Heterocyclic Compounds

Matches 201 - 250 out of 1,056	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2003/002545A1	PEPTOID COMPOUNDS The invention relates to new peptoid compounds of formula (I), as well as their use in the treatment of bacterial infections, such as those caused by vancomycin resistant microorganisms, and to compositions thereof.
WO/2002/100856A1	MACROCYCLES USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE The present invention are macrocycles of the formula (IX), for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disea...
WO/2002/100399A1	MACROCYCLES USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other dise...
WO/2002/096872A1	SUBSTITUTED IMIDATES AS PESTICIDAL AGENTS The invention relates to novel substituted imidates of formula (I) in which Z, n, X, R?1¿ and R?2¿ have the meanings given in the description, methods for the production and use thereof as pesticidal agents.
WO/2002/094791A1	DIAMIDE INVERTEBRATE PEST CONTROL AGENTS CONTAINING A NON-AROMATIC HETEROCYCLIC RING This invention provides compounds of Formula I, their N-oxides and agriculturally suitable salts wherein A and B are independently O or S; J is an optionally substituted 5- or 6-memebered nonaromatic heterocyclic ring; K is taken togethe...
WO/2002/092656A1	METHOD FOR PRODUCING ALIPHATIC POLYISOCYANATES HAVING AN URETDIONE, ISOCYANURATE AND IMINOOXADIAZINDIONE STRUCTURE The invention relates to a novel method for producing aliphatic polyisocyanates having an uretdione, isocyanurate and iminooxadiazindione structure, isocyanates thus produced and the use thereof for producing polyurethane lacquers and co...
WO/2002/092658A1	METHOD FOR PRODUCING POLYISOCYANATES The invention relates to a novel method for producing polyisocyanates, the products produced therefrom and the use thereof.
WO/2002/085838A1	COPPER-CATALYZED FORMATION OF CARBON-HETEROATOM AND CARBON-CARBON BONDS The present invention relaters to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the ...
WO/2002/074792A1	FO-6979 SUBSTANCES AND PROCESS FOR PRODUCING THE SAME (Beauveria) sp. FO-6979 (FERM BP-6681), which belongs to the genus Beauveria and is capable of producing FO-6979-M0, -M1, -M2, -M3 and -M4 substances, is cultured in a medium to thereby accumulate the FO-6979-M0, -M1, -M2, -M3 and -M4 su...
WO/2002/074296A1	REMEDIES FOR SOLID CANCER CONTAINING HYDROXAMIC ACID DERIVATIVES AS THE ACTIVE INGREDIENT Preventives and/or remedies for solid cancer which contain as the active ingredient hydroxamic acid derivatives represented by the following general formula (I): wherein each symbol is as defined in the description; non-toxic salts there...
WO/2002/068586A2	HIV/FIV PROTEASE INHIBITORS With the help of X-ray structural analyses of drug-resistant HIV proteases and molecular modeling, a new type of inhibitor with a small P3 residue has been developed. These inhibitors are effective against HIV and its drug-resistant muta...
WO/2002/066048A1	CRYSTAL MODIFICATION OF A CYCLIC DEPSIPEPTIDE HAVING IMPROVED STRENGTH The invention relates to the use of crystal modification (I) of a cyclic depsipeptide of formula (I) for producing medicaments, particularly for combating endoparasites.
WO/2002/047762A1	SERINE PROTEASE INHIBITORS Compounds of Formula I where R¿5?, R¿6a?, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as anti-inflammatory agents.
WO/2002/046167A1	BENZYL (IDENE)-LACTAMS AND THEIR USE AS 5HT1-RECEPTOR LIGANDS The present invention relates to compounds of the formula I wherein 1) Y is a bridge containing bridging heteroatoms and to their medicinal use; 2) As serotonin 1 (5-HT¿1?) receptor ligands, particularly in psychotherapeutic agents.
WO/2002/044187A2	CYCLIC SALEN-METAL COMPOUNDS AS SCAVENGERS FOR OXYGEN RADICALS AND USEFUL AS ANTIOXIDANTS IN THE TREATMENT AND PREVENTION OF DISEASES This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase activity and methods of using such antioxidan...
WO/2002/028845A1	3-THIOXO-[1,2,4]-OXADIAZINAN-5-ONE AND THEIR USE AS ANTI-ANTHEROSCLEROTIC AGENTS This invention relates to 3/thioxo/[1,2,4]-oxadiazinan-5-one derivatives of formula: (I), wherein R is alkyl, alkenyl, or alkynyl; R¿1? and R¿2? are each independently hydrogen, alkyl, or aryl; and Ar is phenyl, indanyl, benzhydryl, or...
WO/2002/026724A1	CYCLIZED BENZAMIDE NEUROKININ ANTAGONISTS FOR USE IN THERAPY A compound having general formula (I) and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds. The compounds are Neurokinin 1 (NK¿1?) receptor antagonists and are useful...
