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Document Title |
JP2001502677A |
The invention relates to novel oxime derivatives of formula (I), in which A stands for alkadiyl, Ar for optionally substituted aryls or heteroaryls respectively, G for a single bond, optionally an alkandiyl interrupted by heteroatoms (in...
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JP2001048869A |
To readily and environmentally-friendly produce an oxaziridine compound useful as a raw material for various organic synthesis at a low cost by reacting a cycloalkanone with ammonia, and oxidizing the product. A cycloalkanone (e.g. cyclo...
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JP2001502297A |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, antifungal, and for the treatment of cancer. The invention further provides a formulation for admi...
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JP2001502298A |
(57) [Summary] The present invention provides intermediates and methods useful for the production of cryptophycin compounds.
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JP3135659B2 |
PURPOSE: To simply obtain perfluoro-oxyaziridines in high yield which are useful in the preparation of perfluoroaminoether polymers, nitrones, etc., by reacting a specific perfluoroimine with an aromatic peroxyacid in an aprotic solvent ...
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JP3135660B2 |
PURPOSE: To obtain the compound useful as raw materials for polymers with excellent chemical inactivity and thermal stability by specific perfluoroimine and perfluoroalkyl-fluoroformyl peroxides to react with each other. CONSTITUTION: Pe...
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JP2001501916A |
Oxadiazines of formula (I), wherein R<1> is F, Cl or fluoralkoxy and R<2> is alkyl, are prepared by reacting hydrazine derivatives of formula (II) with a dialkoxymethane in the presence of a protic acid catalyst in an inert solvent under...
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JP3132167B2 |
PURPOSE: To obtain a depsipeptide derivative having anthelmintic action at a low cost in high yield by carrying out the polycondensation of a condensation product of an amino acid and an α-chloropropionic acid ester and subjecting the p...
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JP2001500853A |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering th...
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JP2001500496A |
This invention provides a process for preparing diastereomerically pure cryptophycin compounds.
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JP2001500484A |
PCT No. PCT/US97/14800 Sec. 371 Date Feb. 25, 1998 Sec. 102(e) Date Feb. 25, 1998 PCT Filed Aug. 25, 1997 PCT Pub. No. WO98/08812 PCT Pub. Date Mar. 5, 1998This invention provides processes for preparing cryptophycin compounds and novel ...
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JP2001500128A |
This invention provides novel cryptophycin compounds and a process for preparing cryptophycin compounds.
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JP3121355B2 |
The present invention relates to compounds of the formula Orosco wherein R1, R2, R3, X, Y and the dashed line are defined as in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and...
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JP2000516596A |
Pharmacophore models of VLA-4 inhibitors, methods of identifying novel inhibitors and novel inhibitors identified by these methods.
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JP2000319249A |
To obtain a new compound useful as a medicine for treating or preventing virus infection, especially cytomegalovirus infection. A compound of formula I [R1 is H, a (substituted) 6 to 10C aryl, (five to ten-membered aromatic heterogeneous...
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JP2000302676A |
To obtain a medicinal composition capable of protecting and preventing a mitochondoria genome and/or mitochondoria from being damaged by including a specific hydroximic acid derivative as an active ingredient. This medicinal composition ...
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JP3104142B2 |
PURPOSE: To obtain a new benzamide derivative useful as a therapeutic agent for digestive system diseases, having accentuating action on function of digestive tubes and anti-vomiting action. CONSTITUTION: A compound of formula I (R1 is H...
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JP2000290268A |
To selectively obtain a polyisocyanate having excellent reactivity and high compatibility with polyols and solvents, etc., by reacting a polycyclic aliphatic polyisocyanate with carbon dioxide gas using a specific t-phosphine. A polyisoc...
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JP2000290269A |
To selectively obtain a polyisocyanate having excellent reactivity and high compatibility with polyols and solvents, etc., by reacting a polycyclic aliphatic polyisocyanate with carbon dioxide gas using a specific pyridine compound. A po...
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JP2000248043A |
To obtain a polyisocyanate composition excellent in reactivity at low temperature, also good in preservation stability and useful as a raw material for various kinds of polyurethanes by including a specific diisocyanate and a specified p...
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JP2000248045A |
To obtain a polyisocyanate composition excellent in reactivity at low temperature, also good in preservation stability, and useful as a raw material for various polyurethanes by including a specific diisocyanate and a specified polyisocy...
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JP2000510820A |
The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
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JP2000508630A |
PCT No. PCT/EP97/01325 Sec. 371 Date Sep. 18, 1998 Sec. 102(e) Date Sep. 18, 1998 PCT Filed Mar. 17, 1997 PCT Pub. No. WO97/36883 PCT Pub. Date Oct. 9, 1997The invention relates to novel (1,3,4)-oxadiazine derivatives of formula (I), to ...
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JP3061863B2 |
This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating Actinoplanes sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocyli...
