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Matches 1 - 50 out of 6,473

Document Document Title
WO/2019/175897A1
The compounds of Formula I is described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The compounds described herein, their polymorphs, stereoisomers, tau...  
WO/2019/167080A1
The present invention disclosed herein is a bile acid sequestering composition comprising the resin chelate with improved affinity/binding activity towards bile acid(s) and to the process for preparation thereof.  
WO/2019/161224A1
Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.  
WO/2019/129593A3
A method for preparing a substituted fuel additive d is provided. The method comprises carrying out the following reaction: ( a, b, d ) A is selected from halides and -SO3R13, where R13 is selected from hydrogen, alkyl groups and alkali ...  
WO/2019/118785A3
The present disclosure relates generally to therapeutic agents that may be useful inhibitors of Integrated Stress Response (ISR) pathway.  
WO/2019/138362A1
The field of this invention relates to a novel process, suitable for industrial scale manufacture, for the preparation of 4-(4-aminophenyl)morpholin-3-one of Formula (I), the key intermediate of rivaroxaban according to the scheme. In th...  
WO/2019/129592A1
A method for preparing a fuel additive d is provided. The method comprises carrying out the following reaction: (l) The fuel additive d may be used as an octane-boosting additive in a fuel for a spark, ignition internal combustion engine.  
WO/2019/129589A1
An optimised method for preparing a fuel additive f is provided. The method comprises carrying out the following reaction: (c, d, e) Starting material c may be prepared using an optimised method which comprises carrying out the following...  
WO/2019/129594A1
A method for preparing a substituted fuel additive d is provided. The method comprises carrying out the following reaction: Each Y is independently selected from halides, and X is selected from -O- or -NR10-.  
WO/2019/129588A1
Methods for preparing an octane-boosting fuel additive having the following formula: are provided. In a first aspect, the method may comprise carrying out the following reaction: (i), (ii) In a second aspect, the method may comprise: (1)...  
WO/2019/129590A1
A method for preparing a substituted fuel additive d is provided. The method comprises carrying out the following reaction: (a) (b) (d), The fuel additive d may be used as an octane-boosting additive in a fuel for a spark- ignition inter...  
WO/2019/129591A1
A method is provided for preparing a fuel additive having the formula: ( l ) The method comprises carrying out the following reactions: (i) addition of an alkylating agent b to starting material a: (a) to form an intermediate c; and (ii)...  
WO/2019/133901A1
The present invention provides a method of using arylpiperazine derivatives for treating pulmonary fibrosis. The method comprises a step of administering to a pulmonary fibrosis patient in need thereof an effective amount of a compound o...  
WO/2019/116262A1
A hydrofluoroolefin ether represented by the general Formula (I), compositions that include such compounds, and apparatuses and methods for use that include such compositions and compounds, wherein Formula (I) is represented by: Rf-O-CH2...  
WO/2019/114811A1
The present application provides a method for synthesis of Roxadustat. A compound as represented by formula (VIII) is used as a raw material, and is reacted with phenol, a vinyl-containing ether, an acid, hydroxylamine, and then the prod...  
WO/2019/118785A2
The present disclosure relates generally to therapeutic agents that may be useful inhibitors of Integrated Stress Response (ISR) pathway.  
WO/2019/105915A1
The invention provides new heterocyclic compounds having the general formula (IA) wherein A, L, X, Y, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of ...  
WO/2019/102186A1
There is provided compounds of formula (I) or pharmaceutically-acceptable salts thereof, wherein: L, X, R1, R2 and n have meanings provided in the description, which compounds are useful in the treatment of neurodegenerative and neuroinf...  
WO/2019/094732A1
The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds described herein are useful in treating diseases associated with the binding of CREB to CREB-binding protein (CBP) and...  
WO/2019/085684A1
Disclosed in the present invention are a cyanobenzene-containing or thiocyanobenzene-containing compound and applications thereof in organic electroluminescent devices. The compound is formed by cyanobenzene or thiocyanobenzene groups, h...  
WO/2019/090081A1
Provided herein are compounds of Formula (I) or Formula (II), compositions, and methods there of useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.  
WO/2019/090085A1
Provided herein are compounds of formula (I), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions. (Formula I).  
WO/2019/040106A3
The present disclosure relates to compounds according to Formulae disclosed herein, useful for treating diseases.  
WO/2019/067389A1
Methods of treating developmental disorders and/or seizure disorders with etifoxine, a deuterated analog of etifoxine, or a pharmaceutically acceptable salt, solvate, or prodrug thereof are provided. The methods provide therapeutic compo...  
WO/2019/067113A1
Described herein is an hydrofluorocarboximidate of formula (I) where: RH is a linear or branched alkyl group comprising 1 or 2 carbon atoms and (a) Rf1 and Rf2 are independently selected from a linear or branched perfluorinated alkyl gro...  
WO/2019/044736A1
The present invention provides a detection method and detection probe for colibactin and colibactin-producing bacteria. The present invention provides, for example, the detection of myristoyl-asparagine using a tissue sample or stool sam...  
WO/2019/039290A1
Provided are: an actinic ray-sensitive or radiation-sensitive resin composition that has excellent resolution, exposure latitude, and pattern shape properties; and a resist film, a pattern-forming method, a method for producing an electr...  
WO/2019/038379A1
The present invention relates to a non-hygroscopic salt of the compound 2-(3-(4-propylheptyl)morpholino)ethan-1-ol having the INN name delmopinol. In particular, the invention relates to the citrate salt of delmopinol. The present invent...  
WO/2019/040106A2
The present disclosure relates to compounds according to Formulae disclosed herein, useful for treating diseases.  
WO/2019/029211A1
Disclosed by the present invention are an SIRT6 small-molecule allosteric activator and the application thereof, and provided is an SIRT6 small-molecule allosteric activator that contains a derivative as shown in formula (1) or a pharmac...  
WO/2019/031470A1
[Problem] The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. [Solution] The invention provides: a compound represented by formula (I) o...  
WO/2019/020654A1
The present application relates to a spirobifluorene derivative of a specific formula (I) which is suitable for use in electronic devices.  
WO/2019/023147A1
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured.The variables shown in Formula AA are as defined in the claims. The compounds of formula AA are NLRP3 activity modulators and, as such, c...  
WO/2019/023145A1
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured. The variables shown in Formula AA are as defined in the claims. The compounds of formula AA are NLRP3 activity modulators and, as such, ...  
WO/2019/013244A1
Provided is a novel method for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative. More specifically, a method for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative represented by formula (1) is pro...  
WO/2019/003820A1
Provided are: an active ester composition having high curability and exceptional properties such as dielectric properties and heat resistance in the cured product; a cured product of the composition; and a semiconductor sealing material ...  
WO/2018/236913A1
Small molecule calpain modulator compositions and pharmaceutical compositions can be prepared and used as therapeutic agents. Exemplary compositions include non-macrocyclic a-keto amide derivatives. The therarapeutic agents can be used f...  
WO/2018/234805A1
The present invention relates to compounds of formula (I). The compounds may be used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections.  
WO/2018/232675A1
Methylene blue (MB) derivatives selectively detect F-by desilylation reaction to act as a fluorescent probe.  
WO/2018/229415A1
Sulphurised benzoxazine compound for use in the synthesis of a polybenzoxazine, corresponding to the formula (A), (formula I): wherein: each benzene ring of the two oxazine rings bears at least one radical denoted "G"; the two oxazine ri...  
WO/2018/219882A1
The invention relates to a borated benzoxazine compound, particularly for use as a monomer for the synthesis of polybenzoxazine, said borated benzoxazine compound being of formula (A), in which: Z is an at least divalent, aliphatic, cycl...  
WO/2018/215701A1
The invention relates to a halogenated benzoxazine compound, for use particularly as a monomer for the synthesis of polybenzoxazine, said halogenated benzoxazine compound being of formula (A) in which: each benzene ring of the two oxazin...  
WO/2018/215700A1
The invention relates to a halogenated benzoxazine compound, for use in particular as a monomer for the synthesis of polybenzoxazine, said halogenated benzoxazine compound being of formula (A) (the symbol Hal representing at least one ha...  
WO/2018/209445A1
There is described compounds, compositions, methods, and uses, of treating a subject having, suspected or having, or at risk of having, a prion disease, comprising: administering a cholesterol 24-hydroxylase (CH24OH)-activating compound.  
WO/2018/198975A1
Provided is a light-emitting element having excellent luminance life. Disclosed is a light-emitting element comprising a positive electrode, a negative electrode, a first organic layer provided between the positive electrode and the nega...  
WO/2018/173058A1
The present invention provides processes for the preparation of diverse heterocyclic scaffolds from alpha-enaminone building bloc of formula (I).  
WO/2018/174826A1
This invention relates to a method for producing an alkenyl 1 -aminocyclopropane-1 -carboxylic acid of Formula I wherein R1 is a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B ...  
WO/2018/167800A1
The present invention relates to fused bicyclic compounds that are inhibitors of GPR91, their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them. T...  
WO/2018/159834A1
Provided are a donor-acceptor type compound having a novel structure and an application of the donor-acceptor type compound. This enamine compound is represented by general formula (1) (in the formula: R1 represents an electron-accepting...  
WO/2018/154414A1
This invention relates to a method for the manufacture of optically pure (S)-6- chloro-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)- 2H-3,1 -benzoxazin- 2-one. Specifically, this invention relates to a flow synthesis method for t...  

Matches 1 - 50 out of 6,473