WO/2002/024709A2	BICYCLODERIVATIVES AS HERBICIDES Compounds of formula (I), wherein R¿0? is C¿1?-C¿4?alkyl; n¿0? is 0 or from 1 to 8; X is oxygen or sulfur; and Q is a group Q1, Q2, Q3, Q4 or Q5, wherein R¿1? is hydrogen, fluorine, chlorine, bromine or methyl; R¿2? is hydrogen, C�...
WO/2002/024704A1	NOVEL HERBICIDES Compounds of formula (I), in which R¿0? is C¿1?-C¿4?alkyl; n¿0? is O or from 1 to 8; X and Y independently of one another are oxygen or sulphur, and Q is a group Q1, Q2, Q3, Q4, Q4 or Q5 where R¿1? is hydrogen, fluorine, chlorine, b...
WO/2002/020531A2	METHOD FOR PRODUCING ANELLATED TETRAHYDRO-[1H]-TRIAZOLES The invention relates to a method for producing anellated tetrahydro-[1H]-triazoles of formula I wherein the variables R?a¿, Z, Z?1¿, X, W, n and Q have the designations cited in patent claim 1, by cyclising compounds of general formul...
WO/2002/012207A1	CYCLIC OXYGUANIDINE PROTEASE INHIBITORS Cyclic oxyguanidine compounds, including compounds of Formulae (I and II), wherein R?1¿, R?3¿-R?6¿, R?21¿-R?26¿, L, Y, Z, and A are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts t...
WO/2002/004432A1	METHOD FOR PRODUCING 2-ALKYL-3-ARYL- AND -HETEROARYLOXAZIRIDINES AND NOVEL 2-ALKYL-3-ARYLOXAZIRIDINES According to the invention, 2-alkyl-3-aryl- or -heteroaryloxaziridines can be produced particularly advantageously by oxidising suitable N-alkyl-aryl- or -heteroarylaldimines with an aromatic percarboxylic acid or its salt in the presenc...
WO/2002/002541A2	INHIBITORS OF COPPER-CONTAINING AMINE OXIDASES The present invention is directed to 1,3,4-oxadiazine compounds that function as inhibitors of copper-containg amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adh...
WO/2002/002090A2	INHIBITORS OF COPPER-CONTAINING AMINE OXIDASES The present invention is directed to hydrazino compounds that functions as inhibitors of copper-containing amine oxidases commonly known as semicarbazidesensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion...
WO/2001/096305A1	SERINE PROTEASE INHIBITORS Compounds of formula (I) where R¿5?, R¿6a?, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.
WO/2001/081325A2	MACROCYCLIC NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS COMPRISING ALKYL AND ARYL ALANINE P2 MOIETIES The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprisin...
WO/2001/077089A1	NEW NEUROKININ ANTAGONISTS FOR USE AS MEDICAMENTS A compound having the general formula (I) and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.
WO/2001/072696A1	ARTHROPODICIDAL CARBOXANILIDES Compounds of Formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful as arthropodicides wherein A is H; E is H or C¿1?-C¿3? alkyl; or A and E can be taken together to form -CH¿2?-, -CH¿2?CH¿...
WO/2001/070674A1	PROPENECARBOXYLIC ACID AMIDOXIME DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof....
WO/2001/044238A1	PYRAZOLYL BENZYL ETHERS The invention relates to novel pyrazolyl benzyl ethers of general formula (I), a method for producing the same and the use thereof for combating harmful organisms.
WO/2001/044226A1	SERINE PROTEASE INHIBITORS Compounds of formula (I) where R¿5?, R¿6a?, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.
WO/2001/036399A1	AZADIOXACYCLOALKENES The invention relates to azadioxacycloalkenes of general formula (I), in which R?1¿, R?2¿, R?3¿, R?4¿, X, n and the bridging unit W have the meanings given in claim 1. The invention furthermore relates to agents for the treatment of ...
WO/2001/025222A1	METHOD FOR PRODUCING 3-ALKYL-N-NITRO-4H-1,3,5-OXADIAZINE-4-IMINES The invention relates to a method for producing 3-alkyl-N-nitro-4H-1,3,5-oxadiazine-4-imines; whereby a) nitric acid is neutralised using an alkyl amine R-NH¿2? in an aqueous solution at a temperature of between - 10 and + 50 °C and th...
WO/2001/025235A1	MACROCYCLIC QUINAZOLINONES AND THEIR USE AS LOCAL ANESTHETICS Compounds of formula (I) modulate voltage-gated sodium channels and are useful as local anesthetics
WO/2001/025234A1	QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS This invention is directed to novel anesthetic compounds, preferably of formula (Ia), pharmaceutical composition containing these compounds, methods of use and methods for preparing these compounds.
