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WO/2023/034450A1 |
The present disclosure provides, in part, methods for site-specific labeling of proteins/peptides with radiohalogens and compositions resulting from said methods.
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WO/2023/285176A1 |
A process for producing alkyl trifluoroacetates The present invention relates to a process for producing alkyl trifluoroacetates by reacting trifluoroacetic acid with an alkyl alcohol R-OH in an aqueous solution, and wherein the alkyl tr...
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WO/2023/286855A1 |
The purpose of the present invention is to provide an excellent agricultural or horticultural plant disease control agent. Provided are: a formamide derivative represented by general formula [I] and the like (in the formula, X1, X2, X3...
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WO/2023/285977A1 |
The present invention relates to pharmaceutical compositions of ozanimod or a pharmaceutically acceptable salt thereof. In particular, the invention relates to pharmaceutical compositions of ozanimod or a pharmaceutically acceptable salt...
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WO/2023/280630A1 |
The present invention relates to a process for the preparation of substituted amidoximes of formula I, which can be obtained through reaction of nitrile compounds of formula II with free hydroxylamine in the presence of a solvent.
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WO/2023/280773A1 |
The invention relates to chiral 3-sulfinyl benzoic acids of the absolute configuration specified in formulae (I-R) and (I-S) as precursors for the production of herbicidal compounds. In formulae (I-R) and (I-S), X, Z and R' represent gro...
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WO/2023/283453A1 |
The disclosure herein provides phenyl acetamide based compounds of Formula (I), (I-a), (II), and pharmaceutical compositions thereof, for the modulation of IL-17A, useful in the treatment of inflammatory conditions such as psoriasis.
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WO/2023/280772A1 |
The invention relates to benzoic acid amides of general formula (I) as herbicides. In this formula (I), X, R and Z represent groups such as alkyl and halogen.
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WO/2022/269251A1 |
The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein RA, RB, RC and RD are as defined herein.
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WO/2022/258040A1 |
Provided is a heterocyclic compound for a TEAD inhibitor. The heterocyclic compound has the structure shown in formula I, and the groups in formula I are defined as described herein. The heterocyclic compound is used for preventing and/o...
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WO/2022/253645A1 |
A compound of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, which can be used as fungicides.
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WO/2022/255900A1 |
The present invention relates to the field of organic chemistry and pharmaceutics, and more particularly to ligands of the cysteinyl leukotriene receptors CysLT1R and CysLT2R, having the given formulae, where R1, R2, R3 and R4 have the v...
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WO/2022/253033A1 |
The present invention relates to a chemical coupling linker and a use thereof, and a biologically active conjugate prepared by the chemical coupling linker. The present invention also relates to a use of the biologically active conjugate...
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WO/2022/249074A1 |
The present invention discloses a novel fungicidal composition comprising at least one compound of formula (I) or an agriculturally acceptable salt thereof as a component (1), Formula (I) wherein, R, A, L1, R1, and n are as defined in th...
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WO/2022/238247A1 |
The present invention related to compounds of Formula (I) or an agronomically acceptable salt thereof, wherein Q, R2, R3, R4 and R5 are as defined herein. The invention further relates to compositions comprising said compounds, to method...
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WO/2022/219546A1 |
The present application relates to Leukotriene A4 hydrolase (LTA4H) inhibitors of formula (I), for use in the treatment of various disorders.
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WO/2022/215020A1 |
The present invention relates to a novel 1,3,4-oxadiazole thiocarbonyl compound having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof for preparing a m...
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WO/2022/216930A1 |
Disclosed herein are, inter cilia, compounds modulating activity and methods of use thereof for treating MDA-9/Syntenin associated conditions or disorders.
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WO/2022/212769A1 |
The present disclosure generally relates to compounds and compositions for use in imaging agents, methods of use for monitoring and/or treating conditions or diseases related to sphingosine-1-phosphate (S1P) signaling, and processes for ...
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WO/2022/207496A1 |
The present invention relates to 3-(hetero)aryl-5-chlorodifluoromethyl-1,2,4-oxadiazole compounds as well as the uses thereof for controlling harmful microorganisms, in particular phytopathogenic fungi, in crop protection.
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WO/2022/207494A1 |
The present invention relates to 3-(hetero)aryl-5-chlorodifluoromethyl-1,2,4-oxadiazole compounds as well as the uses thereof for controlling harmful microorganisms, in particular phytopathogenic fungi, in crop protection.
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WO/2022/212902A1 |
The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.
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WO/2022/204288A1 |
The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. ...
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WO/2022/194278A1 |
A series of phenol compounds and the use thereof. Specifically disclosed are a compound as represented by formula (III) and a pharmaceutically acceptable salt thereof.
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WO/2022/192562A1 |
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of USP30, and the treatment of USP30-mediated disorders.
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WO/2022/189495A1 |
Disclosed are chiral N-(1,3,4-oxadioazole-2-yl)phenyl carboxylic acid amides of general formula (I) as well as their use as herbicides. In formula (I) X, Z, R and R' represent radicals such as alkyl, cycloalkyl and halogen.
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WO/2022/180080A1 |
The present invention relates to compounds of formula (I) and to salts, solvates, stereoisomers and tautomers thereof useful as anti-proliferative agents and/or as inhibitors of DEAD-box (DDX) RNA helicases. The present invention also pr...
