention provides a novel method for the preparation of a compound represented by formula (I) [wherein R1, R2, R3, R4 and X have the same meanings as those defined in the claims with respect to R1, R2, R3, R4 and X], a pharm...  
WO/2014/081025A1
This invention relates to an I-form crystal of the free form of 3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyetho xy)-5-(3-oxo-[1,2]-oxazinan-2-ylmethyl)benzamide, the crystal, in analysis by X-ray powder diffraction with CuK╬...  
WO/2014/076038A1
The invention is concerned with a compound of formula (I) and pharmaceutically acceptable salts thereof wherein R1 to R3, X and Y are as defined as in the description and in the claims. The compound of formula (I) can be used as a medica...  
WO/2014/056958A1
The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein Y, R1, R2 and R3 are defined in the detailed description and claims. In addition, the present invention relates to metho...  
WO/2014/048547A1
The present invention relates to alpha hydroxy amides including compounds of formula (I) and related compounds and their use in the prophylaxis and treatment of inflammatory disorders and diseases, wherein T1, T2, W and Rw has the meanin...  
WO/2014/046244A1
Provided are a novel production method and production intermediate for an herbicide. Provided are the following: with respect to a trifluoromethanesulfonanilide-type herbicide represented by formula (2): [in the formula, A denotes -CH=CH...  
WO/2014/043019A1
The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are use...  
WO/2014/042263A1
The invention provides a nitrogen-containing saturated heterocyclic compound useful as a renin inhibitor. A compound represented by formula [I] (in the formula, R1 represents a cycloalkyl or alkyl, R22 represents an optionally substitute...  
WO/2014/015935A3
The present invention concerns particular fluorenes, the use of the compound in an electronic device, and an electronic device containing at least one of these compounds. The present invention further concerns a method for producing the ...  
WO/2014/038666A1
A process for producing an optically active amine compound, characterized by asymmetrically hydrogenating a prochiral carbon-nitrogen double bond in the presence of a ruthenium complex represented by general formula (1) or (2) (wherein P...  
WO/2014/031784A1
Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating...  
WO/2014/031012A1
The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablat...  
WO/2014/026893A1
The present invention relates to carbamat-benzoxazinones of formula (I), wherein the variables are defined according to the description, 5 as well as to a process for manufacturing carbamat-benzoxazinones of formula (I), and to the use o...  
WO/2009/021750A3
There are disclosed compounds of Formula (1). Pharmaceutical compositions containing the compounds are also provided. Methods of treatment of Duchenne muscular dystrophy, Becker muscular dystrophy and cachexia using the compounds and com...  
WO/2014/024950A1
The present invention provides a method for producing a 1,4-benzoxazine compound, which is a compound useful as a medicinal agent, in an industrially advantageous manner while avoiding risks with respect to safety and sanitation. Specifi...  
WO/2014/015935A2
The present invention concerns particular fluorenes, the use of the compound in an electronic device, and an electronic device containing at least one of these compounds. The present invention further concerns a method for producing the ...  
WO/2014/015298A1
Peripherally acting cannabinoid agonist compounds, pharmaceutical compositions, and methods of using them are presented.  
WO/2014/011754A1
The present invention provides novel benzoxazinone compounds, pharmaceutical compositions comprising such compounds, and methods of treating disease using such compositions. Pharmaceutical compositions of the invention are particularly u...  
WO/2014/005968A1
The invention relates to a compound of formula (I), wherein i.a. A1is -CH2- or -C(O)-; one of R1 and R2 is hydrogen and the other one is -A2 -C(O)-R3; A2 is NH- or absent; and R3 is (A), (B) or (C) The compounds are preferential agonists...  
WO/2013/000651A8
Fluorinated arylalkylaminocarboxamide derivatives of formula (I) are described wherein W, J, n, R1, R2, R2', R3, R4, R5 and R6 have the meanings as defined in the specification and pharmaceutically salts thereof, pharmaceutical compositi...  
WO/2014/001664A1
An absorbent solution (4), and a method implementing said solution to eliminate acid compounds contained in a gaseous effluent (1), comprising water and at least one nitrogenous compound chosen from the group of hindered tertiary 4-(amin...  
WO/2014/001228A1
The present invention provides difluoro-cyclopentaoxazinyls and difluoroenzooxazinyls of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active...  
WO/2014/000555A1
The present invention relates to a method for preparing Efavirenz crystal I. In particular, the method disclosed in the present invention comprises the steps of: dissolving Efavirenz into an organic solvent or a mixed solvent of an organ...  
WO/2013/191986A1
Provided are compounds which are useful for controlling microorganisms in aqueous or water-containing systems or in systems which are exposed to moisture, including at elevated temperature. The antimicrobial compounds are of the formula ...  