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JP2000507805A |
Methods for producing cryptophycin compounds by bacterial fermentation are disclosed, together with novel compositions produced thereby.
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JP2000505473A |
(57) [Summary] The present invention provides novel cryptophycin compounds that may be useful in disrupting the microtubule system as antitumor agents and for treating cancer. The present invention further provides a preparation for admi...
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JP2000502351A |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the...
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JP3014146B2 |
The present invention provides an efficient process of reacting a bis-indolyl acid of the Formula (II): (II) wherein R1 is a hydrogen or C1-C4 alkyl and R, X, and Y are optional substitutions; to produce a bis-indolyloxallic acid of the ...
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JP2000502050A |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
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JP3011955B2 |
New heterocyclic compounds of formula I In which Het means one of following groups; wherein R11, R13 and R14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, -CH=CH-, or -CH2-CH2-...
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JP2000501067A |
Methods for producing cryptophycin compounds by bacterial fermentation are disclosed, together with novel compositions produced thereby.
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JP3003940B2 |
A process is provided for the preparation of Mn(II) chelates for use as contrast agents in magnetic resonance imaging, said process comprising reacting insoluble manganese (II) oxide with an aqueous suspension comprising a molar equivale...
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JPH11322728A |
To obtain a heterocyclic compound useful for physiologically active substances such as agrochemicals and drugs under mild conditions with ease in a high yield, by applying an amide compound as a starting substance. An amide compound of f...
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JPH11322593A |
To obtain an anticancer agent having an inhibitory activity of the propagation of cancer cells and an inhibitory activity of tubuline by including a specific acetamide derivative. This anticancer agent and tubuline inhibitor contain usua...
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JPH11510831A |
A water-containing composition containing a linear aminoplast-ether copolymer of the formula: I. where the divalent R01 contains a divalent alkyleneoxy containing moiety, Amp is the skeletal residue of an aminoplast, R is hydrogen, alkyl...
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JPH11199570A |
To obtain a new heterocyclic compound having a specified nitrogenous cyclic group and low toxicity, capable of manifesting excellent neurodegeneration inhibitory action and intraencephatic migration and useful for the treatment and preve...
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JPH11508248A |
Compounds of the formula I in which Z is -CO-NHNH2, COOH, COCl, CONHNHCOR4 or CON=C(R4)NMe2 are intermediates for the preparation of compounds of the formula I in which Z is a group a) or b) or c) or d) The end compounds can be used for ...
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JPH11507641A |
The invention relates to multidentate metal complexes having formula (I) wherein M is Fe, In, Ga or Al; the dashed lines represent independently a sigle or a double bond; the hatched lines represent coordination to the metal cation (M); ...
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JPH11507636A |
A cryptophycin compound is provided having the structure: Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins ...
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JPH11171897A |
To obtain the subject new peptide comprising a cyclic depsipeptide having a specific amino acid sequence, having strong cardiotonic effect, antiarrhythmic action and vasodilation action, free from adverse effect of arrhythmia, etc., and ...
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JP2909097B2 |
Herbicidal N-isopropylheteroaryloxyacetanilides of the formula (I) in which A stands for nitrogen or the group C-R3 where R3 stands for halogen, cyano, alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, alkylthio, halogenoalkylthio, alkylsulp...
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JP2874342B2 |
A compound represented by general formula (I) or a salt thereof, excellent in parasiticidal activity as an enthelmintic for animal and man, wherein A represents benzyl which is appropriately substituted or phenyl which may be appropriate...
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JP2873894B2 |
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JPH1149755A |
To obtain a new compound useful for an insecticidal composition without practically damaging helpful insects, circumstances, etc., manifesting low toxicity, strongly exhibiting drug action on drug resistant insects. This compound is expr...
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JPH11500717A |
The application relates to novel heterocycloalkenes, to a number of processes for their preparation and to their use as fungicide.
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JPH10332591A |
To eliminate that a luminescence characteristic is sharply influenced by the pH value of a sample by a method wherein a diaza-cryptand by a specific formula is used as a compound luminophore-ionophore. A diaza-cryptand by a formula is a ...
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JPH10330359A |
To obtain a new compound that has higher herbicidal ability against weeds with higher stability tan the conventional. This new compound is a phenylacetylene derivative represented by formula I [X is H, a halogen, a 1-6C alkyl, a haloalky...
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JP2832473B2 |
A novel process for the preparation of modified, isocyanurate-containing polyisocyanates containing aliphatically and/or cycloaliphatically bonded isocyanate groups involves the chemical modification of some of the isocyanate groups of o...
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JP2833766B2 |
There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents b...
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JPH10512868A |
PCT No. PCT/EP96/00069 Sec. 371 Date Jul. 16, 1997 Sec. 102(e) Date Jul. 16, 1997 PCT Filed Jan. 10, 1996 PCT Pub. No. WO96/22983 PCT Pub. Date Aug. 1, 1996The invention relates to novel substituted arylazadioxacycloalkenes, a plurality ...
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