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Matches 601 - 650 out of 941

Document Document Title
JP2005519874A
The present invention relates to the treatment of Alzheimer's disease and other similar diseases, and more specifically to the use of compounds that inhibit beta-secretase, an enzyme that cleaves amyloid precursor protein to produce A be...  
JP2005518338A
The present invention is directed to the separation of enantiomers of racemates of formula (I). The separation proceeds by applying deemed racemates to continuos enantioselective chromatography like SMB. The methods predominantly is perf...  
JPWO2003068753A1
For stress, which contains a compound represented by the general formula (I) (the symbol in the formula is as described in the specification), a mitochondrial benzodiazepine receptor (MBR) antagonist composed of the compound, and the com...  
JP2005511478A
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.  
JP2005104990A
To obtain a new agonist of a peptide hormone, vasopressin.A compound represented by formulae 1 or formula 2 is provided. The compound has antidiuretic action and is useful for treating polyuria, incontinentia urinae, and the like.  
JP2005089298A
To provide a new naphthalene compound exhibiting HIV-inhibiting activities and its pharmaceutical use, more specifically an HIV-inhibiting agent comprising a compound having a naphthalene structure, its pharmaceutically acceptable salts,...  
JP2005070055A
To provide a means effective for treating a female accompanied with a female sexual dysfunction (FSD), in particular, female sexual arousal dysfunction (FSAD).This assay method for identifying a medicine used for the treatment of the FSA...  
JP2005068138A
To provide a compound having hypolipemic action, such as squalene synthase inhibitory action (cholesterol decreasing action) and triglyceride decreasing action, safer and stronger than ever, and useful as a medicament of a prophylactic, ...  
JP3630449B2
PURPOSE: To obtain a novel tricyclic compound which has antagonist activity at V1 and/or V2 receptors and exhibits in vivo vasopressin antagonist activity and is useful for treatment of diseases characterized by excess renal reabsorption...  
JP2005043377A
To provide medicine that can be used for treating a female with FSD, especially FSAD, and to provide an assay method of the medicine or the like.The method is the assay method for identifying the medicine that can be used for treating fe...  
JP2005503993A
The invention provides compositions and methods for altering insulin secretion using an agent that inhibits calcium efflux via the mitochondrial calcium/sodium antiporter (MCA). Methods of treatment are thereby provided, and are particul...  
JP2005021167A
To provide an effective method for treating a female suffering from female sexual dysfunction (FSD), in particular, female sexual arousal dysfunction (FSAD).A method for assaying an agent capable of potentiating cAMP in the sexual genita...  
JP2005013237A
To provide an effective method for treating a female suffering from female sexual dysfunction (FSD), in particular, female sexual arousal dysfunction (FSAD).The method comprises assaying an agent capable of potentiating cAMP in the genit...  
JP2004346059A
To provide a TGR5 (G protein-coupled receptor) receptor agonist useful for treating various diseases.This TGR5 receptor agonist contains a fused ring compound expressed by formula (1) (wherein ring A is an aromatic ring which may be subs...  
JP2004331659A
To provide a new pharmaceutical having RFRP receptor function regulating action.This RFRP receptor function regulating agent contains a compound expressed by formula (I) [ring A is an aromatic ring which may be substituted; ring B is a b...  
JP2004315500A
To obtain a new medicine useful as a skeletal muscle protective agent.This skeletal muscle protective agent contains a compound having squalene synthase inhibitory activity, or its salt or its prodrug.  
JP2004534057A
The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA anal...  
JP3585552B2
PURPOSE: To keep the lower impressed voltage on an electrode in regeneration of a nicotinamide co-enzyme by incorporating compds., such as substd. or unsubstd. 9H-acridin-2-ones, having a mediation function on an electrode surface. CONST...  
JPWO2002096891A1
Provided are a dihydrodialyloxazepine derivative represented by the following formula [1] or an analog thereof, and a pharmaceutical composition containing these. These compounds show excellent functional gastrointestinal disease improvi...  
JP3563738B2
An amino acid derivative having an angiotensin I-converting enzyme inhibitor activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase inhibitor activity, and represented by general formula (I) wherein R<1> represent...  
JP2004517085A
The present invention relates to compounds of the formula Iwherein R1, R2, R3, X, Y and the dashed line are as defined in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and to th...  
JP2004512318A
A C-nitroso compound having a molecular weight ranging from about 225 to about 1,000 (from about 225 to about 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained b...  
JP2004509954A5  
JP2004509954A
Compounds having the general formula wherein R1a, R1b, R1c, X1, X2, R2, R3, R4, R5, R6, n, Y and Z are as defined in the specification, methods of using such compounds for the treatment of diseases and pharmaceutical composition comprisi...  
JP2004509103A
One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, ser...  
