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WO/2024/070968A1 |
Provided are: an actinic ray-sensitive or radiation-sensitive resin composition containing (A) a resin the polarity of which is increased due to acid activity, (B) a compound which produces an acid when irradiated with actinic rays or ra...
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WO/2024/041634A1 |
The present disclosure provides a compound having USP1 inhibitory activity or functionality and a pharmaceutically acceptable salt thereof. The present disclosure further provides a pharmaceutical composition comprising the compound repr...
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WO/2023/243686A1 |
The present invention provides a compound that exhibits a PLD-inhibitory activity.　The present invention provides a compound having the following structural formula or the like, or a pharmaceutically acceptable salt thereof. (Each symb...
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WO/2023/237651A1 |
The present invention provides methods for the preparation of Compound (I) intermediate compounds and their use for the preparation of compound (I).
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WO/2023/236920A1 |
This disclosure provides compounds of Formula (1), compositions comprising the same, and methods of using the same, including uses in modulating SARM1 and treating various diseases and conditions, e.g., those caused by axonal degeneration.
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WO/2023/237656A1 |
This present invention relates to a crystalline form of (6S)-5-[4'-Fluoro-2- (trifluoromethyl)biphenyl-4-yl]-6-methyl-3,6-dihydro-2H-1,3,
4-oxadiazin-2-one which is the polymorph C, to processes for its preparation, to pharmaceutical com...
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WO/2023/220836A1 |
The present disclosure relates generally to new bifunctional linchpins that react selectively with cysteine residues to invoke cyclization while concurrently introducing a radiometal chelation ligand or silicon-based fluoride acceptor (S...
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WO/2023/217276A1 |
The present invention belongs to the technical field of pesticides, and specifically relates to a heterocyclic substituted aromatic compound, a preparation method therefor, a herbicidal composition and an application. The compound is as ...
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WO/2023/216910A1 |
Provided in the present invention is a new substituted bicyclic heteroaryl compound as represented by formula (A), or a pharmaceutically acceptable salt, an isotopic variant, a tautomer, a stereoisomer, a prodrug, a polymorph, a hydrate ...
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WO/2023/208706A1 |
A process for the preparation of a compound of formula (I) comprising the reaction of: R1-C(O)-NH-NH-C(O)-R2, with R3-CH2-CH2-O-CH2-CH2-R4, in the presence of an alcoholic solvent; wherein R1 and R2 are independently selected from straig...
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WO/2023/192328A1 |
The present disclosure features compounds (e.g., oxaziridine-based compounds), as well as related compositions and methods of use thereof, e.g., for selectively labeling a methionine residue in a target peptide or protein.
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WO/2023/169456A1 |
This disclosure relates to GLP-1 agonists, pharmaceutical compositions, and methods of use thereof.
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WO/2023/148735A1 |
The present disclosure relates to solid state forms of Indoxacarb or its solvate, processes for preparation thereof and agrochemical compositions thereof.
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WO/2023/131943A1 |
The present invention relates to novel di-imine, oxadiazepine and oxadiazine intermediates as key intermediates for preparation of oxadiazine insecticides, the processes of their preparation, purification and use in the preparation of fi...
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WO/2023/117380A1 |
The invention relates to dishwashing products that contain metal complexes of the general formula (I), (Aq+)p[Mn+Lm-](Xo-)r (I), wherein q is 1 or 2 and Aq+ represents a cation, selected from alkali metal cations with q = 1, alkaline ear...
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WO/2023/114615A1 |
A redox-based strategy for bioconjugation of tryptophan uses oxaziridine reagents that mimic oxidative cyclization reactions in indole-based alkaloid biosynthetic pathways to achieve highly selective and rapid tryptophan labeling.
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WO/2023/091464A1 |
The invention relates to compounds that inhibit DUBs, particularly USP9X. The invention also includes methods of inhibiting DUBs, including USP9X, and methods of treating cancers.
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WO/2023/083297A1 |
Provided are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Further provided are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating disea...
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WO/2023/064343A1 |
Provided herein are compounds that modulate glucocerebrosidase (GCase), an enzyme whose activity is associated with neurological diseases and disorders (e.g., Gaucher's disease, Parkinson's disease). Also provided are pharmaceutical comp...
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WO/2023/046939A1 |
The present invention relates to certain macrocyclic compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of a disease associated with and/or caused by prot...
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WO/2023/286053A1 |
The present invention pertains to a process for preparing of methyl chloroformyl[4-(trifluoromethoxy)phenyl]carbamate of formula I as intermediate in the preparation of arthropodicidal indoxacarb, comprising reaction of compound of formu...
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WO/2023/278402A1 |
The present invention provides compounds, compositions thereof, and methods of using the same.
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WO/2022/213935A1 |
Provided is a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof. The compound can be used in the preparation of a drug for treating 1-sphingosine phosphate receptor 1-related diseases, such as autoimmun...
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WO/2022/214053A1 |
A compound of formula (I) as a USP1 inhibitor or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound or the pharmaceutically acceptable salt thereof, and the use thereof in the prevention or t...
