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JP4452017B2 |
Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.
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JP4446736B2 |
A compound of the formula (I): wherein A is an aromatic or heteroaromatic ring system or partially or fully reduced derivatives thereof; Q is hydrogen, C 1 -C 12 straight chain, branched or cyclic alkyl substituted with one or more hydro...
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JP2010065019A |
To provide an easily producible cyclic metal complex having a new molecular function and its ligand.The oxime-type cyclic metal complex is expressed by general formula (1) (wherein R1 and R2 are each the same or different hydrogen atom, ...
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JP4431737B2 |
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JP2009544597A |
The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and...
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JP4383886B2 |
This invention concerns new biocidal compounds of formula (I) wherein R is H or CH3. Of particular interest are two isomers that are named malayamycin A and desmethylmalayamycin A. These isomers, which may be prepared by growing under co...
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JP4381596B2 |
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JP4377221B2 |
The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascu...
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JP4370107B2 |
Cyclic diamine compounds (I) are new. Cyclic diamine compounds of formula (I) and their salts are new. [Image] A : CY 1Y 2OCY 3Y 4, CY 1Y 2SO nCY 3Y 4, CY 1Y 2NRCY 3Y 4, CY 1=NCY 3Y 4 or CY 1Y 2N=CY 3; n : 0-2; Y 1-Y 4H, 1-6C alkyl or 1-...
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JP4364944B2 |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering th...
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JP4366499B2 |
This invention relates to cyclic etheramine derivatives or salts thereof and also to medicaments comprising the derivatives or salts. These cyclic etheramine derivatives are each represented by the following formula (1):wherein Y<1> and ...
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JP4361617B2 |
Diaza-18-crown-6 compounds of the formula I: wherein X is a phenol, naphthol or quinolinol moiety selected from those of the formulae: R1, R2, R3, R4 and R5 are independently selected from hydrogen, halo, cyano, nitro, (C1-C6) alkyl, (C2...
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JP4359500B2 |
The present invention pertains to a process for preparing a compound of Formula I that is achiral, racemic or enantiomerically enriched at the hydroxylation center indicated by * comprising contacting a compound of Formula II with an oxi...
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JP4359433B2 |
This invention provides compounds of Formula I, their N-oxides and agriculturally suitable salts wherein A and B are independently O or S; J is an optionally substituted 5- or 6-memebered nonaromatic heterocyclic ring; K is taken togethe...
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JP4354652B2 |
A group of compounds of, the preparation of, and the methods of use of benzoylpyridazine derivatives and the physiologically acceptable salts and solvates thereof, which have valuable pharmacological properties while well tolerated. They...
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JP4344119B2 |
Photoresist monomers, polymers thereof, photoresist compositions containing the same for preventing acid generated in the exposed area during the course of a photolithography process from being diffused to the unexposed area. The line ed...
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JP4339403B2 |
The single-step preparation of 3-(hydroxyphenyl-1-alkoximinomethyl)dioxazine derivatives of formula (I) from compounds (II), (III) and (V), and the preparation in 2-5 steps from (VII), (VIII), (X), (XI), (XII), (XIV) and (XVI) (via (II),...
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JP4316878B2 |
This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase activity and methods of using such antioxidan...
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JP4306805B2 |
Benzoyl derivatives of the formula I where the variables have the following meanings: R1, R2 are hydrogen, nitro, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulf...
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JP4306822B2 |
Preparation of 3-(1-hydroxyphenyl-1-alkoxyiminomethyl)dioxazine derivatives of formula (I), comprises: (a) rearranging O-hydroxyethyl-O'-alkyl-benzofuran-dionedioxime optionally in the presence of a diluent and optionally in the presence...
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JP2009522236A |
Methods for the synthesis of various novel substituted dipeptide derived nitrogen-containing heterocyclic compounds (I) and their pharmaceutically acceptable salt derivatives are provided. The compounds of the invention are claimed and a...
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JP2009522225A |
The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and...
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JP2009522234A |
The present invention relates to various novel substituted dipeptide derived nitrogen-containing heterocyclic compounds, their pharmaceutically acceptable salt derivatives, and their methods of use.
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JP2009108054A |
To provide a new compound useful for treating infection with vancomycin-resistant bacteria.The new peptoid compound is useful especially against infection with gram-positive bacteria including the vancomycin-resistant and methicillin-res...
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JP4263200B2 |
A method for making a compound of Formula I which is racemic or enantiomerically enriched at chiral center* comprising hydrogenating a compound of Formula V in the presence of a compound of Formula VII wherein: R 1 is F, Cl, or C 1 -C 3 ...
