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Matches 1 - 50 out of 4,290

Document Document Title
WO/2018/095432A1
Provided are certain IDO inhibitors, pharmaceutical compositions thereof, and methods of use thereof.  
WO/2018/093762A1
Furoxan compounds, compositions comprising the same, and methods of making and using the same, are described.  
WO/2018/083241A1
The invention provides modulators of indoleamine 2,3-dioxygenase (IDO1) and their use in the prophylaxis and/or treatment of IDO1-mediated diseases. Specifically, the present invention provides compounds according to Formula (I) an enant...  
WO/2018/081167A1
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurolo...  
WO/2018/080859A1
Disclosed are compounds of Formula I, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein R1, Z1, R2, Z2, J, s and f are as defined in the disclosure. Also disclosed are compositions containing the ...  
WO/2018/081425A1
Described herein are compounds having a hydrogen-bonding group and optionally a functional group for binding (e.g., covalently binding) the compound to another compound (e.g., hyaluronic acid and/or gelatin). A compound of the present in...  
WO/2018/073754A1
The present disclosure relates to 3-substituted 1,2,4-oxadiazole compounds and their derivatives, which are useful as V-domain immunoglobulin suppressor of T-cell activation (VISTA) inhibitors or as dual inhibitors of VISTA and the progr...  
WO/2018/072697A1
Disclosed are an oxadiazole ring-containing compound, a preparation method therefor, and an intermediate, a composite, and an application thereof. The oxadiazole ring-containing compound having the formula in the figure below, and a phar...  
WO/2018/065414A1
Compounds of Formula (I): wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.  
WO/2018/062978A1
The present invention relates to a novel heteroaryl compound, an enantiomer, a diastereomer or a pharmaceutically acceptable salt thereof, and an antiviral composition comprising the same as an active ingredient. The novel compounds repr...  
WO/2018/055135A1
A method of controlling or preventing infestation of useful plants by phytopathogenic microorganisms, wherein a fungicidally effective amount of a compound of Formula (I) wherein the substituents are as defined in claim 1, is applied to ...  
WO/2018/056340A1
The present invention provides a compound having excellent control efficacies against plant diseases. Specifically, the present invention provides a compound represented by formula (1) (wherein: X represents a C3-C5 alkyl group or a NR1R...  
WO/2018/051254A1
The present invention relates to cyclic substituted-1,2,4-oxadiazole compounds of formula (I) and their use to inhibit the programmed cell death 1 (PD1) signalling pathway and/or for treatment of disorders by inhibiting an immunosuppress...  
WO/2018/049632A1
The invention relates to a crystal form of ozanimod. Compared with known forms of ozanimod, the crystal form of ozanimod of the invention has one or more improved features. The invention also relates to a preparation method and a pharmac...  
WO/2018/049404A1
Clostridium difficile infection (CDI) is a public health threat that results in 14,000 annual deaths in the United States. Challenges involve the production of CDI spores that can remain dormant for years and the production of toxins tha...  
WO/2018/047139A1
The present invention relates to compound of formula (I) as therapeutic agents to modulate the TIGIT signalling pathway. The invention also encompasses the use of the compound of formula (I) or a stereoisomer thereof or a pharmaceuticall...  
WO/2018/044663A1
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Formula (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated dis...  
WO/2018/039430A1
Radiofluorinated carboximidamides are disclosed as selective IDO enzyme radioligands and generate specific binding in accordance with IDO expression in vitro. MicroPET experiments indicate [18F]IDO49 specifically accumulate in IDO-expres...  
WO/2018/033149A1
Provided are crystal forms of Ozanimod and a preparation method therefor. The provided crystal forms of Ozanimod comprise a crystal form CS9, a crystal form CS10, and a crystal form CS11 of Ozanimod, and can be used for treating autoimmu...  
WO/2018/030460A1
The present invention provides a compound having excellent control efficacies against pests. Specifically, the present invention provides a compound represented by formula (I):(wherein: G represents a benzene ring or pyridine ring, etc.;...  
