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Matches 301 - 350 out of 1,363

Document Document Title
WO/1998/051665A2
This invention relates to macrocyclic molecules of formula (I) which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). The present invention also relates to pharmaceutical compositions ...  
WO/1998/046581A1
A composition for providing a synergistic treatment for cancer comprising a compound selected from the group consisting of Compound I, Compound II, Compound III, Compound IV, Compound V or a related cryptophycin compound and one or more ...  
WO/1998/045397A1
Novel bleaches, a method for bleaching substrates using these materials and bleaching compositions containing same are reported. The bleaches are N-acyl oxaziridines. Substrates such as fabrics may be bleached in an aqueous solution cont...  
WO/1998/045289A1
The invention concerns novel methoximinomethyldioxazines of formula (I), a plurality of processes for their preparation, and their use as fungicides, as well as novel intermediate products and a process for their preparation.  
WO/1998/043965A1
The invention relates to cyclic thiodepsipeptides, especially 18 to 24-link cyclothiodepsipeptides, cyclic thiodepsipeptides and their salts. These cyclic thiodepsipeptides are of general formula (I), wherein R?1�, R?4�, R?7� and R...  
WO/1998/040365A1
The invention relates to novel alkoximinomethyldioxazine derivatives of formula (I), a method for the production and the use thereof as fungicides, in addition to novel intermediate products and several methods for the production thereof.  
WO/1998/038178A1
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the...  
WO1998024877A3
Novel bleaches, a method for bleaching substrates using these materials and detergent compositions containing same are reported. The bleaches are thiadiazole dioxide derived mono- and di-oxaziridines. Substrates such as fabrics may be bl...  
WO/1998/031682A1
The invention concerns 4-(3-heterocyclyl-1-benzoyl)pyrazoles of formula (I) in which the variables have the following meanings: R?1�, R?3�: hydrogen, nitro, halogen, cyano, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio, alkyl...  
WO/1998/031681A1
The invention concerns benzoyl derivatives of formula (I) in which the variables have the following meanings: R?1�, R?2�: hydrogen, nitro, halogen, cyano, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio, alkylthio halide, alkyl...  
WO/1998/030551A1
Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting comp...  
WO/1998/024877A2
Novel bleaches, a method for bleaching substrates using these materials and detergent compositions containing same are reported. The bleaches are thiadiazole dioxide derived mono- and di-oxaziridines. Substrates such as fabrics may be bl...  
WO1998016503A3  
WO/1998/017653A1
The invention relates to novel oxime derivatives of formula (I) , in which A stands for alkadiyl, Ar for optionally substituted aryls or heteroaryls respectively, G for a single bond, optionally an alkandiyl interrupted by heteroatoms (i...  
WO/1998/017617A1
The use of a fluorocompound comprising a perfluoropolyoxyalkyl/alkylene chain with an average molecular weight of not less than 800 and an atomic group of a cyclic/noncyclic polyether as a low-scattering lubricant/surface modifier (such ...  
WO1998009601A3  
WO/1998/016503A2
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-$g(a) converting enzyme (TACE, tumor necrosis fa...  
WO/1998/015523A1
An industrially excellent alternative process for producing cyclodepsipeptide derivatives, as represented in formula (1), having an excellent vermicidal activity as an animal and human anthelmintic, wherein R�1? represents hydrogen or ...  
WO/1998/014433A1
Compounds of the formula (I) wherein R?1� is a group of formula G?1�, G?2�, G?3�, G?4�, G?5�, G?6� or G?7�; Y is an optionally substituted (C�1?-C�4?) heteroalkyl bridge that, together with the atoms to which it is at...  
WO/1998/009955A1
This invention provides intermediates and processes useful for the preparation of crytophycin compounds.  
WO/1998/009988A1
This invention provides a process for preparing diastereomerically pure cryptophycin compounds.  
WO/1998/009601A2
This invention provides novel cryptophycin compounds and a process for preparing cryptophycin compounds.  
WO/1998/008829A1
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering th...  
WO/1998/008506A1
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, antifungal, and for the treatment of cancer. The invention further provides a formulation for admi...  
WO/1998/008505A1
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering th...  
WO/1998/008812A1
This invention provides processes for preparing cryptophycin compounds and novel intermediates which are useful in such processes.  