WO/2001/023067A1	POLYAMIDE-CONTAINING LIGANDS COVALENTLY BONDED TO SUPPORTS, POLYAMIDE-CONTAINING RESINS, AND METHODS FOR REMOVING METALS FROM SOLUTIONS Compositions and methods for selectively binding metal ions from source solutions are disclosed. The compositions include 1) polyamide-containing ligands covalently bonded to a particulate solid support, and 2) polyamide-containing polym...
WO/2001/021583A1	HYDROXAMIC ACID DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT Hydroxamic acid derivatives represented by general formula (I), nontoxic salts thereof or prodrugs of the same (wherein each symbol is as defined in the description). Because of inhibiting the production of IL-6, the compounds of the gen...
WO/2001/014346A1	MACROCYCLIC COMPOUNDS AND PREPARATION METHODS THEREOF The present invention is directed to a macrocyclic compounds of formula (I), wherein Q, X, R¿1? and R¿5? are as defined herein. Compounds of the invention are useful for therapeutic and prophylactic treatment of bacterial infection in ...
WO/2001/007029A2	SUBSTITUTED GUANIDINES AND THE USE THEREOF A method for the treatment of cancer and pain in an animal subject is disclosed, comprising administering to said animal in need of such treatment an effective amount of a compound of formula (I), wherein R?1¿-R?6¿ are defined herein. ...
WO/2001/000601A1	NOVEL 4-(2-OXODIHYDROOXADIAZINYLPHENYL)AMIDES AND THE USE THEREOF FOR TREATING ANEMIA The invention relates to the area of erythropoiesis, in particular to 4-(2-oxodihydrooxadiazinylphenyl)amides of general formula (I), to methods for producing them and to their use as medicaments, preferably for preventing and/or treatin...
WO/2001/000600A1	N-SUBSTITUTED PERHYDRO DIAZINE The invention relates to N-substituted perhydro-2, 3-diazine of formula (I), wherein the variables Z, R, m and R?A¿ correspond to the definitions given in claim 1. The invention also relates to a method for the production of N-substitut...
WO/2001/000602A1	SUBSTITUTED UREAS The invention relates to substituted ureas of general formula (Ia) and (Ib), wherein variables X, Z, m, R and R?A¿ have the meaning cited in claim 1 and Q represents one of radicals Q1 to Q6: (Q-1), (Q-2), (Q-3), (Q-4), (Q-5), (Q-6), wh...
WO/2000/076985A1	CYCLO-IMINO DEPSIPEPTIDES AND THEIR UTILIZATION IN CONTROLLING ENDOPARASITES The invention relates to cyclo-imino depsipeptides of formula (I), especially 24-membered cyclo-imino depsipeptides. The invention also relates to methods for their preparation and to their utilization in controlling endoparasites.
WO/2000/063195A1	NOVEL HETEROCYCLIC AMINO CARBONYL DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The current invention discloses novel heterocyclic amino carbonyl derivatives useful as nitric oxide synthase inhibitors
WO/2000/046184A1	N?2¿-PHENYLAMIDINE DERIVATIVES The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R?1¿ is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R?2¿ and R?3¿, which may be the same or...
WO/2000/042039A1	AZADIOXACYCLOALKENES AND THEIR USE FOR COMBATING HARMFUL FUNGI AND ANIMAL PESTS The invention relates to azadioxacycloalkenes of formula (I), in which the substituents and the index have the following meanings; Y represents N or CR?a¿, whereby R?a¿ represents H, halogen or alkyl; n equals 0, 1, 2, 3 or 4, whereby ...
WO/2000/034252A2	PROCESS FOR THE PREPARATION OF CRYPTOPHYCIN DERIVATIVES Processes for the preparation of Cryptophycins of the formula (II), wherein G is (C¿1?-C¿12?) alkyl, (C¿2?-C¿12?) alkenyl, (C¿2?-C¿12?) alkynyl, or Ar; R?1¿ is halogen and R?2¿ is OH or glycinate ester; or R?1¿ or R?2¿ may be t...
WO/2000/034253A2	INTERMEDIATES AND REACTION SEQUENCE TO PRODUCE SAID INTERMEDIATES USEFUL FOR THE PREPARATION OF ANTINEOPLASTIC AND ANTIFUNGAL CRYPTOPHYCIN DERIVATIVES A process for preparing a compound of the formula (I) wherein G is (C¿1?-C¿12?) alkyl, (C¿2?-C¿12?) alkenyl, (C¿2?-C¿12?) alkynyl, or Ar; Ar is an aromatic or heteroaromatic group or a substituted aromatic or heteroaromatic group; ...
WO/2000/027795A1	TRANSFECTION REAGENTS Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having general structure (A).
WO/2000/027814A1	AVIDIN DERIVATIVES AND USES THEREOF A covalent conjugate of a 4'-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of formula (I), wherein A is (CH¿2?)¿n? or -CH=CH-, wherein n is an integer from 0-10; B is (CH¿2?)¿n? wherein n is an in...

Matches 201 - 250 out of 1,056	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >