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Matches 401 - 450 out of 1,055

Document Document Title
JP2022528950A
The present invention relates to a novel compound having anticancer activity and a method for producing the same, and more particularly to a novel compound which suppresses the expression of AIMP2-DX2 and exhibits excellent anticancer ac...  
JP2022078213A
To provide membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disor...  
JP7037597B2
The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and ...  
JP6930923B2
A process for preparing (E)-(5,6-dihydro-l,4,2-dioxazin-3-yl)(2- hydroxyphenyl)methanone O-methyl oxime is described which includes: (i) reacting benzofuran-3(2H)-one O-methyl oxime (1) with at least one nitrite selected from n-butyl nit...  
JP2020529439A
In the present invention, the dihydrooxydiajinone compound of the general formula (I): (In the formula, R1, R2, R3And R4As defined herein), methods of preparing compounds, intermediate compounds useful for preparing compounds, pharmaceut...  
JP6746802B2
It is an object of the present invention to provide a novel and advantageous process for commercially preparing of indoxacarb which is racemic or enantiomerically enriched at chiral center from its amide precursor using a new catalytic s...  
JP6746614B2
The present invention provides a urea compound or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be abbreviated as FPRL1) agonist effect, a pharmaceutical composition containing the...  
JP6636031B2
and salts thereof and compositions and uses thereof. The compounds are useful as inhibitors of LSD1. Also included are pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and meth...  
JP2020500186A
Chemoselective conjugation is achieved through redox reactivity by reacting an N-transfer oxidant with a thioether substrate to form a conjugate product in a redox reaction in an aqueous environment. In the embodiment, it is a redox acti...  
JP6586416B2
The present invention relates to macrocyclic amidinourea derivatives of formula 8, methods of preparation and uses thereof, pharmaceutical compositions in particular to be used as chitinase inhibitors in the treatment of a fungal infection.  
JP6581559B2
The invention relates to a photopolymer formulation comprising matrix polymers, writing monomers, and photoinitiators, to the use of the photopolymer formulation for producing optical elements, in particular for producing holographic ele...  
JP6475301B2
The present invention relates to a polyisocyanate composition comprising, on the basis of the total mass of the polyisocyanate composition, 97 weight % or more of a polyisocyanate, and 2.0 mass ppm or more and 1.0×10mass ppm or less of ...  
JP6464970B2  
JP6461113B2
The present invention relates to macrocydic urea derivatives of the formula I (I) in which R1, R2, R3, V and Y are as defined below. The compounds of the formula I are inhibitors of the enzyme TAFIa (activated thrombin-activatable fibrin...  
JP2018531894A
The present invention is a method for modifying an isocyanate in which at least one organic isocyanate having an NCO functional value of more than 1 is oligomerized in the presence of at least one catalyst, wherein the catalyst is an iso...  
JP2018517762A
The present invention is an antibody-or peptide-drug conjugate compound in which one or more cryptophycin derivatives (macrocyclic depsipeptides) are covalently linked by a self-destructive linker that binds to one or more tumor-related ...  
JP2018513118A
The present invention inhibits cyclic compounds of formula (I), as well as programmed cell death 1 (PD-1) signaling pathways and / or is induced by PD-1, PD-L1 or PD-L2. With respect to the use of the compound for the treatment of disord...  
JP6177768B2
The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.  
JP6174600B2
Present invention refers to complex-forming compounds of the general formula and the use and preparation thereof.  
JP6148006B2
The present invention discloses new catalyst systems based on complexes of divalent metals supported by chelating phenoxy ligands for immortal ring-opening polymerisation of cyclic esters and cyclic carbonates.  
JP6111276B2
The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I ar...  
JP2017031058A
To provide a novel cyclic depsipeptide derivative and a pest control agent comprising the same.The present invention provides a cyclic depsipeptide derivative represented by formula (1) or a stereoisomer thereof, and a pest control agent...  
JP6068505B2
The invention relates to a compound of formula (I) wherein A, B, D and R1 to R6 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.  
JP6058482B2
To provide: a novel cyclic macromonomer which may polymerize with another polymerizable monomer to form a crosslinked polymer excellent in mechanical and swelling properties; a crosslinked polymer having a structural unit originating fro...  
JP2016536372A
The present invention provides a method of using a compound and its medicine constituent, or a tablet of a useful new creatine analog and the present invention, and treating and preventing creatine deficiency, in order to treat arbitrary...  
JP2016529240A
The present invention is a method for producing a polyisocyanate containing an iminooxadiazinedione group, wherein at least one monomeric di- and / or tri-isocyanate is a) at least one catalyst, b) 18 ° C ~. The present invention relate...  
JP5856924B2
A polyester film including a cyclic carbodiimide compound represented by the following Formula (O-1) has good film thickness uniformity without increase in viscosity. R1 and R5 represent an alkyl group, an aryl group, or an alkoxy group;...  
JP5826150B2  
JP5826149B2  
JP5806926B2  
JP5782586B2
Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especia...  
JP5779787B2
The present invention relates firstly to the discovery of the previously unknown 24-membered cyclooctadepsipeptides PF1022-V, PF1022-W, XRB-C894, XRB-C942, XRB-C976, XRB-C1010, XRB-C1044, XRB-E922, XRB-E956, XRB-E990, XRB-E1024, XRB-S958...  
JP2015147792A
To provide novel spiro condensed heterocyclic compound having β-secretase enzyme (BACE) inhibitory activity and being effective in treatment of BACE mediated disorders such as Alzheimer's disease, cognitive impairment, Down's Syndrome, ...  
JP5730835B2  
JP5733632B2
The present application relates to novel alkylcarboxylic acids having an oxo-substituted azaheterocyclic partial structure, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their us...  
JP5731414B2
The present invention is directed to a compound represented by the following structural formula or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and method of use of the compounds are also described.  
JP5722555B2
To provide a cyclic carbodiimide compound useful as a terminal blocking agent for a polymer compound.The cyclic carbodiimide compound is represented by formula (i) (in the formula, X represents a specific divalent group or a specific qua...  
JP5722557B2  
JP5701832B2
The present invention provides a method represented by Scheme 1: wherein X represents I, Br, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents hydrogen or a negative charg...  
JP5669124B2  
JP5637950B2  
JP5612317B2
To provide a resin material preventing a liberation of an isocyanate group-containing compound, having an advantageous working environment and an excellent hydrolysis resistance, and applying a small amount of burden on the environment. ...  
JP5564488B2
The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use ...  
JP5529407B2  
JP5531011B2
The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary preventio...  
JP5503149B2
A bifunctional polyazamacrocyclic chelating agent of the formula (I): wherein: and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above ...  
JP5508076B2
To provide a curing agent capable of efficiently curing an aqueous resin containing a carboxyl group or an organic solvent resin.The curing agent comprises a carbodiimide compound (B) represented by the general formula as a curing compon...  
JP5484356B2  
JP5468867B2
To provide a polyester-based fiber which is improved in abrasion resistance and hydrolysis resistance and further has no smell caused by a free isocyanate compound in operation, melting, or the like; and to provide a polyester compositio...  
JP5451453B2  

Matches 401 - 450 out of 1,055