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Matches 701 - 750 out of 1,055

Document Document Title
JP2001502677A
The invention relates to novel oxime derivatives of formula (I), in which A stands for alkadiyl, Ar for optionally substituted aryls or heteroaryls respectively, G for a single bond, optionally an alkandiyl interrupted by heteroatoms (in...  
JP2001048869A
To readily and environmentally-friendly produce an oxaziridine compound useful as a raw material for various organic synthesis at a low cost by reacting a cycloalkanone with ammonia, and oxidizing the product. A cycloalkanone (e.g. cyclo...  
JP2001502297A
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, antifungal, and for the treatment of cancer. The invention further provides a formulation for admi...  
JP2001502298A
(57) [Summary] The present invention provides intermediates and methods useful for the production of cryptophycin compounds.  
JP3135659B2
PURPOSE: To simply obtain perfluoro-oxyaziridines in high yield which are useful in the preparation of perfluoroaminoether polymers, nitrones, etc., by reacting a specific perfluoroimine with an aromatic peroxyacid in an aprotic solvent ...  
JP3135660B2
PURPOSE: To obtain the compound useful as raw materials for polymers with excellent chemical inactivity and thermal stability by specific perfluoroimine and perfluoroalkyl-fluoroformyl peroxides to react with each other. CONSTITUTION: Pe...  
JP2001501916A
Oxadiazines of formula (I), wherein R<1> is F, Cl or fluoralkoxy and R<2> is alkyl, are prepared by reacting hydrazine derivatives of formula (II) with a dialkoxymethane in the presence of a protic acid catalyst in an inert solvent under...  
JP3132167B2
PURPOSE: To obtain a depsipeptide derivative having anthelmintic action at a low cost in high yield by carrying out the polycondensation of a condensation product of an amino acid and an α-chloropropionic acid ester and subjecting the p...  
JP2001500853A
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering th...  
JP2001500496A
This invention provides a process for preparing diastereomerically pure cryptophycin compounds.  
JP2001500484A
PCT No. PCT/US97/14800 Sec. 371 Date Feb. 25, 1998 Sec. 102(e) Date Feb. 25, 1998 PCT Filed Aug. 25, 1997 PCT Pub. No. WO98/08812 PCT Pub. Date Mar. 5, 1998This invention provides processes for preparing cryptophycin compounds and novel ...  
JP2001500128A
This invention provides novel cryptophycin compounds and a process for preparing cryptophycin compounds.  
JP3121355B2
The present invention relates to compounds of the formula Orosco wherein R1, R2, R3, X, Y and the dashed line are defined as in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and...  
JP2000516596A
Pharmacophore models of VLA-4 inhibitors, methods of identifying novel inhibitors and novel inhibitors identified by these methods.  
JP2000319249A
To obtain a new compound useful as a medicine for treating or preventing virus infection, especially cytomegalovirus infection. A compound of formula I [R1 is H, a (substituted) 6 to 10C aryl, (five to ten-membered aromatic heterogeneous...  
JP2000302676A
To obtain a medicinal composition capable of protecting and preventing a mitochondoria genome and/or mitochondoria from being damaged by including a specific hydroximic acid derivative as an active ingredient. This medicinal composition ...  
JP3104142B2
PURPOSE: To obtain a new benzamide derivative useful as a therapeutic agent for digestive system diseases, having accentuating action on function of digestive tubes and anti-vomiting action. CONSTITUTION: A compound of formula I (R1 is H...  
JP2000290268A
To selectively obtain a polyisocyanate having excellent reactivity and high compatibility with polyols and solvents, etc., by reacting a polycyclic aliphatic polyisocyanate with carbon dioxide gas using a specific t-phosphine. A polyisoc...  
JP2000290269A
To selectively obtain a polyisocyanate having excellent reactivity and high compatibility with polyols and solvents, etc., by reacting a polycyclic aliphatic polyisocyanate with carbon dioxide gas using a specific pyridine compound. A po...  
JP2000248043A
To obtain a polyisocyanate composition excellent in reactivity at low temperature, also good in preservation stability and useful as a raw material for various kinds of polyurethanes by including a specific diisocyanate and a specified p...  
JP2000248045A
To obtain a polyisocyanate composition excellent in reactivity at low temperature, also good in preservation stability, and useful as a raw material for various polyurethanes by including a specific diisocyanate and a specified polyisocy...  
JP2000510820A
The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.  
JP2000508630A
PCT No. PCT/EP97/01325 Sec. 371 Date Sep. 18, 1998 Sec. 102(e) Date Sep. 18, 1998 PCT Filed Mar. 17, 1997 PCT Pub. No. WO97/36883 PCT Pub. Date Oct. 9, 1997The invention relates to novel (1,3,4)-oxadiazine derivatives of formula (I), to ...  
JP3061863B2
This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating Actinoplanes sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocyli...  
