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Matches 401 - 450 out of 6,616

Document Document Title
WO/2012/110833A2
The present invention relates to fluorescence lifetime modulators, conjugates comprising fluorescence lifetime modulators moieties and methods of making them. The present invention further relates to the use of the fluorescence lifetime ...  
WO/2011/154827A3
The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can ...  
WO/2012/104865A1
"An insect repelling compound and a process for preparation thereof. The present invention discloses a compound of formula I and a process for preparation thereof. The compound exhibits insect repellent properties. The invention also dis...  
WO/2012/101245A1
The present invention relates to a polymerizable composition comprising at least one ethylenically unsaturated, polymerizable compound and at least one oxime sulfonate compound of the formula (I) QAaBbCc where a is 0, 1, 2, 3, 4 or 6, b ...  
WO/2012/098064A1
The present invention relates to 1,4 Oxazines of formula (I): having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active co...  
WO/2012/097510A1
The invention disclosed a process for the preparation of the HIV drug Efavirenz, also known as DMP-266, starting from 1,4-dichlorobenzene, and its intermediates.  
WO/2012/097511A1
Disclosed is a method for the preparation of the HIV drug Efavirenz, also known as DMP-266, starting from 1,4-dichlorobenzene, and its intermediates.  
WO/2012/095803A1
Disclosed are fluorescent compounds with large Stokes-shift and a process for their preparation. More particularly, disclosed are fluorescent compounds that are colourless. The compounds can be used in compositions for inks, paints and p...  
WO/2012/092873A1
Disclosed in the present invention are a synthetic Rivaroxaban intermediate and a preparation method thereof. The method comprises: morpholine-3-one and 4-fluoro nitrobenzene are used as the raw materials to obtain a compound of formula ...  
WO/2012/094622A2
Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize aryl alcohol derivatives as cross-coupling partners. Embodiments of the invention include methods for the amination of aryl sul...  
WO/2012/090177A2
Compounds of Formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. M...  
WO/2012/064744A3
The invention provides tetrahydroquinoline and related compounds, pharmaceutical compositions, methods of inhibiting RORϒ activity, reducing the amount of IL-17 in a subject, and treating immune disorders and inflammatory disorders usin...  
WO/2012/088314A1
Compounds and compositions comprising compounds including formula (I) that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that activate PKM2 in the treatment of cancer.  
WO/2012/087720A1
Disclosed is a process for making diastereomeric compound of the formula (I): wherein m, n and R1 to R4 are as defined herein. The process of the invention provides the compound of formula (I) in high yield and substantially free of the ...  
WO/2012/079235A1
The invention disclosed a 4 step process for the preparation of Efavirenz, starting from 1,4-dichlorobenzene, and its intermediates.  
WO/2012/081585A1
The present invention provides a method for diastereo-selectively and enantioselectively producing an optically active alcohol compound indicated in formula (IIIa), etc., that includes hydrogenation of a carbonyl compound indicated in fo...  
WO/2012/081582A1
The present invention provides a method for diastereo-selectively synthesizing an alcohol compound, that includes hydrogenation of a carbonyl compound indicated in formula (I) in the presence of a ruthenium compound indicated in formula ...  
WO/2012/076794A1
The present invention relates to a process for functionalizing at least one ribonucleic acid (RNA) molecule, which comprises the following steps: a) providing at least: one linker molecule consisting of an isatoic anhydride or a derivati...  
WO/2012/076428A1
Polytetrahydrobenzoxazines and bistetrahydrobenzoxazines obtainable by (A) reaction of at least one diamine of formula H2N-A-NH2 with a C1 to C12 aldehyde and a C1 to C8 alkanol at 20 to 80°C with elimination and removal of water, (B) r...  
WO/2012/067139A1
Provided is a compound represented by general formula (1). (In the formula, R1 represents a C1-20 aliphatic hydrocarbon group which may have a substituent; and R2-R13 independently represent a hydrogen atom, a halogen atom, or an aromati...  
WO/2012/051692A1
Provided are process for the preparation of (R)- and/or (S)- Rivaroxaban, and compounds which are intermediate compounds used in the processes for the preparation of (R)- and/or (S)-Rivaroxaban.  
WO/2012/025935A3
Disclosed is a process for the synthesis of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one, the process comprising reacting salicylic acid with p-toluenesulfonyl chloride in the presence of a base and an organic solvent, and then combining th...  
WO/2012/048884A1
The invention is directed to a process for the preparation of a cyclic carbamate starting with a chiral propargylic alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, tri...  
WO/2012/048886A1
The invention is directed to a process for the preparation of a cyclic carbamate starting with o-aminobenzyl alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgen...  
WO/2012/038942A1
This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonar...  
WO/2011/071951A3
The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions....  
WO/2012/036233A1
Provided is a novel compound which has MCH R1 receptor antagonistic activity and is represented by formula (I), a pharmaceutically acceptable salt thereof, or a solvate of the same. (In the formula, the portion AA represented by formula ...  
WO/2012/000608A3
The present invention relates to novel beta-aminoaldehyde derivatives of the formulae (I), (II) and (III), in which the substituents R1 to R5 and A have the meaning given in the description, to a novel process for their preparation, to i...  
WO/2012/031298A2
Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-ne...  
WO/2012/025935A2
The invention provides a novel process for the synthesis of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one, the process comprising of reacting the salicylic acid with salicylamide in the presence of p-toluenesulfonyl chloride, base and solven...  
WO/2012/020742A1
Disclosed is a novel compound that acts as an antagonist for P2X3 and/or P2X2/3 receptors. Also disclosed is a pharmaceutical composition that acts as an antagonist for P2X3 and/or P2X2/3 receptors, said composition containing: a compoun...  
WO/2012/010644A1
Process for the synthesis of an isothiocyanate of general formula (I) SCN‑R1-R4-R2 in which R1 and R2 represent, independently of one another, an alkyl, aryl or alkylaryl group, R4 represents a carbonyl, sulphinyl or sulphonyl group or...  
WO/2012/006953A1
Disclosed are oxazine derivatives of formula (I) having BACE inhibitory activity, wherein all of the variables are as defined in the specification, in free form or in salt form, their preparation methods, their medical use and medicament...  
WO/2012/008435A1
Disclosed is a novel biaryl amide derivative represented by formula (1) and having an affinity for the aldosterone receptor; also disclosed is a pharmaceutically acceptable salt thereof. (In the formula, A is any of the groups represente...  
WO/2011/103435A3
Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of building blocks, such as building blocks containing complex and/or pharmaceutically...  
WO/2012/004378A1
The present invention relates spiro- cyclic amine derivatives of the formula (I) wherein R1; R2; R3; Q; -W-T-; R5; Z; and A have the definitions provided in the claims; or a pharmaceutically acceptable salt, a solvate or hydrate thereof ...  
WO/2011/146821A3
The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine...  
WO/2012/004375A1
The present invention relates to bisaryl (thio)morpholine derivatives of the formula (I) wherein R1 is an aryl substitutent selected from phenyl, pyridyl, pyrimidinyl, biphenyl and naphthyl, each optionally substituted with one or more s...  
WO/2011/130194A3
Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantiall...  
WO/2012/000608A2
The present invention relates to novel beta-aminoaldehyde derivatives of the formulae (I), (II) and (III), in which the substituents R1 to R5 and A have the meaning given in the description, to a novel process for their preparation, to i...  
WO/2011/161030A1
The invention relates to heterocyclic substituted methoxyphenyl derivatives having an oxo group, and to the physiologically compatible salts thereof. The invention relates to compounds of formula (I), where R1, R2, R3, R4, R10, X, n, B1,...  
WO/2011/161128A1
The present invention relates to compounds defined by formula I wherein the variables R1x, R2x, R3x, R4x, R5x, R6x, R7x, RNx, R10x, Ax, Zx and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the c...  
WO/2011/156655A2
Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for u...  
WO/2011/154148A1
The invention discloses a number of therapeutic compounds and a method of treating a disorder in mammal.  
WO/2011/154431A1
The present invention relates to novel 5,6-dihydro-2H-[1,4]oxazin-3-ylamine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to ...  
WO/2011/154678A1
Compounds of formula (I), having activities at muscarinic and β2-receptors (MABAs) for use in therapy.  
WO/2011/154827A2
The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can ...  
WO/2010/073254A3
The present invention relates to a process for the preparation of crystalline non-hygroscopic form H1 of efavirenz, and pharmaceutical compositions containing it. In accordance with the present invention efavirenz was dissolved in aceton...  
WO/2011/147279A1
Disclosed is a synthesis method of a compound of formula 1, 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)- 4-fluorophenyl-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-tr iazole-3-one (i.e. aprepitant), which comprises cyclisi...  
WO/2011/146821A2
The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine...  

Matches 401 - 450 out of 6,616