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WO/2022/178228A1 |
The invention provides arylthioether acetamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as bacterial infections, and in inhibiting LpxA activity.
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WO/2022/171176A1 |
Provided are a trifluoromethyloxadiazole compound, and a preparation method therefor and an application thereof, and a fungicide. The compound has a structure shown in formula (I). The trifluoromethyloxadiazole compound can have an excel...
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WO/2022/173795A1 |
Compounds that are selective inhibitors of Smad3 activation are disclosed. The compounds are (3-aryl-1,2,4-oxadiazol-5-yl)-3,4-dihydro-2H-pyrano[2,3-b]py
ridines of structure (I), in which Ar is aryl or heteroaryl. The compounds disclose...
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WO/2022/166764A1 |
The present invention relates to the field of organic chemistry, and in particular, relates to a use of a silicon compound in a cyclization reaction. On one hand, the present invention provides a method for preparing 2-chloro-5-chloromet...
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WO/2022/163446A1 |
The present invention addresses the problem of providing a new compound that binds specifically to intracellular and/or extracellular vesicles, a cellular vesicle stain, and a method for fluorescent staining of cellular vesicles. The p...
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WO/2022/149925A1 |
The present invention relates to a novel oxadiazole phenylalanine derivative and a medical use thereof. A novel tryptophan hydroxylase inhibitor and a pharmaceutical composition, which contain same, inhibit the synthesis of serotonin in ...
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WO/2022/129190A1 |
The present invention relates to the use of (hetero)aryl substituted 1,2,4-oxadiazole compounds for controlling harmful microorganisms, in particular phytopathogenic fungi, in crop protection (formula (I)). It also relates to novel (hete...
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WO/2022/023496A9 |
The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorop...
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WO/2022/122402A1 |
A dye encompassing a donor-acceptor-donor motif comprising a structure according to formulae (1), (2), (3), (4), (5), (6), (7) or (8). Further, a molecular probe, an analyte sensitive layer, a molecularly imprinted polymer, a sensor arra...
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WO/2022/111605A1 |
The present disclosure relates to an aryl or heteroaryl substituted 5-membered aromatic heterocyclic compound and the use thereof. In particular, provided is a compound as shown in formula I or a pharmaceutically acceptable salt thereof,...
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WO/2022/112139A1 |
The present invention provides novel compounds having the general formula (I) wherein R1 to R3 are as described herein, or a pharmaceutically acceptable salt thereof, compositions including the compounds and methods of using the compounds.
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WO/2022/064526A1 |
The present invention relates to solid state forms of Epacadostat of formula-1 which is chemically known as 4- ( { 2- [(amino sulfonyl) amino] ethyl} amino)-N-(3-bromo- 4 - fluoro phenyl) - N' - hydroxy- 1,2,5- oxa diazole- 3 - carboximi...
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WO/2022/055321A1 |
The present invention provides: a compound for a capping layer, represented by formula 1; and an organic light-emitting device including a first electrode, a second electrode, at least a single organic material layer interposed between t...
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WO/2022/050427A1 |
[Problem] To provide a novel method for producing a 1, 3, 4-oxadiazole-2-amine compound which is useful as a precursor of a heterocyclic amide compound that is useful as a herbicide. [Solution] A method for producing a 1, 3, 4-oxadiazole...
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WO/2022/035805A1 |
The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The disclosure...
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WO/2022/028421A1 |
Provided by the present invention are a fluorescent traceable amino acid derivative, a preparation method therefor, and an application thereof, belonging to the technical field of biomedicine. The amino acid derivative provided by the pr...
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WO/2022/029438A1 |
The invention relates to compounds of formula (I): wherein A, RA1, RA2, RB, RC and RD are as defined herein, and associated aspects.
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WO/2022/017836A1 |
The present invention relates to fungicidal compositions comprising, as active components, (R)- 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-t
riazol-1-yl)propan-2-ol (I) and N-(2- fluorophenyl)-4-[5-(trifluoromethyl)-1,2,4...
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WO/2022/015859A1 |
Among the various aspects of the present disclosure is the provision of compositions and methods for targeted treatment and detection of cancers. In particular, the present disclosure is directed to a compounds are from the benzofurazan,...
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WO/2022/008923A1 |
The present invention relates to the use of compounds of Formula (I) as herbicides, wherein Z, W, X1-X4, R1, F2, R3, R4, m and n are as defined herein. The invention further relates to agrochemical compositions comprising a compound of F...
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WO/2022/007461A1 |
Disclosed is an immunomodulator, and the present invention specifically relates to a compound for inhibiting IL-17A and an application of the compound serving as the immunomodulator in the preparation of a drug. Disclosed is an applicati...
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WO/2022/002078A1 |
The present invention relates to the fields of pharmaceutical chemistry and pharmacotherapeutics, and in particular to a compound as represented by general formula I, a racemate, an R-isomer, an S-isomer and a pharmaceutically acceptable...
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WO/2021/262311A1 |
The present disclosure is directed to a compound or compositions comprising the same for decreasing vascular permeability and the prevention or inhibition of metastasis in a cancer.
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