JP2000507805A
Methods for producing cryptophycin compounds by bacterial fermentation are disclosed, together with novel compositions produced thereby.  
JP2000505473A
(57) [Summary] The present invention provides novel cryptophycin compounds that may be useful in disrupting the microtubule system as antitumor agents and for treating cancer. The present invention further provides a preparation for admi...  
JP2000502351A
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the...  
JP3014146B2
The present invention provides an efficient process of reacting a bis-indolyl acid of the Formula (II): (II) wherein R1 is a hydrogen or C1-C4 alkyl and R, X, and Y are optional substitutions; to produce a bis-indolyloxallic acid of the ...  
JP2000502050A
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...  
JP3011955B2
New heterocyclic compounds of formula I In which Het means one of following groups; wherein R11, R13 and R14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, -CH=CH-, or -CH2-CH2-...  
JP2000501067A
Methods for producing cryptophycin compounds by bacterial fermentation are disclosed, together with novel compositions produced thereby.  
JP3003940B2
A process is provided for the preparation of Mn(II) chelates for use as contrast agents in magnetic resonance imaging, said process comprising reacting insoluble manganese (II) oxide with an aqueous suspension comprising a molar equivale...  
JPH11322728A
To obtain a heterocyclic compound useful for physiologically active substances such as agrochemicals and drugs under mild conditions with ease in a high yield, by applying an amide compound as a starting substance. An amide compound of f...  
JPH11322593A
To obtain an anticancer agent having an inhibitory activity of the propagation of cancer cells and an inhibitory activity of tubuline by including a specific acetamide derivative. This anticancer agent and tubuline inhibitor contain usua...  
JPH11510831A
A water-containing composition containing a linear aminoplast-ether copolymer of the formula: I. where the divalent R01 contains a divalent alkyleneoxy containing moiety, Amp is the skeletal residue of an aminoplast, R is hydrogen, alkyl...  
JPH11199570A
To obtain a new heterocyclic compound having a specified nitrogenous cyclic group and low toxicity, capable of manifesting excellent neurodegeneration inhibitory action and intraencephatic migration and useful for the treatment and preve...  
JPH11508248A
Compounds of the formula I in which Z is -CO-NHNH2, COOH, COCl, CONHNHCOR4 or CON=C(R4)NMe2 are intermediates for the preparation of compounds of the formula I in which Z is a group a) or b) or c) or d) The end compounds can be used for ...  
JPH11507641A
The invention relates to multidentate metal complexes having formula (I) wherein M is Fe, In, Ga or Al; the dashed lines represent independently a sigle or a double bond; the hatched lines represent coordination to the metal cation (M); ...  
JPH11507636A
A cryptophycin compound is provided having the structure: Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins ...  
JPH11171897A
To obtain the subject new peptide comprising a cyclic depsipeptide having a specific amino acid sequence, having strong cardiotonic effect, antiarrhythmic action and vasodilation action, free from adverse effect of arrhythmia, etc., and ...  
JP2909097B2
Herbicidal N-isopropylheteroaryloxyacetanilides of the formula (I) in which A stands for nitrogen or the group C-R3 where R3 stands for halogen, cyano, alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, alkylthio, halogenoalkylthio, alkylsulp...  
JP2874342B2
A compound represented by general formula (I) or a salt thereof, excellent in parasiticidal activity as an enthelmintic for animal and man, wherein A represents benzyl which is appropriately substituted or phenyl which may be appropriate...  
JP2873894B2  
JPH1149755A
To obtain a new compound useful for an insecticidal composition without practically damaging helpful insects, circumstances, etc., manifesting low toxicity, strongly exhibiting drug action on drug resistant insects. This compound is expr...  
JPH11500717A
The application relates to novel heterocycloalkenes, to a number of processes for their preparation and to their use as fungicide.  
JPH10332591A
To eliminate that a luminescence characteristic is sharply influenced by the pH value of a sample by a method wherein a diaza-cryptand by a specific formula is used as a compound luminophore-ionophore. A diaza-cryptand by a formula is a ...  
JPH10330359A
To obtain a new compound that has higher herbicidal ability against weeds with higher stability tan the conventional. This new compound is a phenylacetylene derivative represented by formula I [X is H, a halogen, a 1-6C alkyl, a haloalky...  
JP2832473B2
A novel process for the preparation of modified, isocyanurate-containing polyisocyanates containing aliphatically and/or cycloaliphatically bonded isocyanate groups involves the chemical modification of some of the isocyanate groups of o...  
JP2833766B2
There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents b...  
JPH10512868A
PCT No. PCT/EP96/00069 Sec. 371 Date Jul. 16, 1997 Sec. 102(e) Date Jul. 16, 1997 PCT Filed Jan. 10, 1996 PCT Pub. No. WO96/22983 PCT Pub. Date Aug. 1, 1996The invention relates to novel substituted arylazadioxacycloalkenes, a plurality ...  

Matches 701 - 750 out of 1,055