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WO/2021/110968A9 |
The present disclosure provides macrocyclic compounds comprising a 4-amido- 2,4-pentadienoate (APD) moiety. The compounds exhibit toxicity that is selective to the hypoxic micro-environments often found in cancerous tissues. The disclose...
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WO/2022/127704A1 |
Disclosed are a method for preparing a carboxyl cyclic acid anhydride and a prepared product thereof. A method for preparing a compound of formula (II), comprising the steps of reacting a compound of formula (I) with a cyclization reagen...
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WO/2022/129909A1 |
The present invention relates to a group of novel compounds, methods for their manufacture and the use of these compounds as research tools and as pharmaceuticals. The novel compounds are analogues of cannabidiol (CBD). CBD is a non-psyc...
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WO/2022/125800A1 |
The present invention provides compounds, compositions thereof, and methods of using the same.
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WO/2022/123541A1 |
The present disclosure relates to a process for the preparation of pyrazole-oxadiazepine. The process of the present disclosure reduces solvent use, uses inexpensive and easily available reagents. The process is simple, efficient, enviro...
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WO/2022/109117A1 |
The present invention is directed to 3-amino pyrrolidine and piperidine macrocyclic compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treat...
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WO/2022/103899A1 |
The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
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WO/2022/076563A1 |
The instant invention describes macrocyclic compounds having antiproliferation activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.
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WO/2022/069563A1 |
The invention relates to a water-dispersible modified polyisocyanate and use thereof, especially as a crosslinking component in water-soluble or water-dispersible coating compositions. The water-dispersible modified polyisocyanate can be...
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WO/2022/071970A1 |
Compositions with supramolecular structures for use in agricultural methods include a source of micronutrients such as a fertilizer, a supramolecular host chemical or a supramolecular guest chemical configured to engage in host-guest che...
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WO/2022/048025A1 |
The present invention provides a method for synthesizing an atorvastatin calcium intermediate by using a multi-component one-pot method. Specifically, the present invention provides a one-pot synthesis method for 4-(4-fluorophenyl)-2-(2-...
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WO/2021/250240A1 |
The invention relates to a diaza-18-crown-6 derivative having formula (I): wherein: B is a moiety for a covalent bonding reaction; the two A are identical to each other and are a group of formula (II): where: n = 0 to 4; X1, X2, X3, X4 a...
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WO/2021/191035A1 |
The invention relates to compounds of formula (I), (I) and their use as herbicides. In said formula, R1 to R7 represent groups such as hydrogen, halo-gen or organic groups such as alkyl, alkenyl, alkynyl, or alkoxy; X is a bond or a diva...
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WO/2021/188620A1 |
Peptidomimetic N5-methyl-N2-(nonanoyl-L-leucyl)-L-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds for use in methods of inhibiting the replication of noroviruses and coronaviruses in a biological sa...
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WO/2021/175225A1 |
Disclosed in the present invention are a series of tricyclic compounds, and particularly disclosed are a compound shown in formula (I) or a pharmaceutically acceptable salt thereof.
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WO/2021/175223A1 |
Disclosed are a series of benzo 2-azaspiro[4.4]nonane compounds, and specifically disclosed are a compound as represented by formula (P) or a pharmaceutically acceptable salt thereof.
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WO/2021/168567A1 |
A chelator having the general structure (I) for chelating radiometals such as 225Ac under mild conditions is provided. (I) The chelator can be coupled to a biological targeting moiety to facilitate targeted delivery of the chelated radio...
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WO/2021/149767A1 |
Provided are: a heterocyclic derivative and/or a pharmaceutically acceptable salt thereof that can serve as a therapeutic agent and/or a prophylactic agent for a disease in which the sodium channel (Nav) is involved and for various centr...
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WO/2021/123036A1 |
The present invention relates to use of a chelating compound (I) for chromatographic separation of rare earth elements, actinides, and/ or s-, p- and d-block metals, and to a method of chromatographic separation of chelates of rare earth...
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WO/2021/047308A1 |
Disclosed are a polyisocyanate composition and a method for preparing the composition. The composition is formed by polymerizing an aliphatic diisocyanate monomer at least including hexamethylene diisocyanate, and contains an isocyanurat...
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WO/2021/008908A1 |
The invention relates to a method for producing polyisocyanates having a low monomer content, said method comprising the following steps: (i) modifying at least one monomeric diisocyanate to obtain a mixture containing at least one polyi...
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WO/2021/005545A1 |
The present disclosure relates to a process for obtaining an enantiomeric mixture of Indoxacarb crystals having purity in the range of 95% to 99.5%, wherein the enantiomeric mixture comprises crystals of R-isomer and S-isomer. The S-isom...
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WO/2020/157188A1 |
The present invention provides dihydrooxydiazinone compounds of general formula (I) : (I), in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compound...
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WO/2020/160100A1 |
The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
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WO/2020/157201A1 |
The present invention includes name compounds of general formula (I) in which R1, Y, and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositio...
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WO/2020/109189A1 |
The present invention relates to a modified polyisocyanate and use thereof, in particular as a crosslinking component of water-soluble or water-dispersible coatings. The modified polyisocyanate is obtained by a reaction of a system compr...
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