WO/1998/006710A1
Compounds of formula (I), in which A is a substituted or unsubstituted heterocyclyl group; -E-R is -C(=O)-R, -C(=O)O-R, -C(=O)N(R�1?)-R, -C(=O)C(=O)-R, -C(=O)C(=O)O-R, -C(=O)C(=O)N(R�1?)-R or -C(=S)N(R�1?)-R; R is hydrogen or a sub...  
WO/1998/006709A1
The present invention relates to a cyclic urea or thiourea compound comprising (i) a group of formula (I') wherein Q?1� represents an aromatic ring group which may optionally be substituted; and R?1� and R?2� are the same or differ...  
WO/1998/005655A1
Substance PF1022G, a novel cyclodepsipeptide represented by formula (D), is produced together with known cyclodepsipeptides, i.e., Substances PF1022F and PF1022H by culturing a bacterium which produces the Substances PF1022F, PF1022G and...  
WO/1998/005656A1
Oxadiazines of formula (I), wherein R?1� is F, Cl or fluoralkoxy and R?2� is alkyl, are prepared by reacting hydrazine derivatives of formula (II) with a dialkoxymethane in the presence of a protic acid catalyst in an inert solvent u...  
WO/1998/004247A1
The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds...  
WO/1998/004247A2
The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds...  
WO/1998/004913A1
Pharmacophore models of VLA-4 inhibitors, methods of identifying novel inhibitors and novel inhibitors identified by these methods.  
WO/1998/002501A1
The present invention provides a method for scavenging sulfyhydryl compounds from sour hydrocarbon substrates, preferably crude oils, refined distillate streams, and natural gas, by mixing said substrates with preferably substantially wa...  
WO/1997/046542A1
The invention concerns a plurality of novel processes and novel intermediate products for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines which are known (WO-A-95/04728) as initial products for preparing compounds having fungi...  
WO/1997/036883A1
The invention concerns novel (1,3,4)-oxadiazine derivatives of formula (I) in which: R1 and R2, independently of each other, stand for hydrogen, or for alkyl, hydroxylalkyl, alkanoyloxyalkyl, alkoxyalkyl, arylalkoxyalkyl, mercaptoalkyl, ...  
WO/1997/032844A1
The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.  
WO/1997/031632A1
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the...  
WO/1997/027189A1
Compounds of formula (I) in which: A is for alkanediyl optionally substituted as necessary; R stands for cycloalkyl, aryl or benzo condensed heterocyclyl, each of this group optionally being substituted; E stands for -CH= or nitrogen; Q ...  
WO1997018207A3  
WO/1997/023211A1
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering the...  
WO/1997/020945A1
The invention relates to a new process for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms of the formula (I), in which R1, R2, R3, R4 have the meanings given in the description, with the ...  
WO/1997/018207A2
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...  
WO/1997/017322A1
Disclosed are "acid-amide" calixarenes of formula (I) wherein: L is [-CH2-] or [-O-CH2-O-] and may be the same or different between each aryl group; R5 is H, halogen, or C1-C10 aliphatic hydrocarbyl group, C6-C20 aryl group, C6-C20 hydro...  
WO/1997/013504A1
The invention refers to pharmaceutical compositions suitable for the protection of the mitochondrial genome and/or mitochondrium from damages or for the treatment of diseases connected with such damages, said compositions comprising a hy...  
WO/1997/011071A1
A compound of formula (I), wherein R1 and R2 independently are hydrogen, halogen, trifluoromethyl, hydroxy, C1-6-alkyl or C1-6-alkoxy; and R3 is hydrogen or C1-3-alkyl; and A is C1-3-alkylene; and Y is >CH-CH2-, >C=CH-, >CH-O-, >C=N-, >N...  
WO/1997/011064A1
Novel PF1022 derivatives which are cyclic depsipeptides represented by general formula (I) or their salts are useful as a vermicide in the prevention or treatment of vermination.  
WO/1997/007798A1
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, antifungal, and for the treatment of cancer. The invention further provides a formulation for admin...  
WO/1997/008334A1
Methods for producing cryptophycin compounds by bacterial fermentation are disclosed, together with novel compositions produced thereby.  
WO/1997/002256A1
A novel industrial process for producing an anthelmintic depsipeptide derivative represented by structural formula (I), which is excellent in the yield etc.  

Matches 301 - 350 out of 1,363