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JP4259620B2 |
4-(3-Heterocyclyl-benzoyl)-pyrazole derivatives (I) and their salts are new: R1, R3 = H; NO2; halo; CN; 1-6C alkyl, 1-6C alkoxy, 1-6C alkylthio, 1-6C alkylsulphinyl or 1-6C alkylsulphonyl optionally substituted by halo; H2NSO2; (1-6C alk...
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JP2009513510A |
The present invention relates to macro-cyclic compounds of formula (I), wherein R1, is (C1-8)alkyl, (C1-4)alkoxy(C1-4)alkyl, hydroxy(C1-6)alkyl, (C1-4)alkylthio(C1-4)alkyl, (C1-6)alkenyl, (C3-7)cycloalkyl, (C3-7)cycloalkyl(C1-4)alkyl, pi...
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JP2009062355A |
To provide a new nitrogen-containing heterocyclic compound or its salt, and to provide a pest control agent containing the compound as an active ingredient.Provided are a nitrogen-containing heterocyclic compound represented by formula (...
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JP2009510013A |
The present invention provides compounds of formula I where R1 to R4 are as defined herein which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provid...
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JP4202898B2 |
An additive compound comprising a non-borated and/or borated reaction product, in which the reaction product is obtained by reacting a linear or branched, saturated or unsaturated monovalent aliphatic acid having 8 to 22 carbon atoms, ur...
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JP4181632B2 |
Novel cryptophycin compounds are disclosed, together with methods of producing cryptophycins by total synthesis and methods for the use of such cryptophycins in pharmaceuticals to inhibit the proliferation of mammalian cells and to treat...
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JP4176077B2 |
The present invention is comprised of culturing microorganism having ability to produce FKI-1033 substance represented by the formula: in a medium, accumulating FKI-1033 substance in the cultured medium, and isolating FKI-1033 substance ...
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JP4172895B2 |
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JP4160115B2 |
The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form s...
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JP2008222568A |
To provide an oligomer-type chiral salen compound, and to provide a method for producing the chiral compound from a racemic epoxide.The oligomer-type chiral salen compound is represented by formula (1). The method for producing the chira...
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JP4149532B2 |
Arylalkyldiazinone derivs. of formula (I) and their salts are new: B = aromatic heterocycle with 1-4H, O and/or S atoms bonded to N or C (opt. mono-, di- or tri-substd. by Hal, A and/or OA and opt. condensed with a benzene or pyridyl rin...
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JP2008528507A |
The invention describes compositions and kits comprising at least one cardiovascular compound comprising at least one heterocyclic nitric oxide donor group, and, optionally, at least one nitric oxide enhancing compound and/or at least on...
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JP4126121B2 |
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JP2008526912A |
Macrocyclic compounds of the formula in which R1, R3, V1, V2, X1, X2, Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16, 17 or 18, in free base form or in a...
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JP4105805B2 |
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JP4106134B2 |
Production of polyisocyanates is new, in which isocyanates of formula (OCN-CH2)X (I) are obtained by polymerisation in the presence of hydrogen polyfluorides of formula (II) as oligomerisation catalysts, in which X = optionally branched,...
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JP2008520670A |
The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase e...
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JP4104653B2 |
PCT No. PCT/EP96/02170 Sec. 371 Date Nov. 19, 1997 Sec. 102(e) Date Nov. 19, 1997 PCT Filed May 20, 1996 PCT Pub. No. WO96/38165 PCT Pub. Date Dec. 5, 1996The present invention relates to mixtures of avermectins, 22,23-dihydroavermectins...
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JP4090514B2 |
The present invention relates to compounds of the formulaQ is selected from the group consisting ofG is selected from the group consisting of alkyl, substituted alkyl, substituted or unsubstituted aryl, heterocyclo,W is O or NR15;X is O ...
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JP4090070B2 |
An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The ...
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JP2008515827A |
The invention relates to novel 1,3,4-oxadiazine-5-on derivatives of general formula (I), methods for the production thereof, the use thereof for treating and/or preventing diseases, and the use thereof for producing medicaments used for ...
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JP2008092952A |
To provide an effective method for preparation of substituted aryl lactic acid containing cyclodepsipeptides.The invention relates to the new method for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 2...
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JP4070270B2 |
Preparation of (cyclo)allophanates containing(cyclo)aliphatic and/or araliphatic isocyanate groups of formula (I) comprises reacting an isocyanate group-containing (oligo)- oxadiazine-trione of formula (II) with primary or secondary alco...
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JP4065053B2 |
Mono-aza crown ethers of formula (I) are new. X = luminophor residue; and m, r, s = 0-2.
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JP4054063B2 |
PCT No. PCT/EP96/05190 Sec. 371 Date Jun. 4, 1998 Sec. 102(e) Date Jun. 4, 1998 PCT Filed Nov. 25, 1996 PCT Pub. No. WO97/20945 PCT Pub. Date Jun. 12, 1997The present invention relates to a new process for the preparation of substituted ...
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