WO/2013/189930A1
Process for depigmenting keratin materials using novel resorcinol-based compounds The invention relates to compounds of formula (I): in which: ┬Ě R denotes a hydrogen atom or an acetyl group; ┬Ě Y denotes a radical chosen from OR' and NA...  
WO/2013/182263A1
The invention relates to specific phenanthrenes, the use of the compound in an electronic device, and an electronic device containing at least one of said compounds. The invention further relates to a method for producing the compound an...  
WO/2013/181741A1
The present invention relates to compounds having the general Formula I: which absorb UV radiations and protect biological materials as well as non-biological materials from damaging exposure to UV radiations. The present invention also ...  
WO/2013/175053A1
Compounds of formula (I), wherein R1 is as defined in the claims, exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors.  
WO/2013/160418A1
The present invention is directed to novel retinoid-related orphan receptor gamma (ROR╬│) modulators, processes for their preparation, pharmaceutical compositions containing these modulators, and their use in the treatment of inflammator...  
WO/2013/152741A1
A molecule with neuro activities, especially 4-substituent-2-hydroxylmorpholine-3-one, as a new intermediate of neurokinin-1 receptor antagonist Aprepitant, and preparation method thereof.  
WO/2013/148408A1
Disclosed herein are monofunctional benzoxazine compounds having at least one electron-withdrawing group. The monofunctional benzoxazine compounds may be combined with one or more multifunctional benzoxazine compounds to form a unique be...  
WO/2013/143904A1
The present invention relates to compounds based on an oxazoline moiety which liberate Strecker aldehydes under mild and controllable conditions. In addition the invention relates to food products comprising such compounds, and uses of s...  
WO/2013/007371A3
The present invention refers to a method for the kinetic resolution of a chiral primary or secondary amine by treating the amine with a chiral, hydroxamic acid derived reagent of the formula (I). These chiral reagents are particularly us...  
WO/2013/146437A1
[Problem] To provide a novel compound that is useful as an agent for preventing/treating cancer. [Solution] One aspect of the present invention provides a compound expressed by the chemical formula (1) or a pharmaceutically permissible s...  
WO/2013/147711A1
The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. Th...  
WO/2013/141143A1
Provided is a novel photochromic compound with favorable durability wherein the color during coloring is an intermediate color (exhibits double peak properties), color intensity is high, and color fading is rapid. For example, a chromene...  
WO/2013/135218A1
The present solution relates to a method of preparing aprepitant of formula (1) in the desired crystalline form II or I, wherein the intermediate of formula (12) is extracted with a water immiscible high-boiling solvent selected from an ...  
WO/2013/133218A1
The objective of the present invention is to provide a photoelectric conversion element provided with a photoelectric conversion film that can even be produced by means of a continuous vapor deposition process under high temperature cond...  
WO/2013/125211A1
The purpose of the present invention is to provide an optical film that produces a large amount of in-plane retardation and sufficient reverse wavelength dispersion even with a low film thickness. This optical film contains a thermoplast...  
WO/2013/126816A1
Probes for selectively detecting compounds comprising a thiol group and an amino group ("thiols") are disclosed. Exemplary thiols include cysteine, homocysteine, and glutathione. Embodiments of the disclosed probes produce a detectable c...  
WO/2013/124823A1
The present invention provides a process for the preparation of 5-[[(2R,3S)-2-[(1R)-1-[3,5- bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morp holinyl]methyl]-1,2-dihydro- 3H-1,2,4-triazol-3-one (Aprepitant) comprising condensa...  
WO/2013/120448A1
Disclosed is a new method for preparing a methyl substitute of a linezolid intermediate, (S)-2-((3-(3-Fluoro-4-Morpholine phenyl)-2-oxy-5-oxazoline)) (I), wherein the intermediate (I) is obtained by the cyclisation of a 3-Fluoro-4-morpho...  
WO/2013/119791A1
Morpholinoalkyl fumarates, pharmaceutical compositions comprising the morpholinoalkyl fumarates, and methods of using morpholinoalkyl fumarates and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune ...  
WO/2013/116065A1
The present invention provides compounds of Formula I or a pharmaceutical salt thereof, methods of treating hypertriglyceridemia using the compounds; and a process for preparing the compounds.  
WO/2013/103297A1
The present invention relates to functionalized ploy(2-oxazoline) polymers, which are very suitable as a carrier and/or delivery vehicle (conjugate) of drugs, such as small therapeutic molecules and bio-pharmaceuticals. These polymers ar...  
WO/2013/097629A1
A preparation method of amorolfine hydrochloride comprises: with N-methylpyrrolidone as a solvent, in the presence of a palladium catalyst and a base, reacting 4-iodo-tert-amyl benzene with 2-methallyl alcohol, to obtain 3-tert-amylpheny...  

Matches 301 - 350 out of 6,616