JP3497164B2
PCT No. PCT/US92/05463 Sec. 371 Date Jun. 26, 1992 Sec. 102(e) Date Jun. 26, 1992 PCT Filed Jun. 26, 1992 PCT Pub. No. WO93/00095 PCT Pub. Date Jan. 7, 1993This invention relates to compounds of the formula: wherein A1 to A5 form an acce...  
JP3487611B2
PURPOSE: To obtain new compds. useful as dual inhibitors having inhibitory activity against angiotensin converting enzyme and neutral endopeptidase in the treatment of hypertension, congestive heart failure, hepatocirrhosis, etc. CONSTIT...  
JP3479796B2
To obtain a compound having squalene synthase inhibitory action, hypocholesterolemic action, triglyceride-depressive action, thus useful for preventing and treating hyperlipemia and arteriosclerosis, etc. This compound (salt) is expresse...  
JP2003534230A
[Chemical 1]  
JP2003321461A
To obtain a new fused biphenyl derivative having tachykinin receptor antagonism, especially NK1 receptor antagonism.The fused biphenyl derivative is expressed by general formula (1) (wherein A ring and B ring express each a benzene ring ...  
JP3462234B2
PURPOSE: To obtain a new heterocyclic compound, having excellent choline esterase inhibiting activity and antidepressant action and useful as a therapeutic or a preventing agent for senile dementia. CONSTITUTION: The compound of formula ...  
JP2003531824A
Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The novel analogs can be formulated into op...  
JP2003300962A
To provide a benzodiazepinedione derivative acting as a non-peptide platelet aggregation inhibitor.This benzodiazepinedione derivative is provided for a therapeutic composition which strongly inhibits the bonding of fibrinogen to GPIIbII...  
JP2003530388A
A compound having the general formula (I) and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.  
JP3446052B2  
JP2003261450A
To obtain an antimycotic agent that contains a zofimarin derivative bearing an oxazepane ring, or a pharmacologically acceptable ester or salt thereof as an active ingredient.The antimycotic agent contains the zofimarin derivative repres...  
JP2003176268A
To provide an enamine compound which is an organic photoconductive material usable for electrophotographic photoreceptor, etc., with a high charging potential, high sensitivity, and manifesting sufficient optical response in a low- tempe...  
JP2003119137A
To provide a compound and its pharmaceutically permissible salt effective for suppressing the HIV proliferation of affected cell of latency phase and enabling the suppression of the proliferation of virus in the latency phase from the in...  
JP2003081873A
To provide a new medicine that is useful as a prophylactic or therapeutic for organ functional disorder, organ insufficiency, obesity and their deuteropathy and a new medicine having the ubiquinone-increasing action.The prophylactic or t...  
JP2003064063A
To provide a compound which has lowering activity of cholesterol and triglyceride-reducing activity and is useful for preventing or treating hyperlipemia.The compound represented by formula [I] [R1 is 3- carboxypropyl, 1-carboxyethyl, or...  
JP2003500392A
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate rece...  
JP2002537260A
The present invention relates to dibenzo-azepine derivatives and their use as alphaV integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphaVbeta3, alphaVbe...  
JP2002241368A
To provide an excellent neuropeptide Y(NPY) antagonist, i.e., an antifeeding agent, a therapeutic agent for myocardial infarction, a therapeutic agent for angina pectoris and an antihypertensive agent.A compound represented by the formul...  
JP2002234879A
To provide a method for producing an amide compound in high efficiency by a Beckmann rearrangement of an oxime compound in a liquid phase under a mild reaction condition.This method for producing an amide compound such as - caprolactam f...  
JP2002518451A
Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits...  
JP2002518481A
Compounds of formula (I), wherein W is a cyclic group of the type (2); (3); Y is represented by the formula (II); these compounds inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzh...  
JP2002517488A
The present invention is directed to a process for the preparation of a compound of formula (X-a):or a pharmaceutically acceptable salt form thereof, wherein:R1 is selected from the group consisting of:C1-5 alkyl substituted with 0-5 R1a...  
JP2002161086A
To provide a zofimarin derivative useful as a medicament (especially, an antimycotic agent), and a pharmacologically acceptable ester or salt thereof.This new compound is a zofimarin drivative of the general formula (I) (wherein, R1 is f...  
JP3286056B2
PURPOSE: To obtain a tricyclic condensed heterocyclic derivative, having excellent inhibiting activities against choline esterases and inhibiting actions on uptake of monoamines and useful as a therapeutic and preventing agent for senile...  
JP3283628B2
PURPOSE: To obtain a new compound having action to inhibit a squalene synthetic enzyme and antifungal action and useful in treatment for hypercholesterolemia, coronary arteriosclerotic disease, infection of fungi, etc. CONSTITUTION: A co...  

Matches 601 - 650 out of 941