WO/2018/028557A1
The present invention relates to a series of tricyclic compounds and the use thereof as receptor agonists of 1-phosphate sphingosine 1 subtype (S1P1), and in particular to the compounds shown in formula (I), and tautomers or pharmaceutic...  
WO/2018/029242A1
Compounds of formula (I), wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.  
WO/2018/024208A1
A compound as an indoleamine-2,3-dioxygenase 1(IDO1) inhibitor, and an application thereof in the field of IDO1-related diseases, and in particular a compound as shown in formula (I) and a pharmaceutically acceptable salts thereof.  
WO/2018/024188A1
Provided are a polycyclic compound and a manufacturing method, pharmaceutical composition, and application thereof. The structure of the polycyclic compound and an isomer, prodrug, solvate, hydrate, stable isotopic derivative, or pharmac...  
WO/2018/022802A1
The invention provides antifungal compounds, antifungal compositions, and intermediates for the preparation of antifungal compounds and antifungal compositions. The invention also provides methods of inhibiting fungi and methods of treat...  
WO/2018/015449A1
Compounds of the formula (I), wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.  
WO/2018/015447A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.  
WO/2018/015458A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.  
WO/2018/011746A1
The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their ta...  
WO/2018/011747A1
The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their ta...  
WO/2018/009256A1
The present invention relates to ampakines, including low impact ampakines, and pharmaceutical compositions and methods employing ampakines for treating central nervous system (CNS) disorders, including attention deficit disorders. Novel...  
WO/2017/222474A1
The present invention provides processes for the preparation of ataluren. Intermediates for preparing ataluren are also provided.  
WO/2017/219083A1
The present invention relates to novel compounds which active HIV expression in latently infected cells. More particularly, the invention relates to pharmaceutical compositions comprising the novel compounds and their use in activating H...  
WO/2017/220485A1
Compounds of the Formula (I), wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.  
WO/2017/215617A1
Disclosed are a crystal form of ozanimod, a crystal form of a hydrochloride thereof, and a preparation method therefor. The crystal form of ozanimod and the crystal form of a hydrochloride thereof can be applied to treatment for autoimmu...  
WO/2017/211649A1
The present invention relates to novel trifluoromethyl oxadiazoles of the formula (I), or an N-oxide, and/or their agriculturally useful salts; to their use for controlling phytopathogenic fungi; to a method for combating phytopathogenic...  
WO/2017/211652A1
The present invention relates to novel trifluoromethyloxadiazoles of the formula (I), or an N-oxide, or their agriculturally useful salts; to their use for controlling phytopathogenic fungi; to a method for combating phytopathogenic harm...  
WO/2017/213252A1
The present invention provides a compound having excellent control efficacies against pests. Specifically, the present invention provides a compound represented by formula (I): (wherein: A is a single bond, etc.; m is any one integer of ...  
WO/2017/211650A1
The present invention relates to novel trifluoromethyloxadiazoles of the formula I, or an N-oxide, and/or their agriculturally useful salts; to their use for controlling phytopathogenic fungi; to a method for combating phytopathogenic ha...  
WO/2017/209155A1
Provided are: a novel sulfonamide compound having ribonucleotide reductase inhibitory activity or a salt thereof; and a pharmaceutical composition which contains this sulfonamide compound or a salt thereof as an active ingredient. A comp...  
WO/2017/207757A1
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.  
WO/2017/198700A1
The present invention relates to treatment of cancer, in particular to methods of sensitising cancer cells to an anti-cancer therapy by administering an effective amount of a modulator of Volume Regulated Anion Channels, i.e. a VRAC modu...  
WO/2017/198852A1
Compounds of Formula (IA) or Formula (IB): (IA/IB) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.  
WO/2017/195149A1
Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases.  
WO/2017/196544A1
The present invention includes novel compounds useful for labeling biomolecules. The present invention further includes a novel method of labeling a biomolecule using a compound of the invention. The present invention further includes a ...  
WO/2017/193034A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2017/191000A1
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...  
WO/2017/193030A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2017/193041A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2017/192304A1
The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic di...  

Matches 1 - 50 out of 4,290